• Proceedings of the Korean Society of Medical Physics Conference
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• 2004.11a
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• pp.91-95
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• 2004

Several MRI studies have reported reductions in temporal lobe volumes in Alzheimer's disease (AD). Measures have been usually obtained with regions-of-interest (ROI) drawn manually on selected medial and lateral portions of the temporal lobes, with variable choices of anatomical borders across different studies. We used the automated voxel-based morphometry (VBM) approach to investigate gray matter abnormalities over the entire extension of the temporal lobe in 10AD patients (MM5E 22)and 22 healthy controls. Foci of significantly reduced gray matter volume in AD patients were detected in both medial and lateral temporal regions, most significantly in the right and left posterior parahippocarmpal gyri. At a more flexible statistical threshold (P<0.01, uncorrected for multiple comparisons), circumscribed foci of significant gray matter reduction were also detected in the right amygdala/enthorinal cortex, the anterior and posterior borders of the superior temporal gyrus bilaterally, and the anterior portion of the left middle temporal gyrus. These VBM results confirm previous findings of temporal lobe atrophic changes in AD, and suggest that these abnormalities may be confined to specific sites within that lobe, rather than showing a widespread distribution.

• Progress in Medical Physics
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• v.9 no.3
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• pp.175-184
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• 1998

The dose distribution evaluation program for the stereotactic radiosurgery treatment planning system using a gamma knife has been built in order to work on PC. And this custom-made dose distribution is compared with that of commercial treatment planning program. 201 source position of a radiation unit were determined manually using a gamma knife collimator draft and geometrical coordinates. Dose evaluation algorithm was modified for our purpose from the original KULA, a commercial treatment planning program. With the composed program, dose distribution at the center of a spherical phantom, 80 mm in diameter, was evaluated into axial, coronal and sagittal image per each collimator. Along with this evaluated data, the dose distribution at a arbitrary point of inside the phantom was compared with those from KULA. Radiochromic film was set up at the center of the phantom and was irradiated by gamma knife, for the verification of dose distribution. In result, the deviation of the dose distribution from that of KULA is less than ${\pm}$3%, which is equivalent to ${\pm}$0.3 mm in 50% isodose distribution for all examined coordinates and film verification. The custom-made program, GPl is proven to be a good tool for the stereotactic radiosurgery treatment planning program.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.38 no.10
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• pp.1147-1155
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• 2014

Biomechanical models are often used to predict muscle and joint forces in the human body. For estimation of muscle forces, the body and muscle properties have to be known. However, these properties are difficult to measure and differ from person to person. Therefore, it is necessary to predict the change in muscle forces depending on the body and muscle properties. The objective of the present study is to develop a numerical procedure for estimating the muscle forces in the human lower extremity under uncertainty of body and muscle properties during rising motion from a seated position. The human lower extremity is idealized as a multibody system in which eight Hill-type muscle force models are employed. Each model has four degrees of freedom and is constrained in the sagittal plane. The eight muscle forces are determined by minimizing the metabolic energy consumption during the rising motion. Uncertainty analysis is performed using a first-order reliability method. The one-standard-deviation range of agonistic muscle forces is calculated to be about 150-300 N.

• Korean Journal of Psychosomatic Medicine
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• v.9 no.1
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• pp.81-92
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• 2001

Stress has been linked to the pathophysiology and pathogenesis of various psychiatric illnesses. Over the past few years, our understanding of the brain and neuroendocrine systems that are linked to stress responses has increased enormously. This article reviews a series of animal and human studies to understand what are the central pathways by which stress is perceived, processed, and transduced into a neuroendocrine response. We focus on the limbic-hypothalamic-pituitary-adrenal(LHPA) axis and several neurotransmitter systems such as norepinephrine, CRF, serotonin, acetylcholine, and dopamine. LHPA stress circuit is a complex system with multiple control mechanisms which are altered in pathological states. CRF and related peptides in the central nervous system appear to enhance behavioral responses to stressors. Norepinephrine systems are also activated by stressors and cause the release of catecholamines from the autonomic nervous system. CRF-norepinephrine interaction makes a feed-forward system which may be important for an organism to mobilize not only the pituitary system but also the central nervous system, in response to environmental challenges. The interactions among several neurotransmitters and endocrine systems appear to play key roles in mediating various behavioral and psychological stress responses involving abnormal responses to stressors such as anxiety and affective disorders.

• Journal of Biomedical Engineering Research
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• v.19 no.5
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• pp.519-530
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• 1998

In this paper, the basic study on the design of the flexible keel of the energy-storage prosthetic foot was performed in order to Improve the walking performance and Increase the activities of the below knee amputees. Based on the analysis of the anthropometric data and the normal gait on two dimensional sagittal plane available In the literature, we presented a model of the basic structure of the flexible keel of the prosthetic foot. The model of the basic structure was composed of the simple beams, and linear rotational spring and damper. Laminated carbon fiber-reinforced composites were selected as the material of the basic structure model of the flexible keel In order to apply the high strength and light weight materials to the basic structure of the flexible keel of the prosthetic foot. The recoverable strain energy In response to the change of beam shape was calculated bur the finite element analysis and it was suggested that the change of beam shape could be the design variable in flexible keel design. The simulation process was systematically designed by using orthogonal array table in order to design the flexible keel structure which could store the more recoverable strain energy. finite element analysis was carried but according to the design of simulations by using the finite element program ABAQUS and the flexible keel structure of the energy-storage prosthetic foot was obtained from the analysis of variance(ANOVA). The dynamic simulation model of the prosthetic walking using the flexible keel structure was made and the dynamic analysis was carried but during one walk cycle. Based on the above results, an effective design process was presented for the development of the prosthetic fool system.

