• Proceedings of the Korean Society of Applied Pharmacology
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• 1993.04a
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• pp.97-97
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• 1993

본 연구과제에서는 적출판류간실험법 (isolated perfused liver technique)을 약물의 간독성 유발 및 보간작용에 관한 실험법으로 개발하고자 butylated hydroxyanisole (BHA) 을 이용하여 보간실험을 하였다. BHA를 식이투여한 흰쥐로부터 적출한 간에 간독성 모델물질로 2,6-dichlorophenolindophenol (DCPIP) 을 관류시켜 관류액내의 DCPIP의 유리형, 환원형, glucuronide, sulfate 포합체의 대사체를 측정하여 DCPIP 외 대사양상을 관찰하였으며, 동시에 간세포 손상으로 관류액내로 유출된 lactate dehydrogenase (LDH)의 활성도를 측정하여 DCPIP예 의할 간세포독성 유발정도를 간접적으로 측정하여 대조군과 비교하였다. 그리고 BHA에 의한 보간작용이 약물대사효소의 변와에 기인한 것인가를 관찰하기 위하여 모델약물로 7-ethoxycoumarin (EC) 이나 EC의 phase I 대사산물인 7-hydroxycoumarin (HC) 을 관류시켜 관류액내의 HC의 유리체, glucuronide 포합체, sulfate 포합체로의 대사량을 측정하여 약물대사시 약물의 활성화에 관계하는 phase I mixed function oxidase (MFO) 효소와 약물의 해독화에 관계하는 phase II 포합효소 (UDP-glucuronyltranesferase(UDPGT)와 sulfotransferase (ST))의 활성도 변화를 측정하여 대조군과 비교하였다. 간독성 모델물질인 DCPIP를 적출한 흰쥐의 간에 관규시켰을때 BHA 전처리군이 LDH가 유출되기 시작하는 시간이 대조군에 비하여 유의적으로 늦었으며, LCH가 유출량도 유의적으로 감소되어 DCPIP에 의한 간독성 유발능력이 BHA에 의하여 감소됨을 관찰하였다. 아울러 DCPIP의 대사체중 환원체와 glucuronide 포합체의 생성량이 증가되어 BHA에 의하여 quinone reductase와 UDPGT 활성도가 증가되었음을 알 수 있었다. 그리고 BHA 전처리에 의하여 MFO효소계와 ST의 활성도에는 변화가 없었으나 UDOGT 의 활성도는 약 2.2배 증가되었다. 이상의 결과로 BHA에 의한 보간작용은 간독성 물질을 활성화시키는 phase I MFO 효소의 활성도에는 변화없이 해독작용에 관여하는 phase II효소들의 활성도 증가에 기인된 것을 알 수 있었다. 그리고 이러한 결과는 적출한 관류간실험법은 여러 약물의 보간효과를 관찰하는 실험법으로 적합할 것으로 사료되었다.

• Journal of Advanced Technology Convergence
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• v.1 no.2
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• pp.01-09
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• 2022

Recently, safety issues in companies and public institutions are no longer a task that can be postponed, and when a major safety accident occurs, not only direct financial loss, but also indirect loss of social trust in the company and public institution is greatly increased. In particular, in the case of a fatal accident, the damage is even more serious. Accordingly, as companies and public institutions expand their investments in industrial safety education and prevention, open AI learning model creation technology that enables safety management services without being affected by user behavior in industrial sites where high-risk situations exist, edge terminals System development using inter-AI collaboration technology, cloud-edge terminal linkage technology, multi-modal risk situation determination technology, and AI model learning support technology is underway. In particular, with the development and spread of artificial intelligence technology, research to apply the technology to safety issues is becoming active. Therefore, in this paper, an open cloud platform design method that can support AI model learning for high-risk site safety management is presented.

• Journal of Software Assessment and Valuation
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• v.16 no.2
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• pp.53-62
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• 2020

In the end-user domain of an IoT environment, there are more and more intelligent M2M devices that provide resources to create and share application services. Therefore, it can be very useful to manage trust by transferring the role of the existing centralized service provider to end users in a P2P environment. However, in a decentralized M2M computing environment where end users independently provide or consume services, mutual trust building is the most important factor. This is because malicious users trying to build malfunctioning services can cause security problems in M2M computing environments such as IoT. In this paper, we provide an integrated analysis and approach for trust evaluation of M2M application services, and an optimized trust evaluation model that can guarantee reliability among users of the M2M community.

• Journal of the Korean Institute of Gas
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• v.5 no.1
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• pp.60-72
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• 2001

This paper presents the user-interactive productivity analysis model based on material balance as well as deliverability equations equipped with EOS model to perform a productivity analysis for Gorae V structure, Donghae-1 gas field. This model is designed to be able to analyse the productivity in the case of reservoir contacting with the aquifer. Also, in order to investigate the effect of condensation on productions, condensation phenomenon is considered as an apparent skin effect in the computation of bottomhole pressure from average reservoir pressure. By utilizing the developed model, we investigate the productivity analysis for B2 layer of Garae V structure with the various production cases in volumetric and non­volumetric reservoirs that contact with aquifer. From the results in the case of 5500 MMSCF/year of production and reservoir-aquifer contacting angle 270$^{\circ}C$ with aquifer size of 10 times greater than reservoir, B2 layer could maintain peak production rate even after 8.5 years of production by considering the bottomhole pressure which is estimated above the operating pressure of 1298 psia. It is also found that condensate will be formed after 1100 days of production and existed throughout the reservoir at 1270 days. Note that the computed reservoir pressure of B2 layer is maintained sufficiently high enough for production due to the water influx into the reservoir, and skin effect caused by condensation is not significant.

