• Journal of Physiology & Pathology in Korean Medicine
• /
• v.23 no.1
• /
• pp.50-56
• /
• 2009

The present study was designed to investigate the effects of Phamacopuncture therapy using Cervi Pantotrichum Cornu (PC) at BL23 BL52 on the regional cerebral blood flow (rCBF) and mean arterial blood pressure (MABP) in normal rats, then the related mechanisms were also investigated. In addition, the present author also investigated the effects of phamacopuncture therapy at BL23.BL52 on the rCBF in cerebral ischemic rats. The results in normal rats were as follows; PC (3 mg/kg and 5 mg/kg) at BL23 BL52 significantly increased rCBF but decreased MABP. This result suggests that PC at BL23 BL52 significantly increased rCBF by dilating pial arterial diameter. Increase of PC (5 mg/kg)-induced rCBF was significantly inhibited by pretreatment with indomethacin (1 mg/kg, i.p.), an inhibitor of cyclooxygenase and methylene blue ($10{\mu}g/kg$, i.p.), an inhibitor of guanylate cyclase. Decrease of PC (5 mg/kg)-induced MABP was significantly increased by pretreatment with methylene blue but was decreased by pretreatment with indomethacin. These results suggested that the action of PC (5 mg/kg) was mediated by guanylate cyclase. The results in cerebral ischemic rats were as follows ; The rCBF was significantly and stably increased by PC (5 mg/kg) during the period of cerebral reperfusion, which contrasted with the findings of rapid and marked increase in Control group. In conclusion, these results suggest that phamacopuncture therapy using Carthami flos at BL23 BL52 can increase rCBF in normal state, and improve stability of rCBF in ischemic state. In addition, the present author also suggest that related mechanisms are involved in guanylate cyclase pathway.

• Biomolecules & Therapeutics
• /
• v.5 no.2
• /
• pp.117-124
• /
• 1997

The analgesic effects of DA-5018, a new caosaucin derivative, were evaluated in various experimental pain models. Drugs were administered subcutaneously or topically. When drugs were administered subcutaneously, 1) the $ED_{50}$ of DA-5018, morphine . HCI, capsaicin and acetaminophen were 0.091-2.0, 0.3-4.3, 1.4-26.5 and 45.4-643 mg/kg, respectively in various pain or inflammatory models including acetic acid writhing, formalin, tail flick, Randall-Selitto, hot plate and crouton oil-induced ear edema test, 2) the AD2 values (the dose for doubling of pain threshold of vehicle control) of DA-5018, capsaicin and ketoprpgin were 1.07 $\pm$ 0. 18, 23.47$\pm$4.46 and 2.97$\pm$0.43 mg/kg in Freund's complete adjuvant (FCA)-induced arthritic pain model. And by topical application, 1) neither DA-5018 0.3% cream nor Zostrix-HP (capsaicin 0.075%) were effective in formalin test, 2) although DA-5018 0.3% cream significantly inhibited the croton oil-induced ear edema being better than Zostrix-HP and Kenofen (ketoprofen 3%). 3) In FCA model, DA-5018 0.3% cream reversed the decreased pain threshold of arthritic rat from 136.4 g (day 0) to 289.0 g (day 5) and 250.1 g (day 10), which was similar to Zostrix-HP. These results suggest that DA-5018 administered subcutaneously has a potent and broad analgesic spectrum than nonsteroidal antiinflammatory drugs against acute and chronic pain, and by topical application it exerts comparable analgesic and antiinglammaatory effects to capsaicin cream.

