• Sleep Medicine and Psychophysiology
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• v.2 no.1
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• pp.55-64
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• 1995

During sleep, relatively major respiratory physiological changes occur in healthy subjects. The contributions and interactions of voluntary and metabolic breathing control systems during waking and sleep are quite different Alterations of ventilatory control occur in chemosensitivity, response to mechanical loads, and stability of ventilation. The activities of intercostal muscles and muscles involved in regulating upper airway size are decreased during sleep. These respiratory physiological changes during sleep compromise the nocturnal ventilatory function, and sleep is an important physiological cause of the nocturnal alveolar hypoventilation. There are several causes of chronic alveolar hypoventilation including cardiopulmonary, neuromuscular diseases. Obstructive sleep apnea syndrome (OSAS) is an important cause of nocturnal hypoventilation and hypoxia. Coexistent cardiopulmonary or neuromuscular disease in patients with OSAS contributes to the development of diurnal alveolar hypoventilation, diurnal hypoxia and hypercapnia. The existing data indicates that nocturnal recurrent hypoxia and fragmentation of sleep in patients with OSAS contributes to the development of systemic hypertension and cardiac bradytachyarrhythmia, and diurnal pulmonary hypertension and cor pulmonale in patients with OSAS is usually present in patients with coexisting cardiac or pulmonary disease. Recent studies reported that untreated patients with OSAS had high long-term mortality rates, cardiovascular complications of OSAS had a major effect on mortality, and effective management of OSAS significantly decreased mortality.

• Proceedings of the Korean Society of Computer Information Conference
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• 2010.07a
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• pp.129-132
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• 2010

작금의 현대 사회 사람들은 바쁜 일상생활로 인해 짧아진 수면과 불면증 등의 각종 수면장애를 겪고 있으며, 여러 가지의 요소로 인하여 수면의 방해를 받게 되면, 여러 질병 및 생활 장애를 겪을 수 있어 수면의 중요성은 날로 주목받고 있다. 본 논문에서는 수면을 이루는 침실의 수면 환경 데이터를 수집하여 얻어진 조건 데이터들과 수면간의 관계를 분석하고 이를 바탕으로 시뮬레이션 모델을 추출하여 개개인에 따른 최적의 환경을 제공할 수 있다. 따라서 수면 과정에 따라 신체의 감각 및 자극에 대한 반응을 알고, 사람의 신체 상황에 따른 차이점 및 안정적인 패턴 및 조건을 정의하며 수면 패턴을 분석 및 솔루션 제공을 할 수 있다. 또한 차후에는 수면의 특정 상황만 아니라 식사, 출근, 등과 같은 유기적인 생활(유비쿼터스 환경)의 한 부분에도 상황에 따른 적절한 실내 환경 변화를 제공해주어서 좀 더 쾌적한 일상생활을 영위할 수 있도록 도움을 주게 되는 측면으로 확대 하려한다.

• The Journal of the Convergence on Culture Technology
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• v.9 no.1
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• pp.443-448
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• 2023

Over the past five years, the number of patients with sleep disorders has increased by about 250,000 from 840,000 in 2017 to 1.09 million in 2021. In addition, sleep disorder is a factor that causes dementia risk factors, and furthermore, the population with sleep disorder is a very important policy issue in terms of stable health insurance financial management in the future in terms of national health management in the super-aging trend. Therefore, this study aims to establish an efficient treatment environment in medical institutions responsible for the current status of polysomnography and effective reimbursement policies for the recently increasing population with sleep disorders, and appropriate sleep management policies for future sleep disorders through correct implementation. We are trying to find out the actual condition and improvement plan through interviews with related organizations and experts.

• Journal of the Korea Convergence Society
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• v.8 no.12
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• pp.179-187
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• 2017

The purpose of this study was to identify factors influencing sleep disturbance among benign prostate hyperplasia (BPH) patients in South Korea. A trained reporter filled out the questionnaire by explaining and reading the sentences to 164 BPH patients in J city. The questionnaire consisted of international prostate symptom score (IPSS), anxiety, depression, sleep disturbance. There was a statistically significant difference in sleep disturbance of participants according to income, regular exercise, and number of disease. There were statistically significant correlations between sleep disturbance and IPSS (r=.45, p<.001), anxiety (r=.59, p<.001), depression (r=.42, p<.001). The influential factors for sleep disturbance were anxiety (${\beta}=.41$, p<.001), income (${\beta}=-.36$, p<.001), IPSS (${\beta}=.28$, p=.021). These factors accounted for 41.2% of the variance in sleep disturbance. The result of this study can be used as a basic data for development of a management strategy considering convergent relationship between IPSS and anxiety in order to decrease sleep disturbance of BPH patients.

