• Analytical Science and Technology
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• v.22 no.6
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• pp.498-503
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• 2009

Lung cancer is the main cancer on the world today, due to the high case fatality. Lung cancer can devide into two major types, such as small-cell lung cancer (SCLC) and non-small-cell lung cancer (NSCLC). Mutations in the epidermal growth factor receptor (EGFR) have been described in patients with advanced NSCLC. Mutations in the EGFR are associated with clinical and radiographic responses to EGFR tyrosine kinase inhibitors gefitinib and erlotinib. Thus, the detection of EGFR mutation can offer an effective information in clinical decision-making. In this study, We developed very simple, cheep and rapid mutation detection system by chip-based isothermal amplification method. The method described here has shown the advantages of rapid amplification, high sensitivity, and specificity. Also, it will be useful for rapid and reliable clinical diagnosis of EGFR mutation.

• Journal of Korea Water Resources Association
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• v.56 no.5
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• pp.325-336
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• 2023

In August 2022, even though flood damage occurred in the metropolitan area due to heavy rain, drought warnings were issued in Jeolla province, which indicates that the regional drought is intensified recent years. To cope with regarding intensified regional droughts, many studies have been conducted to identify spatial patterns of the occurrence of meteorological drought, however, case studies of spatial clustering for water shortage are not sufficient. In this study, using the estimations of water shortage in the Han River Basin in 2030 of the Master Plans for National Water Management, the spatial characteristics of water shortage were analyzed to identify the hotspot areas based on the Local Moran's I and Getis-Ord Gi^*, which are representative indicators of spatial clustering analysis. The spatial characteristics of water shortage areas were verified based on the p-value and the Moran scatter plot. The overall results of for three anayisis periods (S0(1967-1983), S1(1984-2000), S2(2001-2018)) indicated that the lower Imjin River (#1023) was the hotspot for water shortage, and there are moving patterns of water shortage from the east of lower Imjin River (#1023) to the west during S2 compared to S0 and S1. In addition, the Yangyang-namdaecheon (#1301) was the HL area that is adjacent to a high water shortage area and a low water shortage area, and had water shortage pattern in S2 compared to S0 and S1.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.28 no.3C
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• pp.179-186
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• 2008

Pressuremeter test estimates the deformational properties of soil from the relationship between applied pressure and the displacement of cavity wall. It is general to utilize the reloading curve for the estimation of deformational properties of soil because the initial loading curve can be affected by the disturbance caused by boring. On the other hand, the instrumental resolution or the variation of measured data makes it hard to estimate the maximum shear modulus from pressuremeter test results. This study suggested the methodology estimating the maximum shear modulus from pressuremeter test directly, based on the curve fitting of reloading curve. In addition, the difference was taken into account between the stress state around the probe in reloading and that of the in-situ state. Pressuremeter tests were conducted for 15 cases using a large calibration chamber, together with a number of reference tests. The maximum shear moduli taken from suggested method were compared with those from empirical correlation and bender element test.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.28 no.1A
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• pp.69-78
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• 2008

In this study, in order to verify the reinforcement effects of the cracked concrete tubes and culverts, static load test was conducted. After the load carrying capacity of the original concrete tubes (nominal diameter 0.8 m, 1.0 m, 1.5 m) and box culverts (inner width 2.0 m. 2.5 m) was reduced by the cracking test, the cracked concrete specimens were strengthened by installing profile with steel stiffener and high strength mortar. And then, the maximum load tests were conducted the renewal concrete tubes and box culverts. According to the method application, the load carrying capacity increased 1.66~3.50 times than it of the original tubes before applying the method. In case of the original box culverts, the load carrying capacity increased 1.66~3.10 times than the case before installing profile and high strength mortar. Also non-linear analysis was carried out by using the commercial FEM program of ABAQUS 6.6. Solid (C3D8R) elements and concrete damage plasticity option was applied to the analysis. For reflecting confined reinforcing bars in the analysis, the composite material properties were used.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.26 no.5A
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• pp.887-899
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• 2006

The aim of this study is to investigate a correlation between fundamental data on aerodynamic characteristics of bridge girder cross-sections, such as aerodynamic force coefficients and flutter derivatives, and their aerodynamic behaviour. The section model tests were carried out in three stages. In the first stage, seven deck configurations were studied, namely; Six 2-edge girders and one box girder. In this stage, changes in aerodynamic force coefficients due to geometrical shape of girders, incidence angle of flow, wind directions and turbulence intensities were studied by static section model tests. In the second stage, the dynamic section model tests were carried out to investigate the relativity of static coefficients to dynamic responses. And finally, the two-dimensional (lift-torsion) aerodynamic derivatives of three bridge deck configurations were investigated by dynamic section model tests. The aerodynamic derivatives can be best described as a representation of the aerodynamic damping and the aerodynamic stiffness provided by the wind for a given deck geometry. The method employed here to extract these unsteady aerodynamic properties is known as the initial displacement technique. It involves the measurement of the decay in amplitude with time of an initial displacement of the deck in heave and torsion, for various wind speeds, in smooth flow. It is suggested that the proposed aerodynamic force coefficients and flutter derivatives of bridge girder sections will be potentially useful for the aeroelastic analysis and buffeting analysis.

