• Applied Chemistry for Engineering
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• v.19 no.5
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• pp.457-465
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• 2008

Development of various medical systems was accomplished through the progress of biotechnological method for therapy of human diseases. Furthermore, drug delivery systems have been investigated to carry the bioactive materials such as drug or gene in the body effectively. The most important thing in this system is to develop biomedical polymers having biocompatibility, biodegradability, and non-toxicity. Chitosan, a natural polymer, has been importantly considered as biomedical materials due to its good biocompatibility and various bio-active characteristics. Since the property of chitosan is differently explained according to the crystalline structures of chitin, the study for structural analysis of chitin has to proceed to apply as a biomaterial. From this point of view, this article introduced the analysis of crystalline structural of chitin, general property of chitosan and potential characteristics of low molecular weight water-soluble chitosan (LMWSC) as a biomaterials. Furthermore, chemical modification of LMWSC using various functional groups was also performed to enhance its bioavailability and emphasize their potential as drug delivery carriers (DDS).

• KSBB Journal
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• v.8 no.3
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• pp.237-242
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• 1993

Chitin-based fibers have low mechanical strength and hence cannot be used as surgery fiber due to fast degradation In tissues. A new fiber Chitulose was made by mixing chitin with cellulose, both of which have similar structure. A mixture of dimethylacetamide (DMAc) and 6% lithium chloride (LiCl) was found to be an effective solvent system for dissolvoing chitin and cellulose. The Chitulose fiber made by wet spinning of a mixture of chitin and cellulose resulted in the highest degree of strength and flexibility when the ratio of chitin to cellulose was 1.5; 0.2. The fiber maintained mechanical structure even after autoclaving, indicating thermal stability. A biodegradability test of the Chitulose fiber by imbeding in a rat showed that degradation was initiated in 14 days and completely done in 40 days.

• Composites Research
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• v.22 no.4
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• pp.41-49
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• 2009

Natural fiber reinforced composites are emerging as low-cost, lightweight, recyclable, and eco-friendly materials. These are biodegradable and non-abrasive. Due to eco-friendly and biodegradable characteristics of natural fibers, they are being considered as potential candidates to replace the conventional fibers. The chemical, mechanical, and physical properties of natural fibers have distinct features depending upon the cellulose content of the fibers which varies from fiber to fiber. The mechanical properties of composites are influenced mainly by the adhesion between matrix and fibers. Several chemical and physical modification methods of fiber surface were incorporated to improve the tiber-matrix adhesion resulting in the enhancement of mechanical properties of the composites. This paper outlines the works reported on natural tiber reinforced composites with special reference to the type of fibers, polymer matrix, processing techniques, treatment of fibers, and fiber-matrix interface.

• Proceedings of the Materials Research Society of Korea Conference
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• 2009.11a
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• pp.43.1-43.1
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• 2009

Bone plate는 골절된 뼈의 골 유합을 지지하기 위해서 정형외과, 신경외과, 성형외과 및 치과 등에서 널리 사용되고 있다. 하지만 기존의 bone plate는 대부분 금속으로 제작되어 있어 장기간 이식에 따른 부식 및 천연골 강도저하 등으로 인해 1~2년 후 재수술을 해야 하는 문제점을 갖고 있다. 본 연구에서는이런 금속 bone plate의 단점을 개선하고자 생체적합성이 우수한 생분해성 고분자 bone plate를 제작하였다. 사용된 고분자는 생체적합성과 생분해성이우수한 PVA(polyvinly alcohol)와 강도를 유지하기 위한 PMMA(poly methyl methacrylate)를 사용였다. Electrospinning 법으로 PVA와 PMMA fibrous mat를 제작하여 각 mat를 적층시킨 후 열압착을 하여 강도를 증가시킨 PMMA/PVA Mutlilayer bone plate을 제작하였다. 제작된 PMMA/PVA Mutlilayer bone plate의 생체적합성 평가를 위해 MTT assay, 생분해 특성을 관찰하기 위해 Micro-CT와 SBF(simulated body fluid) 내에서의 용해도를 관찰하였다. 또한조골세포의 부착과 분화에 미치는 영향을 SEM(scanning electron microscope)을통해 관찰하였고, 조골세포의 유전자 발현에 미치는 영향을 RT-PCR을통해 확인하였다.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.16 no.9
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• pp.6403-6410
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• 2015

Medical polymer PLGA is biocompatible, biodegradation, mechanical characteristic and biostability, and the degradation time can be adjust by controlling the number of monomer. In this paper, PLGA membranes have different composition ratio by L/D type was prepared by phase transition method. And the PLGA membrane in phosphate buffered saline(PBS) at the different test temperatures for different periods of time to examined for change in mass and measured the pH of degradation media. Measurement of Tg and surface structure was performed using a DSC and Stereoscopic microscope. As the molecular weighter increase, hydrolysis rate was decrease in geometrical progression. According to the composition ratio by L/D type, degradation rate and the change of pH are large.

• Journal of Biomedical Engineering Research
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• v.16 no.4
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• pp.395-402
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• 1995

The intravoxel spin phases in magnetic resonance imaging (MRI) usually vary due to susceptibility differences of materials to be imaged. The phase variation in the voxel results in a reduction of the signal intensity. This signal intensity reduction is known as the susceptibility effect in MRI and has been studied extensively. In this paper, a new spectral decomposition technique Is proposed and the signal change due to the susceptibility effect can be analyzed. A pulse sequence for the spectral decomposition of the susceptibility was developed and applied to susceptibility imaging of venous blood possessing paramagnetic properties. The computer simulations and their corresponding experimental results obtained using both a phantom and human volunteers are reported. Key words : susceptibility effect in MRI : spectral decomposition of susceptibility effect.

