• The Bulletin of The Korean Astronomical Society
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• v.45 no.1
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• pp.69.3-69.3
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• 2020

우주개발과 활용이 주요 화두가 된 현대에 보다 빠르고 정확한 우주환경 예보는 전략적으로 매우 중요하다. 이에 우리는 광대역태양영상분광망원경(Wide-Field Solar Spectro-Imaging Telescope, Post SOlar Flare Telescope: PSOFT)을 활용한 태양전면 영상분광감시체계를 구성하고자 한다. 전세계 세 곳에 PSOFT를 배치하여 우주환경에 중대한 영향을 주는 요소인 태양의 플레어와 홍염 분출과 같은 현상과 표면의 다양한 활동들을 실시간으로 관측 분석하고자 한다. PSOFT는 30cm 구경의 광학계에 고속영상분광기를 결합하여 태양 전면의 분광영상을 약 1초각의 영상해상도와 5분의 시간해상도로 획득한다. 태양 전면을 슬릿으로 스캔하는 방식으로 H alpha와 Ca II 854.2nm선의 분광정보를 획득하는데 팁틸트 미러를 이용하여 1차적인 시상보정과 함께 스캔모션을 함께 구현함으로써 1)광학계 구조를 단순화하고, 2) 빠른 스캔이 가능하다. PSOFT로 얻은 태양전면 채층분광영상 데이터는 정밀한 우주환경 예보에 필요한 플레어나 홍염분출의 발생초기 정보를 제공할 뿐 아니라 태양 저층대기에서 발생하는 자기재연결, 파동 등에 대한 통계적 연구자료를 제공할 것으로 기대한다.

• Journal of the Korean BIBLIA Society for library and Information Science
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• v.17 no.1
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• pp.99-113
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• 2006

As society has more interest in reading activities, it has become possible to secure social value of libraries through the promotion of reading. In this regard, the study aimed to analyze social tasks that the libraries face and suggest concrete methods through bibliographical examination. Currently, various regions of the nation have an increasing interest in libraries, particularly, children's libraries. The public libraries can expand their social roles by meeting these social requests. As a variety of activities by the public libraries to promote reading have helped people recognize the importance of libraries, more aggressive reading promotion activities are considered to help expand the roles of the public libraries and secure social base. Accordingly, the libraries need to take the initiative in implementing various measures by establishing a committee to adjust various reading promotion activities in the government and the public and private sectors, coming up with legal base, pursuing development of voluntary reading promotion programs, establishing an information network for reading and books, publishing book reviews, leading campaign for reading and reading promotion activities, supporting reading at home and expanding award system with regard to the promotion of reading.

• Proceedings of the Korea Water Resources Association Conference
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• 2022.05a
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• pp.185-185
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• 2022

상수도 관망의 운영 단계에서 비정상상황의 발생은 필연적으로 발생하며, 비정상상황 발생 시상수도 관망 내 설치된 제수 밸브의 차폐를 통해 해당 구역의 격리 후 복구를 진행한다. 일반적으로 제수밸브를 통해 격리될 수 있는 최소 구역은 세그먼트로 정의하고, 제수밸브 설치 시 세그먼트의 격리로 인한 상수도 관망의 피해를 줄일 수 있도록 위치를 선정한다. 제수 밸브를 통한 격리 시 상수도 관망의 흐름 경로와 유향, 유속의 변화와 같은 수리적 특성 변화가 불가피하다. 지난 '19년도에 발생했던 3건의 수질 사고가 수리적 특성 변화에서 기인했던 것을 고려할 때, 제수밸브 차폐로 상수도 관망의 부분 격리 시 발생 가능한 수리적 특성 변화에서도 수질 사고가 야기될 가능성이 있다. 기존 제수밸브 위치를 결정한 연구들을 보면, 대부분 제수밸브 위치에 따라 결정된 세그먼트의 격리 시 수압 저감을 고려하여, 격리 시에도 상수도 관망의 성능을 최대한 유지할 수 있도록 결정하는 것이 일반적이다. 다만, 앞서 언급한 것과 같이 격리 시 발생 가능한 수리적 특성 변화로, 수압 저감 외에도 예기치 못한 수질 사고의 발생 원인이 되기도 한다. 이에 따라 제수밸브의 최적위치를 결정할 때 수리적 특성 변화를 고려해야 예지치 못한 2차 피해를 줄일 수 있을 것이다. 이에 본 연구는 그래프이론을 활용하여 격리 전후 관로의 유향 변화를 최소화하도록 제수밸브 최적 위치 결정하는 방법론을 제안한다. 그래프이론은 망의 형태를 가지는 상수도 관망의 연결성을 정량화할 수 있으며, 본 연구에서는 수리학적 거리 인자를 적용하여 격리 시에도 각 수요절점이 최소 경로를 확보할 수 있도록 유도하였다. 해당 방법론은 가상 관망에 적용하여 수리학적 거리 인자에 따른 설계와 기존 상수도 관망 성능 극대화 설계 안을 비교하였다. 또한 수질 사고 위험도 인자를 정의하여 해당 인자에 따른 각 설계 안의 효과를 분석하였다. 본 연구는 향후 수질 사고를 고려한 밸브 시스템의 설계 및 운영에 활용할 수 있을 것으로 기대한다.

