• Journal of Yeungnam Medical Science
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• v.16 no.1
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• pp.69-75
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• 1999

Imidapril(Tanatril$^{(R)}$), a newly developed ACE inhibitor, has been used to treat hypertension and congestive heart failure. This study was designed to assess the antihypertensive effect and safety of Imidapril(Tanatril$^{(R)}$) in patients with essential hypertension. 5-10mg of imidapril(Tanatril$^{(R)}$) was administered once a day in 30 patients with essential hypertension and followed up for 8 weeks. We tested the drug's effectiveness, safety, and the incidence of imidapril induced dry coughs. After 8 weeks of treatment with imidapril, 76.2%(16/21) of patients showed lowered blood pressure and 47.6% showed normal blood pressure. The overall incidence of adverse effects was 33.3%(7/21), and among these adverse effects, dry cough was shown in only 9.5%. Thus, we concluded that imidapril(Tanatril$^{(R)}$) is as safe and effective as other ACE inhibitors, especially with imidapril showing very little incidence of dry cough compared to other ACE inhibitors.

• Journal of the Korean GEO-environmental Society
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• v.19 no.9
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• pp.13-19
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• 2018

Recently, there have been various problems aroused on the domestic infrastructures as the domestic cities become old. Accordingly, the national concerns grow on the urban railway and the related structures, which brings the national interests are brought on the research on the maintenance and rehabilitation of the old infrastructures. The underground structure of urban railway are checked with the strain gages or fiber brag grating (FBG) sensors on the railway. However, these methods are known to have resolution limitations on the investigations of the specified abnormal section. Therefore, the applicability of the Brillouin Optical Correlation Domain Analysis (BOCDA) based distributed fiber optic sensor system on the railway was evaluated in this study. The constructed BOCDA fiber optic sensor system shows high resolution of 10, 20, 50, 100 cm and capability of continuous monitoring on overall or specified section within 2 km range. The applicability evaluation was performed on the 250 m distribution of fiber optic sensors abandoned railway for continuous monitoring. The applicability of the system on the specified area was evaluated with wheel load testing. As a result, data loss tends to increase with the reduction of spatial resolution from 1.0 m to 0.1 m. Even though the measuring speed is reduced with lower spatial resolution, data accuracy increases on the location and deformation. The system can be applicable to various structures if the proper distribution method is invented later.

• Tunnel and Underground Space
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• v.27 no.4
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• pp.230-242
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• 2017

Seismic velocities measured from in-situ tests (n=177) and through rock core samples (n=1,035) are reviewed in light of construction standards, widely used standards as a first-hand approximation of rock classification solely based on seismic velocities. In-situ down hole tests and refraction survey for soft rocks showed seismic velocities of 1,400~2,900 m/s which is faster than those specified in construction standards. For moderate~ hard rocks, in-situ down hole tests and refraction survey showed 2,300~3,800 m/s which roughly corresponds with the range specified in the construction standards. A similar trend is also observed for seismic velocities measured from rock core samples. The observed differences between construction standards and seismic velocities can be explained in two ways. If construction standards are correct the observed differences may be explained with seismic velocities affected by underlying fast velocities and also possibly with selection of intact cores for velocity measurement. Alternatively, construction standards may have intrinsic problems, namely artificial discrete boundaries between soft rocks and moderate rocks, application of foreign standards without consideration of geologic setting and lack of independent verification steps. Therefore, we suggest a carefully designed verification studies from a test site. We also suggest that care must be exercised when applying construction standards for the interpretation and accessment of rock mass properties.

