• Title/Summary/Keyword: 생물학적 네트워크

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Bioinformatic Analysis of the Canine Genes Related to Phenotypes for the Working Dogs (특수 목적견으로서의 품성 및 능력 관련 유전자들에 관한 생물정보학적 분석)

  • Kwon, Yun-Jeong;Eo, Jungwoo;Choi, Bong-Hwan;Choi, Yuri;Gim, Jeong-An;Kim, Dahee;Kim, Tae-Hun;Seong, Hwan-Hoo;Kim, Heui-Soo
    • Journal of Life Science
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    • v.23 no.11
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    • pp.1325-1335
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    • 2013
  • Working dogs, such as rescue dogs, military watch dogs, guide dogs, and search dogs, are selected by in-training examination of desired traits, including concentration, possessiveness, and boldness. In recent years, genetic information has been considered to be an important factor for the outstanding abilities of working dogs. To characterize the molecular features of the canine genes related to phenotypes for working dogs, we investigated the 24 previously reported genes (AR, BDNF, DAT, DBH, DGCR2, DRD4, MAOA, MAOB, SLC6A4, TH, TPH2, IFT88, KCNA3, TBR2, TRKB, ACE, GNB1, MSTN, PLCL1, SLC25A22, WFIKKN2, APOE, GRIN2B, and PIK3CG) that were categorized to personality, olfactory sense, and athletic/learning ability. We analyzed the chromosomal location, gene-gene interactions, Gene Ontology, and expression patterns of these genes using bioinformatic tools. In addition, variable numbers of tandem repeat (VNTR) or microsatellite (MS) polymorphism in the AR, MAOA, MAOB, TH, DAT, DBH, and DRD4 genes were reviewed. Taken together, we suggest that the genetic background of the canine genes associated with various working dog behaviors and skill performance attributes could be used for proper selection of superior working dogs.

Genetic Diversity and Molecular Phylogenetic Relationships of the Genus Sarcocheilichthys Fish in Korea (한국산 중고기속(Sarcocheilichthys) 어류의 유전적 다양성과 분자계통학적 유연관계)

  • Ji-Wang Jang;Jae-Goo Kim;Jae-Geun Ko;Bong-Han Yun;Yang-Seop Bae
    • Korean Journal of Ichthyology
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    • v.36 no.2
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    • pp.139-155
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    • 2024
  • Using the cytb gene region of the mitochondrial DNA of eight populations of Sarcocheilichthys nigripinnis morii and five populations of S. variegatus wakiyae, which belong to the genus Sarcocheilichthys from Korea, the genetic diversity and molecular phylogenetic relationships of each population were examined. As a result of the analysis, it was confirmed that the S. variegatus wakiyae population had higher genetic diversity than the S. nigripinnis morii population. In the phylogenetic tree of genus Sarcocheilichthys fish in Korea based on the cytb gene, the Yeongsan River (YSR) population of S. variegatus wakiyae forms a clade with the Tamjin River (TJR), Yeongsan River (YSR), and Seomjin River (SJR) population of S. nigripinnis morii, and genetic relationships that do not align with the current classification system were observed. Meanwhile, on the nuclear DNA phylogenetic tree, S. variegatus wakiyae and S. nigripinnis morii could be clearly distinguished, showing mitonuclear inconsistency where mitochondrial and nuclear DNA conflicted on the phylogenetic tree. The Seomjin River (SJR) population of S. nigripinnis morii was translocated to the Dongjin River (DJR) population, haplotype from which crossbreeding was presumed to have occurred was confirmed. Among the rivers flowing into the East Sea, the S. nigripinnis morii population is known to have been introduced and inhabit only the Hyeongsan River (HSR), and it is presumed to be a population formed by translocation from the Han River (HR) population, with a haplotype representing a unique genetic group also confirmed. The Han River (HR), Geum River (GR), and Mangyeong River (MGR) populations of S. nigripinnis morii formed a genetically identical population with S. czerskii and S. soldatovi distributed north of the Yalu River, and accordingly, a taxonomic reexamination was required through morphological and molecular phylogenetic studies by securing various specimens.

