• Journal of the Korean Society of Food Science and Nutrition
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• v.44 no.5
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• pp.657-663
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• 2015

Ionizing radiation induces cell damage through formation of reactive oxygen species. The present study was designed to evaluate the protective effects of post-treatment with hesperetin against ${\gamma}$-irradiation-induced cellular damage and oxidative stress in BALB/c mice. Healthy female BALB/c mice were exposed to ${\gamma}$-irradiation and administered hesperetin (25 mg/kg and 50 mg/kg, b.w., orally) for 7 days after 6 Gy of ${\gamma}$-irradiation. Exposure to ${\gamma}$-irradiation resulted in hematopoietic system damage manifested as decreases in spleen indexes and WBC count. In addition, hepatocellular damage characterized by increased levels of aspartate aminoransferase (AST) and alanine aminotransferase (ALT) in plasma. However, post-irradiation treatment with hesperetin provided significant protection against hematopoietic system damage and decreased AST and ALT levels in plasma. The results indicate that ${\gamma}$-irradiation induced increases in lipid peroxidation and xanthine oxidase (XO) as well as decreases in antioxidant enzymes (superoxide dismutase, catalase, and glutathione peroxidase) and glutathione (GSH) in the liver. These effects were also attenuated by post-treatment with hesperetin, which decreased lipid peroxidation and XO as well as increased antioxidant enzymes and GSH. These results show that post-treatment with hesperetin offers protection against ${\gamma}$-irradiation-induced tissue damage and oxidative stress and can be developed as an effective radioprotector during radiotherapy.

• Journal of Animal Science and Technology
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• v.49 no.6
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• pp.801-818
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• 2007

This study was carried out to determine the effects of processing methods of barley as a proper source of grain in diets of Hanwoo on fermentation pattern in the rumen fluid and digestibility of the diets, the growth performance and carcass characteristics of Hanwoo. The degree of ruminal pH change in the cows fed diets of the Corn(corn basis) and GDRB(ground and dry-rolled barley) tended to be greater than those in the cows fed other two diets (ground barley, GB and dry-rolled barley, DRB). The diet of GDRB showed the lowest ruminal pH(5.5), indicating the rapid degradation of the diet in the rumen. Although ammonia concentration was not affected by diet, the GR and DBR diets maintained the low concentrations of ruminal ammonia compared with other two treatments. And the effects of feeding processed barley grain on body weight gain and meat quality of Hanwoo steers were as follows. Steers fed DRB diet had the highest body weight, 683.0kg at 28 months old, while those fed the GDRB showed the lowest body weight, 653.3kg. The average daily gain(ADG) was similar between the steers fed Corn and GR throughout the whole period, but the GDRB showed the lowest ADG. The steers fed the DRB showed the significant increase in ADG(0.89kg/d from 19 to 23 months old and 0.43kg/d from 24 to 28 months old) compared with those fed other diets. Feeding diets containing corn and/or barley did not influence live body weight, cold carcass weight, carcass yield, back-fat thickness and carcass grade of Hanwoo steers.

• The Korean Journal of Nuclear Medicine Technology
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• v.15 no.1
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• pp.3-9
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• 2011

Purpose: Generally dual energy X-ray absorptiometry has been used for the purpose of evaluation of osteoporosis and treatment. Recently the interest of obesity came to be high and body percent fat test is increasing. Existing measure of body fat have to scan the whole body can be evaluated, but only lumbar spine and hip measurements was assumed to be whole body fat as well as improving the software. It tries to check whether the part measured value not being whole body measurement has the validity or not compared with the value calculated with the method that it is different, it forgives through a correlation with a (BIA) and (BMI). Materials and Methods: In 2010, the body percent fat was measured among the examinee coming to the Asan Medical Center public health care center from March till August against 90 females more than 40 years old through (DXA) and BIA. BMI utilized the value which wrote an hight and weight measured through the body measuring instrument in the examinee information and is automatically calculated. In addition, it classified as the low weight ($13-18.5kg/m^2$), normal ($18.5-25kg/m^2$), and corpulence ($25-30kg/m^2$) based on BMI and so that it could check whether there was the difference according to the weight or not BMI and BIA and correlation between DXA were analyzed in each group. The statistical program for the analysis used SPSS 12.0. Results: The comparison of DXA at 3 which it divides into the low weight and normal and corpulence groups and BIA did not show the difference noted statistically in all groups and the between group comparison was exposed to do not have a meaning. The body percent fat measured by the correlation analysis result DXA at the state that it doesn't divide into the group showed the high correlation (r=0.908, p0.01) noted statistically compared with BMI and showed the high correlation noted statistically in a comparison with BIA (r=0.927, p0.01). Conclusion: It confirmed that the whole body percent fat presumed from the part bone density measurement showed the excel correlation compared with BIA and BMI and information is high. There is still no clear standard about the presumed whole body percent fat and it is difficult to evaluate the fat evaluation by the bone mineral density measurement. However, it is determined that the information offering which is more objective through the comparative study with the body percent fat which is very efficient and in that it can obtain till the information about a fat as well as diagnosis of the osteoporosis through the bone density checkup is measured by the afterward telegraph bone density checkup and is clinically useful is possible.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.51 no.7
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• pp.599-607
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• 2006

