• Journal of the Korean Society of Food Science and Nutrition
• /
• v.24 no.6
• /
• pp.1026-1038
• /
• 1995

Although aloe lost a lot of its previous popularity in modern clinical uses as medicine numerous scientific researches still have claimed the beneficial properties(curing and general tonic effect) of aloe gel. Whereas considerable contradictory reports have helped to confuse the aloe gel issue and continually aroused controversy about aloe gel efficacy. However health food, cosmetic and medicinal products made from aloe gel are widely available in the world market especially in U.S.A. so the growing of Aloe plant and the processing of A. vera gel have become big industries in some countries. In some previous papers the salicylic acid, one of the common trace gel components, was thought to have an analgetic and antinflammatory effect. Large amount of Mg ion in the gel was suggested to act as anesthetic, Mg-lactate as antihistamic, and Aloctin A(a glycoprotein) as wound healer by promoting the cell growth. The carboxypeptidase and bradykinase activity in the gel were proposed to have the pain relieving and antiinflammatory effect. But any of thes etheories concerining the physiological action of the trace gel components has not been demonstrated by modern pharmacology, and failed to be supported by clinical research. It was suggested by some research workers that trace amount of anthraquinone compounds in the gel play an important role to act as false substrate inhibitors for PG and TX production(antiprostanoid effect), by which, they believed, inflammation, burn and frostbite, and infected wound could be healed. This hypothesis has not been substantiated. Butthe suggested antimicrobial action, antidiabetic, and antidotic effect of aloe gel are likely to be attributed to the trace anthraquinone compounds. In a lot of recent experimental reports it has been claimed that aloe gel polysaccharides(acetylglucomannan, acetylmannan, and glycoprotein) have the antimicrobial, antinflammatory, antitumour, and infected wound healing effect by immunoenhancement. It is hoped that these effects will be soon documented in clinical studies, then the controversy on aloe gel beneficial effect will cease. In the 30 days subchronic toxicity test the lowest observed adverse effect level of acemannan(acetylmannan) on dog was 5.0 mg/kg, IP. But the aloe gel is generally agreed to be harmless and non toxic even for the internal use such as health food. In the case of idiosynrasy one must keep the delayed type hypersensitivity reaction of aloe gel in mind. In conclusion it seem to be impossible to simply refuse a lot of evidences made by research workers who have claimed aloe gel's beneficial effects and to deny the fact that there had been long therapeutic histories of Aloe plants.

• Neonatal Medicine
• /
• v.15 no.1
• /
• pp.32-37
• /
• 2008

Purpose : Perinatal asphyxia is an important cause of neonatal mortality and subsequent lifelong neurodevelopmental handicaps. Although many treatment strategies have been tested, there is currently no clinically effective treatment to prevent or reduce the harmful effects of hypoxia and ischemia in humans. In the clinical setting, maternal hyperthermia induces adverse effects on the neonatal brain, but recent studies have shown that hyperthermic pretreatment (PT) plays some role in hypoxic-ischemic (HI) injuries of the developing brain. The present study investigated the effect of hyperthermic PT on HI brain injuries in newborn rats. Methods : HI was produced in 7-day-old neonatal rats by unilateral common carotid artery ligation, followed by hypoxia with 8% oxygen at $38^{\circ}C$ for 2 hours. Twenty-four hours before HI, one-half of the pups were exposed to a $40^{\circ}C$ environment for 2 hours. The severity of the brain injury was assessed 7 days after the HI. Results : Hyperthermic PT reduced the gross and histopathologic findings of brain injury from 64.7 to 31.2% (P<0.05). There were no differences in location and severity of injury between the pretreated and control brains. Conclusion : These findings indicate that hyperthermic PT provides neuroprotective benefits on HI in the developing brain. Also, these findings suggest maternal hyperthermia may have protective effect on perinatal HI brain injuries.

• The Korean Journal of Food And Nutrition
• /
• v.28 no.2
• /
• pp.302-312
• /
• 2015

This study was conducted to evaluate the effects of constitutional diets in comparison with general low calorie diets in obese women. The subjects were 52 adult obese women that participated in a calorie restriction diet program (control group, n=16) or a constitutional diet program (experimental group, n=36) for 8 weeks. The subjects in the experimental group were classified as negative (Yin) or positive (Yang) constitution. The obesity management program focused on the calorie restriction diet (300~400 kcal reduction per day) for the control group, whereas, for a constitutional diet without calorie restrictions was allowed for the experimental group. Daily intakes of nutrient and food were assessed using a 24 hr recall method. Body measurements and blood biochemical parameters were measured at baseline and after 8 weeks. After the intervention, weight, body fat, BMI, waist circumference and hip circumference decreased significantly in both the control and experimental group. Energy intake increased from 1,679.6 kcal to 1,810.6 kcal along with significant increase in protein, carbohydrate, fiber, calcium, phosphorus, iron, zinc, vitamin A, vitamin $B_1$, vitamin $B_2$, niacin and vitamin C in the experimental group. Calcium intake increased from 54.0% to 72.4% of DRI in the experimental group. Hemoglobin concentrations were significantly decreased in the control group, but were increased in the experimental group. In addition, blood glucose, serum total cholesterol and triglyceride were significantly decreased in the experimental group. In conclusion, consumption of a constitutional diet without calorie restrictions for 8 weeks was effective for weight reduction with improvement of blood glucose, serum cholesterol and triglyceride.

