• Proceedings of the Korea Database Society Conference
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• 2000.11a
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• pp.27-37
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• 2000

o An Enriched conceptualization of BM o Needs further research on: - An Integrative framework for BM research - A dynamic. evolutionary account of BM - Empirical validation of the analysis models - Draw practical implications and guidelines for business (omitted)

• The Journal of the Korean bone and joint tumor society
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• v.11 no.1
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• pp.105-109
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• 2005

This journal reports three cases diagnosed with schwannomatosis in which no clinical symptoms of type 2 neurofibromatosis. The chief complain was pain. In adolescence and adult group, all masses were found. The locations were brachial plexus, popliteal fossa and hand. No hearing impairment, vertigo, tinnitus and visual disturbance was observed in any of the case. Family history was negative. In all cases, there was no evidence of vestibular schwannoma on cranial MRI imaging study. In all cases, Tinel sign was positive. Pathologic diagnosis was positive for schwannoma. Further study and case collection is needed to idenity the clinical manifestation, clinical course and genetic characteristic of schwannomatosis.

• The Korean Journal of Zoology
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• v.36 no.1
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• pp.6-13
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• 1993

연두금파리 유충의 뇌와 복신경절에 분포하는 세로토닌 면역반응성 세포를 면역조직화학적 방법을 이용하여 동정하였다. 세로토인세포는 뇌에 28개, 제1식도하신경절의 첫째마디에 6개, 둘째마디에 10개 그리고 세째마디에 6개가 각각 존재하였다. 그리고 앞가슴신경절에 6개, 가운데가슴신경절에 4개 그리고 됫가슴신경절에 4개가 각각 위치하였다. 또한 복부신경절에서는 첫새 마디부터 일곱째 마디까지 각각 4개가 존재하였고 마지막마디인 여덟째마디에서는 단지 두개의 세포만이 관찰되었다. 결국 연두금파리 유충의 중추신경계에는 모두 94개의 세로토닌 면역반응성 세포들이 분포하였다. 이들 세포로부터 뻗어나온 축색들은 뉴로파일내에서 분지하거나 횡연합섬유를 이루었다.

• Proceedings of the KSAR Conference
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• 2004.06a
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• pp.269-269
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• 2004

배아줄기 세포는 신경퇴행성 질환의 치료 수단으로 많은 가능성을 가지고 있는 것으로 알려져 있다. 본 연구에서는 중풍 동물모델에서 수중미로 학습을 이용하여 중풍 치료제로서 인간배아줄기 세포의 인지 및 기억력 장애에 대한 기능 회복의 효능을 검토하였고, 인간배아줄기 세포의 신경세포 보호효과를 규명하기 위하여 면역조직화학 염색법을 이용하여 해마내의 세포사멸을 측정하였으며, 인지 및 기억증진의 작용을 규명하기 위하여 아세틸콜린성 신경세포의 활성도를 측정하였다. (중략)

• The Monthly Diabetes
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• s.239
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• pp.20-22
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• 2009

발이 저린다거나, 다리에 벌레가 기어가는 느낌이 들기도 하고, 누웠다가 일어나면 어지러운 증상을 보이고 발에 상처가 생겨도 아프지 않다면 신경병증을 의심해 봐야한다. 신경병증은 당뇨병환자의 절반이상에서 경험하는 가장 흔한 합병증으로서, 직접적으로 생명을 위협하지는 않지만 생활의 불편함을 초래하여 삶의 질을 떨어뜨리고, 장기적으로 다른 합병증과 연관돼 문제를 일으킬 수 있다. 증상은 매우 다양하여 구분이 어렵고 당뇨병이 오래될수록 발생할 확률이 높아지는 것으로 보고되고 있다.

• Proceedings of the Korea Information Processing Society Conference
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• 2019.05a
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• pp.464-466
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• 2019

CNN 은 합성곱 연산을 사용하는 인공신경망의 한 종류이다. 이러한 인공 신경망에서는 훈련 데이터에 대한 과도한 학습으로 인해 시험 데이터에 제대로 반응하지 못하는 오버피팅이 발생할 우려가 있다. 이를 해결하기 위해 DropOut 과 DropConnect 를 사용할 수 있다. 본 논문에서는 DropOut 과 DropConnect 를 통한 학습 정도를 실험을 통해서 비교해보고, 인공 신경망에서 이 방법의 효과를 살펴본다.

