• The Journal of the Petrological Society of Korea
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• v.26 no.1
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• pp.13-43
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• 2017

In the Hapcheon area, hypersthene-bearing monzonite (mangerite) and syenite are recognized. The main minerals of syenite are alkali feldspar, plagioclase, amphibole, biotite, and quartz. Anhedral hornblende and biotite are interstitial between feldspar and quartz, indicating that the hydrous minerals were crystallized later on. Based on petrochemical studies of major elements, syenite is alkaline series, metaluminous, and I-type. The variation patterns in the trace and rare earth elements of mangerite and syenite show the features of subduction-related igneous rock such as depletion of HFSE, relative enrichment in LILE to LREE, and negative Nb-P-Ti anomalies. Based on the experimental data and petrographic characteristics of the syenite, Hapcheon syenitic magma is considered to be formed by partial melting in a dry system. SHRIMP U-Pb zircon data yield the Triassic age as $227.4{\pm}1.4Ma$ in mangerite, $215.3{\pm}1.2Ma$ in syenite, and $217.9{\pm}2.6Ma$ in coarse-grained syenite, respectively. The mangerite age is similar to those of post-collisional plutonic rocks in Hongseong (226~233 Ma), Yangpyeong (227~231 Ma), and Odaesan (231~234 Ma) areas in the Gyeonggi Massif. Syenites were intruded after about 10 Ma. The features seen in the mangereite and syenite rocks can be explained by models such as the continental collision and slab break-off and the lithosphere thinning and asthenosphere upwelling model.

• Journal of the Mineralogical Society of Korea
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• v.32 no.1
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• pp.15-39
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• 2019

An ultramafic complex occurs as an isolated lenticular body in the Andong area. The Andong ultramafic complex comprises ultramafic and mafic rocks, but mainly peridotites. The complex extends for several kilometer to ENE direction, adjacent to the Andong fault line. This study is for petrochemistry of the peridotites within the ultramafic complex and characteristics of asbestos occurrences. The peridotites are igneous origin, ranging from lherzolite to wehrlites and are characterized by high Fo olivine ($Fo_{0.85-0.87}$), Mg clinopyroxene ($Mg_{87.5-93.5}$), and tremolitic to tschermakitic hornblende. Geochemically, these rocks show high magnesium number (mainly Mg = 85.3-87.38) and transitional element and low alkali element contents. The peridotites host asbestos, including chrysotile, tremolite and actinolite asbestos, but dominated by amphibole asbestos. The amphibole asbestos are found along small fault face, and cleavage and fracture showing several cm to ten cm in width as slip and oblique fibers, while the chryostiles occur at cleavage and vein showing several mm-cm in width as cross and slip fibers. They are confirmed by PLM, XRD and SEM results. Overall characteristics of peridotites from the Andong ultramafic complex and occurrences of the asbestos are similar to those of worldwide orogenic related Alpine type ultramafic rocks and serpentinized ultramafic bodies in Chungnam, Korea, respectively.

• The Journal of the Korean bone and joint tumor society
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• v.20 no.1
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• pp.7-13
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• 2014

Purpose: As well as patient survival, the restoration of postoperative function such as ambulation is important in limb salvage operations for treatment of malignant bone tumors involving the proximal femur. The authors analyzed clinical outcomes of limb salvage operations using tumor prostheses for metastatic or primary malignant bone tumors in the proximal femur. Materials and Methods: From February 2005 to January 2014, 20 cases (19 patients) with malignant bone tumor involving the proximal femur with pain or complicated pathologic fracture were treated with segmental resection and limb salvage operations with tumor prostheses. Mean age was 63.1 years (range 35-86). Fourteen patients were male and six ones were female. The mean follow-up period was 20 months (1-94 months). There were 15 cases of metastatic bone tumor, 4 cases of osteosarcoma, and 1 case of multiple myeloma. The primary tumors of the metastatic bone tumors included 4 lung cancers, 3 hepatocellular carcinomas, and 3 renal cell carcinomas. Other primary tumors were breast cancer, thyroid cancer, colon cancer, prostate cancer, and malignant spindle cell tumor, each in 1 case. Modular tumor prostheses were used in all cases; (Kotz's$^{(R)}$ Modular Tumor prosthesis (Howmedica, Rutherford, New Jersey) in 3 cases, MUTARS$^{(R)}$ proximal femur system (Implantcast, Munster, Germany) in 17 cases). Perioperative pain was assessed with Visual Analogue Scales (VAS). Postoperative functional outcome was assessed with Musculoskeletal Tumor Society (MSTS) grading system. Results: Out of 20 cases (19 patients), 11 cases (10 patients) survived at the last follow-up. Average postoperative survival of the 9 deceased patients was 10.1 months (1-38 months). VAS score improved from pre-operative average of 8.40 (5-10) to 1.35 (0-3) after operation. Average postoperative MSTS function score was 19.65 (65.50%, 7-28). The associated complications were 2 local recurrences, 3 hematomas, 3 infections, 2 scrotal swellings, and 1 dislocation. There was no case of periprosthetic fracture or loosening. Conclusion: Limb salvage operation with tumor prosthesis is an appropriate treatment for early pain reduction and functional restoration in malignant bone tumors in the proximal femur with pain an/or complicated pathologic fractures.