The Senile Cyborg: Science, Technology, and Aging in Ghost in the Shell: Stand Alone Complex (노쇠한 사이보그: <공각기동대 Stand Alone Complex>로 본 노화와 과학기술)

  • Park, Hyung Wook
    • Journal of Science and Technology Studies
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    • v.13 no.1
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    • pp.41-76
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    • 2013
  • Based on an analysis of the Japanese animation director Kamiyama Kenji's Ghost in the Shell: Stand Alone Complex series, this paper discusses two important subjects in modern technoscience-cyborg and old age. In fact, age has been an important social and political category in the modern world, along with gender, race, and class. However, age has not been a significant research topic for STS scholars. Even though many of these investigators have extensively explored the complex relationship between gender and technoscience, especially after the publication of Donna Haraway's "Cyborg Manifesto" (1991), few of them have been interested in how age is reconfigured by modern science and technology. If women, as Haraway has claimed, can have a different political and cultural outlook by becoming cyborgs, then, can we expect a similar socio-cultural transformation with regard to the interaction between cyborg and old age? Do the elderly experience lesser age discrimination through the growth of biomedicine and technoscience? Indeed, it is believed that seniors are increasingly becoming cyborgs with advancing age, since their declining bodily functions are consistently replaced and assisted by various biomedical technologies. Does this enable them to overcome ageism and age discrimination as well as their alleged physiological and mental limitations? As an answer to this question, Mike Featherstone has asserted that becoming a cyborg in old age could make the wrinkled skin a mere mask and create diverse new possibilities that were hitherto unavailable to an aging person. Based on my reading of Ghost in the Shell, however, I analyze a more complex set of problems when the senile cyborg is created through the encounter between the elderly and technoscience. I argue that while the senile cyborg could challenge traditional family ideology and nationalism it would leave ageism intact and define a new individualistic life form through a body controlled within the globalized internet and capitalist economy.

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Genetic Diversity and Relationship of the Genus Barbatula (Cypriniformes; Nemacheilidae) by Mitochondrial DNA Cytochrome b Partial Gene in Korea (한국산 종개속(Barbatula) 어류의 유전적 다양성 특성 연구)

  • An, Jung-Hyun;Yu, Jeong-Nam;Kim, Byung-Jik;Bae, Yang-Seop
    • Korean Journal of Ichthyology
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    • v.33 no.2
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    • pp.107-116
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    • 2021
  • Two stone loaches (Nemacheilidae, Cypriniformes), Barbatula toni (Dybowski, 1869) and B. nuda (Bleeker, 1864), have been recognized in the Korean waters to date. Recently, due to indiscriminate artificial introduction as well as the change of their habitats induced by natural disasters, it seems to be concerned about the damage of species-specific geographic boundaries. We examined the genetic difference of two Korean Barbatula species by the haplotype network based on the Cytochrome b sequences of mitochondrial DNA and the phylogenetic relationships among them including Barbatula fishes occurring around the Korean peninsula. As a result, three and 29 haplotypes were obtained from B. toni and B. nuda, respectively, and totally three clades comprising "toni group", "nuda hangang group", and "nuda donghae group" were identified. The sequence variable sites among them was 10~24%, showing a difference of interspecific level. Phylogenetic relationships of the latter group, especially, forms an independent cluster discriminating with other two groups as well as the Chinese, Japanese, Russian, and European Barbatula species, suggesting the possibility of the specific level divergence.

