• Korean Journal of Clinical Pharmacy
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• v.15 no.2
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• pp.100-104
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• 2005

건강한지원자에서 세프라딘 250 mg 캡슐을 오전 09:00시와 오후22:00시에 경구투여하여 세프라딘의 약물동태학적 주기변화 (생체리듬)를 검토하였다. 혈장중 세프라딘의 농도는 두 투여시간에서 유의성 있는 차이를 보여주었다. 혈장농도곡선하면적 (AUC)은 오후 때 보다 오전 투여시에 유의성 있게 증가되었으며, 생물학적반감기$(t_{1/2})$는 오후 때 보다 오전 투여시에 더 연장되었다. 전신청소를 $(CL_t)$은 오후 때 보다 오전 투여시 유의성 있게 감소되었다.

• The Korean Journal of Pesticide Science
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• v.17 no.3
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• pp.155-161
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• 2013

The residue patterns of clothianidin and thiacloprid, insecticides registered in the ginseng, were investigated to predict pre-harvest residues limits (PHRL). Pesticides were treated under Korea GAP (Good Agricultural Practices) with the recommended dose (single dose) and twice of recommended dose (double dose). Samples were collected 11 times over 42 days (each 0, 2, 5, 8, 12, 16, 20, 24, 28, 33, 42 days after treatment). Residues of clothinidin and thiacloprid were analyzed by UPLC/TQD. Biological half-life of clothinidin in single dose and double dose were 14.6 days and 10.2 days and that of thiacloprid were also 9.7 days and 11.2 days, respectively. The PHRL of ginseng on 10 days before harvest was 0.3 mg/kg in clothianidin and 0.18 mg/kg in thiacloprid.

• The Korean Journal of Nuclear Medicine
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• v.30 no.1
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• pp.77-85
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• 1996

Radioiodine($^{131}I$) has been used for the treatment of Graves' hyperthyroidism since the late 1940's and is now generally regarded as the treatment of choice for Graves' hyperthyroidism who does not remit following a course of antithyroid drugs. But for the dose given, several different protocols have been described by different centers, each attempting to reduce the incidence of long-term hypothyroidism while maintaining an acceptable rate control of Graves' hyperthyroidism. Our goals were to evaluate effective half-life and predict absorbed dose in Graves' hyperthyroidism patients, therefore, to calculate and readminister radioiodine activity needed to achieve aimed radiation dose. Our data showed that the mean effective $^{131}I$ half-life for Graves' disease is 5.3 days(S.D=0.88) and mean biologic half-life is 21 days, range 9.5-67.2 days. The mean admininistered activity and the mean values of absorbed doses were 532 MBq(S.D.=254), 112 Gy (S.D.=50.9), respectively. The mean activity needed to achieve aimed radiation dose were 51MBq and marked differences of $^{131}I$ thyroidal uptake between tracer and therapy ocurred in our study. We are sure that the dose calculation method that uses 5 days thyroidal $^{131}I$ uptake measurements after tracer and therapy dose, provides sufficient data about the effective half-life and absorbed dose of $^{131}I$ in the thyroid and predict the effectiveness of $^{131}I$ treatment in Graves' hyperthyroidism.

• The Korean Journal of Pesticide Science
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• v.16 no.4
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• pp.288-293
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• 2012

The dissipation patterns of amisulbrom in cucumber under a greenhouse condition was investigated to establish biological half-life and pre-harvest residue limit (PHRL). Amisulbrom residue in/on cucumber on the day of application under standard application condition was $0.15mg\;kg^{-1}$ and decreased to $0.06mg\;kg^{-1}$ after 5 days after treatment, so that biological half-life calculated 3.6 day, while initial concentration of amisulbrom twice application 3 days interval under standard application condition was $0.35mg\;kg^{-1}$ and decreased to $0.09mg\;kg^{-1}$ after same period and the biological half-life calculated 2.4 day. PHRL was suggested by prediction curve calculated from the decay constant of amisulbrom at standard rate. For example, $1.83mg\;kg^{-1}$ at 5 days before harvest and $1.03mg\;kg^{-1}$ at 2 days before harvest were suggested.

• Korean Journal of Environmental Agriculture
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• v.22 no.2
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• pp.130-136
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• 2003

An organophosphorus insecticide, chlorpyrifos and an arylnitrile fungicide, chlorothalonil commonly used far apple were subjected to a residual investigation under field conditions to ensure safety of terminal residues at harvest. After pesticides were applied at standard rate in apple tree fer 15 days for chlorpyrifos and 30 days far chlorothalonil, persistence of their residues in apple was investigated by several interval. At harvest, residual concentrations of chlorpyrifos and chlorothalonil in apple were 1.3 and 2.4mg/kg, respectively, and the residue levels were higher than MRL 1.0 mg/kg in Korea. As well fitted by the first-oder kinetics, biological half-lives of the pesticide residues in apple were 9.3 days for chlorpyrifos and 32.2 days for chlorothalonil. During the storage, half-lives of chlorpyrifos and chlorothalonil were 35.0 and 56.3days at room temperature, and 120.7 and 182.8 days at 412, respectively. Distribution of chlorpyrifos residue in flesh, fruit skin and stalk cavity of each apple corresponded to 0.1% 22.8% and 77.1%, respectively. In case of chlorothalonil, residue in flesh, fruit skin and stalk cavity was 4.4%, 10.4% and 85.2%, respectively.