• Journal of Korean Society on Water Environment
• /
• v.28 no.1
• /
• pp.84-93
• /
• 2012

The study was conducted to analyze the spatio-temporal changes in water quality of the major 36 sampling stations of Nakdong River, depending on each station, season using the 17 water quality variables from 2000 to 2010. The result was verified to interpret the characteristics of water quality variables in a more accurate manners. According to the Principal component analysis (PCA) and Exploratory factor analysis (EFA) results; the results of these analyses were identified 4 factors, Factor 1 (nutrients) included the concentrations of T-N, T-P, $NO_{3}-N$, $PO_{4}-P$, DTN, DTP for sampling station and season, Factor 2 (organic pollutants) included the concentrations of BOD, COD, Chl-a, Factor 3 (microbes) included the concentrations of F.Coli, T.Coli, and Factor 4 (others) included the concentrations of pH, DO. The results of a Cluster analysis indicated that Geumhogang 6 was the most contaminated site, while tributaries and most of the down stream sites of Nakdong River were mainly affected by each nutrients (Factor 1) and organic pollutants (Factor 2). The verification consequence of Confirmatory factor analysis (CFA) from Exploratory factor analysis (EFA) result can be summarized as follows: we could find additional relations between variables besides the structure from EFA, which we obtained through the second-order final modeling adopted in CFA. Nutrients had the biggest impact on water pollution for each sampling station and season. In particular, It was analyzed that P-series pollutant should be controlled during spring and winter and N-series pollutant should be controlled during summer and fall.

• Childhood Kidney Diseases
• /
• v.6 no.2
• /
• pp.243-250
• /
• 2002

Amyloidosis comprises a diverse group of systemic and local diseases characterized by organ involvement by the extracellular deposition of fibrils composed of subunits of a variety of normal serum proteins. Secondary amyloidosis is caused by the deposition of amyloid A(AA) protein in chronic inflammatory disease. Juvenile rheumatoid arthritis(JRA) has been known to be the most common cause of secondary amyloidosis. We experienced one case of secondary renal amyloidosis in a 12-year-old girl who had suffered from JRA for several years who had visited our renal clinic to evaluate the proteinuria with microscopic hematuria which was detected by chance at school urine screening examination. Apple green birefringence was observed under polarized light with Congo red stain at)d characteristic electron microscopic findings was also noted in renal tissues which was obtained by percutaneous renal biopsy. In our knowledge, this is the first case report of secondary renal amyloidosis developed in pediatric age in Korea.

• Journal of Korean Clinical Health Science
• /
• v.6 no.1
• /
• pp.1074-1082
• /
• 2018

Purpose: This study intends to understand the correlation between career satisfaction and career decision self - efficacy and career maturity of nursing students, and to examine whether career satisfaction and career decision-making self-efficacy affect career maturity. Methods: The data analyzed using IBM SPSS Statistics 20 were collected from April 1, 2016 to April 15, 2014 in 184 students at the four-year college of Nursing in J city. Results: The results of the analysis of the correlation between major satisfaction, career decision self-efficacy and career maturity of nursing college students indicate that there was a positive correlation with career maturity (r=.428, p<.001), career decision self-efficacy (R=.442, p<.001) and majors' satisfaction (r=.605, p<.001) either. likewise, career maturity and career maturity were positively correlated with career maturity and career satisfaction. Conclusions: Therefore, it is possible to enhance and improve adaptation to major through conversations in conjunction with counseling and career guidance from the entrance, and maintaining intimate and solid relationship between the students and professors, also, the students and senior of whom, leading to intensify positive implication to future career.

• The Journal of Korean Medicine
• /
• v.18 no.1
• /
• pp.385-398
• /
• 1997

The location and local arrangement of motor, sensory neurons within brain stem, nodose ganglia, spinal ganglia and sympathetic ganglia projecting to rat's kidney and meridian point BL 23, GB 25 were investigated by HRP immunohistochemical methods following injection of 5% WGA-HRP into left kidney and meridian point BL 23, GB 25. Following injection of WGA-HRP into left kidney, anterogradely labelled sensory neurons were founded within either nodose ganglia and spinal ganglia. The sensory neurons innervating rat's left kidney were observed within spinal ganglia $T_{7}{\sim}L_3$. Sympathetic motor neurons innervating rat's left kidney were labelled within left suprarenal ganglia, either celiac ganglia, superior mesenteric ganglia, and sympathetic chain ganglia $T_{1}{\sim}L_3$. Sympathetic chain ganglia were concentrated in $T_{12}{\sim}L_1$. The sensory neurons innervating rat's meridian point BL 23 were founded within spinal ganglia $T_{2}{\sim}L_2$. They were numerous in spinal in ganglia $T_{10}{\sim}T_{12}$. Sympathetic motor neurons innervating rat's meridian point BL 23 were observed in suprarenal ganglia and greater splanchnic trunk, sympathetic chain ganglia from $T_1$ to $L_3$. They were concentrated in $T_{12}{\sim}L_3$. The sensory neurons innervating rat's meridian point GB 25 were labelled within spinal ganglia $T_{6}{\sim}T_{13}$. They were numerous in from T10 to $T_{12}$. Sympathetic motor neurons innervating rat's meridian point GB 25 were labelled within greater splanchnic trunk and sympathetic chain ganglia $T_{12}{\sim}L_3$. They were concentrated in $T_{13}{\sim}L_1$. This results neuroanatomically imply that the location of rat's motor and sensory neurons innervating meridian point BL 23 and GB 25 were closely related that of innervating kidney.

