• Title/Summary/Keyword: 성장 호르몬

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Sexual Differentiation and Androgen Sex Reversal of Oreochromis niloticus (나일틸라피아의 성분화와 호르몬에 의한 성전환)

  • KIM Dong Soo;BANG In Chul;KIM In-Bae
    • Journal of Aquaculture
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    • v.1 no.1
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    • pp.53-66
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    • 1988

  • Histological study was conducted to determine the initial treatment time and treatment period of hormone for sex reversal in accordance with gonadal development and sexual differentiation in Oreochromis niloticus. The effects of various concentrations and various treatment periods of 17$\alpha$-methyltestosterone (MT) on sex reversal, growth, and condition factor were also evaluated. Paired primodial gonads were formed 9 days after hatching, when germ cells began their gradual multiplication and development into gonial ones. Sex differentiation of gonads either into ovaries or testes became histologically discernible about 20 days after hatching with formation of ovarian cavity and efferent duct. All feed treated with MT at 15 ppm for 10 days or more produced populations of males $95\%$ or above. All male populations were produced at 15 ppm MT for 40 days, and 30 ppm for 30 and 40 days. Growth of hormone-treated-fish was faster than that of untreated ones and the condition factor of hormone-treated-fish was greater than that of untreated ones 77 days after hatching.

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Determination of Growth Hormone cDNA in Brook Trout, Salvelinus fontinalis (Brook trout (Salvelinus fontinalis) 성장호르몬 cDNA의 염기배열 결정)

  • 이종영;권혁추;김세연;박홍양
    • Journal of Aquaculture
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    • v.11 no.3
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    • pp.327-335
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    • 1998

  • Amplification of brook trout growth hormone cDNA using polymerase chain reactiono (PCR) produced a nucleotide of 1,120 bp which contained the 5'non-coding region (13bp), an open reading frame (ORF) coding a growth hormone polypeptide consisting of 210 amino acids (630 bp), and a 3'non-coding region (477 bp). In open reading frame s signal peptide of 22 amino acid and 2 potential disulfide bond sites deduced by 4 cysteine residues were obser-bed. Brook trout growth hormone has 97.1%, 94.8%, 94.3%, 91.9%, 66.2%, 63.5%, 62.9%, 62.3%, 53.8% and 48.1% amino acid identity with that of Atlantic salmon, chum salmon, rainbow trout, coho salmon, tuna, tilapia, yellow tail, carp, flounder and eel, respectively.

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The comparison of predicted adult height change and height gain after gonadotropin-releasing hormone agonist and combined growth hormone treatment in girls with idiopathic central precocious puberty (진성 성조숙증으로 진단 받은 여아에서 gonadotropin-releasing hormone agonist 단독치료 및 growth hormone의 병합치료 시 예측 성인키의 변화 및 성장 획득의 비교)

  • Seo, Ji-Young;Yoon, In-Suk;Shin, Choong-Ho;Yang, Sei-Won
    • Clinical and Experimental Pediatrics
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    • v.49 no.3
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    • pp.305-311
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    • 2006

  • Purpose : GnRH analogues(GnRHa) are used to treat central precocious puberty(CPP). However, in some patients, the GV decrease is so remarkable that it impairs predicted adult height(PAH); and there fore, the addition of growth hormone(GH) is suggested. We analysed the growth changes during two years and final adult height(FAH) in girls with idiopathic CPP treated with combined therapy, compared with those of girls treated with GnRHa alone. Methods : For the analysis, we classified the patients, who was treated for longer than two years, into three groups depending on the initial PAH and combination of GH; PAH_L, treated with GnRHa and PAH less than midparental height(MPH) - 5 cm. PAH_H, treated with GnRHa and PAH greater than MPH - 5 cm. GnRHa＋GH, combined GH treatment, regardless of PAH before treatment. We analysed the GV and PAH change during the first two years and FAH. Results : In PAH_L, the PAH(SDS) at first year of therapy was significantly increased to $153.5{\pm}6.5cm(-1.4{\pm}1.3)$ from $149.7{\pm}6.4cm(-2.1{\pm}1.3)$ before treatment(P=0.004). In PAH_H, there was no significant increase in PAH during the two years of treatment. During the first year of combination of GH and GnRHa, GV and PAH increased significantly. We observed significant increases in FAH, comparing to the initial PAH in the PAH_L and GnRHa＋GH groups. The height gains(FAH - initial PAH) were significantly higher in the PAH_L and GnRHa＋GH groups than that in the PAH_H group. Conclusion : This study suggests the FAH and height gains are improved in patients, whose predicted adult height before treatment was shorter than those with higher predicted adult height, with the treatment of GnRHa alone or in combination with GH. GH could not improve the final adult height, but compensated the growth in patients whose growth velocity was decelerated by GnRHa alone.

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