• Journal of Korean Medical classics
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• v.13 no.2 s.17
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• pp.58-67
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• 2000

통과대문왕팔괘차서도화문왕팔괘방위도적연구(通過對文王八卦次序圖和文王八卦方位圖的硏究). 득도요여하결론(得到了如下結論). 1. 최초명명위문왕팔괘차서도화문왕팔괘방위도적인시소옹(最初命名爲文王八卦次序圖和文王八卦方位圖的人是邵雍). 문왕팔괘차서도화문왕팔괘방위도수연몰유시문왕소화적확체적근거(文王八卦次序圖和文王八卦方位圖雖然沒有是文王所畵的確切的根據), 단시종추연복희이(但是從推演伏羲易), 동사상결합(同事相結合), 최종확립여금적역학체계적인시문왕(最終確立如今的易學體系的人是文王). 이차환부합현금적역리(而且還符合現今的易理), 인차구유일정설복력(因此具有一定說服力). 2. 재문왕팔괘차서도중삼남유일양이음구성(在文王八卦次序圖中三男由一陽二陰構成). 삼녀유일음이양구성(三女由一陰二陽構成). 저가이용음양호근적원리진행설명(這可以用陰陽互根的原理進行說明). 3. 복희팔괘방위도현시모종공간상(伏羲八卦方位圖顯示某種空間相). 이문왕팔괘방위도칙현시사시(而文王八卦方位圖則顯示四時). 팔절적변화화만물생장적류행주기등시간상적변화(八節的變化和萬物生長的流行周期等時間上的變化). 4. 문왕팔괘방위도동사시적오행상일치(文王八卦方位圖同四時的五行相一致). 시상생관계(是相生關係), 팔괘당중각유양개목김토(八卦當中各有兩개木金土). 시유우형흔왕성(是由于形흔旺盛), 수화각유일개시유우기흔왕성(水火各有一개是由于氣흔旺盛). 5. 문왕팔괘방위도재표면상간호상시오행상생적관계(文王八卦方位圖在表面上看好象是五行相生的關係). 단시(但是), 상호성대면적팔괘적오행도성상극관계(相互成對面的八卦的五行都成相剋關係). 화동측상임적감수(和東側相臨的坎水) 간토(艮土) 진목(震木) 손목도시성상극관계(孫木都是成相剋關係). 종차가이지도상극시발전만물적주체(從此可以知道相剋是發展萬物的主體). 6. 대우복희팔괘전화위문왕팔괘적원리(對于伏羲八卦轉化爲文王八卦的原理), 수유각종이론제출(雖有各種理論提出). 단시상무확체적설법(但是尙無確切的說法). 7. 복희팔괘주요체현천도화외상등(伏羲八卦主要體現天道和外象等), 문왕팔괘측체현인사화내정등(文王八卦側體現人事和內情等). 8. 복희팔괘위체(伏羲八卦爲體), 문왕팔괘위용(文王八卦爲用). 복희팔괘중(伏羲八卦中), 위변화적주체적천지즉건곤위우중축(爲變化的主體的天地卽乾坤位于中軸). 문왕팔괘중(文王八卦中), 위변화적대용적일월즉감리위우중축(位變化的大用的日月卽坎離位于中軸). 9. 복희팔괘도속우표현춘천적변화지상적제일괘도(伏羲八卦圖屬于表現春天的變化之象的第一掛圖), 생괘도화창조도(生掛圖和倉曹圖), 문왕팔괘도칙속우표현하천적변화지상적제이괘도(文王八卦圖則屬于表現夏天的變化之象的第二掛圖), 장괘도화발전도(長掛圖和發展圖). 10. 문왕팔괘도시류행이치기용적역지용(文王八卦圖是流行以致其用的易之用), 표현무질서화혼란(表現無秩序和混亂), 위화여괴리상호란무적난음난양지상(韋和與乖離相互亂舞的亂陰亂陽之象). 11. 문왕팔괘도화낙서적변화원리상일치(文王八卦圖和洛書的變化原理相一致), 가이장낙서적수직접대응도문왕팔괘도중(可以將洛書的數直接對應到文王八卦圖中). 우명낙서팔괘도(又名洛書八卦圖). 구수도혹일구역(九數圖或一九易). 12. 문왕팔괘도적상대응적수자지합도위십(文王八卦圖的相對應的數字之合都爲十). 저예시료성괘도십수도적출현(這豫示了成掛圖十數圖的出現).