• Journal of the Korean Society of Food Science and Nutrition
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• v.24 no.2
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• pp.195-201
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• 1995

In this study we wanted to investigate the effect of taurine supplement on the lipid peroxide formation and the activities of glutathione(GSH) dependent enzyme in diabetic model mice. We induce type I diabetes mellitus with alloxan injeciton in ICR mice and type II with high calorie diet in genetically hyperglycemic KK mice. Taurine was given in drinking water at the level of 5%(w/v) for seven days. In type I diabetic model, the malondialdehyde(MDA) of liver and islet significantly increased compared to control group and they significantly decreased by taurine supplement. In type II diabetic model, the concentration of MDA was not changed by taurine supplement. The activities of GSH-peroxidase(GPX) of liver and islet increased in type I diabetic group while decreased in type II. GPX activities were not changed by taurine supplement in the liver of both types but increased in the islet of type II. Taurine supplement has no effect on the activities of GSH S-transferase(GST) in both types. From these results, we suggest that taurine supplement protect against lipid peroxide formation in diabetic model of type I.

• Journal of the Korea Society of Computer and Information
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• v.11 no.5 s.43
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• pp.39-52
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• 2006

As accelerates the technical evolution of high-speed network and progresses the digitalization of broadcasting network, TV channel service through satellite/cable/terrestrial networks becomes more stable and mature. However, TV channel service using IP network such as IPTV is recently emerging. Especially, when it comes to current mosaic EPG(Electronic Program Guide) as a channel guide, the implementation of EPG via IP network is under developing. Furthermore, the personal target mosaic EPG is not provided at all in the IPTV. This paper proposes a construction method of mosaic system which can support fixed and personalized mosaic EPG using IP network for viewers. The fixed mosaic EPG is made several steps as follows ; First, H/E generates several mosaic A/V streams. Then, which are transmitted to the STB in terms of multicasting via IP network. Finally, mosaic EPG is displayed on TV through STB. In addition, this paper describes a construction model of the personalized A/V mosaic EPG that represents each person's favorite channels according to their tastes and interests. As for the contributions. The TV channel guide using IP network enable viewer to select channel more easily with practical adaptation of multi-channel expansibility and sufficient usability. In addition, through personal mosaic EPG, a number of viewers can compose their own mosaic EPG and enjoy a variety of channel easily in accordance with their preferences. Finally, the personal mosaic EPG can prohibit non-adult users from connecting adult-only contents more efficiently.

• Journal of the Korean Society for information Management
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• v.21 no.1
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• pp.187-207
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• 2004

Recently there has been a growing interest in the investigation and development of the next generation web - the Semantic Web. From the perspective of a information science, the next generation web - Semantic Web is a metadata initiative. It is reason that one of important stage of Semantic Web Construction is adding formal metadata that describes a Web resource's content and so people can find easy material using metadata. In this paper, 1 designed new application profile metadata architecture as a way to serve as interoperability between various open digital libraries using different information architecture in Semantic Web environment. Based on new application profile metadata architecture, 1 developed union metadata automatic generation and union search algorithm to integrate heterogeneous huge-scale metadata in the open digital library.

• Journal of Korea Multimedia Society
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• v.11 no.11
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• pp.1491-1500
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• 2008

This paper proposes an intelligent surveillance system to recognize suspicious patterns of the human behavior by using the Hidden Markov Model. First, the method finds foot area of the human by motion detection algorithm from image sequence of the surveillance camera. Then, these foot locus form observation series of features to learn the HMM. The feature that is position of the human foot is changed to each code that corresponds to a specific label among 16 local partitions of image region. Therefore, specific moving patterns formed by the foot locus are the series of the label numbers. The Baum-Welch algorithm of the HMM learns each suspicious and specific pattern to classify the human behaviors. To recognize the inputted human behavior pattern in a test image, the probabilistic comparison between the learned pattern of the HMM and foot series to be tested decides the categorization of the test pattern. The experimental results show that the method can be applied to detect a suspicious person prowling in corridor.

• Journal of the Korean Institute of Intelligent Systems
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• v.5 no.4
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• pp.41-55
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• 1995

In this paper, an optimal idenfication method using fuzzy-neural networks is proposed for modeling of nonlinear complex systems. The proposed fuzzy-neural modeling implements system structure and parameter identification using the intelligent schemes together wlth optimization theory, linguistic fuzzy implication rules, and neural networks(NNs) from input and output data of processes. Inference type for this fuzzy-neural modeling is presented as simplified inference. To obtain optimal model, the learning rates and momentum coefficients of fuzzy-neural networks(FNNs) are tuned automatically using improved modified complex method and modified learning algorithm. For the purpose of its application to nonlinear processes, data for route choice of traffic problems and those for activateti sluge process of sewage treatment system are used for the purpose of evaluating the performance of the proposed fuzzy-neural network modeling. The results show that the proposed method can produce the intelligence model with higher accuracy than other works achieved previously.

• The KIPS Transactions:PartD
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• v.12D no.4 s.100
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• pp.553-568
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• 2005

In order to integrate distributed biological information sources physically or virtually, it is necessary to overcome the heterogeneity of information sources and support a superior generality and adaptation in order to satisfy user's various demands. In this paper, we present a flexible and general XML query engine of a wrapper system in designing the middleware system to integrate data as well as application programs. Since this query engine applies user-defined XML view, it is possible to composite flexible integrated query. The query processing in a wrapper requires view composition, query translation into local sources, and generation of XML documents from local query results. We present a query processing model based on the view tree, where the n views and the XML queries are represented by the view tree. Moreover, to confirm the generality of our query processing model, we present a methodology of query processing for relational databases, web sources, and application programs whose return types of query results are relational tuples or XML documents.