• Proceedings of the ESK Conference
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• 1997.04a
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• pp.190-195
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• 1997

Medilog SAC847 수면종합분석시스템을 이용하여 침대와 온돌에서 성인 남 자가 수면시 피험자의 뇌전도, 턱근전도, 다리근전도, 심전도, 안전도(눈) 등의 생리신호를 동시 측정하여수면단계기록국제기준에 근거하여 NREM 4단 계와 REM 단계의 수면시간을 산정 하였다. 수면감을 평가하기 위하여 침대 와 온돌에서 수면시 입면지연시간과 NREM 단계4의 수면시간 비중을 고찰한 결과 침대수면이 온돌수면보다 입면지연 시간이 더짧게 나타났으며 나머지 NREM 4단계와 REM 단계에 소요된 수면시간은 서로 비슷하게 나타났다. 본 연구를 통한 수면생리신호 분석연구는 쾌적침대개발에 활용하고자 한다.

• Tuberculosis and Respiratory Diseases
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• v.47 no.2
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• pp.231-238
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• 1999

Background: Nocturnal hypoxemia occurs in patients with chronic obstructive pulmonary disease(COPD) and the detection and treatment of nocturnal hypoxemia should be part of the management of COPD patients. We performed this study to evaluate the factors influencing to sleep related arterial oxygen desaturation($SaO_2$) in patients with COPD. Methods: Resting and exercise cardiopulmonary function test, polysomnography, and $SaO_2$ during resting, exercise and sleep were measured in 12 patients with COPD. Results: The $SaO_2$ fell twice as much during sleep as during maximal exercise($13.1{\pm}9.3%$ fall in nocturnal $SaO_2$ vs. $6.4{\pm}3.3%$, p<0.05). Fall in nocturnal $SaO_2$ was well correlated with mean exercise $SaO_2$(r=-0.78, p<0.05), minimum exercise $SaO_2$(r=-0.90, p<0.01), and resting $SaO_2$(Cr=-0.82, p<0.05). Lowest sleep $SaO_2$ was well correlated with mean exercise $SaO_2$(r=0.80, p<0.05), lowest exercise $SaO_2$(r=0.90, p<0.01), and resting $SaO_2$(r=0.84, p<0.05). Conclusion: Resting and exercise $SaO_2$ was well correlated with nocturnal $SaO_2$, but exercise study add no additional information to predicting the nocturnal oxygen desaturation in patients with COPD.

• Tuberculosis and Respiratory Diseases
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• v.46 no.6
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• pp.836-845
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• 1999

Background : Obesity is present in the majority of adult patients with obstructive sleep apnea(OSA) and is considered to be a major risk factor for its development. A reduction in body weight has been associated with substantial improvement in the severity of apnea. However, a variety of treatment strategies for obesity have yielded limited sucess. This study was done to determine resting energy expenditure(REE) in patients with obstructive sleep apnea and the correlation between the severity of sleep apnea and REE, and to investigate whether leptin influences REE and correlated with the severity of sleep apnea in 39 patients with OSA and 45 controls matched for obesity. Method : Overnight polysomnography was performed on all subjects using standard techniques. Measurements of REE were made using a Sensormedic Vmax 229 and a canopy system. Serum leptin concentration was measured by human leptin RIA kit of LINCO Research INC. Results : REE was greater in patients with OSA compared with controls, but there was no difference between the two groups on REE%. And also there was no significant correlation between anthropometric data, polysomnographic data and REE%. Serum leptin was linearly related to body mass index(BMI), apnea index, apnea hypopnea index and lowest arterial oxygen saturation($SaO_2$) but not related to REE%. Conclusion : This study suggests the followings. Firstly patients patients with sleep apnea have a pattern of obesity characterized by energy homeostasis at an elevated body weight set-point. In order to achieve a lower body weight in these patients, it may be necessary to increase energy expenditure by increasing physical activity. Secondly leptin level was not correlated with REE, suggesting that leptin may predominantly regulate body fat by altering eating behavior rather than calorigenesis. Lastly leptin level was significantly correlated with the severity of sleep apnea. These elevated level of leptin in patients of sleep apnea may be related to the obesity, however it needs further studies to determine the relationship between the severity of sleep apnea and serum leptin.

