• Journal of the Korean Orthopaedic Association
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• v.54 no.1
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• pp.1-8
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• 2019

Globally, the elderly population is increasing rapidly, which means that the number of deformity correction operations for elderly spine deformity patient has increased. On the other hand, for aged patients with deformity correction operation, preoperative considerations to reduce the complications and predict a good clinical outcome are not completely understood. First, medical comorbidity needs to be evaluated preoperatively with the Cumulative Illness Rating Scale for Geriatrics or the Charlson Comorbidity Index scores. Medical comorbidities are associated with the postoperative complication rate. Managing these comorbidities preoperatively decreases the complications after a spine deformity correction operation. Second, bone densitometry need to be checked for osteoporosis. Many surgical techniques have been introduced to prevent the complications associated with posterior instrumentation for osteoporosis patients. The preoperative use of an osteogenesis inducing agent - teriparatide was also reported to reduce the complication rate. Third, total body sagittal alignment need to be considered. Many elderly spine deformity patients accompanied degenerative changes and deformities at their lower extremities. In addition, a compensation mechanism induces the deformed posture of the lower extremities. Recently, some authors introduced a parameter including total body sagittal alignment, which can predict the clinical outcome better than previous parameters limited to the spine or pelvis. As a result, total body sagittal alignment needs to be considered for elderly spine deformity patients after a deformity correction operation. In conclusion, for elderly spine deformity patients, medical comorbidities and osteoporosis need to be evaluated and managed preoperatively to reduce the complication rate. In addition, total body sagittal alignment needs to be considered, which is associated with better clinical outcomes than the previous parameters limited to the spine or pelvis.

• Journal of Yeungnam Medical Science
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• v.14 no.1
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• pp.197-208
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• 1997

The purpose of this study was to evaluate the amount and interrelationship of the soft and hard tissue change after mandibular setback surgery in skeletal Class III malocclusion. The sample consisted of 25 adult patient (12 male and 13 female) who had severe anteropostrior skeletal discepancy. These patient had received presurgical orthodontic treatment and surgical treatment which is bilateral sagittal split ramus osteotomy. The presurgical and postsurgical lateral cephalograms were evaluated. The computerized statistical analysis was carried out with SPSS/PC program. The result were as follows: 1. After mandibular bilateral sagittal split ramus osteotomy, lower facial soft. tissue horizontal posterior changes were high significance value. but vertical soft tissue changes were low significance value. 2. After mandibular bilateral sagittal split ramus osteotomy, relative upper lip protrusion increased(p<0.01) and relative lower lip protrusion decreased(p<0.01) and lower facial soft tissue thickness increased(p<0.01).

• Development and Reproduction
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• v.11 no.1
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• pp.13-20
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• 2007

In all female mammals, reproductive system is one of the first biological systems to show age-related decline. Female mammals in reproductive aging, though the phenomena is somewhat species-specific, start to show declining fertility and changes of numerous physiological functions. This review will present a current information on the aging of the female reproductive hormonal axis and introduce three useful rodent models for studying this field. Middle age($8{\sim}12$ months old) in female rats and mice is comparable to the stage prior to the entry of menopause in human. In this period pulsatile and surge GnRH secretion from hypothalamus gradually attenuated, then reduced pulsatile and surge LH secretion is followed consequently. This age-related defects in GnRH-LH neuroendocrine axis seem to be highly correlated with the defects in brain signals which modulate the activities of GnRH neuron. Many researchers support the idea which the age-related hypothalamic defects are the main cause of reproductive aging, but some ovarian factors such as inhibin response also could contribute to the induction of reproductive senescence. Some rodent models are quite valuable in studying the reproductive aging. The follitropin receptor knockout(FORKO) mice, both of null and haploinsufficient state, could produce depletion of oocyte/follicle with age. Dioxin/aryl hydrocarbon receptor(AhR) knockout mice also show severe ovarian defects and poor reproductive success early in their life compared to the age-matched normal mice. Further studies on the reproductive aging will be a great help to evaluate the benefits and risks of hormone replacement therapy(HRT) and to improve the safety of HRT.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.10 no.12
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• pp.3902-3909
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• 2009

