• The Journal of Korean Orthopaedic Ultrasound Society
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• v.5 no.1
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• pp.50-59
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• 2012

In the domain of orthopaedic surgery, application of regional nerve block for surgery or pain control in upper and lower extremities has been increased. By performing regional block of popliteal (sciatic), femoral, proximal saphenous nerve and ankle block under guidance of ultrasound, not only the safety, but also success rate of the procedure has increased, and amount of local anesthetics could be used less, too. Since the perineural single injection or continuous catheterization of diluted local anesthetics was performed more precisely and easily by the guidance of ultrasound, postoperative pain could be controlled without complications of PCA such as nausea, vomiting, etc. We will discuss about this ultrasound guided regional nerve block.

• The Journal of Korean Physical Therapy
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• v.11 no.3
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• pp.151-158
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• 1999

Neuropathy is a common and often debilitating complication of diabetes, Diabetic peripheral neuropathy(DN) includes a variety of different disorders that affect the peripheral nervous system. The most common type of DN is the predominantly sensory distal polyneuropathy. Typically, symptoms begin in the foot and proximally during the course of the discease, reflecting the fact that longer fibres are involved earlier that shorter ones. Reviewed the pathogenesis, the diagnosis of DN, the gait pattern and the excercise, the treatment of pain in DN patient.

• The Journal of Korean Academy of Sensory Integration
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• v.14 no.1
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• pp.50-59
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• 2016

Objective : The goal of this study was to investigate neurological mechanism of emotional regulation and to examine the relationship between the regulation and sensory processing. Subjective : Emotional regulations are mainly processed in limbic system, particularly the basal-lateral group of amygdala takes on a major role in the regulations. The basal-lateral group of amygdala links to thalamus directly and/or indirectly which processes sensory information together. This sensory information connects to orbital and medial prefrontal cortex. Inadequate sensory processing may cause difficulties in emotional regulations and behaviors because of a circuit linking the amygdala, the thalamus, and the orbital and medial prefrontal cortex. These difficulties and impairments has been reported in neurological studies for children with ASD and ADHD. Conclusion : Neurological states are different between the normal children and children with ASD and ADHD and these represent various aspects in sensory processing, emotional regulations and behaviors. Thus, therapists working with children with ASD and ADHD need to understand mechanisms of sensory processing and emotional regulations in order to provide adequate treatments.

• Proceedings of the Korean Information Science Society Conference
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• 2007.06b
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• pp.36-40
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• 2007

miRNA 유전체학의 중요한 이슈로 miRNA가 조절하는 목표 유전자를 예측하는 작업과 miRNA가 목표 유전자를 조절하는 메커니즘이 무엇인지 규명하는 것을 들 수 있다. 본 논문에서는 생물학적 특징들과 다층 퍼셉트론 신경망을 이용하여 miRNA의 목표 유전자를 예측하고 해당 miRNA 조절 메커니즘 타입을 분별해주는 시스템을 제안하고 실제 데이터를 사용하여 그 성능을 평가한다. 실험적으로 검증된 데이터를 사용하여 제안 시스템을 평가해본 결과, 다층 퍼셉트론 신경망을 사용할 경우 84.63%의 정확도로 miRNA의 목표 유전자를 예측할 수 있었고, 87.90%의 정확도로 miRNA가 목표 유전자를 조절하는 메커니즘을 분별할 수 있었다. 학습 데이터가 충분히 많아진다면 제안 시스템의 예측 성능은 더욱 높아질 것으로 예상된다.

• Journal of the Korean Society of Radiology
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• v.17 no.7
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• pp.1165-1170
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• 2023

In this study, we aimed to develop a cost-effective neuro-modulation device for use in neuroscientific and clinical medical imaging applications. To achieve this, we designed and fabricated a brain neuro-modulation device with a material cost of less than $500, and subsequently evaluated its performance. The measured performance was found to be comparable to existing medical devices (TENS), with the developed device being compact in size, measuring less than 3 cm by 3 cm. The outcomes of this study are expected to be applicable in accelerating research and development in related fields, as well as in the rapid commercialization of neuro-modulation technology. Furthermore, it is anticipated that this work will contribute to advancements in functional radiological medical imaging technology and enhance accessibility to brain science and brain stimulation technology.

• Proceedings of the KSAR Conference
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• 2001.10a
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• pp.32-36
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• 2001

난소의 재형성 과정은 난소 내 여러 조절인자들에 의해 조절되는 성장 및 퇴행 과정을 반복하는 특징을 가지고 있다. 황체는 주기적 성장과 퇴행을 보이며 과립세포의 세포자멸사 (apoptosis)를 통해 황체의 퇴행이 일어나게 된다지. 이러한 세포자멸사 과정은 난소의 정상 생리에 매우 중요하다. ATP 는 자율신경으로부터 세포외 유출을 통해 분비되어 근육 수축, 신경전달체계, 외분비 및 내분비 호르몬의 분비, 면역반응, 염증, 혈소판 응집, 동통 및 심장기능의 조절 등 매우 다양한 생물학적 기능에 영향을 미친다. 이러한 작용은 세포 표변에 존재하는 purinoceptor를 통해 이루어지는 것으로 알려져 있다. ATP는 일반적으로 세포 내에서는 에너지원으로서 작용하나 세포외부에 존재하는 ATP의 경우에는 조절물질로 작용하여 어떤 세포에 있어서는 세포용해를 일으키기도 하며, 어떤 세포에서는 세포자멸사를 유발하기도 한다. 세포 내에 존재하는 ATP는 세포의 주요한 에너지원으로 사용되며 살아있는 세포에서는 세포막을 통과하지 못하는 반면 세포 외에 존재하는 ATP는 말초신경계 혹은 중추신경계에 있어서 매우 중요한 신경전달물질로 작용하고 있다. (중략)