• Applied Biological Chemistry
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• v.18 no.4
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• pp.219-227
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• 1975

In order to investigate the possibility of wine-making with the grape variety cultivating in Korea, the basic analysises were carried out; analysis of the grape maturity during ripening period, the composition of grape juice, and the chemical components of wine from different varieties. Also the yeasts existing naturally on the grape were isolated and identified. For the selection of strain, the characteristics of 6 strains were studied. The results obtained were summarized as follows. 1. The reducing sugar content increased considerably during two weeks after the ordinary grape-gathering period. 2. The sugar content was highest in Muscat bailey A, which could be fermented naturally. The other varieties, Campbell Early, Steuben, and Alden needed chaptalisation for wine-making. 3. The permanaganate number and the methanol content of wine from all varieties were lower than french wine. 4. The sensory evaluation of wine showed that the pink wine was appreciated better than the red wine of same variety and the foxy taste of wine from hybrid grape influenced little to Korean. 5. The selected 6 strains were identified as Saccharomyces chevaliers, Saccharomyces capensis and Saccharomyces globosus. The strain No. 3 and No. 4 showed the most excellent characters for wine-making.

• Korean Journal of Food Science and Technology
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• v.30 no.5
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• pp.1179-1183
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• 1998

Effects of gamma irradiation on beef spoilage were investigated by determination of the peroxide value, TBA value and total volatile basic nitrogen for 10 days at $4^{\circ}C$ or $25^{\circ}C$ after gamma irradiation up to 5 kGy in air or vacuum package. The total lipid contents were $4.4{\sim}4.7%$ and were not significantly changed by gamma irradiation up to 5 kGy. The peroxide value and thiobarbituric acid value increased with the elapse of the storage period. The level of lipid oxidation was higher at $25^{\circ}C$ than at $4^{\circ}C$ and higher in air package than in vacuum package and increased depending on the incremental irradiation doses level. Volatile basic nitrogen showed a lower content in the vacuum packaged samples irradiated at $3{\sim}5\;kGy$ than in non-irradiated samples over the storage period.

• Journal of The Korean Society of Agricultural Engineers
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• v.62 no.1
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• pp.1-16
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• 2020

The APEX model has been developed for assessing agricultural management efforts and their effects on soil and water at the field scale as well as more complex multi-subarea landscapes, whole farms, and watersheds. Recently, a key component of APEX application, named APEX-Paddy, has been modified for simulating water quality by considering paddy rice management practices. In this study, the performance of the APEX-Paddy model was evaluated using field data at Iksan experimental paddy sites in Korea. The discharge and pollutant load data during 2013 and 2014 were used to both manually and automatically calibrate the model. The APEX auto-calibration tool (APEX-CUTE 4.1) was used for model calibration and sensitivity analysis. Results indicate that APEX-Paddy reasonably performs in predicting runoff discharge rate and nitrogen yield. However, sediment and phosphorus yield is not correctly predicted due to the limitation of model schemes. With APEX-Paddy, the performance in reproducing the discharge and nitrogen yield is found to be a satisfactory level after manual calibration. The manually calibrated model performed better than the automatically calibrated model in nearly all comparisons. For runoff, manual calibration reduced PBIAS while R² and NSE values of the automatically calibrated model were the same as the manual calibration. For T-N, NSE and PBIAS were reduced when using manual calibration, whereas R² value was the same as manual calibration. The limitation of the APEX-Paddy model for predicting sediment, as well as the phosphorous yield, was discussed in this study.

• Korean Journal of Food Science and Technology
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• v.43 no.3
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• pp.263-270
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• 2011

This study was performed to acquire processing and reducing factors of difenoconazole during ginseng processing, and to establish the maximum residue limits of ginseng and its commodities. Difenoconazole was used in two fields (Wonju and Icheon) containing 6 year old ginseng plants. The amount of residue at Wonju and Icheon were

• Journal of The Korean Society of Grassland and Forage Science
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• v.3 no.2
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• pp.58-66
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• 1983

This experiment was carried out to investigate the effects of the nitrogen rates and cutting heights on the appearance dry weight and death of new bud (branch and tiller) of sorghum-sudangrass hybrid (Sorghum bicolor (L.) Moench). The cultivar used in the present study was Pioneer 988. The experiment was arranged as a split plot design and undertaken in the Experimental Livestock Farm of Agriculture Coll., Seoul Nat'l Univ. in Suweon, 1981 and 1982. The results obtained are summarized as follows: 1. The appearance and death of branch and tiller were not influenced with high nitrogen fertilization. 2. The frequency of the branching was decreased as the low stubble height, and the rate of the tillering was decreased in the high stubble height. 3. The yield of forage mostly depended on the tiller regardless of cutting height, and minor portion of the yield was resulted from the branch. 4. The low cutting height resulted in the increased number of dead bud (p<0.05).