• Journal of the Institute of Electronics Engineers of Korea SC
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• v.39 no.6
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• pp.1-8
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• 2002

This paper presents a generalized minimum-variance self-tuning controller with a PID structure using neural network which adapts to the changing parameters of the nonlinear system with nonminimum phase behavior and time delays. The neural network is used to estimate the controller parameters, and the control output is obtained through estimated controller parameter. In order to demonstrate the effectiveness of the proposed algorithm, the computer simulation is done to adapt the nonlinear nonminimum phase system with time delays and changed system parameter after a constant time. The proposed method compared with direct adaptive controller using neural network.

• Journal of The Korean Society of Inherited Metabolic disease
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• v.20 no.1
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• pp.1-13
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• 2020

Purpose: Gaucher disease (GD), which is the most prevalent lysosomal storage disorder worldwide, is caused by mutations in the glucocerebrosidase gene (GBA). GD is divided into three clinical subtypes based on the appearance of neurological symptoms. Type 1 GD is a chronic non-neuronopathic disease, and types 2 and 3 are acute neuronopathic and chronic neuronopathic forms, respectively. Neuronopathic GD types 2 and 3 are characterized by increased levels of glucosylceramide (GlcCer) and glucosylsphingosine (GlcSph) in the brain, leading to massive loss of neurons. Methods: DNA damage and subsequent apoptosis of H4 cells were observed following neuroglioma H4 cell culture with GlcCer or GlcSph. Neuronal cell apoptosis was more prominent upon treatment with GlcSph. Results: When H4 cells were treated with GlcSph in the presence of tubacin, a histone deacetylase 6 inhibitor (HDAC6i), attenuation of both DNA damage and a reduction in the protein expression levels of GlcSph-induced apoptosis-associated factors were observed. Conclusion: These findings indicated that GlcSph played a prominent role in the pathogenesis of neuronopathic GD by inducing apoptosis, and that HDAC6i could be considered a therapeutic candidate for the treatment of neuronopathic GD.

• Journal of the Korea Institute of Military Science and Technology
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• v.14 no.5
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• pp.920-931
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• 2011

Nerve agents are irreversible inhibitors of the cholinesterase enzyme. Exposure causes a progression of toxic signs, including hypersecretions, fasciculations, tremor, convulsions, respiratory distress, epileptiform seizures, brain injuries and death. A combined regimen of prophylaxis and therapy is the most effective medical countermeasure for dealing with the threat of nerve agent poisoning to military personnel. In this paper, the author investigated the updated technologies regarding various pre- and post-treatment drugs for nerve agents detoxification which are under development in several countries including Korea. Some characteristics of active ingredients in the formulations of drugs, their action mechanisms, and effectiveness were analyzed. Additionally, part of experimental data on the transdermal patch studied in ADD using beagle dogs was introduced.

• Applied Microscopy
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• v.42 no.1
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• pp.17-26
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• 2012

Histologic and microstructural changes during the postembryonic development of the wolf spider Arctosa kwangreungensis were studied using light and scanning electron microscopy to examine the relationship between a morphological differentiation and behavioral properties. The postembryo with abdominal yolk sac was stayed inactive in the egg case because its muscular and visual systems were not fully developed to a functional level. The first instar spiderlings, developed from the postembryo by a first molting process, started to exhibit its pigmentation on their body cuticles. In particular, undifferentiated cell clusters of central nervous system (CNS) were densely distributed within the cephalothorax, and highly differentiated abdominal ganglion was observed. They had a characteristic visual system looks more like its adult counterpart, and had segmented appendages looks more like the tiny spiders containing well oriented muscular system. After 3rd instar, spiderlings grew more rapidly with accordance to their consistent growth and periodical molting processes. Thus, the relative area of CNS with respect to cephalothorax was gradually decreased, instead a pair of venom glands, musculature, and connectives occupied the residual area. It has been revealed that the early development of spider can be controled by the feeding condition of larval period, since histologic and microstructural differentiations in both appendages and optic system were completed at the second instar. In particular, behavioral properties of the wandering spiders that depend on vision and their running ability were deeply related to physiological differentiation of the microstructural development.