• Korean Journal of Clinical Laboratory Science
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• v.54 no.1
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• pp.38-48
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• 2022

Carcinoembryonic antigen (CEA) is an oncofetal antigen primarily detected in the peripheral blood of cancer patients, particularly in those with colorectal cancer. CEA is considered a valuable target for antigen-specific immunotherapy. In this study, we induced the anti-tumor immunity for CEA through the administration of a dendritic cell (DC) vaccine. However, there was a limitation in inducing tumor regression in the DC vaccinated mice. To enhance the efficacy of anti-tumor immunity in MC38/CEA2 tumor-bearing mice, we evaluated the effects of DC vaccine in combination with cyclophosphamide (CYP). Administration of CYP 100 mg/kg in mice resulted in significant inhibition of tumor growth in the 2-day tumor model, whereas a lower inhibition of tumor growth was seen in the 10-day tumor model. Therefore, the 10-day tumor model was selected for testing chemo-immunotherapy. The combined CYP and DC vaccine not only increased tumor antigen-specific immune responses but also induced synergistic anti-tumor immunity. Furthermore, the adverse effects of CYP such as weight loss and immunosuppression by regulatory T cells and myeloid-derived suppressor cells showed a significant reduction in the combined chemo-immunotherapy treatment compared with CYP alone. Our data suggest that chemoimmunotherapy with the DC vaccine may offer a new therapeutic strategy to induce a potent anti-tumor effect and reduce the adverse effects of chemotherapy.

• Journal of the Korea Convergence Society
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• v.13 no.1
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• pp.269-282
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• 2022

The purpose of this study is not only to explore the effects of emotional labor on job stress but also to investigate the moderating effects of grit and social support between emotional labor and job stress. A survey was conducted for 804 call center counselors in Daegu, Daejeon and Suwon to figure out research questions, and the collected data were analyzed with SPSS 25.0. The results of the data analysis are as follows. First, emotional labor of customer counselors was found to have a positive effect on job stress. Second, in the relationship between emotional labor and job stress of customer counselors, grit showed different results according to sub-factors. The higher the Perseverance of Effort, the higher the job stress, and the higher the Consistency of Interest, the lower the job stress. Third, in the relationship between emotional labor and job stress of customer counselors, supervisor support of social support had a moderating effect, while peer support had no moderating effect. It shows that in order to prevent job stress of customer counselors, who have a high intensity of emotional labor, it is necessary to intervene to help them develop a positive perception of themselves through non-cognitive factors such as grit and the support provided by a trusted target. In addition, appropriate intervention methods and educational environment should be supported.

• Journal of The Korean Association For Science Education
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• v.43 no.2
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• pp.73-86
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• 2023

This study compared the characteristics of scientific emoticons made by general and science-gifted elementary students. To do this, fifth graders (n=53) at a general elementary school in Gyeonggi province and fifth graders (n=35) at a gifted science education institute in Seoul were selected. Scientific emoticons written by the students were compared according to the number and types. Analysis of the results reveal that the science-gifted students made more scientific emoticons than the general students for thirty minutes. In the comparison of the types of scientific emoticons, there were some similarities and significant differences between general students and science-gifted students. Overall, however, it was found that science-gifted students made more various types of scientific emoticons than general students in 'form' aspects (e.g., generative form of text, descriptive form of text, and expressive form of image) and 'information' aspects (e.g., emotion, construction level, excess of curriculum level, scientific disciplines, and use of scientific knowledge) of the texts and the images in the scientific emoticons. The scientific emoticons made by general and science-gifted elementary students included very few misconceptions. Educational implications of these findings are discussed.

• Proceedings of the Korea Water Resources Association Conference
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• 2021.06a
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• pp.438-438
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• 2021

