• 대한후두음성언어의학회지
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• 제18권1호
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• pp.39-43
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• 2007

Background and Objectives: There are few studies reported that specifically examine the phonetic characteristics and voice handicap index (VHI) in patients with Allergic Rhinitis. This study was designed to examine phonetic characteristics and VHI in adult patients with allergic rhinitis. Materials and Methods: Forty-two male patients diagnosed as allergic rhinitis were given skin-prick test and others, aged from 20 to 56 years, and were compared with a 16 male control group with no pathology and in the same age group. The VHI was used to measure the changes of patient's perception. Acoustic and aerodynamic analysis test were done, and a nasalance test performed to measure rabbit, baby, and mother passage. Acoustic rhionometry (AR) was performed to evaluate nasal volume and nasal crosssectional area. Statistical analysis was done using independent sample t-test. Results: VHI showed significantly different score in the studied group, higher than that of control group. AR graph showed that there was no significant differences of nasal volume and nasal cross-sectional area. The Shimmer and SFF value in the group of allergic patients were higher than in the control group. MPT value in the group of allergic patients was lower than in the control group. Nasalance in allergic patients showed hypernasality all passage. Conclusion: We suggest that patients with allergic rhinitis have considerable voice problems. Most of them have hypernasality, which may be a compensatory mechanism by nasal obstruction.

• 대한후두음성언어의학회지
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• 제21권2호
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• pp.121-127
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• 2010

Background and Objectives : Unilateral vocal fold paralysis is generally treated using injection laryngoplasty or voice therapy. However, the decision of treatment method is dependent on clinician's preference and hospital facilities without specific criteria. The purpose of the study was to examine factors predictive of voice therapy outcome in patients with unilateral vocal fold paralysis. Materials and Method : 38 patients diagnosed as unilateral vocal fold paralysis, aged from 24 to 81 years and undergone voice therapy more than 1 month were included. After 3 to 12 (mean 5.1) sessions of voice therapy, subjects had divided into responder group (RG, 28 patients) and non-responder group (NRG, 10 patients) according to G scale change. Paramters of perceptual assessment, acoustic and aerodynamic measure, and videostroboscopy were compared between two groups, and factors predictive of voice therapy result were analyzed. Results : RG patients showed significantly reduced rough, breathy, asthenic voice after voice therapy. Change of MPT and MFR was more substantial in RG than in NRG. By videostroboscopy, RG patients showed significantly more mucosal wave symmetry, glottal closure, reduced glottal gap index during the closed phase of phonation, while NRG patients showed more occurrences of abnomal supraglottic activities during phonation (p < 0.05). Poor outcome of voice therapy significantly associated with increased asthenic scale, short MPT, and less glottal closure (p=0.02). In addition, 90% of patients with MPT more than 5 seconds were in RG, whereas 56% of patients with MPT less than 5 secondes were in RG. Conclusion : Voice therapy is useful for large proportion of patients with unilateral vocal fold paralysis as an initial treatment method. However, patients with large asthenia scale, large glottic gap or MPT less than 5 seconds tend to have poor voice therapy outcome, and early injection laryngoplasty maybe recommended for these patients.

• 대한두경부종양학회지
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• 제19권1호
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• pp.34-40
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• 2003

Objective: To analyze the treatment-related parameters after the radiotherapy of T1N0 squamous cell carcinoma of the glottic larynx. Materials and Methods: Between October 1989 and August 2000, 54 patients with histologically proven T1N0 squamous cell carcinoma of the glottic larynx who received definitive radiation therapy in Department of Radiation Oncology, Asan Medical Center were analyzed. They were all males with age ranged from 31 to 80 years (median 61 years). 1997 AJCC stages were 31 T1a, 23 T1b. Patients were treated with 4-MV X-rays with a parallel-opposed two-field technique. Ten patients received 66.0-68.4Gy at 1.2Gy per fraction twice daily, 21 patients received 64.8-66.6Gy at 1.8Gy per fraction once daily, and 23 patients received 66.0Gy at 2.0Gy per fraction once daily. Follow-up period was 16-119 months (median 56 months). Results: 5-year overall survival and local control rates for patients with T1 lesions were 87.0% and 88.5%, respectively. 5-year local control with larynx preservation rate was 90.5%. Host and tumor-related prognostic factors including age, stage, anterior commissure involvement and tumor bulk proved not to be significant. Only shorter overall treatment time among treatment-related factors had correlation with imporved local control. Conclusion: Comparable high local control rate with organ preservation was achieved with primary radiation therapy and salvage surgery. Shortening of overall treatment time is related to improved local control rate. To determine the optimal fractionation scheme, randomized trial is mandatory.