• The Journal of the Korean bone and joint tumor society
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• v.9 no.1
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• pp.12-17
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• 2003

Purpose: In this report we are going to discuss about the functional evaluation and the outcome of treatment of metastatic tumor in the lower extremities treated with tumor prosthetic arthroplasty. Materials and Methods: This report is based on nine patients diagnosed as a metastatic tumor and treated by tumor prosthetic arthroplasty, from June 1998 to December 2001. Age of the patients ranged from 49 to 63 with the average of 56.3. The average follow up period was 23.4 months. Two patients had lung cancer, three had breast cancer, two had renal cancer, one colon cancer, and one had multiple myeloma. All these were primary cancers. The site of metastasis were six in proximal femur, two in distal femur, and one in proximal tibia. Tumor excision was performed after biopsy in following the principle of primary tumor management. Excision with wide surgical margin was tried as possible could. Six cases were treated with tumor prosthesis, and the other three cases were reconstructed with bone cement and arthroplasty. Results: The functional evaluation in the extremities at the last follow up was performed on Enneking evaluation score with 6 categories. The highest scored 26, and the lowest scored 10, with an average of 19.5. A case in which the patient died 15 days after the operation was excluded from the evaluation. Among the categories, emotional acceptance to postoperative function and pain relief were highly scored. At the final follow up, seven patients survived, and one colon cancer patient died 68 days after operation. Conclusion: Metastatic tumor occurring in joints of lower extremities could be treated in accordance to the treatment principle of primary tumor. By insertion of tumor prosthesis, we can get satisfactory results of function in the lower extremity and pain relief especially. So, this aspect of medical favor must be considered in treating patients.

• Journal of the Korean Geotechnical Society
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• v.27 no.10
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• pp.35-43
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• 2011

The area to be studied is the place where the main line rail way will be constructed in accordance with the scheduled construction project of Yeongju dam, and is a fold and mylonite zone over several km that is formed by ductile-shearing effect. The ductile shear zone, which has been transformed by faulting for long geological time, shows a complicated geological structure. Due to the recrystallization of mineral caused by transformation in deep underground (>8km), a mylonite zone with lamellar structure has properties distinguished from other fault zones formed by transformation near earth surface <2km). To see the properties of mylonite, this study analyzed the transformation rate of sample rocks and the shape of constriction structure accompanied with transformation. While the transformation of fault zone shows a round oblate, the mylonite zone shows a prolate form. Transformation rate in fault zone was measured to be less than 1.2 compared to the state before transformation while the measured rate in mylonite zone was 2.5 at most. Setting the surface of discontinuity as the base, the unconfined compressive strength of slickenside can be categorized in sedimentary rocks, and a change of strength was observed after water soaking over certain time. Taking into account that the weathering resistance of the rock based on mineral and chemical organization is relatively higher, its engineering properties seems to result from the shattered crack structure by crushing effect. When undertaking tunnel construction in mylonite zone, there should be a special care for the expansion of shattered cracks or the fall of strength by influx of ground water.

• Journal of the Korean Society of Food Science and Nutrition
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• v.38 no.2
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• pp.142-145
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• 2009

The cytotoxic activity against human cancer cells and anti-tumor effect in Balb/c mice of a 70% ethanol extract from masou salmon (MSE) was investigated. The cancer cell lines including human breast adenocarcinoma (MCF-7), human lung carcinoma (A549), human hepatoblastoma (HepG2), human gastric carcinoma (AGS), human cervical adenocarcinoma (HeLa) and transformed primary human embryonal kidney (293) exposed to MSE decreased cell viability as indicated by the MTT assay. The MSE shows significant cytotoxicity on MCF-7, A549, HepG2, AGS and HeLa cells, and are more active than 293 cells. The treatment with 1 mg/mL MSE resulted in 9.2%, 12.7%, 16.6%, and 16.9% cell survival against A549, MCF-7, HepG2, and AGS cells, respectively. Moreover, anticancer effect in vivo of MSE was tested in the animal system using Balb/c mice transplanted sarcoma-180 cells. MSE showed inhibition of tumor growth and the rate of inhibition was 44.7% and 55.7% at the 25 mg/kg body weight and 250 mg/kg body weight, respectively. Thus, we suggest that MSE could be a beneficial material for human cancer prevention.