• Journal of the Korean Geosynthetics Society
• /
• v.6 no.3
• /
• pp.17-23
• /
• 2007

To construct an ideal geosynthetic reinforced soil retaining wall (GRS-RW), the facing of the wall should be flexible enough to accommodate a large deformation of the supporting ground and to develop the large tensile force in reinforcements during wall construction as long as the stability is ensured, but should be rigid enough to be stiff and stable as well as durable and aesthetically acceptable for a long life time when the wall is in service. Facing conditions during the construction and service of the wall are quite different. So it is difficult to be satisfied all these conditions with the current construction method which is mainly used in reinforced wall construction in Korea. Most of this contradiction could be solved by the staged construction procedure. According to the results of cases and references analyses, stage construction procedures make it possible to accommodate large deformation of the supporting ground and backfill without losing the stability of the wall, and to derive the tensile strength of reinforcement causing deformation of the facing. When the facing is a full-height rigid one, it also appeared almost impossible to occur a local shear failure of the active zone, and pull-out failure of reinforcements. Therefore, GRS-RWs having a full-height rigid facing have been constructed by the staged construction procedures that matched well with the theory of reinforced soil, which had outstanding stability and durability, and thus could be used for railways and bridge abutments in Korea in the future.

• Journal of the Korean Institute of Landscape Architecture
• /
• v.43 no.3
• /
• pp.92-100
• /
• 2015

Unlike most other planning processes, brownfield planning generally requires a high level of technical and legal expertise due to potential site contamination. To successfully engage in inclusionary decision making, an adaptive collaboration strategy for brownfield planning is therefore critical. This study examines how a communicative planning approach can be used to overcome the challenge of enabling experts from different fields to work alongside lay people from the local community to achieve a properly balanced collaboration in brownfield planning. After identifying appropriate indicators for collaboration through a literature review of established communicative planning theory, these indicators are applied to the brownfield planning process, highlighting critical points of collaboration such as site prioritization, assessment, remediation, and redevelopment throughout. The results suggest the critical need for an adaptive model focusing on three aspects: 1. Facilitation of a balanced dialogue between the experts with social, cultural, and design-based knowledge and the ones with scientific and engineering-based knowledge, 2. Preparation of an appropriate tool for risk communication with the lay people, 3. Development of decision support system for the integration of expert-oriented technical data and public opinion-oriented subjective data.

• Journal of dental hygiene science
• /
• v.6 no.3
• /
• pp.153-158
• /
• 2006

Bleaching of vital and nonvital teeth is becoming a more commonly used treatment in the dental office and at home. To improve appearance and remove discoloration, the teeth of specific patients are treated with a variety of bleaching agents. The typical bleaching agents contains carbamide or hydrogen peroxide as the active component. The purpose of the review article was to summarize and discuss the available information concerning the effect of peroxide releasing bleaching agent on dental restorative materials and restorations. Information from all original scientific full papers or reviews listed in PubMed or ISI Web Science were included in the review. Bleaching may exert a negative influence on restorations and restorative materials. Advice is provided based on the current literature to minimize the impact of bleaching treatment on restorative materials and restorations.

• Journal of Life Science
• /
• v.28 no.7
• /
• pp.778-785
• /
• 2018

Autophagy is a complex signaling process and has been implicated in tumor suppression and anticancer therapy resistance. Autophagy can produce tumor-suppressive effect by inducing autophagic cell death, either in collaboration with apoptosis. In this current study, we found that celecoxib (CCB), a nonsteroidal anti-inflammatory drug (NSAID) with multifaceted effects, induced autophagy including enhanced LC3 conversion (LC3-I to LC3-II) and reduced autophagy substrate protein p62 level in multidrug-resistant (MDR) cancer cells. CCB sensitized human multidrug resistant (MDR) cancer cells to the ansamycin-based HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin (17-AAG), a benzoquinoid ansamycin, which causes the degradation of several oncogenic and signaling proteins, by inducing autophagic cell death and apoptosis. CCB significantly augmented 17-AAG-mediated level of LC3-II/LC-I, indicating the combined effect of 17-AAG and CCB on the induction of autophagy. Autophagic degradation of mutant p53 (mutp53) and activation of caspase-3 in 17-AAG-treated MDR cells were accelerated by CCB. Inhibition of caspase-3-mediated apoptotic pathway by Z-DEVD-FMK, a caspase-3 inhibitor, did not completely block CCB-induced cell death in MCF7-MDR cells. In addition, treatment of MDR cells with Z-DEVD-FMK failed to prevent activation of autophagy by combined treatment with 17-AAG and CCB. Based on our findings, the ability of clinically used drug CCB to induce autophagy has important implications for its development as a sensitizing agent in combination with Hsp90 inhibitor of MDR cancer.