우리나라의 수질오염총량관리제도는 수계 내 모든 유역을 관리대상으로 동일 기준유량 조건에 동일한 대상물질로 관리하고 있지만, 본류는 지류의 영향을 받고 있으며 지류는 사람이 거주하는 지역 인근에 있어 본류 수질에 직접적인 영향을 미치고 있다. 이는 지류의 시급한 개선이 필요한 오염물질의 실질적인 관리가 어려워 이를 개선하기 위해 오염도가 높은 지류의 총량관리를 위한 지류총량제도의 추가 도입이 필요한 실정이다. 본 연구에서는 지류총량제 시행에 따른 효과를 예측하기 위해 팔당수계 유역을 소유역 단위로 분할하고 HSPF 모형을 적용하여 팔당수계 소유역 지류에서의 수질 변화 양상이 본류에 미치는 영향을 분석하였다. 연구대상지역은 팔당수계 중권역 유역(남한강 하류 유역, 경안천 유역, 북한강 하류 유역)으로 구분하고 유역 유출 및 수질 모델링은 지류하천을 포함하는 57개 소유역을 대상으로 수행하였다. 입력자료는 공간자료(표고, 경사, 토지이용, 토양도 등)와 기상자료(춘천, 양평, 이천, 수원관측소)는 2008년~2018년의 강수량, 최고기온, 최저기온, 평균풍속, 평균습도 등의 시단위 자료를 사용하였다. 모의결과, BOD는 남한강 하류유역의 주요 지천 유역인 복하천, 양화천, 청미천 및 흑천 유역에서 0.54~0.56mg/L의 범위로 주변 유역보다 높게 나타났으며, 경안천 유역은 경안천 유역의 중·하류 유역에서 2.63~4.22mg/L의 범위로 높게 나타났고, 북한강 유역은 조종천 하류 및 북한강 상류 유역에서 1.36~3.31mg/L의 범위로 주변 유역보다 높게 나타났다. T-P는 남한강 하류 유역은 주요 지천 유역인 복하천, 양화천, 청미천 유역에서 0.07~0.19mg/L의 범위로 주변 유역보다 높게 나타났고, 남한강 하류 유역의 중간 지점 유역인 한강(E1, E2, E4, E6)에서 높게 나타났다. 경안천 유역은 중·하류 유역의 좌안측 유역인 경안(A4, A3, B2, B1, F9)에서 0.1~0.14mg/L의 범위로 높게 나타났으며, 북한강 유역은 전체 유역에서 0.06mg/L 이하로 남한강 하류 및 경안천 유역보다 전반적으로 낮게 나타났다. 이와 같이 지류총량관리에 HSPF 모형의 적용은 가능하였으나 HSPF 모형을 이용한 소유역 단위의 유량 및 수질 예측을 위해서는 기존의 유량 및 수질 관측망을 소유역 단위로 좀 더 정밀하게 계획하는 것이 필요하다고 판단된다.

• Korean Journal of Poultry Science
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• v.50 no.2
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• pp.81-90
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• 2023

Animal welfare was introduced relatively late to Korea in comparison with Western countries. Nonetheless, the Korean government has continuously improved animal welfare-friendly regulations as policy instruments. Given the current situation, it is predicted that spontaneous settlement of the animal welfare policies will be difficult and may cause conflict in the farm animal industry. To identify and categorize conflicts caused by animal-welfare-related policies in the last five years, we investigated the awareness of animal welfare among Korean hen farms and the level of compliance with the animal welfare regulations. We collected a sample of 53 egg-laying chicken farm operators (e.g., owners or head managers) was collected through the on-site survey (90% confidence level (Z-score: 1.65) and 10.18% tolerance, based on a number of 797 egg-laying farms in 2020). Ethical conflicts on the farms were categorized into three different types according to the hen farm's ethical awareness level: passive, moderate, and active. Additionally, we investigated the correlation between compliance with regulations and ethical consideration. This study confirmed that compliance with animal welfare-related regulations significantly correlated to the level of ethical consideration of farm operators. Interestingly, we also observed that farm operators did not comply with the regulation despite their high level of awareness of animal welfare. This conflict implies contradiction and unresolved ethical dilemmas. Therefore, this study argues that the policies cause conflict in the field despite the certain level of effectiveness on animal welfare regulations.

• Journal of Venture Innovation
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• v.4 no.1
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• pp.39-50
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• 2021

This was empirical research aimed at determining the effects of emotional labor, Resilience and service environment, on the performance of Long-term Care Hospital Employee. The participants were 180 employees working in long-term care hospitals in Gyeonggi-do. The collected data were analyzed using the SPSS statics19.0 program. The study were analyzed by frequency analysis and descriptive statistics, ANOVA, Scheffe? test, Pearson correlation coefficients, and stepwise regression. As a result of the study, age, marriage status, career, and position affected performance among the general characteristics.tion coefficients, and stepwise regression. As a result of the study, the average performance was 91.25 (±12.46) points, emotional labor was 41.25 (±4.21) points, Resilience was 52.89 (±6.37), and the service environment was 78.93(±15.3) points. The performance showed a positive correlation with emotional labor(r=.326, p<.001) service environment (r=.384, p=.005) and Resilience (r=.417, p<.001) of Long-term Care Hospital Employee. Service environment was the biggest factor affecting performance, and the second was resilience. The explanatory power of this regression model was 48.2% and was statistically significant (F=58.249, p<.001).