• Journal of the Korean Institute of Gas
• /
• v.15 no.2
• /
• pp.82-87
• /
• 2011

Heat transfer oils are used in applications such as heating systems of chemical plant, refinery heat exchange systems, gas plant process, injection molding systems, and pulp and paper processing. These oils are extremely stable and resistance to thermal and oxidative degradation. In the event of a spill or accidental release of heat transfer oils, it can be ignite easily when there is an ignition source. This paper discusses the flammability and thermal stabilities of new and used oils. The flammability of the oils are assessed by measuring changes in flash point and auto ignition temperature. The thermal stability of oils are evaluated by the thermal screening unit ($TS^u$) and the differential scanning calorimeter (DSC). From the experimental results, it is suggested to give fire hazard characteristics to safe precautions for the proper use and treatment of heat transfer oils.

• Proceedings of the Korean Society of Computer Information Conference
• /
• 2014.07a
• /
• pp.485-487
• /
• 2014

여러 종류의 공포를 통해 플레이어들이 가장 공포를 느끼는 효과적인 연출 방법을 사용하여 개발한 게임인 '사이코메트리 psychometry'를 연구 재료로 20대 여성 FGT(Focus Group Test)를 통해 나타난 설문을 바탕으로 어떤 요소들이 플레이어들에게 두렵게 다가왔는지를 파악하고 그 이유에 대해 작성, 또 문제의 더 나은 해결 방법을 제시하였다.

• Proceedings of the Korean Society of Computer Information Conference
• /
• 2014.07a
• /
• pp.489-491
• /
• 2014

본 논문에서는 청강문화산업대학교 게임전공 2014학년도 졸업 작품인 '사이코메트리(Psychometry)' 게임 내에서 등장하는 연출용 이펙트 사운드에 따른 플레이어의 반응을 테스트하고 그 결과를 도출한다. 이 테스트 결과에 따라 플레이어가 게임을 플레이하면서 가장 자극을 받는 이펙트 사운드가 무엇이며, 그 이유를 연구하고 추후 개발에 적용하여 게임 내에서 플레이어에게 사운드를 가장 효과적으로, 영향력 있게 전달할 수 있도록 게임을 설계하는 것을 목표로 한다.

• Korean Journal of Ecology and Environment
• /
• v.49 no.4
• /
• pp.393-399
• /
• 2016

This study was conducted to investigate whether the presence of mcy gene and microcystin production are related to morphological characteristics of Korean Microcystis species. We isolated 6 different species of Microcystis (M. aeruginosa, M. ichthyoblabe, M. flos-aquae, M. novacekii, M. viridis and M. wesenbergii) from drinking water supply dams (Yeongchun, Ankei, Gachang), and used microscopic method for morphological identification, molecular method for amplifying a partial region of mcyB gene and ELISA method for microcystin analysis. In the present study, 80% of M. aeruginosa strains contained mcy gene, followed by 45% (10 strains) of M. icthyoblabe, 33% (1 strain) of M. wesenbergii, and 11% (4 strains) of M. flos-aquae. Each percentage of mcy gene in Microcystis morphospecies was similar to that of microcystin production in Microcystis morophospecies. In conclusion, the present study shows that molecular method using mcy gene primers can be used as an indirect indicator for the monitoring of toxic cyanobacteria (Microcystis).