• Clinical Pain
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• v.18 no.1
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• pp.8-15
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• 2019

Objective: To determine the relationship between cervical sagittal parameters and the degree of the cervical disc degeneration at each cervical level by using cervical plain radiographs and disc degeneration grading. Method: This study analyzed 110 patients with posterior neck pain. Cervical radiographic measurements included the occipito-cervical (O~C2) angle; sagittal Cobb angles of C1~C2, C2~C7; and sagittal vertical axis (SVA) of C1~C7 and C2~C7. The degenerations of cervical discs at each level were evaluated through Pfirrmann grading system by magnetic resonance images of the cervical spine. The correlations between the cervical sagittal measurements and the disc degeneration at each level were analyzed by Spearman's correlation. Results: A significant correlation was found for the C2~C7 angle with disc degenerations at C2~C6 levels. O~C2 angle was correlated significantly with disc degenerations at C2~C4 and C5~C7 levels. There was significant correlation between C1~C2 angle and disc degeneration at C6~C7 level. No significant relationship was found between the cervical SVA and the cervical disc degeneration at all cervical levels. Conclusion: Cervical sagittal parameters representing cervical angles (C2~C7, O~C2, and C1~C2 angles) were significantly correlated with the degree of the cervical disc degeneration. These findings suggest that the loss of the natural cervical lordosis rather than loss of natural SVA could be correlated with progression of the cervical disc degeneration.

• The Journal of Internal Korean Medicine
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• v.44 no.5
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• pp.823-829
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• 2023

Objectives: This study reports the case of a patient with right hemiparesis after a left thalamic infarction, in which the patient experienced improved clinical symptoms (hemiparesis, constipation) after treatment with a complex Korean medicine treatment. Methods: A 81-year-old male patient diagnosed with acute left thalamic infarction was treated with daily acupuncture and herbal medicine (Boyanghwanoh-tang-gagam) three times a day. Jowiseunggi-tang extract granules were administered to treat constipation by adjusting the dosage according to the reported symptoms. The patient's clinical course was assessed using changes in Modified Barthel Index (MBI) score, Manual Muscle Testing (MMT) grade, and defecation frequency . Results: The patient's MBI score improved from 35 to 69 and was discharged with the ability to walk under supervision. The MMT grade also improved from 3/4 to 5/5 in the upper/lower extremities. Other clinical symptoms, including constipation, also improved, leading to the discontinuation of magnesium medication. Conclusion: These findings suggest that complex Korean medicine treatments, including herbal medicine and acupuncture, may be an effective treatment for post-stroke hemiplegic patients.

• Journal of the Korean Society of Radiology
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• v.82 no.5
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• pp.1274-1280
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• 2021

Acute necrotizing encephalopathy (ANE) is a rare but distinctive type of influenza-associated encephalopathy characterized by symmetric multiple lesions with an invariable thalamic involvement. Although the exact pathogenesis of ANE remains unclear, the most prevalent hypothesis is the "cytokine storm," which results in blood-brain-barrier breakdown. We present the case of a 10-year-old boy with fulminant ANE confirmed with serial MRI studies, including diffusion-weighted imaging and susceptibility-weighted imaging. A comparison of these serial images demonstrated detailed and longitudinal changes in MRI findings during the clinical course corresponding to pathophysiological changes. Our case clarifies the pathogenesis of ANE brain lesions using serial imaging studies and suggests that early immunomodulatory therapy reduces brain damage.

• Journal of the Korean Society of Radiology
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• v.84 no.3
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• pp.745-749
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• 2023

Gerstmann-Sträussler-Scheinker (GSS) disease is a rare hereditary prion disease which is clinically characterized by a progressive cerebellar ataxia followed by cognitive impairment. We report a rare case of GSS disease in a 39-year-old male patient who complained of a progressive gait disturbance followed by dysarthria with cognitive impairment, after five months from the onset of initial symptom. His brain MRI scan revealed multifocal symmetric diffusion restricted lesions with T2/FLAIR hyperintensities in bilateral cerebral cortices, basal ganglia, and thalami. His family members also manifested similar symptoms in their 40-50s, suggesting the possibility of a genetic disease. Finally, he was genetically diagnosed with GSS disease by real-time quaking-induced conversion and prion protein (PRNP) gene sequencing test.