• Proceedings of the Korea Water Resources Association Conference
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• 2012.05a
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• pp.683-683
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• 2012

영상 수위 계측 방법은 카메라와 목자판만으로 이루어진 비교적 간단한 시스템과 육안으로 수위를 직접 확인할 수 있다는 장점을 가지고 있으나 실제 하천에서 장기간 운영시 목자판이 하천수와 직접 접촉하면서 필연적으로 발생하는 오염, 훼손, 부유물 부착 및 걸림 등의 이유로 목자판의 시인성이 떨어지면서 수면을 정확히 인식하지 못하여 오측이 증가하는 문제점이 발생하였다. 본 연구는 이와 같은 기존 수면인식방법의 문제점을 해결하기 위하여 새로운 수면인식방법을 제안한다. 새로운 수면인식방법은 목자판 영역과 수역이 포함된 시차가 있는 두 장 이상의 연속적인 영상에서 유수의 이동, 바람에 의한 물결 등으로 인해 초래된 수역의 요동을 판단하여 수면을 인식하고 수위를 계측하는 방법이다. 이 방법의 성능을 검증하기 위하여 목자판이 오염된 경우에 대하여 실내 및 현장 실험을 실시하였다. 두 경우의 실험결과에서 모두 기존 수면인식방법에서는 오염된 부분을 수면으로 잘못 인식하였으나, 새로운 방법에서는 수면을 정확하게 인식하여 올바른 수위를 측정할 수 있었다. 따라서 새로운 수면인식방법을 이용하면 기존 수면인식방법보다 정확도를 향상시킬 수 있을 것이며, 홍수시 목자판에 부유물이 걸리거나 목자판이 일부 파손된 경우, 목자판이 다단으로 설치된 경우 등에서도 수면을 정확하게 인식할 수 있을 것으로 기대된다.

• Journal of Oral Medicine and Pain
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• v.35 no.3
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• pp.193-202
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• 2010

The purpose of this study was to determine the sites of narrowing/obstruction and to measure the regional severity of narrowing through the evaluation of dynamic changes in upper-airway of healthy subjects. The selected 9 subjects were proved not to have any sleep-related disorder such as snoring or obstructive sleep apnea through clinical examination, radiological examination, sleep study with a portable recording system. Afterward, the Electron Beam Tomography was performed during the waking and sleeping state of subjects, with their mandible in resting and protruded position. Intravenous injection of Dormicum$^{(R)}$ was used for the induction of sleep. The maximum and minimum cross-sectional areas at each airway level during tidal ventilation were measured and the Collapsibility Index for each level of cross-section was also computed. In a comparison with results under variable conditions, the result was showed that the significant difference between each airway level divided with upper, middle, lower region of upper airway is not observed in the average minimum cross-sectional areas and Collapsibility Index. The significant difference only between in wake and sleep state was observed in the average minimum cross-sectional area at the lower region. Also, in wake state, the significant difference between resting and protrusive position of mandible for the average minimum was also observed in cross-sectional area at middle region. In sleep state, no significant difference between resting and protrusive position of mandible was observed in cross-sectional area and the Collapsibility Index.

• Sleep Medicine and Psychophysiology
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• v.13 no.2
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• pp.45-51
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• 2006