• Journal of Korean Tunnelling and Underground Space Association
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• v.11 no.1
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• pp.71-83
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• 2009

Shotcrete is an important primary support for tunnelling in rock. The quality control of shotcrete is a core issue in the safe construction and maintenance of tunnels. Although shotcrete may be applied well initially onto excavated rock surfaces, it is affected by blasting, rock deformation and shrinkage and can debond from the excavated surface, causing problems such as corrosion, buckling, fracturing and the creation of internal voids. This study suggests an effective non-destructive evaluation method of the tunnel shotcrete bonding state applied onto hard rocks using the impact-echo (IE) method and ground penetration radar (GPR). To verify previous numerical simulation results, experimental study carried out. Generally, the bonding state of shotcrete can be classified into void, debonded, and fully bonded. In the laboratory, three different bonding conditions were modeled. The signals obtained from the experimental IE tests were analyzed at the time domain, frequency domain, and time-frequency domain (i.e., the Short- Time Fourier transform). For all cases in the analyses, the experimental test results were in good agreement with the previous numerical simulation results, verifying this approach. Both the numerical and experimental results suggest that the bonding state of shotcrete can be evaluated through changes in the resonance frequency and geometric damping ratio in a frequency domain analysis, and through changes in the contour shape and correlation coefficient in a time-frequency analysis: as the bonding state worsens in hard rock condition, the autospectral density increases, the geometric damping ratio decreases, and the contour shape in the time-frequency domain has a long tail parallel to the time axis. The correlation coefficient can be effectively applied for a quantitative evaluation of bonding state of tunnel shotcrete. Finally, the bonding state of shotcrete can be successfully evaluated based on the process suggested in this study.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.29 no.3D
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• pp.373-379
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• 2009

Cost estimation in the early phase enables government to plan public budgeting more efficiently by providing information about construction cost. However, cost estimation in the early phase is difficult to predict because only a little information can be utilized. The cost estimation method now being used by the government is calculated by length of the road multiplied by unit cost per length and shows high error rate because it cannot reflect the unique characteristics of each project. As the project is being proceeded, level of available information also changed. So, reflecting available information of a project is important. This paper divided early phase into two parts : planning phase and early design phase, and developed cost estimation model considering level of available information of each phase. Total 143 cases are utilized to find influencing variables and develop cost estimation model and model validation is done by adopting required accuracy level. This cost estimation model reflecting level of available information can be applied to public budgeting, feasibility test, and comparison between routes.

• Journal of Ethics
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• no.97
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• pp.279-306
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• 2014

This study presents the leadership model that is to build of ethical and cultural leadership. This model is to operat the functions of a systemof leadership that based on the universal principles of life, that is performed bybalance and harmonized judgment of the ideal ethical oughtfulness and cultural values, and practise ethically through relationship, process, and skill of leadership. And this model turn out to lead a real impact and then overcome conflict, problem solving, motivation. To check the validity of leadership, this study analysis the case study of leadership of King Sejong. His leadership is based at heaven that on the basis of the universal principles of life. The ideal ethical oughtfulness is to cares for people and the value of the cultural is to cherish the people's will. His leadership is to be balance and harmonized judgment of the ideal ethical oughtfulness and the cultural values by practice of virtues through relationship, process, and skill of leadership. Leadership relationship is a equal role relationship that are the children of the sky, thus to be coexistence and harmonyin close collaboration. Leadership process is a process of transvaluation to ensure the validity of the values by rational discussion and persuasion. Leadership skills led to active obedience through leading by example and love of learning. King Sejong' leadership is the leadership that ethical and cultural leadership become well-implemented.

• 한국노년학
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• v.29 no.2
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• pp.489-511
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• 2009

While late-life suicide has been increasing and become an important issue for public health in Korea, little is known about the phenomenon and its contributing risk factors based on which effective preventive measures can be made. Since suicidal ideation is a major precursor to attempted and completed suicide, the objective of the present study was to reveal primary contributors to suicidal ideation. Data were collected from a cross-sectional survey of 247 community-dwelling Korean older adults (age≥60) in the mid-size city in Korea. The statistical methodology employed a robust hierarchical regression procedure that iteratively downweights outliers. Based on the stress-diathesis model, the study examined major diathesis and stressors directly explaining suicidal ideation. The study also explored the significant interaction among these factors. The findings revealed that living alone and depression were significant main antecedents of suicidal ideation. In addition, neuroticism X life events and neuroticism X depression were significant interaction terms with the strongest explanatory power, which provides an empirical evidence to support the stress-diathesis model in explaining suicidal phenomenon of the Korean elderly. The result demonstrates the theoretical implication as well as the practical implication for developing and implementing late-life suicide prevention strategies. Limitations and directions for future research are discussed.

• 한국노년학
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• v.29 no.1
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• pp.259-273
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• 2009

Purpose: This research was conducted to determine the effects of a multifactorial fall prevention program applying HSEP(Home Support Exercise Program) on physical balance and gait, leg strength, fear of falling and falls efficacy of the community-dwelling elderly. Method: The design of this study was a nonequivalent control group pretest-posttest design. There were 20 subjects in the experimental group and 21 in the control group. The fall prevention program consists of HSEP and fall related education. The intervention was performed for once a week in the senior citizen center and twice a week at home for 8 weeks. Results: There were significant differences in physical balance and gait, leg strength(hip extensor, hip flexor, knee flexor, ankle plantarflexor, ankle dorsiflexor) and falls efficacy between the experimental group and control group. Conclusion : The fall prevention program applying HSEP used in this study was very effective in increasing physical balance and gait, leg strength and falls efficacy. Finally this study would recommended that a fall prevention program applying HSEP should be extended to community facilities such as elderly welfare center and nursing home.