• 대한두경부종양학회지
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• 제19권1호
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• pp.58-62
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• 2003

Purpose: To evaluate the efficacy of positron emission tomography with 2-[F-18] fluoro-2-deoxy-D-glucose in discrimination of response in the nasopharyngeal carcinoma patients who treated with radiotherapy. Methods and Materials: Twenty-four patients who underwent FDG-PET scan before and after radiotherapy for no disseminated head and neck carcinoma at the Asan Medical Center between August 2001 and September 2002 were evaluate by prospective analysis. First FDG-PET scan performed before radiotherapy within 1 month, and second FDG-PET scan performed 1 month after radiotherapy. FDG-PET images were analyzed by standard uptake value (SUV). Follow-up period was more than 6 months. Results: The pretreatment SUV was 3.4-14.0 (median: 6.0) and posttreatment SUV was ground level-7.7 (median: 2.0). The overall sensitivity and specicity of FDG-PET to evaluate residual tumors in the nasopharyngeal carcinoma patients were 94% and 94%. Conclusion: FDG-PET is effective in evaluation of radiation response in the nasopharyngeal carcinoma. We think that the timing of one month after finished radiotherapy FDG-PET scan was not too fast to evaluation of radiation response.

• 대한두경부종양학회지
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• 제19권1호
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• pp.9-15
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• 2003

Purpose: To introduce our early experience with intensity-modulated radiotherapy (IMRT) in the treatment of nasopharyngeal carcinoma. Methods and Materials: Eight patients who underwent IMRT for no disseminated nasopharyngeal carcinoma at the Asan Medical Center between September 2001 and November 2002 were evaluate by prospective analysis. According to the 1997 American Joint Committee on Cancer staging classification, 5 had Stage III, and 3 had Stage IVB disease. The IMRT plans were designed to be delivered as a 'Simultaneous Modulated Accelerated Radiation Therapy' (SMART) using the 'step and shoot' technique with a MLC (multileaf collimator). Daily fractions of 2.2-2.5Gy and 1.9-2Gy were prescribed and delivered to the GTV and CTV and clinically negative neck node, respectively. The prescribed dose was 70A-79.0Gy to the gross tumor volume (GTV), 60Gy to the clinical target volume (CTV) and metastatic nodal station, and 46Gy to the clinically negative neck. All patients also received weekly cisplatin during radiotherapy. Acute and late normal tissue effects were graded according to the Radiation Therapy Oncology Group (RTOG) radiation morbidity scoring criteria. Results: Follow-up period was ranging from 5 to 18 months. All patients showed complete response and loco-regional control rate was 100% but one patient died of malnutrition due to treatment related toxicity. There were no Grade 3 or 4 xerostomia and all patients had experienced improvement of salivary gland function. Conclusion: 'Simultaneous Modulated Accelerated Radiation Therapy' (SMART) boost intensity-modulated radiotherapy technique allows parotid sparing as evidenced both clinically and by dosimetry. Initial tumor response and loco-regional control was promising. It is clinically feasible. A larger population of patients and a long-term follow-up are needed to evaluate ultimate tumor control and late toxicity.