• Journal of Yeungnam Medical Science
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• v.16 no.1
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• pp.25-33
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• 1999

Benzodiazepines(BZDs) are among the most widely prescribed drugs in the world. They are potent anxiolytic, antiepileptic, hypnotic, and muscle relaxing agents. There is an emerging model of the role of several neural systems in anxiety and their relation to the mechanism of action of BZDs. It has been postulated that BZD drugs exert their anxiolytic action by regulating GABAergic transmission in limbic areas such as the amygdala, in the posterior hypothalamus, and in the raphe nuclei. The involvement of the amygdala in the behaviors triggered by fear and stress has been suggested by many previous studies. In this review, reports about regulatory effects of endogenous BZD receptor ligands on the perception of anxiety and memory consolidation were summerized. These findings further support the contention that BZD receptor ligands modulate memory consolidation of averse learning tasks by influencing the level of stress and/or anxiety that accompanies a learning experience. The findings suggest that the decrease in the limbic levels of BZD-like molecules seen after the various behavioral procedures represent a general response to stress and/or anxiety, since it occurs in proportion to the level of stress and/or anxiety that accompany these tasks. In addition, these findings further support the hypothesis that the $GABA_A$/BZD receptor complex in limbic structures plays a pivotal role in the stress and anxiety.

• The Journal of the Korea Contents Association
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• v.14 no.12
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• pp.854-862
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• 2014

Attention deficit hyperactivity disorder (ADHD) students' intellctual defects, learning problems, and poor academic achievements seem to be due to significantly lower intelligence compared to the normal students, but rather the characteristic of inability to pay attention at a given time can be seen as the more attributing reason. In this study, a comparison between the ADHD students and the normal students will be performed using a fMRI analysis in order to differentiate the brain function between the two groups during a working memory task performance and to assess the difference in the activated regions of the brain. Clinical survey examinations and fMRI measurements were performed for a group of 26 elementary students from the Incheon area. The stimulus of fMRI was a working memory. Cartography statistically analyzed parameters and the Statistical Package of Social Sciences using single-sample t-test, two-sample t-test, were analyzed by multiple regression analysis, the statistical significance level was p<0.05 in, respectively. The disproportionate developments could be seen in the ADHD students group such as the frontal cortex, parietal cortex, thalamus, and caudate nucleus, among others. In addition, as some students felt the increase in the difficulty of working memory task performance, the orbitofrontal cortex and the hippocampus were activated, which seems to be the result of an effort for looking for an answer. More types of ADHD students needs to be secured as research subjects, and more stimulations for fMRI experiments should be considered as it would be useful in the overall evaluation of brain function.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.28 no.4
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• pp.383-391
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• 1995

In order to find out the distribution of neuropeptide Y (NPY) recently known as the gonadotropin (GtH) stimulation neurohormone in the brain tissues of marine teleost, detection and localization of NPY like substance in brain of two rockfish species, Sebastes oblongus and S. schlekeli were done by immunohistochemisty. Distribution of GtH cells in hypophysis were also observed by aldehyde fuchsin (AF)-fast green-orange G stain to compare with gonadal phases of the rockfish species. NPY immunoreactive cells were detected in olfactory bulb, telencephalon and mesencephalon of the brain, and NPY immunoreactive fibers were distributed not only in olfactory bulb, telencephalon and mesencephalon but also in optic nerve, hypothalamus and optic tectum. Regardless of ovarian maturation in two rockfish species, NPY immunoreactive fibers were observed in the neurohypophysis adjacent to the AF negative cells in the rostral pars distalis of hypophysis in both species. Moreover, the fibers were distributed in the rostral and proximal pars distalis near to the GtH cells of the hypophysis in both species possessing the growing or mature oocytes. Slight AF stainable GtH cells were detected in hypophysis of two species before parturition (S. oblongus) and in mature stage (S. schlegeli), but AF stainability of the cells in the proximal pars distalis after parturition was more increased than that of the cells Tn mature stage or before parturition. The size and nucleus diameter of GtH cells in S. oblongus and S. schlegeli before parturition were significantly bigger than those of GtH cells in individuals after parturiton (S. oblongus) or with resting ovary (S. schlegeli) (P<0.01).

• Journal of Korean Society of Environmental Engineers
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• v.36 no.12
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• pp.821-827
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• 2014

The 4major river project has caused changes in flow and water quality patterns in major rivers in Korea including the Nakdong River where several toxicant release accidents have had occurred. Three dimensional hydrodynamic model, the Environmental Fluid Dynamics Code (EFDC), was applied to evaluate the effect of geomorphological change of the river on the advection and dispersion patterns of a conservative toxic pollutant. A hypothetical scenario was developed using historical data by assuming a toxic release from an upstream location. If there is a toxic release at the Gumi Industrial Complex, the toxic material would be detected after 2.22 and 9.83 days at Chilgok and Gangjung weir, respectively, in the new river system. It was estimated that they took at least 12 times longer than those with the river conditions before the project. Effect of relocation of intake towers for Daegu Metro City to upstream of Gumi City was also evaluated using the developed modeling system. It was observed that hydraulic residence time would be increased due to decreased flow rate and thus due to lowered water level. However, peak concentration differences were found to be about 2% lower in both places due to increased dispersion effect after the relocation.