• Journal of Venture Innovation
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• v.5 no.1
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• pp.145-154
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• 2022

This study briefly compares the first-cycle certification of nursing hospitals with the second-cycle certification, reviews the changes and achievements of the second-cycle certification and the third-cycle certification, and examples of challenges and solutions in the process of preparing the third-cycle certification. In this study, it is suggested as follows. First, in order to see the practical effect of certification intended by the government, the exhibition is prepared in a short period of time before certification. Second, after the implementation of the nursing hospital certification system, research on the hospital performance of the medical institution certification system is insufficient in terms of quality and quantity. Therefore, in order to see the effect on the certification system, various research support is also required so that research on this can be actively conducted. Third, design certification standard guidelines from a long-term perspective so that the standard guidelines for certification do not change significantly, and certify not only the guidelines but also individual standards and forms that can be used by medical institutions. Fourth, in the four-cycle certification, accurate and realistic guidelines for infection control and quarantine ward operation support should be developed. The importance of managing infectious diseases will be highlighted in the future due to COVID-19. Fifth, medical institutions can improve the quality of medical care in nursing hospitals and have competitiveness if their daily activities, not short-term certification preparation, are carried out in accordance with certification standards, which affects performance. Sixth, when preparing for certification, nursing hospital officials have problems in organizing documents or processing administratively in the short term as in the past. This is also based on the certification criteria for the usual business process.

• Journal of Korea Water Resources Association
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• v.57 no.4
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• pp.301-310
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• 2024

The spatial and temporal non-uniform distribution of precipitation makes water management difficult. Due to climate change, nonuniform distribution of precipitation is worsening, and droughts and floods are occurring frequently. Additionally, the intensity of droughts and floods is intensifying, making existing water management systems difficult. From June 2022 to June 2023, most of the water storage rates of major dams in the Yeongsan river and Seomjin river basin were below 30%. In the case of Juam dam, which is the most dependent on water use in the basin, the water storage rate fell to 20.3%, the lowest ever. Pyeongnim dam recorded the lowest water storage rate of 27.3% on May 4, 2023. Due to a lack of precipitation starting in the spring of 2022, Pyeongnim dam was placed at a drought concern level on June 19, 2022, and entered the severe drought level on August 21. Pyeongrim dam and Suyangje(dam) have different operating institutions. Nevertheless, the low water level was not reached at Pyeongnim dam through organic linkage operation in a drought situation. Pyeongnim dam was able to stably supply water to 63,000 people in three counties. In order to maximize the use of limited water resources, we must review ways to move water smoothly between basins and water sources, and prepare for water shortages caused by climate change by establishing a consumer-centered water supply system.

• Industry Promotion Research
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• v.9 no.1
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• pp.149-157
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• 2024

The purpose of this study is to objectively examine the effects of integrated art therapy on cognitive function and depression in the early dementia elderly, and to identify and discuss the process of change in the early dementia elderly through a comprehensive analysis through behavior change observation diary. As a research method, a mixed study was designed using in-depth analysis through qualitative studies as well as quantitative studies on the effect of integrated art therapy on cognitive function and depression in the elderly with early dementia. The quantitative study conducted a pre-post examination of 20 elderly people with early dementia using the day care center in P-gu, Suwon, and the qualitative study analyzed the behavioral change observation diary of 10 elderly people with early dementia. These findings show that first, integrated art therapy had a significant effect on the cognitive function of the elderly with early dementia (p<.001, t=-5.871). Second, integrated art therapy had a significant effect on the depression of the elderly with early dementia (p<.001, t=5.325). Third, the integrated art therapy program changed to a positive attitude before and after cognitive function and depression of the elderly with early dementia. By revealing the effect of integrated art therapy on cognitive function and depression of the elderly with early dementia through the results of this study, it is meaningful as basic data for research related to the elderly with early dementia as well as providing effective information on integrated art therapy programs related to the elderly with early dementia.

• The Mathematical Education
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• v.63 no.2
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• pp.187-207
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• 2024

In this study, we explored the feasibility of automatically scoring descriptive assessment items using GPT-4 based ChatGPT by comparing and analyzing the scoring results between teachers and GPT-4 based ChatGPT. For this purpose, three descriptive items from the permutation and combination unit for first-year high school students were selected from the KICE (Korea Institute for Curriculum and Evaluation) website. Items 1 and 2 had only one problem-solving strategy, while Item 3 had more than two strategies. Two teachers, each with over eight years of educational experience, graded answers from 204 students and compared these with the results from GPT-4 based ChatGPT. Various techniques such as Few-Shot-CoT, SC, structured, and Iteratively prompts were utilized to construct prompts for scoring, which were then inputted into GPT-4 based ChatGPT for scoring. The scoring results for Items 1 and 2 showed a strong correlation between the teachers' and GPT-4's scoring. For Item 3, which involved multiple problem-solving strategies, the student answers were first classified according to their strategies using prompts inputted into GPT-4 based ChatGPT. Following this classification, scoring prompts tailored to each type were applied and inputted into GPT-4 based ChatGPT for scoring, and these results also showed a strong correlation with the teachers' scoring. Through this, the potential for GPT-4 models utilizing prompt engineering to assist in teachers' scoring was confirmed, and the limitations of this study and directions for future research were presented.