The purpose of this study was to investigate the spontaneous therapy, TENS(transcutaneous electrical nerve stimulation) and ice therapy after induction of DOMS(delayed onset muscle soreness) through application of eccentrically exercise in ralation to biceps brachii muscle of opposite-dominance. And to explain this, we analyzed VAS(visual analogue scales), peak torque, RMS(roots mean square) when exercising elbow joint. The subjects were 30 adults without any physical defect. Subjects were divided into three groups that spontaneous therapy, TENS therapy and ice therapy after DOMS induction, choosen movement could get the maximal peak torque in angular velocity of $60^{\circ}$/sec, and mearsured peak torque, RMS and VAS. 1. The VAS was significantly decreased after 3 days application of TENS than other groups(p<.05). 2. The peak torque was significantly increased after 3 days application of TENS than other groups(p<.05). 3. The RMS was significantly increased after 3 days application of TENS than other groups(p<.05). This study showed that TENS therapy application were effective treatment strategy on DOMS than spontaneous therapy and ice therapy. Therefore, it could be considered as a treatment method in the patients with DOMS.

• Development and Reproduction
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• v.9 no.1
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• pp.1-5
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• 2005

The hypothalamo-pituitary-gonadal hormone axis is centrally controlled by a complex regulatory network of excitatory and inhibitory signals, that is dormant during infantile and juvenile periods and activated at puberty. The kisspeptins are the peptide products of the KiSS-1 gene and the endogenous agonists for the G protein-coupled receptor 54(GPR54). Although KiSS-1 was initially discovered as a metastasis suppressor gene, a recent evidence suggests the KiSS-1/GPR54 system is a key regulator of the reproductive system. Yet the actual role of the KiSS-1/GPR54 system in the neuroendocrine control of gonadotropin secretion remains largely unexplored, the system could be the first missing link in the reproductive hormonal axis. Central or peripheral administration of kisspeptin stimulates the hypothalamic-pituitary-gonadal axis, increasing circulating gonadotropin levels in rodents, sheep, monkey and human models. These effects appear likely to be mediated via the hypothalamic GnRH neuron system, although kisspeptins may have direct effects on the anterior pituitary gland. The loss of function mutations of the GPR54(GPR54-/-) have been associated with lack of puberty onset and idiopathic hypogonadotropic hypogonadism(IHH). So kisspeptin infusion may provide a novel mechanism for HPG axis manipulation in disorders of the reproductive system.

• The Korean Journal of Pharmacology
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• v.28 no.1
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• pp.1-9
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• 1992

Catecholamines, serotonin and their metabolites were measured in the posterior hypothalamus of urethane-anesthetized normotensive Wistar Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) using brain microdialysis which is a recently developed experimental method to measure the release of neurotransmitters and their metabolites at the localized brain area in vivo. Microdialysis probe was implanted stereotaxically to the rat posterior hypothalamus and perfused by Ringer's solution. Monoamines and their metabolites were quantified by reverse phase high performance liquid chromatography with electrochemical detection. In vitro recovery test of microdialysis showed that there exist inverse relationship between the perfusion flow rate and the relative recovery of neurochemical compounds. The estimated extracellular concentration of dopamine was about 32 nM, of norepinephrine 50 nM, of epinephrine 50 nM, of serotonin 73 nM, of 3, 4-dihydroxyphenylacetic acid (DOPAC) 281 nM, of homovanillic acid (HVA) 181 nM, and of 5-hydroxyindoleacetic acid (5HIAA) 3767 nM in the hypothalamic perfusate of the normotensive rat. There was no difference in the basal level of monoamines between the SHR and the WKY. In contrast, the level of DOPAC, HVA and 5HIAA in SHR was higher than that in the WKY, This study demonstrated that the microdialysis technique should be an applicable tool for in vivo measurement of central neurochemical substances.