Analysis of Research Trends in Relation to the Yellow Sea using Text Mining (텍스트 마이닝을 활용한 황해 관련 연구동향 분석연구)

  • Kyu Won Hwang;Kim Jinkyung;Kang Seung-Koo;Kang Gil Mo
    • Journal of the Korean Society of Marine Environment & Safety
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    • v.29 no.7
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    • pp.724-739
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    • 2023
  • Located in the sea area between South Korea, North Korea, and China, the Yellow Sea plays an important role from a geopolitical perspective, and recently, as the use of marine space in the Yellow Sea is expanding, its social and economic values have been increasing further. In addition, owing to rapid climate changes, the need for joint response and cooperation between Korea and China is increasing in various fields, including changes in the marine environment and marine ecosystem and generation and movement of air pollutants. Accordingly, in this study, core topics were derived from research papers with the Yellow Sea as a keyword, and research trends to date were explored through author network analysis. As a specific research method, research papers related to the Yellow Sea published between 1984 and 2021 were extracted from the Web of Science database and were classified into four periods to derive core topics using topic modeling, a type of text mining. Furthermore, the influences of major research communities, researchers, and research institutes in the appropriate fields were identified through analyzing the author network, and their implications were presented. The analysis results indicated that the core topics of research papers on the Yellow Sea had changed over time, and differences existed in the influence (centrality) of key researchers. Finally, based on the results of this study, this study aims to identify research trends related to the Yellow Sea, major researchers, and research institutes and contribute to research cooperation between Korea and China regarding the Yellow Sea in the future.

Promotion of Plant Growth by Submergence and the Action Network of Hormones (침수에 의한 식물의 생장 촉진과 호르몬들의 작용 네트워크)

  • Cho Young Jun;Lee Young Na;Park Woong June
    • Journal of Life Science
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    • v.15 no.1 s.68
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    • pp.112-117
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    • 2005
  • Plants living riverside show diverse resistance responses to submergence. The promoted petiole elongation of semi-aquaitc plants, e.g., such as Ranunculus sceleratus and Rumex palustris, is one of the adaptive responses mediated by the plant hormone ethylene. The gaseous hormone is trapped in submerged plant tissues and enhances the petiole growth by increasing sensitivity of the tissues to some plant hormones including auxin. Due to the stimulated growth of petioles, the leaves finally reach the water surface and can respirate again. At the water surface, the accumulated ethylene diffuses out from the tissues to the air. As a result, the increased hormone sensitivity decreases again, and thus the growth rate reduces to the basal level as before. The increased auxin sensitivities by ethylene observed in Ranunculus sceleratus, revealed by the changes in the auxin dose-response curves, indicate the increase of affinities of the receptors to auxin. However, the molecular mechanism of the affinity regulation remains still largely unknown, because the identity of the auxin receptor is still unclear.

Robust Plan Generation and Dynamic Execution for Intelligent Web Service (지능적인 웹서비스를 위한 강건한 계획 생성과 동적 실행 방법)