• The Journal of the Korea institute of electronic communication sciences
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• v.8 no.2
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• pp.345-353
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• 2013

This study was conducted to clarify the effect of sleeping disorder on the life stress of the university student on the side of cooking for himself, housing noise, dissatisfaction in school life, ill health, problem in future and a sense of values. A self-boarding student apart from a family (p<.042) had a higher sleeping stress. Noise of housing environment (p<.002), life dissatisfaction in university (p<.007), ill health (p<.010), life stress (p<.004) led to a more sleeping stress. Both gloomy prospects (p<.002) and a sense of values (p<.001) disturbed a university man's sleep. Cooking food for oneself, housing noise, displeasure in university life, ill health, gloomy prospects and a sense of values gave risen to the university student's sleeping disorder.

• Sleep Medicine and Psychophysiology
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• v.21 no.1
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• pp.5-13
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• 2014

Objectives: Depression, sleep complaints and cognitive impairments are commonly observed in the elderly. Elderly subjects with depressive symptoms have been found to show both poor cognitive performances and sleep disturbances. However, the relationship between sleep complaints and cognitive dysfunction in elderly depression is not clear. The aim of this study is to identify the association between sleep disturbances and cognitive decline in late-life depression. Methods: A total of 282 elderly people who underwent nocturnal polysomnography in a sleep laboratory were enrolled in the study. The Korean version of the Neuropsychological Assessment Battery developed by the Consortium to Establish a Registry for Alzheimer's Disease (CERAD-K) was applied to evaluate cognitive function. Depressive symptoms were assessed with the geriatric depression scale (GDS) and subjective sleep quality was measured using the Pittsburg sleep quality index (PSQI). Results: The control group ($GDS{\leq}9$) when compared with mild ($10{\leq}GDS{\leq}16$) and severe ($17{\leq}GDS$) depression groups, had significantly different scores in the Trail making test part B (TMT-B), Benton visual retention test part A (BVRT-A), and Stroop color and word test (SCWT)(all tests p<0.05). The PSQI score, REM sleep duration, apnea-hypopnea index and oxygen desaturation index were significantly different across the three groups (all indices, p<0.05). A stepwise multiple regression model showed that educational level, age and GDS score were predictive for both TMT-B time (adjusted $R^2$=35.6%, p<0.001) and BVRT-A score (adjusted $R^2$=28.3%, p<0.001). SCWT score was predicted by educational level, age, apnea-hypopnea index (AHI) and GDS score (adjusted $R^2$=20.6%, p<0.001). Poor sleep quality and sleep structure alterations observed in depression did not have any significant effects on cognitive deterioration. Conclusion: Older adults with depressive symptoms showed mild sleep alterations and poor cognitive performances. However, we found no association between sleep disturbances (except sleep apnea) and cognitive difficulties in elderly subjects with depressive symptoms. It is possible that the impact of sleep disruptions on cognitive abilities was hindered by the confounding effect of age, education and depressive symptoms.

• Sleep Medicine and Psychophysiology
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• v.18 no.1
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• pp.23-28
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• 2011

Objectives: REM sleep behavior disorder (RBD) has received little attention in epidemiologic studies. This study aimed to determine the prevalence of probable REM sleep behavior disorder (pRBD) in the elderly population and its clinical features. Methods: A random sample of 1,588 was selected from a roster of 14,050 elderly population living in Osan city. The subjects were asked to fill out the REM sleep behavior disorder screening questionnaire (RBDSQ). Subjects whose score were 5 or higher on RBDSQ underwent a diagnostic phase of person-to-person assessment by experts in RBD. Results: Among 1,588 subjects, 886 elderly subjects participated in the screening phase and 123 subjects were assessed in the diagnostic phase. Eleven subjects were diagnosed as having pRBD, so prevalence was 1.5% (95% CI=0.70-2.30%). The frequency of depression and cognitive decline was significantly increased in patients with pRBD compared to subjects without pRBD, and there was no difference in sleep disturbances between two groups. Conclusions: Probable REM sleep behavior disorder is not rare in the elderly but frequently under-recognized. More attention should be paid to evaluation and treatment of RBD.