• 농업생명과학연구
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• 제46권4호
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• pp.57-68
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• 2012

본 연구는 관광객의 증가 및 개발로 인해 식생의 파편화가 진행되고 있는 해안 곰솔림을 대상으로 효율적인 보전과 관리를 위한 기초자료를 제공하기 위하여 곰솔 우점림에 조사구 70개($20{\times}20m$)를 설치하여 수행하였다. 경상북도 동부 해안가 곰솔림의 군집분석 결과 곰솔림은 3개의 군집(곰솔-소나무군집, 곰솔-아까시나무군집, 곰솔-소나무-팽나무군집)으로 구분되었으며, 다수응답순열절차 검정 결과, 군집은 유의성 있게 나타났다. 지표종 분석 결과, 유의한 종은 소나무, 작살나무, 노간주나무, 산철쭉 등 19종이 분석되었다. 곰솔림의 개체군 구조는 12~26 cm의 직경급이 우점하는 것으로 나타났으며 고봉형 양상(hump-shape pattern)으로 나타났다. 종다양도(H')는 목본층에서 $1.033{\pm}0.234{\sim}1.629{\pm}0.226$, 초본층에서 $2.448{\pm}0.232{\sim}2.545{\pm}0.318$ 사이로 나타났다.

• 한국엔터테인먼트산업학회논문지
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• 제15권4호
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• pp.113-125
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• 2021

이 연구는 21세기 이후 새롭게 대두되고 있는 하이브리드의 개념을 연극 공간으로 적용하여 특별히 관객이 적극적으로 극에 개입하고 참여하는 '관객 참여형 연극'에 관한 새로운 접근을 시도해 보는 것에 목적을 두었다. 사실, '하이브리드'는 이미 오랜 시간 인류의 문화 형성과 전승 가운데 주요한 동력을 제공해 왔으며 이를 무대 위로 다루는 연극에서 또한 그 혼종성은 의미 있는 원리로 작용해 왔다. 이전의 극장과 텍스트 중심의 전통적인 연극에서는 '현존과 부재', '현실과 허구' 그리고 '즉자와 대자'의 측면에서 그 혼종성이 오직 무대 위의 한정적 움직임으로 제한된 바 있다. 하지만 20세기 아방가르드 이후 '해체'의 정신을 바탕으로 객석과 무대 사이의 경계가 무너지고 그 사이에서 하이브리드는 이전의 '무대 한정적 하이브리드'에서 '무대를 넘어 객석을 포함하는 연극 공간 전체'의 하이브리드로 확장되기에 이른다. 다시 말해, 객석과 관객은 이제 동등한 연극적 요소로서 다른 요소들과 동등한 수평적 연결 구조를 통해 함께 뒤섞이게 되었으며 이를 바탕으로 이전과는 전혀 다른 새로운 결과물이 형성되는 것이다. 따라서, 관객 참여형 연극은 이전의 전통적인 연극 공간 안에서 가장 이질적인 '객석과 무대', '관객과 배우' 사이의 일종의 하이브리드 현상으로 '혼종화된 관객', '혼종화된 공간' 그리고 '혼종화된 텍스트'라는 독특한 정체성으로 또 다른 접근이 가능할 것이다.

• 정보처리학회논문지:컴퓨터 및 통신 시스템
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• 제11권12호
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• pp.453-460
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• 2022

고성능 양자 컴퓨터의 개발이 기대됨에 따라 잠재적인 양자 컴퓨터의 공격으로부터 안전한 양자 후 보안 시스템 구축을 위한 연구들이 활발하게 진행되고 있다. 대표적인 양자 알고리즘 중 하나인 Grover 알고리즘이 대칭키 암호의 키 검색에 사용될 경우, 암호의 보안 강도가 제곱근으로 감소되는 안전성의 문제가 발생할 수 있다. NIST는 암호 알고리즘의 공격에 필요로 하는 Grover 알고리즘의 비용을 기준으로 추정한 양자 후 보안 강도를 대칭키 암호에 대한 양자 후 보안 요구사항으로 제시하고 있다. 대칭키 암호의 공격에 대한 Grover 알고리즘의 추정 비용은 해당하는 암호화 알고리즘의 양자 회로 복잡도에 의해 결정된다. 본 논문에서는 NIST의 경량암호 공모전 최종 후보에 오른 SPARKLE의 AEAD군인 SCHWAEMM 알고리즘의 양자 회로를 효율적으로 구현하고, Grover 알고리즘을 적용하기 위한 양자 비용에 대해 분석한다. 이때, 암호화 순열 과정 중에 사용되는 덧셈기와 관련하여 CDKM ripple-carry 덧셈기와 Unbounded Fan-Out 덧셈기에 따른 비용을 같이 비교한다. 마지막으로, 분석한 비용과 NIST의 양자 후 보안 요구사항을 기반으로 경량암호 SPARKLE SCHWAEMM 알고리즘에 대한 양자 후 보안 강도를 평가한다. 양자 회로 구현 및 비용 분석에는 양자 프로그래밍 툴인 ProjectQ가 사용되었다.