• Journal of the Korean Society for Marine Environment & Energy
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• v.7 no.3
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• pp.146-151
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• 2004

Cyclodextrin compounds including 2-hydroxypropyl-β-cyclodextrin(β-HPCD) though to be accelerate the biodegradation of PAHs molecule by increasing solubility of PAHs through detaining PAHs in their's cavity. However, only this mechanism is not sufficient to explain the enhancement of PAHs biodegradation by β-HPCD. To find out possible additional role of β-HPCD in the enhancement of PAHs biodegradation, biodegradation rates of pyrene and benzo[a]pyrene (B[a]P) by a PAHs degrading Novosphingobium pentaromtivorans US6-1 strain were compared between with and without addition of β-HPCD. Changes of bacterial biomass were also measured simultaneously. In addition catechol 1,2-dioxygenase activity was determined depending on pre-incubation conditions. As a result, β-HPCD accelerate the degradation rate of pyrene by strain US6-1 and especially the β-HPCD amendment was obligatory for the degradation of B[a]p. Bacterial biomass was responsible for β-HPCD, however, PAHs compounds such as pyrene and B[a]P did not contribute to the bacterial biomass. Catechol 1,2-dioxygenase specific activity of US6-l cells pre-cultured in MM2 medium containing l％ β-HPCD was higher than that of cells pre-cultured in ZoBell medium. The former case also showed similar activity compared to that of cells serially starved in MM2 medium after grown in ZoBell medium. These results imply that the presence of β-HPCD accelerate the degradation of PAHs by increasing the bacterial biomass as well as by increasing the water solubility of PAHs.

• The monthly packaging world
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• s.217
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• pp.45-56
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• 2011

바이오 플라스틱은 탄소저감, 인체 무해성, 플라스틱의 대체재로서 주목을 받고 있으나 아직 해결할 과제가 남아 있는 실정이다. 그 중에서 시급한 것은 (1) 가격 경쟁력 확보, (2) 내열성, 가공성, 내충격성 등 물성 개선, (3) 가공기술 개발, 응용분야 확대, (4) 분해기간 조절에 따른 유통기간이 1년 이상인 제품에 적용성 등 보완 연구, (5) 표준화, 규격기준 제정 작업 등이 필요하다. 특히 고추장, 된장, 김치, 젓갈, 치즈, 발효유 등 발효식품 포장재의 경우 제품 중에 미생물이 살아 있는 경우가 있고, 유통기한이 길기 때문에 분해기간을 장기화할 필요가 있다. 또한 유통중 및 보관 중 이산화탄소 등 가스 발생 우려가 있는 농산물, 수산물, 식품류 등은 포장재에 숨쉬는 기능 등 유사 생체막 기능 부여가 필요한 실정이다. 현재 바이오 폴리머 생산기술이 계속 발전하고 있고, 또한 가격 경쟁력도 강화되고 있어 급속한 시장 확대도 개대할 수 있는 수준이다. 석유계 플라스틱의 생산단가는 kg당 1.5~2달러 수준인 반면, 생분해 플라스틱인 PLA, 지방족폴리에스터, TPS, PHB 등은 kb당 4~5 달러 수준이다. 또한 이를 보완한 바이오매스 플라스틱은 약 2달러 수준을 유지하고 있다.

• Bulletin of Food Technology
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• v.20 no.4
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• pp.37-49
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• 2007

중금속은 인류가 금속을 이용하기 시작하면서 위험인자로 대두되기 시작하여 산업화 과정과 함께 환경오염을 초래하였고 나아가 식품을 오염시키는 원인물질로 작용함으로써 인간의 건강을 위협하기에 이르렀다. 중금속은 체내에서 분해되기 어렵고 배출이 쉽지 않아 생물체에 축적되면 먹이 연쇄를 따라 농축되므로 먹이사슬의 최종소비자인 사람에게 식품의 중금속 오염은 심각한 문제다. 특히 수은, 납, 카드뮴은 식품 중에서 공통적으로 볼 수 있는 독성물질로 생체조직과 강한 결합을하여 생체 내에 축적되어 천천히 제거되는 유해물질이다. 본문에서는 국내.외의 연구결과를 토대로 식품의 중금속 오염현황, 위해성, 관리방안에 대해 살펴보고자 한다.

• Proceedings of the Optical Society of Korea Conference
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• 2003.02a
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• pp.294-295
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• 2003

OCT(Optical Coherence Tomography) 기술은 기본적으로 낮은 가간섭성 광원의 빛을 대상물에 주사하여 피대상물의 내부구조에 따른 각종 광학정 수치를 높은 수직 분해능으로 깊이별로 얻어낼 수 있는 기술이다. 현재 많은 생체 연구그룹에서 OCT의 개발과 응용에 대해 적극적인 연구가 진행 중에 있으며, 그 적용분야를 확대하고 있는 추세이다. OCT에 관련된 대표적인 연구분야로서 조직의 미세 단층영상, 혈류 가시화 및 각종 생체조직에 따른 복굴절율 변화 측정 등이 있다.(중략)