• Tuberculosis and Respiratory Diseases
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• v.45 no.2
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• pp.404-415
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• 1998

Background: Sleep apnea syndrome, which occurs in 1~4 % of the adult population, frequently has different cardiovascular complications such as hypertension, ischemic heart disease, cardiac arrythmia as well as sleep-wake disorder such as excessive daytime hypersomnolence or insomnia. Mortality and vascular morbidity are reported to be significantly higher in sleep apnea syndrome patients than in normal population. According to the recent studies, autonomic dysfunction as well as hypoxemia, hypercapneic acidosis, and increased respiratory effort, may playa role in the high prevalence of cardiovascular complications in patients with sleep apnea syndrome. However the cause and mechanism of autonomic neuropathy in patients with sleep apnea syndrome are not well understood. We studied the existence of autonomic neuropathy in patients with sleep apnea syndrome and factors which influence the pathogenesis of autonomic neuropathy. Method: We used the cardiovascular autonomic neuropathy(CAN) test as a method for evaluation of autonomic neuropathy. The subjects of this study were 20 patients who diagnosed sleep apnea syndrome by polysomnography and 15 persons who were normal by polysomnography. Results: Body mass index and resting systolic blood pressure were higher in sleep apnea group than control group. Apnea index(Al), respiratory disturbance index(RDI) and snoring time percentage were significantly higher in sleep apnea group compared with control group. But there were no significant differences in saturation of oxygen and sleep efficiency in two groups. In the cardiac autonomic neuropathy test, the valsalva ratio was significantly low in sleep apnea group compared with control group but other tests had no differences between two groups. The CAN scores and corrected QT(QTc) interval were calculated significantly higher in sleep apnea group, but there were no significant correlations between CAN scores and QTc interval. There were no significant data of polysomnography to correlate to the CAN score. It meant that the autonomic neuropathy in patients with sleep apnea was affected by other multiple factors. Conclusion: The cardiovascular autonomic neuropathy test was a useful method for the evaluation of autonomic neuropathy in patients with sleep apnea syndrome and abnormalities of cardiovascular autonomic neuropathy were observed in patients with sleep apnea syndrome. However, we failed to define the factors that influence the pathogenesis of autonomic neuropathy of sleep apnea syndrome. This study warrants futher investigations in order to define the pathogenesis of autonomic neuropathy in patients with sleep apnea syndrome.

• Sleep Medicine and Psychophysiology
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• v.1 no.2
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• pp.163-171
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• 1994

Objectives: Symptoms of sleep apnea consisted of insomnia, excessive sleepiness during daytime, impaired cognitive functions and emotional disturbances. It was not so well known how these symptoms are correlated with various parameters of sleep and respiration, and what kind of psychophysiological processes are involved in development of these symptoms. Methods: In sixty patients with sleep apnea, sleep and respiration were studied by polysomnography of one night, also symptoms of sleep apnea were evaluated with the scales of insomnia, daytime sleepiness, emotional disturbance and cognitive impairment We studied correlations between apnea symptoms, and various parameters of sleep and respiration such as sleep efficiency, number severity of apnea, $O_2$ desaturation and number of snoring. Results: The result showing significant correlations are as follows. The patients with better sleep in insomnia scale showed more number of apnea, particularly more central type, and much more snoring in stage 3 sleep and mild desaturation of $O_2$. Excessive sleepiness during daytime correlated significantly with stage 1 sleep and its snoring, but correlated negatively with stage 2 sleep. However, no significant correlation was found with degree of $O_2$ desaturation. Emotional disturbance was more apparent in the patients with severe $O_2$ desaturation and smaller amounts of stage 4 sleep. Cognitive function was more impaired in cases of more REM sleep and less apnea. Conclusions: Symptoms of sleep apnea may occur through different causes and processes. The evaluation of apnea symptoms may be helpful to understand in some degree the condition of sleep and respiration during sleep in clinical setting.

• Proceedings of the Korea Information Processing Society Conference
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• 2012.11a
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• pp.243-245
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• 2012

대표적인 수면장애로 수면 무호흡증과 코골이가 있는데 수면다원검사를 통해 진단할 수 있다. 그러나 수면다원검사는 비용적, 공간적, 시간적 제약이 수반되기 때문에 이를 해결하려는 연구가 대두되고 있다. 수면장애와 그 요인을 검출하기 위해 가속도센서, 소음센서, 온도센서, 습도센서로 구성된 측정 장치에서 획득한 데이터와 건강, 운동, 생활습관 데이터를 활용하여 어떤 요인에 의해 수면장애의 정도가 악화되고 개선되는지를 사용자에게 제공하는 의사결정 지원시스템을 설계한다. 또한 홈 게이트웨이와 뷰어 역할에 스마트 폰을 사용하여 일반인이 보다 쉽게 측정하고 측정결과와 추론결과를 지속적으로 확인할 수 있는 시스템을 제안한다.