• 대한두경부종양학회지
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• 제37권2호
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• pp.43-50
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• 2021

Background/Objectives: Shoulder function is an important aspect of health related quality of life (QOL). Neck dissection impairment index (NDII) is a simple shoulder-specific questionnaire. This study aimed to evaluate the association between QOL and NDII in patients who underwent neck dissection to validate the Korean version of NDII. Materials & Methods: This study enrolled 74 patients with head and neck cancer who underwent neck dissection from December 2013 to April 2014. Patients completed questionnaires on QOL including the European Organization of Research and Treatment of Cancer 30-item Core QOL questionnaire (EORTC QLQ-C30) and NDII which was translated into Korean. Validity was evaluated by calculating the Pearson correlation coefficient between NDII and EORTC QLQ-C30. Results: We compared preoperative, postoperative within a week, 1st and 3rd months NDII scores. The total NDII scores were 14.7, 47.4, 33.7 and 34.3 each. Clinical variables including gender, site of primary tumor, performing revision neck dissection, radiotherapy and flap reconstruction were not significantly associated with NDII. However NDII mean score of patients who underwent unilateral neck dissection over 3 levels is most increased after operation. During all periods NDII scores were significantly associated with functioning score. Although other scores are lower correlation than function scores, global health status scores and symptom scores are also correlation with NDII. Conclusion: NDII was valid instrument and can be used not only in the clinical practice to assess shoulder dysfunction but also in the simple instrument to evaluate global QOL in Korea patients with having neck dissection.

• 정보보호학회논문지
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• 제33권3호
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• pp.401-410
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• 2023

본 논문에서는 NIST LWC 최종후보 중 하나인 SPARKLE을 64-비트 ARMv8 프로세서 상에서 최적화하는 방안에 대해 제안한다. 제안 방법은 두 가지로서 ARM A64 명령어를 이용한 구현과 NEON ASIMD 명령어를 이용한 구현이다. A64 기반 제안구현은 ARMv8 상에서 가용한 레지스터를 효율적으로 사용할 수 있도록 레지스터 스케줄링을 수행하여 최적화한다. 최적화된 A64 기반 제안구현을 활용할 경우 Raspberry Pi 4B에서 C언어 참조구현보다 1.69~1.81배 빠른 속도를 얻을 수 있다. 두 번째로, ASIMD 기반 제안구현은 하나의 벡터명령어를 통해 3개 이상의 ARX-box를 병렬적으로 수행하도록 데이터를 병렬적으로 구성하여 최적화한다. 최적화된 ASIMD 기반 제안구현은 A64 기반 제안구현보다 일반적인 속도는 떨어지지만, SPARKLE256에서 SPARKLE512로 블록 크기가 증가할 때 A64 기반 제안구현에서는 속도가 2.1배 느려지는 것에 비해 ASIMD 기반제안구현에서는1.2배밖에 느려지지 않다는 장점이 있다. 따라서 기존 SPARKLE보다 더 큰 블록 크기를 갖는 SPARKLE 변형 블록 암호 또는 순열 설계 시 ASIMD 기반 제안구현이 더 효율적이므로 유용한 자료로써 활용 가능하다.