• Korean Architects
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• no.11 s.427
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• pp.18-32
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• 2004

영예의 대통령상이 수여되는 한국건축문화대상의 대상이 올해부터 '비주거'와 '주거'로 나뉘어 확대, 시상한다. 그 첫번째 수혜자로 비주거부문은 김삭식 건축사(주.금성 종합건축사사무소 대표)가 설계하고, (주)금호산업이 시공한 '광주광역시청사'가 주거부문에는 김종국(주.종합건축사사무소 건원)건축사가 설계하고, 현대산업개발(주)이 시공한 '아이파크 삼성동'이 국내 준공건축물들을 대상으로 한 2004한국건축문화대상에서 영예의 대상으로 각각 선정됐다. 또 올해 한국건축문화대상에서는 KT여의도사옥 등 6작품이 본상을 차지한 것을 비롯해 우수상 등 모두 22개 작품이 수상작으로 선정됐다. "불이 - Architecture in NatureㆍNature in Architecture"를 주제로 공모한 일반 및 신인ㆍ학생 대상의 계획건축물부문에서는 박종대, 윤새봄, 김정희(인하대학교 건축공학과대학원 건축의장연구실)씨가 공동 출품한 'Plankton House'가 금상을 차지한 것을 비롯해 은상 2팀, 동상 3팀 입선 22점 등 모두 28개 팀이 입상했다. 올해 한국건축문화대상에는 준공건축물부문 89점, 계획건축물부문 252점 등 총 341개 작품이 응모했다. 비주거 부문의 대상을 차지한 광주광역시청사는 "관 건물의 이미지를 탈피하여 하나의 문화 건물로 탈바꿈하려는 시도가 특히 돋보이는 작품으로 시공에도 많은 어려움이 있었음에도 불구하고 완성도가 우수한 작품"이란 평을 받았다. 또한 주거 부문의 아이파크 삼성동은 "아파트이면서도 주상복합의 이미지를 구현시키면서 판상형 형태에서 벗어나 탑상형 배치에 의한 낮은 건폐율 적용으로 친환경적인 단지를 이루고 있으며, 특히 시공이 매우 우수한 작품"이란 평을 받았다. 한편 올해부터 우리나라 건축문화발전을 위해 기여한 건축인을 발굴해 시상하는 '올해의 건축인상'을 제정, 그 첫번째 수상자로 김석철 건축사(아키반건축도시연구원 건축사사무소)와 이창남 건축사(센구조 건축사사무소)가 선정되어 건설교통부장관상을 받았다. 시상식은 지난 11월 24일 서울 종로구 세종로 세종문화회관 컨벤션홀에서 개최되어 대상의 비주거부문 수상작의 설계자인 김상식 건축사에게 대통령상 그리고 시공자인 (주)금호산업에게는 건설교통부장관상, 건축주인 광주광역시장에게는 국무총리상이 수여됐다. 또한 주거부문 수상작의 시공자인 현대산업개발(주)에게 대통령상 그리고 설계자인 김종국 건축사에게는 국무총리상, 건축주인 현대산업개발(주)에게는 건설교통부장관상이 수여됐다. 또 KT 여의도빌딩 등 본상 6개 작품의 설계자 및 시공자에게는 건설교통부장관상 등 정부포상이, 준공건축물부문 우수상 입상자 전원에게는 각각 대한건축사협회장상, 서울경제신문사장상이 수여됐다. 계획건축물부문의 금상 수상자에게는 건설교통부장관상과 상금이 수여되었으며, 은상과 동상, 입선작은 대한건축사협회장상과 상금이 각각 수여됐다. 아울러 동상이상 수상자 중 영어 인터뷰심사를 거쳐 2명을 선발, ARCASIA 학생잼버리대회 파견 특전이 주어진다. 건설교통부와 대한건축사협회, (주)서울경제신문이 공동주최하고 대한주택공사 등 건설관련 5개 단체가 후원하는 한국건축문화대상은 올해로 13회째 개최되고 있다. 더욱이 올해에는 대통령상을 두 부문으로 나누어 시상하는 등 그 폭이 넓어져 수상자에게 더 큰 영예를 주었으며, 시간이 흐를수록 그동안 기성 건축인들의 창작의욕 고취는 물론 건축저변을 크게 확대하였다는 평과 아울러 우리 건축문화 창달에 기여해 한국건축문화대상은 명실공히 국내 건축인은 물론 일반 국민의 대표 건축축제로 자리매김하고 있다.