  • Hwang, Gyeong-Sun;Lee, Seung-Hui;Lee, Geon-Myeong
    • Proceedings of the Korean Institute of Intelligent Systems Conference
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    • 2007.04a
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    • pp.320-323
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    • 2007
  • 웹 서비스와 같은 분산된 환경에서, 특정 서비스를 수행하기 위해서는 원격의 컴퓨터나 사이트상에서 다중 에이전트들의 협업을 통해 이루어진다. 이때 서비스는 여러 에이전트들의 복잡한 행위들에 의해 구성된다. 또한 지능적인 서비스를 위해서는 에이전트들의 상태정보, 목적정보, 그리고 계획정보 등을 이용한다. 특히 계획정보는 에이전트들이 일련의 행위들로 구성된다. 하지만 계획수립을 위한, 기존 연구들 대부분은 정적으로 기술된 서비스 명세와 초기상태 정보를 이용하여 특정 목표를 만족시키는 단일 계획 생성 방법을 연구해왔다. 따라서 계획수립이 실행 도중에 기대하지 않은 네트워크 장애나 방해 등으로 서비스 수행을 실패하는 경우, 그 계획은 무효가 되고 다시 계획을 생성 해야만 한다. 그러나 다시 계획을 생성하기 위해서는 많은 시간을 소비하게 될 뿐만 아니라 태스크 중복이 불가피하므로 매우 비효율적이다. 이 논문에서는 강건한 계획수립과 그 계획을 실행하기 위한 효과적인 방법을 제안한다. 즉, 계획수립의 재생성을 피하기 위한 방법으로 단일 계획수립 대신에 실행 가능한 다중 계획들로 표현된 강건한 계획을 생성하는 것이다. 강건한 계획의 행위들이 실행되는 동안, 각 단계마다 실행 가능한 행위를 선택한 후, 그 행위를 실행한다. 그러나 선택된 행위가 실행결과를 낼 수 없을 경우, 대체 가능한 서브 계획 경로를 선택하여 실행한다. 강건한 계획을 표현하기 위해 페트리 넷 기반의 방법을 제안한다. 강건한 계획 생성 방법에서는 이용 가능한 모든 계획들을 입력으로 사용한다. 그 계획수립 방법은 HTN 계획수립기로 잘 알려진 JSHOP2 계획수립기내에 구현하였다. 계획 실행 방법으로는 주어진 강건한 계획에 대하여 행위들이 직접 실행하수 있도록 한다.며 용량에 의존하는 양상을 보였다. $H_2O_2$에 의해 유발(誘發)된 DNA의 손상은 catalase와 deferoxamine에 의해 억제되었지만 DPPD는 억제시키지 못했다. 배기음(排氣飮)은 $H_2O_2$에 의해 유발(誘發)된 ATP의 소실을 회복시켰다. 이러한 실험결과 $H_2O_2$에 의해 유발(誘發)된 세포(細胞)의 손상(損傷)은 지질(脂質)의 과산화(過酸化)와는 다른 독립적인 기전에 의해 일어남을 나타낸다. 결론 : 이러한 결과들로 볼 때 Caco-2 세포(細胞)에서 배기음(排氣飮)이 항산화작용(亢酸化作用)보다는 다른 기전을 통하여 Caco-2 세포안에서 산화제(酸化劑)에 의해 유발(誘發)된 세포(細胞)의 사망(死亡)와 DNA의 손상(損傷)을 방지할 수 있다는 것을 가리킨다. 따라서 본 연구(硏究)는 배기음(排氣飮)이 반응성산소기(反應性酸素基)에 의해 매개된 인체(人體) 위장관질환(胃腸管疾患)의 치료(治療)에 사용할 수 있을 가능성(可能性)이 있음을 제시하고 있다.에 이를 이용하여 유가배양시 기질을 공급하는 공정변수로 사용하였다 [8]. 생물학적인 폐수처리장치인 활성 슬러지법에서 미생물의 활성을 측정하는 방법은 아직 그다지 개발되어있지 않다. 본 연구에서는 슬러지의 주 구성원이 미생물인 점에 착안하여 침전시 슬러지층과 상등액의 온도차를 측정하여 대사열량의 발생량을 측정하고 슬러지의 활성을 측정할 수 있는 방법을 개발하였다.enin과 Rhaponticin의 작용(作用)에 의(依)한 것이며, 이는 한의학(韓醫學) 방제(方劑) 원리(原理)인 군신좌사(君臣佐使) 이론(理論)에서 군약(君藥)이 주증(主症)에 주(主)로 작용(作用)하는 약물(藥物)이라는 것을 밝혀주는

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Development of Basic Research for Establishing the Apple IPM System in Korea: Dr. Lee Soon-Won's Research Case (한국형 사과 병해충종합관리(IPM) 체계 수립을 위한 기초연구의 전개: 이순원 박사의 연구 사례)