The experiments were carried out to develop simulation model for estimating the yield of soybean in upland and paddy field condition. Field experiments were done at National Institute of Crop Science in 2005. The evaluated soybean cultivars were Taekwangkong, Daewonkong, and Hwangkeumkong. Soybean seeds were planted by hill seeding with 3-4 seeds and row and hill spacing were $60{\times}10cm$ in upland and $60{\times}15cm$ in paddy field. Seeds were sown on row (without making ridge) and on the top of ridge in upland and paddy field, respectively. Field parameters were measured yield components ($plants/m^{2}$, pod no./plant, and 100-seed weight, seed yield and growth characteristics (stem length, leaf area at each stage, and dry weight of shoot) and after measuring they were compared the relationships with seed yield and yield components and seed yield and growth characteristics. Seed yield of soybean was affected by cultivars and planting density. Seed yield was higher in upland than paddy field due to the higher planting density in upland field. The upland soybeans generally had lower 100-seed weight than that of paddy field. Seed yield of soybean in a paddy field was greatest in Taekwangkong and followed by Daewonkong and Hwangkeumkong. The harvest index of taekwangkong and Hwanggumkong was higher in upland than paddy field, however, it was higher in paddy field than upland in Daewonkong. Seed yield was greatest in Daewonkong in both experimental fields. The greatest stem length was observed in taekwangkong and Hwanggumkong (R6) in late growth stage in paddy field. Dry weight of shoot and pod, pod number, stem length, and stem diameter were higher grown in paddy field than grown in upland. Crop growth rate (CGR) of cultivars was higher in paddy field after 8 WAS(weeks after sowing) and it was greatest at 13 WAS in Daewonkong among the cultivars. In upland field, CGR was greatest in Taekwangkong and then followed by Daewonkong and Hwanggumkong during 12 and 15 WAS. There was no significant relationships between 100-seed weight and seed yield in both experimental fields. A significant positive relationship was observed between seed number and seed yield. The correlation coefficients between leaf area and shoot dry weight were about 0.8 during the whole growth stage except 5 WAS and 4-5 WAS in paddy field and upland, respectively. This experiment was done just one year and drained paddy field condition was not satisfied drained condition successfully at 7th leaf age of soybean by the heavy rain, so we suggest that the excessive soil water reduced seed yield in paddy field and the weather condition should be considered for utilizing of these results.

• Korean Journal of Weed Science
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• v.14 no.1
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• pp.62-70
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• 1994

This study was conducted to find out if there are some differences in germination, growth and morphological characteristics between rice(Oryza saliva) and barnyardgrass(Echinochloa crus-galli) under various cropping patterns and to abtain the fundamental information on weed control method in direct seeded rice. Rice was broadcast on soil-surface(Broadcast rice), drill seeded in soil(Drilled rice) and barnyardgrass was drill seeded in soil(Barnyardgrass) under dry(Dry condition) and water direct seeded condition(Water condition). Also rice was transplanted with 8-day seedlings(8 -day-old seedling) and 25-day seedlings(25-*day-old seedling) under transplanting condition(Transplanting condition) At 1, 2, 3, 5, 7, 10, 15 and 20 days after seeding or transplanting(DAS/T), plants were harvested to examine their germination, growth and morphology. The major results were as follows ; Until 5 DAS/T growth of rice and barnyardgrass were well established under dry condition but under water condition growth of shoots was mainly elongated. At 20 DAS/T barnyardgrass had greater plant height and shoot fresh weight than rice under direct seeded condition, while plant height and shoot fresh weight of rice was greater than those of barnyardgrass under transplanting condition. Root length of barnyardgrass was greater under the dry, drilled, direct seeded conditions than that of rice under the water, broadcast, transplanting condition, respectively. And root fresh weight of rice under direct seeded condition was similar to that of barnyardgrass but that of rice under transplanting condition was significantly greater than that of barnyardgrass. Barnyardgrass only formed mesocotyls and its length increased with increased depth of seeding. Leaf stage and leaf area of barnyardgrass was greater under the dry, drilled than those of rice under water, broadcast conditions, respectively, while those of rice was greater than those of barnyardgrass under transplanting condition. Chlorophyll contents were higher in barnyardgrass, dry direct seeded rice, transplanted rice, water direct seeded rice in descending order.