• The Korean Journal of Zoology
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• v.32 no.3
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• pp.275-280
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• 1989

Present study examined the endogenous release of luteinizing hormone releasing hormone (LHRH) from superiused hypothalamic sBces derived from Korean native cattie (KNC). In addition, the in vitro secretory pattern of LHRH release in '(NC was compared with that in imported cattle such as Holstein cow. The median eminences (ME) of hypothalamic tissues were disseded out, sliced and quici'ly placed in ice-cold superfilsion chamber. Superhision chambers containing ME slices were maintained in a constant temperature water-bath at 37$^{\circ}C$. Effluents were colleded on ice at 10 min intervals for a 4 hr superfusion period, and kept -2$0^{\circ}C$ prior to LHRH radloimmunoassay. LHRH release was analyzed by the PULSAR algorithm. The spontaneous release of LHRH from both cows was episodic during a 4 hr superhision period. The mean LHRH release, pulse amplitude and pulse interval m KNC were 11.08 $\pm$ 1.50 pg/min/mg x 10-$^2$, 21.43 1 7.28 pg/mg x 10-$^2$, and 39.42 $\pm$ 3.08 min, which were quite similar to those observed in Holstein cows. The basic charaderistics of the LHRH pulse generator of '(NC appears important for a better understanding about the endocrine function of KNC.

• Journal of the korean academy of Pediatric Dentistry
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• v.29 no.3
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• pp.345-353
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• 2002

Bone morphogenetic proteins(BMPs) are secretory signal molecules which have a variety of regulatory functions during morphogenesis and cell differentiation. To evaluate roles of BMPs and their receptors on mouse sagittal suture development, we have examined their expression patterns in serial sections of sagittal sutures by in situ hybridization during embryonic stages(E15-E18). BMP-2 and BMP-3 were expressed in the osteogenic front and parietal bone on embryonic 15day, from E16 in hair follicle. BMP-4 was strongly expressed in the osteogenic front and weakly expressed in the mesenchyme and parietal bone. BMP-S was expressed in the hair follicles. BMP-6 was not expressed in this study. BMP-7 was expressed in parietal bone during embryonic stage. BMPR-IB was expressed in the osteogenic front, but BMPR-IA was not. From these datas, we suggest that the BMP-4 regulates the early commitment of mesenchymal cells to the osteogenic lineages, the BMP-2 and BMP-3 may be involved in regulating the differentiation of osteoblast precursor cells. BMP-7 was involved in maintenance of differentiated osteoblasts. BMPs were key signaling molecules that regulate early calvarial bone morphogenesis, mediated by BMPR-IB.

• The Korean Journal of Zoology
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• v.39 no.4
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• pp.337-351
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• 1996

Melatonin Is a multifunctional hormone secreted from the pineal gland in the middle of cerebrum and cerebellum. Its synthesis and release reflect photopedod;Photopedod is a yearly predictable ambient factor that most animals utilize as an environmental cue for maximum survival. Hamsters maintaln reproductive activity in summer during which day length exceeds night time. Upon the advent of autumnal equinox they undergo gonadal regression. The photoperiodic effects are prevented by removal of the pineal gland and restored by the timed repiacument of melatonin. The results suggest that melatonin constitutes part of control mechanism whereby environmental information is transduced to neuroendocrine signal responsIble for the functional integrity of the reproductive system. From the studies for the action site of melatonin following the treatment of photopedod or melatonin in the lesion of a spedflc portion of hypothalamus, suprachiasmatic nuclei and pars tuberalis are shown to be a consensus site for melatonIn. The action of melatonin. In the regulation of reproduction is largely unknown. It is mainly due to the lack of acute effect of melatonin on gonadotropin secretion. However, reduction of the gonadotropln release and augmentation of the hypothalamic gonadotropin-releasing hormone (GnRH) content by long-term treatment of melatonln Indicate that constant presence of melatonln may partidpate in the regulation of sexual activity via the GnRH neuronal system. The action mechanism by which melatonin exerts Its effect on GnRH neuron needs to be eluddated. The inability of opiold analogues to affect the reproductive hormones in sexually regressed animals by inhibftory photopedod and melatonin suggests that the opioldergic neuron may be a prime intervening mediator. Recent cloning of melatonin receptor will contribute to investigate its anatomical Identification and the action mechanism of melatonin on target tissues at the molecular level.