• Prospectives of Industrial Chemistry
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• v.18 no.4
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• pp.1-9
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• 2015

최근 신체의 손상된 조직 및 세포를 재생하기 위해 약물 전달이 가능한 생체재료에 관한 연구가 활발히 이루어지고 있다. 이러한 생체재료 개발을 위해 생체적합하며 생분해성이 뛰어난 천연고분자가 큰 각광을 받고 있다. 기존의 약물 전달을 위한 고정화 방법은 화학적 가교가 널리 이용되어 왔으나, 이 방법의 여러 단점들이 보고된 바 있다. 이러한 단점을 극복하기 위해 광반응성 천연고분자를 이용한 약물광고정화 방법이 연구되어 왔다. 본 글에서는 광고정화를 위해 합성되는 여러 광반응성 천연고분자의 종류 및 특성과 생체재료로써의 활용 방안을 소개하고자 한다.

• Polymer Science and Technology
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• v.5 no.6
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• pp.537-543
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• 1994

• Polymer Science and Technology
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• v.24 no.3
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• pp.254-260
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• 2013

• Proceedings of the KSME Conference
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• 2007.05a
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• pp.1254-1258
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• 2007

Electro-active polymer (EAP), one of the smart materials, is a new alternative offering ultra-precise movements and bio-compatibility. We present the results of the design, fabrication, and performance evaluation of a fabricated diaphragm-type polymer actuator using segmented polyurethane(SPU). This paper illustrates the relationship between the elastic modulus and maximum deflection as a key property of the Maxwell stress effect and also presents the relationship between the dielectric constant and maximum deflection as a key property of the electrostriction effect, especially in polymer actuators using SPU. A diaphragm-type actuator was used to induce an equation of the vertically distributed load by using a fully clamped circular plate as the boundary condition. To verify the equation, the results were compared to the data measured from load cell. In the near future, a low-cost check valves and bio-robot can be applied by its actuators.

• Applied Chemistry for Engineering
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• v.4 no.1
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• pp.188-195
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• 1993

Polyelectrolyte complexes and graft copolymers as biomaterials were synthesized from the water soluble cellulose derivatives. Polyelectrolyte complexes have been prepared from carboxymethyl cellulose (CMC) and gelatin. Graft copolymers(Mc-g-AA) were synthesized by grafting acrylic acid (AA) onto methyl cellulose(MC). (Mc-g-AA) and gelatin polyelectrolyte complexes were also prepared. The optimum conditions of each sample were investigated after chemical crosslinking or heat treatment. The preliminary results show that these materials might be interesting for biomedical applications.

• Applied Chemistry for Engineering
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• v.19 no.5
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• pp.457-465
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• 2008

Development of various medical systems was accomplished through the progress of biotechnological method for therapy of human diseases. Furthermore, drug delivery systems have been investigated to carry the bioactive materials such as drug or gene in the body effectively. The most important thing in this system is to develop biomedical polymers having biocompatibility, biodegradability, and non-toxicity. Chitosan, a natural polymer, has been importantly considered as biomedical materials due to its good biocompatibility and various bio-active characteristics. Since the property of chitosan is differently explained according to the crystalline structures of chitin, the study for structural analysis of chitin has to proceed to apply as a biomaterial. From this point of view, this article introduced the analysis of crystalline structural of chitin, general property of chitosan and potential characteristics of low molecular weight water-soluble chitosan (LMWSC) as a biomaterials. Furthermore, chemical modification of LMWSC using various functional groups was also performed to enhance its bioavailability and emphasize their potential as drug delivery carriers (DDS).