Obstructive sleep apnea (OSA) syndrome disrupts normal sleep. However, there were few studies to evaluate the asymmetric distribution, the one of the important factors of normal sleep in OSA subjects. We hypothesized that asymmetry would be broken in OSA patients. 49 male subjects with the complaint of heavy snoring were studied with polysomnography. We divided them into two groups based on the apnea-hypopnea index (AHI) fifteen: 13 simple snoring group (SSN, average AHI $5.9{\pm}4.4$) and 32 OSA group (average AHI $47.3{\pm}23.9$). We compared split sleep variables between the first half and the second half of sleep within each group with paired t-test for the evaluation of asymmetry. Changes of sleep architecture of OSA were higher stage 1 sleep% (S1), total arousal index (TAI), AHI, and mean heart rate (HR) and lower stage 2 sleep% (S2), REM sleep%, and mean arterial O2 saturation (SaO2) than SSN subjects. SWS and wake time after sleep onset (WASO) were not different between two groups. In split-night analysis, OSA subjects showed higher S2, slow wave sleep% (SWS), spontaneous arousal index (SAI), and mean HR in the first half, and higher REM sleep% and mean SaO2 in the second half. Those were same pattern as in SSN subjects. Mean apnea duration and longest apnea duration were higher in the second half only in the OSA. No differences of AHI, ODI, WASO, and S1 were found between the first and the second half of sleep in both groups. TAI was higher in the first half only in the SSN. SWS and WASO seemed to be influenced sensitively by simple snoring as well as OSA. Unlike our hypothesis, asymmetric distributions of major sleep architecture variables were preserved in OSA group. Losing asymmetry of TAI might be related to pathophysiology of OSA. We need more studies that include large number of subjects in the future.

• Korean Journal of Psychosomatic Medicine
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• v.11 no.2
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• pp.196-204
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• 2003

Objectives: It is known that sedative hypnotics would make cross tolerance with alcohol and deteriorate quality of sleep in alcoholics. Light therapy is effective non-pharmacological intervention for sleep disturbance in circadian phase disorders, jet-lag, shift-work and age-related sleep disorders. Authors would investigate the effects of morning light therapy on sleep of patients with alcohol dependence during recovery state without withdrawal symptoms. Methods: 13 patients with alcohol dependence who have not any alcohol withdrawal symptom were recruited. Light therapy during 1 hour in the morning had been administered by 2500 Lux light box through serial 3 days. Sleep state of subjects were assessed by sleep log and the subjective satisfaction at sleep was by 100 mm visual analogue scale. Sleepiness, depressive mood, anxiety were evaluated by 100mm visual analogue scale at 8 AM, 2 PM and 8 PM. For assessment of performance ability that would be associated with sleepiness and vigilance, trail making test A, B and digit symbol substitution test were performed by two times on base line and 4th day. Univariate repeated-measures ANOVAs were performed for each measures except performance tests which were analysed by paired t-test. Results: Sleep latency and sleep efficiency were significantly improved with light therapy and satisfaction at sleep was. There was no significant difference in sleepiness at 2 PM with light therapy but sleepiness at 8 AM significantly decreased and at 8 PM increased. The time to complete Trail making test and digit symbol substitution test were significantly shortened at 4th day compared with baseline. Fatigue at 8 AM were not significantly changed with light therapy but at 2 PM and 8 PM significantly decreased. Depressive mood and anxiety were not significantly changed with light therapy. Conclusion: Although this study had some limitations, it showed that light therapy would be effective modality on sleep disturbance of patients with alcohol dependence who have recovered from alcohol withdrawal symptoms. It is proposed that short term light therapy could be used clinically for alcoholics with insomnia. In the future, long term controlled studies using more objective tools for sleep are required to further investigate the effect of light therapy in alcoholics.

• Proceedings of the ESK Conference
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• 1995.04a
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• pp.175-180
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• 1995