• The Journal of the Petrological Society of Korea
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• v.19 no.3
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• pp.227-244
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• 2010

Abundant spinel lherzolite xenoliths showing distinctively different textural types such as protogranular, porphyroclastic, and mylonitic texture are trapped in the basaltic rocks from southeastern part of Jeju Island. These xenoliths show the textural spectrum from coarse-grained protogranular through porphyroclastic with bimodal grain size to fine-grained and foliated mylonitic texture. They tend to decrease in grain sizes and show more linear grain boundaries and more frequent triple junctions from protogranular through porphyroclastic to mylonitic. Spinel has different occurrence mode according the textural type. Spinel is always associated with orthopyroxene in protogranular texture, whereas it is scattered and independent of orthopyroxene in mylonitic texture. Additionally, porphyroblast from porphyroclastic and mylonitic textures has internal deformation features such as kink band, undulatory extinction and curved lamella, whereas neoblast is strain-free. These textural features indicate increasing degree of static/dynamic recrystallization from protogranular through porphyroclastic to mylonitic texture. The mg#[$=100{\times}Mg/(Mg+Fe_t)$] of olivine, orthopyroxene and clinopyroxene is relatively constant (ol: 88-91; opx: 89-92; cpx: 89-92) regardless of textural differences. The mg# of constituent minerals, NiO content (0.3~0.4 wt%) and MnO content (0.1~0.2 wt%) of olivine are similar to those of mantle xenoliths worldwide, also indicating that studied spinel lherzolite xenoliths were mantle residues having experienced 20~25% partial melting. The geochemical and textural characteristics have close relations showing that LREE and incompatible trace elements content of orthopyroxene and clinopyroxene increases from protogranular through porphyroclastic to mylonitic. These observations suggest that the studied mantle xenoliths experienced metasomatism by LREE enriched melt or fluid after partial melting, indicating a close relation between deformation and metasomatism. The metasomatism was possibly confined to narrow shear zones from where porphyroclastic and mylonitic textured xenoliths originated. These shear zones might favorably drive the percolation of LREE-enriched melts/fluids responsible for the metasomatism in the lithospheric mantle below the Jeju Island.

• Proceedings of the Korean Journal of Food and Nutrition Conference
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• 2001.12a
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• pp.127-127
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• 2001

Chitosan에 Ttichoderma viride 유래의 cellulase를 처리하여 효소분해함으로써 고분자량 chitooligosaccharides를 얻었다. 생산된 올리고당을 HPLC로 분석한 결과 octamer 이상의 것이 전체 올리고당 중 49.3%에 달하는 비교적 고분자 화합물로 구성된 chitooligosaccharides의 혼합물이었다. MTT검색법에 의하여 고분자량 chitooligosaccha- rides의 정상세포주와 암세포주에 대한 세포독성을 실험하였다. 정상세포주인 아프리카 초록원숭이의 신장세포에 대한 $IC_{50}$/(50% 저해농도)값은 1,107.95$\mu$g/ml로 정상세포에 대한 독성은 거의 없었다. 폐암세포주인 A549, 방광암세포주인 J82, 대장암세포주인 SNU-C4, 위암세포인 SNU-1, 유방암세포주인 ZR75-1에 대한 $IC_{50}$/값은 각각 421.06$\mu$g/ml, 417.99$\mu$g/ml, 445.54$\mu$g/ml, 380,65$\mu$g/ml, 460.49$\mu$g/ml로 in vitro 종양세포 증식억제 활성을 나타내었다.

• Journal of Chest Surgery
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• v.38 no.9 s.254
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• pp.656-659
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• 2005

Pulmonary mucormycosis is very rare but has a devastating opportunistic fungal infection in immunocompromised hosts. The infection usually occurs in patients with hematologic malignancy, chronic renal failure, diabetes mellitus, or in solid organ transplant recipients. We experienced a case of pulmonary mucormycosis associated with renal cadeveric allograft recipient who had uncontrolled diabetes mellitus. The patient was successfully treated by surgical resection with Amphotericin B therapy.

• The Korean Chronic Disease News
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• no.318
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• pp.1-26
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• 2007

만성질환 관리분야 새 역사 창출/병원 등 필수공익사업장 지정/한국，2050년 세계최고 '노령국'/처방전 바코드 전면확대 '추진'/보호자 없는 병원 시범사업 실시/"암환자.사망자 매년 1%씩 증가"/만성 신장병환자 물.과일 다량섭취 금기/당뇨환자 인슐린 저항성 검사가 중요/인도네시아, 한국 수액사업 벤치마킹/"만성질환 신약개발에 초점"-LG생명과학, 5년간 4천억원 투입/만성질환 의약품생산 증가세 계속/미국 VGX제약, 오송단지에 2억달러 투자/엔케이바이오, 제주에 메티컬리조트 건립/평생건강관리기관 역할 수행/주민에게 도움 줄 수 있는 내실 있는 사업 전개/2005년 시도별 생명표 및 사망원인통계 결과