• Journal of Hospice and Palliative Care
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• v.11 no.1
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• pp.51-54
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• 2008

Qualify of life is the main consideration in pain management and palliative care for patients with advanced cancer. Cancer pain is primarily relieved with pharmacological therapy including aretaminophen, nonsteroidal anti-inflammatory drugs, adjuvant analgesics, and opioids. In addition to pharmacological therapy, the neurolytic celiac plexus block is claimed to be an effective approach in management of advanced pancreatic cancer pain. We report our patient who has been treated for advanced cancer pain with multiple neurolytic blocks. The clinical result suggests that combined neurolytic blocks improved the quality of life of patient who had advanced ranter pain by reducing both the intensity of pain and opioid consumption, without serious complications.

• Journal of the Korea Convergence Society
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• v.8 no.11
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• pp.461-476
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• 2017

The purpose of this study was to investigate the existing theories related to overtraining syndrome and to examine the mechanism of overtraining syndrome from the viewpoint of brain science by examining domestic and foreign literature related to the relationship between overtraining syndrome and brain neurotransmitter. The aim of this paper is to provide basic data that can improve the understanding of the mechanism of overtraining syndrome and the role of neurotransmitters and neuromodulators. The results of this study and a number of hypotheses about the overtraining syndrome were proposed, each with strengths and weaknesses. Similar symptoms that occur when the concentration of serotonin in the neurotransmitter increases are related to signs and symptoms of overtraining syndrome. However, it has not been validated to date because it can not distinguish the mechanism of the mediator between the central nervous system and the peripheral nerves. This study suggests that the mechanism of overtraining syndrome will provide important basic information to understand the complex causes of overtraining syndrome through the interaction of existing theory and brain neurotransmitter. Although there has been a lack of studies on the mechanism of overtraining syndrome and brain neurotransmitters so far, we hope that this study will provide an opportunity for more and more people to broaden their understanding of overtraining syndromes.

• Journal of Korean society of Dental Hygiene
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• v.24 no.3
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• pp.219-227
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• 2024

Objectives: The pulp is the center of the tooth containing nerves and blood vessels. The condition in which the pulp becomes inflamed due to caries or periodontitis is called pulpitis. Pulpitis is a difficult-to-treat disease and causes peripheral nerve tissue changes and severe pain; however, the relationship between neuronal activity and voltage-gated sodium channel 1.7 (Nav1.7) expression in the trigeminal ganglion (TG) during pulpitis has not been well studied. In this study, we found that experimentally induced pulpitis activates Nav1.7 expression in the periphery, leading to neuronal overexpression in the TG. Thus, we sought to identify ways to regulate this process. Methods: Acute pulpitis was induced in rat maxillary molars by treating the pulp with allyl isothiocyanate (AITC). Three days later, in vivo optical imaging was used to record and compare neural activities in the TG. Western blotting was used to identify molecular changes in terms of the expression of extracellular signal-regulated kinase (ERK), c-Fos, transient receptor potential ankyrin 1 (TRPA1), and collapsin response mediator protein-2 (CRMP2) in the brain stem. Results: The results confirmed the neurological changes in the TGs of the pulpitis model, and histological and molecular biological evidence confirmed that increased Nav1.7 expression induced by pulpitis leads to pain. Furthermore, selective inhibition of Nav1.7 resulted in changes in neural activity, suggesting that pulpitis induces increased Nav1.7 expression, and that effective control of Nav1.7 could potentially reduce pain. Conclusions: The inhibition of overexpressed Nav1.7 channels may modulate nociceptive signal processing in the brain and effectively control pain associated with pulpitis.

• The Zoological Society Korea : Newsletter
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• v.18 no.2
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• pp.12-20
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• 2001

2000년도 노벨 의학상은 스웨덴의 아비스 칼슨 박사 등 3명 이 수상했다. 그들은 신경전달 물질(neurotransmitter) 중 도파민 (dopamine)과 시냅스(synapse)에 관한 연구로 항 우울제 치료제인 프로작 (prozac)을 개발하여 신경, 정신질환 치료제 개발에 기여한 공로였다. 도파민과 GABA는 신경전달 물질 중의 하나로 도파민은 운동, 정서, 행동, 희노애락 등을 조절하는 것으로 이상 분비될 때 파킨스씨병, 정신분열증, 우울증 등을 유발시킨다. GABA는 억제성 신경전달물질로 이상 분비시 간질 등을 유발시킨다. 도파민과 GABA의 분비는 시냅스 후(postsynapse) 수용체에서 그 기능이 조절된다. 그러나 마약성인 코카인, 헤로인, 몰핀, 암페타민 등 중 독성약물뿐만 아니라 일상 생활에서 흔히 접할 수 있는 흡연, 술 등에 의해서도 그 분비 이상을 초래한다. 따라서 본 논단에서는 최근 뇌신경생물 실험실에서 진행되고 있는 신경전달 물질 중에 도파민 및 GABA 분비에 대 한 연구결과를 바탕으로 소개 하고자 한다.