• Journal of Agricultural Extension & Community Development
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• v.21 no.1
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• pp.219-244
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• 2014

Agricultural extension service in Ethiopia was started in early 1950s with mandate of transferring local research outputs and technologies to farmers, and importing technologies and improved practices from abroad. Extension service provided in this early time was limited to areas surrounding the experiment stations. Since then, Ethiopian Agricultural extension service has passed through at least five stages: the land grant extension system, the Comprehensive Package Programs, the Minimum Package Projects, the Peasant Agricultural Development Program, and the Participatory Demonstration and Training Extension System (PADETS). The comprehensive package extension program was initially implemented in selected pilot areas and eventually to be scaled up to cover about 90% of the farming community within 15-20 years time. The program used demonstration plots managed by development agents and used to train farmers organized through various field days. However, since all of these programs were operational in only small areas, the vast majority of the country was out of their reach. Through Participatory Demonstration and Training Extension System, the extension service in Ethiopia has come under the spotlight and government debates and external reviews are putting additional scrutiny on the system. Despite this long history, the system is still in its infancy in terms of coverage, communication and institutional pluralism. Currently in Ethiopia the Agricultural extension is provided primarily by the public sector, operating in a decentralized manner through which extension is implemented at the district level. Therefore, the main focus of this paper is to scrutinize the past, the present and the future Agricultural extension system in Ethiopia.

• Korean Journal of Clinical Pharmacy
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• v.8 no.2
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• pp.95-100
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• 1998

Piroxicam-$\beta$-cyclodextrin은 piroxicam을 $\beta$-cyclodextrin으로 포접시킨 비스테로이드성 항염증약물이다. 이러한 포접형 약물은 위장관에서의 흡수속도가 증가하는 것으로 외국자료에서 보고되고 있으며 이는 이 약물의 위장관 내성에 보다 나은 영향을 끼칠 수 있음을 시사하고 있다. 본 연구는 정상성인 한국인을 대상으로 randomized, crossover design에 의해 piroxicam-$\beta-cyclodextrin(Brexin^{(R)})$과 piroxicam 확산정$(Feldene^{(R)})$ 흡수속도를 비교하고자 하였다. 건강한 성인 8명의 피험자를 2군으로 나누어 시험약 또는 대조약을 각각 20 mg씩 20일의 휴약 기간을 두고 이중 맹검으로 교차 투여하였다. 시험약 또는 대조약의 투여 후 24시간 동안 일정 간격으로 채혈하여 HPLC 방법으로 혈장 내 piroxicam 농도를 측정하였다. $AUC_{0-24}\;({\mu}g/mL)$는 piroxicam-$\beta$-cyclodextrin군에서 $56.1\pm4.9$, piroxicam군에서 $57.3\pm5.6$으로 통계적인 유의성이 없었으나, 투여 후 0.5시간에서의 혈중농도는 piroxicam-$\beta$-cyclodextrin군 $2.9\pm0.4\;{\mu}g/mL$, piroxicam군 $1.6\pm0.3\;{\mu}g/mL$으로 통계적인 유의성을 보였다(p<0.05). 또한 최고혈중농도는 piroxicam-$\beta$-cyclodextrin$(4.3\pm0.5\;{\mu} g/mL)\;piroxicam(3.5\pm0.3\l{\mu}g/mL)$,으로 유의성이 있었으며(p<0.05), 흡수 속도상수는 piroxicam-$\beta$-cyclodextrin$(3.00\pm0.49\;h^{-1}), \;piroxicam(1.80\pm0.21\;h^{-1})$이었다(p<0.1). 이상의 결과에서, piroxicam-$\beta$-cyclodextrin정은 piroxicam 확산정과 비교하여 흡수되는 정도는 서로 비슷하지만 흡수 초기의 혈장농도 및 흡수속도상수에서 보다 빠른 약동학적 특성을 나타내었다.