• Title/Summary/Keyword: 생물소재

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식품신소재의 바이오 생산 - 생물 전환 기술

  • 오태광
    • The Microorganisms and Industry
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    • v.20 no.1
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    • pp.34-37
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    • 1994

  • 본고에서는 광범위하고 앞으로의 전망이 밝은 식품신소재중 효소 또는 미생물에 의해서 전환 또는 합성되는 몇가지 분야에 대해서 기술해 보고자 한다. 기술분야는 기능성 올리고당, 식이섬유, 당알콜을 포함하는 탄수화물소재, 신감미료, 단백분해 peptide 등을 포함한 단백, 펩타이드 소재 및 지질계 소재에 대해서 한정적인 범위에서 기술하고저 한다.

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Anti-inflammatory Activity of Antimicrobial Peptide Protaetiamycine 2 Derived from the Protaetia brevitarsis seulensis (흰점박이꽃무지 유래 항균 펩타이드 프로테티아마이신 2의 항염증활성)

  • Lee, Joon Ha;Baek, Minhee;Lee, Hwa Jeong;Kim, In-Woo;Kim, Sun Young;Seo, Minchul;Kim, Mi-Ae;Kim, Seong Hyun;Hwang, Jae Sam
    • Journal of Life Science
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    • v.29 no.11
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    • pp.1218-1226
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    • 2019

  • The white-spotted flower chafer Protaetia brevitarsis seulensis is a medicinally beneficial and important edible insect species. We previously performed an in silico analysis of the Protaetia brevitarsis seulensis transcriptome to identify putative antimicrobial peptides and then tested their antimicrobial and hemolytic activities. These peptides had potent antimicrobial activities against bacteria and yeast without inducing hemolysis. In the present study, the cationic antimicrobial peptide, protaetiamycine 2, was selected for further assessment of its anti-inflammatory properties in mouse macrophage Raw264.7 cells. Protaetiamycine 2 treatment of Raw264.7 cells suppressed LPS-induced nitric oxide production and reduced the expression of inducible nitric oxide synthase and cyclooxygenase-2, as determined by real-time PCR and western blotting. The expression of proinflammatory cytokines ($TNF-{\alpha}$, IL-6, and $IL-1{\beta}$) was also attenuated through the MAPKs and $NF-{\kappa}B$ signaling. We also confirmed that protaetiamycine 2 bound to bacterial cell membranes by a specific interaction with LPS. Collectively, these data obtained from LPS-induced Raw264.7 cells indicated that protaetiamycine 2 could have both antimicrobial and anti-inflammatory properties.

  • https://doi.org/10.5352/JLS.2019.29.11.1218 인용 PDF KSCI HTML