• Korean Journal of Organic Agriculture
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• v.17 no.1
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• pp.111-125
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• 2009

Pitamin is a component of pine bark extract that exhibits antimicrobial activity and a variety of physiological effects. This study was earned out to investigate the effects of dietary pitamin as an organic livestock feed additive in broiler chickens. A 35 day trial was conducted to determine the influence of dietary premix containing 5% pitamin; investigated parameters included blood lipids, growth performance, quality characteristics of carcasses, and changes of caecal microbials in broiler chickens. Chickens were randomly divided into groups that were untreated (control), treated conventionally with antibiotics in the absence of premix, received 0.1 % or 0.2% premix containing 5% pitamin. Plasma lipids were lower in groups fed diets with pitamin premix (p<0.05). The body weight gain from broiler chickens fed with the diet containing 0.1% pitamin premix and antibiotics was similar, and was significantly higher than that of the other groups (p<0.05). The weight of breast muscle and thigh meat of carcasses was similar, and was higher than that of the control group (p<0.05). Abdominal fat and thymus index from chickens receiving either pitamin-supplemented premix was significantly lower and increased, respectively, that of the antibiotic and control groups (both p<0.05). The chickens on the pitamin premix-supplemented diets evidenced significantly higher caecal levels of Bifidobacterium species as compared with the chickens on the control diet (p<0.05). These results suggest that feeding a diet supplemented with a 0.1% premix containing 5.0% pitamin for 35 days maintains the production of broiler chickens at a level comparable to that obtained from the use of antibiotics.

• Korean Journal of Ecology and Environment
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• v.43 no.2
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• pp.288-297
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• 2010

This study was to evaluate the ecological stream health through the Multimetric Fish Assessment Index (MFAI) along with fish fauna analysis based on the tolerance and trophic guilds at Miho stream in 2008 and 2009. Also, we analysed total mercury concentration in fish tissues to examine heavy metal contamination. Total sampled fish were 40 species and 2,557 individuals and Zacco platypus was the most dominant with 35% relative abundance. It was sampled with 11.4% RA for Korean endemic species (10 species 291 individuals) less than average RA 39.3% for the Geum river watersheds. According to the tolarance guild analysis, tolerant species was more dominant with 58.9% RA (15 species, 1,507 individuals) than sensitive species with 6.6% RA. Trophic guild analysis also suggested that omnivores were more dominant (60.5% RA) than insectivores (31.5% RA). Riffle-benthic species was also sampled with 7.7% RA. Ecological stream health based on the MFAI were averaged 25.3 (n=3) with fair-poor condition in 2008 and also 26.3 (n=3) with fair condition in 2009, just slightly increased than 2008. Qualitative habitat evaluation index was averaged 134 (n=3) with fair condition but most of sites had sediment accumulation that reflected substrate degradations proceeding. From the result of total mercury accumulation in fish tissues, kidney and liver tissues showed the highest but the lowest for gill tissues. Overall mercury concentration were not exceed the national standards by Korean Federation of Drug and Administration (KFDA). Consequently, our result could correspond with the characteristics of Miho stream where point sources such industrial complexes and wastewater treatment plant widely distributed around the stream along the gradient of up and downstream.

• Journal of Aquaculture
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• v.11 no.4
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• pp.573-580
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• 1998

