• Journal of Life Science
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• v.32 no.8
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• pp.601-610
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• 2022

P. tenebrifer (PT) belongs to the Diptera order and Stratiomyidae family. Recently, insect industry have been focused as food, animal feed and environmental advantages. γ-aminobutyric acid (GABA) and melatonin have been associated with regulating sleep and depression. GABA is the primary inhibitory neurotransmitter and is synthesized via biotransformation of monosodium glutamate (MSG) to GABA by lactic acid bacteria. In this study, we first used a GABA-enhanced PT extract, wherein GABA was enhanced by feeding MSG to PT. The underlying mechanisms preventing stress and insomnia were investigated in a corticosterone (CORT)-induced endoplasmic reticulum (ER) stress and chronic restraint stress (CRS)-exposed mouse model, as well as in pentobarbital (45 mg/kg)-induced sleep behaviors in mice. In the present study, the GABA peak was detected in high-performance liquid chromatography-evaporative light scattering detector (HPLC-ELSD) analysis and showed in Ptecticus tenebrifer water extract (PTW) but not in non-PTW extract. The results showed that PTW and Ptecticus tenebrifer with 70% ethanol extract (PTE) exerted neuroprotective effects by protecting against CORT-induced downregulation of phosphorylated extracellular signal-regulated kinase 1/2 (ERK1/2) and cAMP-response element binding protein (CREB) expression. In addition, PTW (300 mg/kg) significantly reduced CORT levels in CRS-exposed mice. Furthermore, PTW (100 and 300 mg/kg) significantly reduced sleep latency and increased total sleep duration in pentobarbital (45 mg/kg)-induced sleeping behaviors, which was related to serum melatonin levels. In conclusion, our results suggest that PTW exerts anti-stress and sleep-enhancing effects by regulating serum CORT and melatonin levels.

• Journal of Life Science
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• v.22 no.8
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• pp.1077-1084
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• 2012

This study investigated the effects of Origanum majorana essential aroma therapy on electrical activity in the brain as evaluated by an electroencephalogram (EEG). The subjects were 29 healthy female young adults, and their sleep quality was assessed by using the Pittsburgh Sleep Quality Index. EEG electrodes were attached at the frontal, temporal, occipital, and parietal lobes according to the international 10-20 system. Subjects were exposed to organic Origanum majorana essential aroma (50 ${\mu}l$) for a period of 3 minutes each before, during, and after aromatherapy. Subjects with good sleep quality showed that Origanum majorana essential aroma increased the theta power at the frontal and temporal lobes of both cerebral hemispheres, the left parietal lobe, and the right occipital lobe. Furthermore, Origanum majorana essential aroma decreased the alpha power at the left occipital lobe and the beta power at the right temporal lobe. On the other hand, subjects with poor sleep quality showed an increase in the theta power at the temporal lobe of both cerebral hemispheres and a decrease in the alpha power at the left parietal lobe by Origanum majorana essential aroma therapy. It is concluded that Origanum majorana essential aroma therapy diminishes the state of wakefulness in the brain; alpha and beta powers were both decreased in the subjects with good sleep quality, but only alpha power was decreased in the subjects with poor sleep quality. Moreover, Origanum majorana essential aroma therapy has a sleep-inducing effect in both subjects with good sleep quality and poor sleep quality.

• 건강소식
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• v.34 no.1
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• pp.32-33
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• 2010

환경오염과 스트레스로 인해 뇌로 들어가는 산소 공급이 제대로 이루어지지 않거나 영양공급이 원활하지 않을 경우 수면을 유도하는 호르몬의 일종인 멜라토닌의 생성이 줄어들게 된다. 그로 인해 생기는 신체적 이상 증세가 바로 불면증이다. 불면증 치료에는 다양한 방법이 있지만 꾸준한 요가 또한 효과가 탁월하다. 특히 어깨와 머리 주변의 긴장을 풀어주면 아주 효과적이다.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2019.05a
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• pp.566-567
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• 2019

개인이 스스로 자신의 건강 기록을 관리 가능한 스마트 헬스(s-Health), 웨어러블 컴퓨팅 기기들과 모바일 기기들이 헬스케어 도구로서 활용되기 시작하면서 모바일 기반의 헬스케어(m-Health)가 부상하고 있으며, 현재 여러 가지 Light Care 제품이 있으나 수면 유도 및 기상 유도 등과 같이 간단한 색상으로 LED Spectrum을 이용한 제품과 리모콘을 이용한 조명 색상을 조절하는 제품에 그치고 있다. 이에 본 논문에서는 실제 사용자의 스트레스와 생활환경 등의 다중인지 요소를 이용해 스트레스 완화를 위한 LED 조명을 조정하며, 그 정보를 수집하여 헬스 케어 플랫폼과 연계한 컨텐츠를 구현하고자 한다.