  • Ahn, Jeong Joon;Oh, Hyeonseok;Choi, Kyung San;Choi, Kyung-Hee;Do, Yun-Su;Lee, Sun-Young;Lee, Dong-Hyuk
    • Korean journal of applied entomology
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    • v.60 no.1
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    • pp.1-13
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    • 2021
  • The concept of integrated pest management (IPM) first developed in the 1950s, and the concept of economic control via pest management was established in the 1960s. Research on IPM began in the United States and Europe, and IPM studies in Korea started with citrus insects and paddy field pests following the distribution of high-yield varieties of rice. Apple IPM in Korea began with research on pest control using chemical pesticides and pesticides resistant to insect pests, studies on the ecology of insect pests and their natural enemies, and the exploitation of sex pheromones on insect pests. Since the 1990s, IPM research and field projects have been carried out simultaneously for farming households. In the 2000s, the development of pest monitoring and forecasting models centered on mating disturbances, database programs for pests, and networks for sharing information. IPM technology has expanded via the development of unmanned forecasting systems and automation technologies in the 2010s.

Current status and prospects of citrus genomics (감귤 유전체 연구 동향 및 전망)

  • Kim, Ho Bang;Lim, Sanghyun;Kim, Jae Joon;Park, Young Cheol;Yun, Su-Hyun;Song, Kwan Jeong
    • Journal of Plant Biotechnology
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    • v.42 no.4
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    • pp.326-335
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    • 2015
  • Citrus is an economically important fruit tree with the largest amount of fruit production in the world. It provides important nutrition such as vitamin C and other health-promoting compounds including its unique flavonoids for human health. However, it is classified into the most difficult crops to develop new cultivars through conventional breeding approaches due to its long juvenility and some unique reproductive biological features such as gamete sterility, nucellar embryony, and high level of heterozygosity. Due to global warming and changes in consumer trends, establishing a systematic and efficient breeding programs is highly required for sustainable production of high quality fruits and diversification of cultivars. Recently, reference genome sequences of sweet orange and clementine mandarin have been released. Based on the reference whole-genome sequences, comparative genomics, reference-guided resequencing, and genotyping-by-sequencing for various citrus cultivars and crosses could be performed for the advance of functional genomics and development of traits-related molecular markers. In addition, a full understanding of gene function and gene co-expression networks can be provided through combined analysis of various transcriptome data. Analytic information on whole-genome and transcriptome will provide massive data on polymorphic molecular markers such as SNP, INDEL, and SSR, suggesting that it is possible to construct integrated maps and high-density genetic maps as well as physical maps. In the near future, integrated maps will be useful for map-based precise cloning of genes that are specific to citrus with major agronomic traits to facilitate rapid and efficient marker-assisted selection.

Effects of Orchard Environments and Landscape Features on the Population Occurrence of Major Lepidopteran Pests in Apple Orchards (과원 환경과 경관 요소가 사과원 주요 나방류 해충 발생에 미치는 영향)

  • Kim, Hyangmi;Jung, Chuleui
    • Korean journal of applied entomology
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    • v.60 no.1
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    • pp.79-90
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    • 2021
  • Landscape composition and structure are important factors determining biological diversity including pests and natural enemires in agricultural ecosystem. This study was conducted to indentify effect of landscape composition on occurrence of lepidopteran pest population in Geochang, Gyoungdnam. For this, orchard characteristics and management practices were surveyed in 80 conventional apple orchards in Geochang, Korea, along with the monitoring of pest population densities. The landscape features of each surveyed orchard also obtained by extracting information from the public-service map. Grapholita molesta was the most dominat and damaging pest followed by Phyllonorycter ringoniella and Carposina sasakii in trap catches. Adoxophyes paraorana occurrences were low. Farmers spray insecticides and fungicides ap. 12.4 times per year respectively while acaricides were sprayed 2.4 times. Major landscape features such as surrounding apple orchard or paddy field did not influence the pest populations but presence of plum, peach, wild peach, graph, and even abandoned orchards significantly resulted in higher pest population mostly on G. molesta. C. sasakii population was higher in orchards with grape, peach, and P. ringoniella with peach, grape, abandoned orchards and jujube. Results highlight the need of landscape management not only for the rural amenity but also for increasing functional diversity of agroecosystem as well as reducing pest population.