Red spotted grouper, Epinephelus akaara is distributed in the south and west coasts of Korea. The natural stocks of the fish are decreasing sharply year by uear because of reckless overfishing. This research was carried out to understand general informations on maturation, sex composition and sex-reversals of the fish. Annual fishing uields of red spotted grouper in the castal area of Byonsan Peninsular of Kora decreased over 10% from 1992 to 1994. The main fishing season was from May to July with fishing gear of Hand-lines. Gonadosomatic index (GSI) and condition factor were highest on early and late July, respectively, thus main spawning reriod was assumed from late July to early August. The relationship between total length (X) and body weight (Y) for wild adults was represented as a regression, Y=$0.0169X^{2.9705}$, ($r^2$=0.96). Frequency of sex of wild red spotted gouper showed that the number of female below 38cm in total length was more than that of male, and hermaphrodite mainly occurred from 28cm to 32cm in total length the frequency of male and female were almost same. Also hermaphrodite occurred mainly between 25~29cm. Sex reversal ration of the adults reared in a tank for a year with different sexual compositions revealted that the frequency of female reversed from male was more than that of male reversed from female at 1:1 and 1:2 stocking densities of female and male, respectively. Also, about 20% of female was reversed to male when all females were reared. And the size of the fish reversed to male was larger than that of non-reversed female.

• Korean Journal of Veterinary Research
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• v.32 no.1
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• pp.35-39
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• 1992

SMZ is one of the most widely used antibacterial agents in veterinary medicine. It is also used as a growth promotant in many species of domestic animals There are marked species differences in its metabolism and pharmacokinetics. However, its pharmacokinetic and metabolism in rabbits. which are ragarded not only as good laboratorty animals hut also as good economical animals in its own, are lacking. Sex-differences in drug metabolism are well recognized in wide range of animal species including rats. Males are known to he more active than females. It is also know that there are Significant differences in the direction of metabolic pathways. But recently, female goats are reported to be more active in the metabolie capacity of SMZ than the other sex by Dutch researchers at Utrecht. Therefore, it is not easy to make general conclusicn of having higher SMZ metal-die capacity in the male compared to the opposite sex in every animal species. In this regard, the study on metabolic pattern of SMZ in rabbits, which are regarded as hervivorous, is of interest because the dietary habbits of rabbit are comparable to thai of goal, NEW Zealand White rabbits of each sex were given SMZ(35mg/kg) as a bolus injection into the marginalean, vein in order to study its pharmacokinetic profiles(using plasma) anc metabolic pattem(24h urine) as specified in the methods anc materials. 1. In the rabbit, the major metabolic pathway of SMZ was the acetylation(the formation of $N_4AcSMZ$). There were hydroxylation pathways(50HSMZ, $6CH_2OHSMZ$) as well, in the metabolism of SMZ in the rabbit, but minor pathways. 2. No sex differences in the metabolic direction of SMZ and its metabolites formation were found from the urinary excreted metabolites of SMZ out of 24h collected urine. 3. The concentration-time curves of SMZ(35mg/kg, iv) in the plasma compartment were fitted to a one-compartment open model when using a computer program(NONLIN). There was also no difference in the pharmacokinetic pattem of SMZ between two sexes. 4. The emergence of $N_4AcSMZ$ metabolized from SMZ was very fast in the plasma of the rabbit The elimination of $N_4AcSMZ$ was prolonged as compared to that of the parent drug Vie found no sex difference in the elimination pattern of $N_4AcSMZ$ in the rabbit.

• Journal of Life Science
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• v.19 no.7
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• pp.983-993
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• 2009

The effects of Monascus-fermented Korean red ginseng (MFRG) on the contents of serum lipids and tissues lipid peroxidation was investigated in alcohol feeding rats (AC group). Serum contents of total lipid and free fatty acid in alcohol feeding rats were significantly increased, but these increases tended to decrease in the AMFRG group. Serum triglyceride content was also significantly decreased in the AMFRG group compared to other groups. Serum content of total-cholesterol was significantly increased in AC group compared to normal control (NC) group, whereas there was no significant difference between the AC and AMFRG groups. Content of HDL-cholesterol in serum was slightly increased in the AC group compared to the NC group, but this increase in the AC group was more significantly increased in the AMFRG group. At the same time, atherogenic index (AI) was also significantly decreased in the AMFRG group compared to the AC group. Contents of thiobarbituric acid reactive substances (TBARS) in the liver, heart, spleen and testes were significantly increased in the AC group compared to the NC group, but these increases were significantly less in the AMFRG group. Contents of liver nonheme ion was increased in the AC group and was significantly decreased in the AMFRG group, which suggested that lipid peroxidation contents are inversely correlated with liver nonheme ion content. Hepatic glutathione concentration was significantly decreased in the AC group, but this content was significantly increased in the AMFRG group and it showed the antioxidant abilities of glutathione. These results suggested that Monascus-fermented Korea red ginseng has anti-atherogenic index (AI) effects as well as antioxidative activities through reduced tissue oxidative stress in alcohol feeding rats.