• Journal of the Society of Naval Architects of Korea
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• v.43 no.3 s.147
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• pp.294-303
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• 2006

A surface piercing propeller (SPP) in tunnel has been proposed recently as a new propulsion system for a high speed air cavity ship. The purpose of the present study is to investigate the characteristics of the SPP in tunnel through a series of model tests. A model propulsion system is placed on a dummy body made of Acrylics. The tunnel is divided into two regions by a guide vane extending from the inlet to the center of the propeller shaft. Air has been supplied from an air nozzle placed at the bottom of the dummy body and the changes in propeller performances caused by the air flow are investigated. The measurements are done for open water and in-tunnel conditions, both for fully and partially submerged propeller. The influence of the guide vane configurations on the propeller performance is also studied. The experiments are performed at the variable pressure circulation water channel of Inha University

• Special Issue of the Society of Naval Architects of Korea
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• 2007.09a
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• pp.107-117
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• 2007

A surface piercing propeller (SPP) in tunnel has been proposed recently as a new propulsion system for a high speed air cavity ship. The purpose of the present study is to investigate the characteristics of the SPP in tunnel through a series of model tests. A model propulsion system is placed on a dummy body made of Acrylics. The tunnel is divided into two regions by a guide vane extending from the inlet to the center of the propeller shaft. Air has been supplied from an air nozzle placed at the bottom of the dummy body and the changes in propeller performances caused by the air flow are investigated. The measurements are done for open water and in-tunnel conditions, both for fully and partially submerged propeller. The influence of the guide vane configurations on the propeller performance is also studied. The experiments are performed at the variable pressure circulation water channel of Inha University.

• Journal of Oral Medicine and Pain
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• v.35 no.3
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• pp.193-202
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• 2010

The purpose of this study was to determine the sites of narrowing/obstruction and to measure the regional severity of narrowing through the evaluation of dynamic changes in upper-airway of healthy subjects. The selected 9 subjects were proved not to have any sleep-related disorder such as snoring or obstructive sleep apnea through clinical examination, radiological examination, sleep study with a portable recording system. Afterward, the Electron Beam Tomography was performed during the waking and sleeping state of subjects, with their mandible in resting and protruded position. Intravenous injection of Dormicum$^{(R)}$ was used for the induction of sleep. The maximum and minimum cross-sectional areas at each airway level during tidal ventilation were measured and the Collapsibility Index for each level of cross-section was also computed. In a comparison with results under variable conditions, the result was showed that the significant difference between each airway level divided with upper, middle, lower region of upper airway is not observed in the average minimum cross-sectional areas and Collapsibility Index. The significant difference only between in wake and sleep state was observed in the average minimum cross-sectional area at the lower region. Also, in wake state, the significant difference between resting and protrusive position of mandible for the average minimum was also observed in cross-sectional area at middle region. In sleep state, no significant difference between resting and protrusive position of mandible was observed in cross-sectional area and the Collapsibility Index.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• 2010.04a
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• pp.389-391
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• 2010

The Free surface influenced the wake behind a circular cylinder and its effects were investigated experimentally in a circulating water channe with the variation of water depth Instantaneous velocity fields were measured in this paper. the measured results has been compared with each other to investigate the flow characteristics of the circular cylinder's 2-dimensional section at $Re=1.0\times10^3$ using 2-frame grey level cross correlation PIV method. The flow around the circular cylinder with free surface affected the wake structure. especially, in case of d=1.0D, the boundary layer was measured in the whole area. The separation point and boundary layer of the circular cylinder could be controlled by the water depth.

• Journal of Navigation and Port Research
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• v.34 no.5
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• pp.331-336
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• 2010

The free surface influenced the wake behind a circular cylinder and its effects were investigated experimentally in a circulating water channel with the variation of water depth. Instantaneous velocity fields were measured in this paper. The measured results has been compared with each other to investigate the flow characteristics of the circular cylinder's 2-dimensional section at $Re=1.0{\times}10^3$ using 2-frame grey level cross correlation PIV method. The flow around the circular cylinder with free surface affected the wake structure. Especially, in case of d=1.0D, the boundary layer was measured in the whole area. The separation point and boundary layer of the circular cylinder could be controlled by the water depth.

• Journal of the Korean Society of Food Science and Nutrition
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• v.45 no.3
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• pp.313-320
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• 2016

In the present study, we examined whether or not an herbal mixture extract (HME) has attenuation effects on immobilization stress and sleep disturbance in rats. Immobilization stress was induced by restricting movement using a constraint box for 2 h, and sleep disturbance was induced by exposure to 300 lx of constant light for 24 h and injection of caffeine (1 mg/kg, i.p.). Rats were orally treated with distilled water (vehicle) or HME for 3 weeks at different doses of 10, 30, and 100 mg/kg/d (HME I, II, and III, respectively). In the immobilization model, HME III treatment significantly decreased adrenal gland weight, whereas HME II and III treatment reduced plasma levels of cortisol. HME II and III also reduced the level of IL-6. In the sleep disturbance model, HME II and III meaningfully reduced the plasma level of cortisol, and the increased plasma level of melatonin. HME III significantly increased body weight. HME reduced immobilization stress and ameliorated disturbance in rats. These findings suggest that HME may have beneficial potential for attenuation of sleep disturbance and stress.