산업계를 중심으로 많은 직장에서 교대제 근무가 실시되고 있으나, 교대작업에 관한 작업시간의 단축이 요구되고 있는 실정이다. 교대제근무의 도입에 따라 직장내에서 취하는 수면과 이러한 수면후 아침 일찍 작업을 계속하는 경우도 일반화 되고 있다. 일반적으로, 수면시간은 적어도 7시간 정도 취하는 것이 이상적 이라고 일본 후생성 등에서 권장하고 있지만, 직장에 따라서는 심야 근무의 종료시간등의 문제때문에, 반드시 이러한 수면의 장려시간이 지켜지는 경우는 많지 않다. 따라서, 수면량의 부족 및 그에 따른 수면의 질적 저하가 다음날 작업시에 작업자의 심신반응에 좋지않은 영향을 미치게 될것이라는 것은 쉽게 예상할 수가 있다. 이러한 점을 배경으로, 본 연구는 신경감각작업의 대표적인 예의 하나인 열차운전에 종사하는 운전사을 대상으로 새벽에 하는 작업에 대해 전날밤에 취한 수면의 양.부가 작업시에 작업자의 자각적 피로감에 양향을 미친는 가를 사례적으로 연구하여 분석한 것이다.

• Proceedings of the Korea Water Resources Association Conference
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• 2004.05b
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• pp.1173-1177
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• 2004

현재 다양한 분야에서 널리 사용되고 있는 지하투과레이더(Ground Penetrating Radar, GPR)를 이용하여 지하수면 및 함수량을 추정하였다. 비피압대수층 내에서의 얕은 포화대(saturated zone) 깊이을 산정하는 연구(livari and Doolittle, 1994, van Overmeeren, 1994)와 포화대 상부 습윤대(wetting fronts)의 거동를 조사한 연구(Vellidis et al, 1990) 등에 활용된 바 있는 GPR 기숙을 바탕으로 비피압대수층의 통기대와 포화대 내의 함수량 및 지하수면 추정을 위한 기초 실험을 수행하였다. 지하수면 및 함수량의 현장 적용성을 검증하기 위해서는 시간과 경제적인 면에서 비효율적인 점을 고려하여 사질토로 구성된 실험용 토조를 제작하여 건조시 획득된 GPR 자료, 지하수면의 변화에 따른 GPR 이미지를 비교하여 그 적용성을 검토하고 시${\cdot}$공간적 지하수면의 정확한 추정을 위해서 삼차원으로 비교${\cdot}$검토할 수 있도록 하였으며, GPR 자료의 정확성을 검증하기 위해서 토조 하부에 액주계(piezometer)를 설치하였다. 본 연구에서 적용된 GPR 실험은 획득된 이미지의 해석에 다소 어려움이 있지만 토양을 교란시키지 않고 비교적 간편하게 함수랑 및 지하수면의 위치를 파악하는데 매우 효과적이며, 추가적으로 GPR을 이용한 다양한 실험이 수행된다면 GPR 기술은 향후 기존 방법에서 쉽게 판단하기 어려운 시${\cdot}$공간적인 함수량 및 지하수의 분포 특성을 효율적으로 파악하는데 매우 큰 도움을 줄 수 있을 것이다.

• Journal of Life Science
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• v.22 no.5
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• pp.613-620
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• 2012

To evaluate the effects of sleep habits on the powers of beta waves and the sensory motor rhythm of the electroencephalogram (EEG), female college student subjects were divided into four groups, according to their sleep habits, as follows: GSHG (Good Sleep Habit Group), CSHG (Common Sleep Habit Group: late bedtime), CSDG (Cognitive Sleep Disorder-Delayed Sleep Phase Syndrome Group), and NSDG (Non-cognitive Sleep Disorder-Delayed Sleep Phase Syndrome Group). Brain function was stimulated by reading a book for 3 min in the morning (9~12 am) and the EEG was measured. According to the results, the powers of the beta waves and sensory motor rhythm were not different during the resting period among the four groups. However, during the reading stimulation period, the powers of beta waves and the sensory motor rhythm in the GSHG were significantly greater than in the other groups ($p$ <0.05). Beta powers during stimulation also increased in all brain areas in the GSHG ($p$ <0.05). Interestingly, these were decreased in the frontal and temporal lobes in the CSHG by the reading stimulation ($p$ <0.05). On the other hand, sensory motor rhythm, which represents focusing efficacy, only improved in the GSHG. These results indicate that the brain's focusing function during the reading stimulation was not properly operating in the morning in the female college students who had a delayed bedtime and bad sleep habits.