• The Korean Journal of Pharmacology
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• v.25 no.1
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• pp.13-21
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• 1989

The circadian rhythm of spontaneous motor activity was not significantly altered by $T_4$(4mg/kg, i.p. inj. once a day for 5 days: $T_4$) and PTU (fed ad lib in 0.01% drinking water for 5 weeks: PTU). The plasma thyroxine level was markedly increased by $T_4$ but reduced by PTU, and the plasma thyrotropin level was markedly increased by PTU but moderately increased by $T_4$. Clonidine slightly increased the plasma CS level, but the clonidine effect was significantly enhanced by $T_4-pretreatment$. The brain NE and MHPG contents were little affected by $T_4$ but the NE content was significantly decreased by PTU. The SS-induced increase of plasma CS level was moderately decreased by PTU but increased by $T_4$. However, clonidine significantly inhibited the SS-induced increase, and the inhibitory effect of clonidine was not significantly affected by PTU and $T_4$, respectively. The brain MHPG content and MHPG/NE ratio were significantly decreased by clonidine but increased by SS. The clonidine- and SS-induced changes of brain MHPG content and MHPG/NE ratio were not altered by $T_4$. PTU did not affect the SS-induced increase of brain NE turnover but significantly attenuated the clonidine-induced decrease. The SS-induced increases of brain MHPG content and MHPG/NE rtatio were markedly inhibited by clonidine, and the inhibitory effect of clonidine was not affected by $T_4$ and PTU, respectively. These results suggest that the responses to swim-stress is not signigicantly affected by the alteration of thyroid function and that the hypothalamo-adenohypophysis-adrenocortical stimulation in response to swim-stress seems to be mediated via hypothalamic noradrenergic activation, and the stress response may be inhibited by the agonistic activity of clonidine on the presynaptic ${\alpha}_2-adrenoceptor$.

• Journal of the korean academy of Pediatric Dentistry
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• v.30 no.3
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• pp.391-405
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• 2003

Craniosynostosis, known as a premature fusion of cranial sutures, is a developmental disorder characterized by precocious differentiation and mineralization of osteoblasts in the calvarial sutures. Recent genetic studies have demonstrated that mutation in the homeobox gene Msx2 causes Boston-type human craniosynostosis. Additionally, the phenotype of Dlx5 homozygote mutant mouse presents craniofacial abnormalities including a delayed ossification of calvarial bone. Furthermore transcription of osteocalcin, a mature osteoblast marker, is reciprocally regulated by the homeodomain proteins Msx2 and Dlx5. These facts suggest important roles of osteocalcin, Msx2 and Dlx5 genes in the calvarial bone growth and suture morphogenesis. To elucidate the function of these molecules in the early morphogenesis of mouse cranial sutures, we have first analyzed by in situ hybridization the expression of osteocalcin, Msx2 and Dlx5 genes in the developing parietal bone and sagittal suture of mouse calvaria during the embryonic (E15-E18) stage. Osteocalcin mRNA was found in the periosteum of parietal bones from E15, and gradually more highly expressed with aging. Msx2 mRNA was intensely expressed in the sutural mesenchyme, osteogenic fronts and mildly expressed in the dura mater during the embryonic stage. Dlx5 mRNA was intensely expressed osteogenic fronts and the periostem of parietal bones. To further examine the upstream signaling molecules of transcription factor Msx2 and Dlx5, we have done in vitro experiments in E15.5 mouse calvarial explants. Interestingly, implantation of BMP2-, BMP4-soaked beads onto the osteogenic fronts after 48 hours organ culture induced etopic expressions of Msx2 and Dlx5 genes. On the other hand, overexpression of $TGF{\beta}1$, GDF-6, -7, FGF-2, -4 and Shh did not induce the expression of Msx2 and Dlx5. Taken together. these data indicate that transcription factor Msx2 and Dlx5 play critical roles in the calvarial bone and suture development, and that BMP siganling is involved in the osteogenesis of calvarial bones and the maintenance of cranial sutures through regulating these two transcriotpn factors. Furthermore, different expression patterns between Msx2 and Dlx5 suggest their specific functions in the osteoblast differentiation.

• Journal of Korean Orthopaedic Sports Medicine
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• v.5 no.1
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• pp.41-44
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• 2006

Purpose: To evaluate the short-term results of arthroscopic ACL reconstruction using fresh frozen Achilles allograft Materials & Methods: From March 2002 to March 2004, arthroscopic ACL reconstructions using fresh frozen Achilles allograft were performed in 25 knees of 25 patients. The average age at operation was 30.1 years (range, 18-50 years) and the average follow-up was 17 months (range, 12 to 27months). Preoperative and follow-up clinical results were evaluated using the Lysholm knee score, IKDC knee rating system, physical examination and KT-2000 arthrometer. Results: The Lachman test was positive in 25 patients preoperatively and 18 patients(72%) had negative results at latest follow-up. The average side-to-side differences of anterior tibial translation using KT-2000 arthrometer under loading of 301b were improved from $7.9{\pm}2.4mm\;to\;2.6{\pm}1.6mm$. The average Lysholm score was improved from $61.1{\pm}13.9\;to\;93.5{\pm}5.3$ points. The IKDC grade was abnormal(C) or severely abnormal(D) in 25 cases preoperatively They improved 22(88%) of normal(A) or nearly normal(B) and 3(12%) of abnormal. Conclusion: Short term results of ACL reconstruction using Achilles allograft was acceptable. Achilles allograft can be a reasonable graft alternative to autograft for ACL reconstruction.