• Textile Coloration and Finishing
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• v.6 no.4
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• pp.92-99
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• 1994

혈액이 이물질과 접촉하면 응고하는 성질은 생명유지를 위해서는 단단히 중요한 일이나, 인공재료를 이용하여 질병을 치료하고자 할 때는 이러한 혈전형성은 장애요인으로 작용한다. 1960년대부터 최근까지 항혈전성을 가진 재료에 대한 연구가 활발히 전개되고 있는데 그 동향도 조금씩 변모하여가고 있고, 접근해가는 방식이 여러가지로 세분화되고 있다. 여러 논문과 총설, 혹은 서적을 참고로 하면 재료의 분류를 항혈전을 일으키는 메카니즘을 몇가지로 나누고 여기에 포함되는 것들을 열거하는 방식을 채택하고 있다. 한편, 의료에 직접적으로 관여하는 재료는 대부분이 섬유고분자재료가 차지하고 있으며 이분야의 관계자들의 의료에의 공헌도는 아주 높으며 의료 관계자로부터의 기대 또한 크다. 특히 혈액과 접촉하여 혈책적합성을 나타내는 재료또한 대부분이 섬유고분자재료가 차지하고 있기 때문에 섬유고분자재료의 입장에서 이들을 분류하고 각각의 항혈전성 메카니즘과 응용방식의 이해가 우선되어야 할 것이며, 이를 바탕으로 해야 좀더 진보된 형태의 항혈전성 섬유고분자재료의 발달이 가능하리라 본다. 따라서, 이 논문에서는 항혈전성을 나타내는 각각의 섬유고분자들을 그 중심으로 하여 항혈전성 재료를 소개하고자 한다.

• Polymer(Korea)
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• v.30 no.6
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• pp.512-518
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• 2006

A biodegradable polymer poly((R) -3-hydroxybutyric acid) (PHB) was conjugated with a hydrophilic polymer poly(ethylene glycol) (PEG) by the ttansesterification reaction to form the amphiphilic block copolymer. PHB with low molecular weight ($3000{\sim}30000$) was appropriated for the drug delivery materials. High molecular weight PHB was hydrolyzed by an acid-catalyst to produce the low molecular weight one. Amphiphilic block copolymer was formed the self-assembled polymeric micelle system in the aqueous solution that the hydrophillic PEG was wraped the hydrophobic PHB. Generally, polymeric micelle forms the small particle between $10{\sim}200nm$. These polymeric micelle systems have been widely used for the drug delivery systems because they were biodegradable, biocompatible, non-toxic and patient compliant. The hydroxyl group of PEG was substituted with carboxyl group which has the reactivity to the ester group of PHB. Amphiphilic block copolymer was conjugated between PHB, and modified PEG at $176^{\circ}C$ which was higher than the melting point of PHB. Transesterification reaction was verified with DSC, FTIR, $^1H-NMR$. In the aqueous solution, critical micelle concentration (CMC) of the mPEG-co-PHB copolymer measured by the fluororescence scanning spectrometer was $5{\times}10^{-5}g/L$. The shape and size of the nanoparticle was taken by dynamic light scattering and atomic force microscopy. The size of the nanoparticle was about 130 nm and the shape was spherical. Our polymeric micelle system can be used as the passive targeting drug delivery system.

• Proceedings of the Korean Society of Dyers and Finishers Conference
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• 2003.04a
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• pp.132-136
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• 2003

최근 셀룰로오스 섬유에 대해 위생적이고 건강성을 강조하는 항균 방취 가공을 부여하기 위한 연구가 활발히 진행되고 있다. 지구상에서 생물체에서 얻는 키틴은 셀룰로오스 다음으로 그 생산량이 많은 천연고분자 물질이다. 키토산은 키틴을 탈아세틸화 함으로써 얻어지는 다수의 아미노기를 갖는 천연다당계열의 생체적합성, 생분해성 고분자이다. 특히 키토산은 우수한 항균ㆍ방취 기능성 부여와 대전방지등의 효과를 나타내어 우수한 가공제로 사용된다. (중략)

• Polymer Science and Technology
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• v.15 no.4
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• pp.438-448
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• 2004

최근 노인 인구가 증가함에 따라 뇌혈관질환, 암 질환이 증가하고 있으며, 생활환경의 변화에 따른 성인병 발병 연령이 점차 낮아져 건강에 대한 관심이 증가하고 있다. 이에 따른 병의 조기 발견을 위한 여러 진단방법이 발전되고 있으며 최첨단 진단방법인 핵 자기공명 단층촬영술 (MRI, magnetic reasonance image)의 사용이 증가되고 있다.(중략)