• Proceedings of the Korean Society of Developmental Biology Conference
• /
• 2003.10a
• /
• pp.117-117
• /
• 2003

체외에서 한우 난포란의 감수분열과 배발달 능력의 획득에는 단백질 합성이 수반되어야 한다. 그러나 이러한 변화와 관련된 연구 보고는 거의 전무한 실정이다. 본 실험은 난자의 핵성숙과 관련된 세포질내 단백질 변화를 파악하기 위하여, 체외성숙 시간에 다른 배발달율과 세포질내 단백질을 비교하여 배발달능력 획득과 관련 있는 단백질을 규명하고자 실시하였다. 한우 난소에서 2-8mm의 가시난포로부터 난포란을 회수하였다. 회수된 난포란은 10% FBS와 호르몬이 첨가된 TCM199 용액에서 18시간 또는 24시간 체외성숙을 실시하였다. 난자 세포질내 단백질 변화는 2D gel electrophoresis를 이용하였고, 유의적인 변화를 나타낸 spot은 peptide mass fingerprinting을 통하여 단백질 동정을 실시하였다. 체외수정은 fer-TALP 용액을, 체외배양은 CR1aa 용액을 배양 3일째까지는 0.3% BSA, 그 이후에는 10% FBS와 난관상피세포를 첨가하여 사용하였다. 통계분석은 t-test를 이용하였다. 난자의 세포질에 대한 이차원전기영동 결과 29개의 단백질 spot들을 확인하였다. 한편 체외성숙 18시간째에 PB가 출현된 난자는 PB가 출현되지 않은 난자에 비하여 15개의 spot에서 유의적인 변화를 나타냈다. 이들 중 4개의 단백질 spot은 낮았고, 11개 spot의 수준은 높은 경향이었다. 체외성숙 18시간째와 24시간째의 배발달율을 조사한 결과 18시간째에서 유의적으로 높은 배반포 발달율을 나타냈다. 그리고 체외성숙 18시간과 24시간째 난자의 세포질내 단백질 spot들의 변화를 비교한 결과 PB가 출현된 난자 세포질에서 단백질의 변화와 유사한 경향이었다. 그러나 2개의 단백질 spot은 상반된 경향을 나타냈다. 따라서 본 실험에서 난자의 핵성숙과 관련 있는 15개의 spot을 확인하였고, 이들 단백질 spot중에서 2개가 배발달 능력과 관련이 있을 것으로 사료된다.보다는 육질등급에 많은 영향을 받는 것으로 판단된다. 한편 육질 1등급에서 배발달율이 낮은 이유는 육질 향상을 목적으로 암소를 비육 하는 경우 발생하는 번식장애와 밀접한 관계가 있는 것으로 사료된다.각각 가장 높았다. 배양 8일째 배반포의 세포수에 있어서 총세포수와 TE 세포수는 차이가 없었으나, ICM 세포수가 l0mg 첨가군에서 가장 높았다. 본 실험 결과에서 체외성숙 배지에 NEAA와 EAA 첨가가 배발달율에는 효과가 없었지만, 첨가농도의 증가에 따라 ICM 세포수가 증가하였다. 한편 체외성숙 배지에 LAH 첨가는 첨가 농도가 높을수록 배발달율은 낮았지만 ICM 세포수는 증가하였다.에 Csk가 관여하고 있음을 알 수 있다. 결론적으로 성적 성숙에 따른 생쥐 정소 내 Src-Csk loop의 발현과 Src kinase 활성의 변동은 정소 내 간충조직, 세정관 상피의 증식 및 기능적 분화 과정을 매개하는 생리적 활성분자 수용체 하위의 신호전달 과정에 Src-Csk loop에 의한 조절가능성을 확인할 수 있었다.rugrene의 향기성분이 주요 성분군으로 확인되었다. 2. 생강나무에서 생강의 향기를 발산하는 성분으로는 $\beta$-myrcene, o-terpinolene, phellandrone, ι-limonene, $\beta$-eudesmol, $\delta$-cadinone, elemol, trans-caryophyllene으로 동정되었으며 그 중에서도 phellandrene, $\beta$-eudesmol이 주된 역할을 하는 성분으로 확인하였다. 유의적인 관련성이 나타났고, 복부 비만의 지표인 허리엉덩이둘레비는 GPT, alkaline phosphatase, 공복시 혈당 및 MCV 등 다양한 건강지표와 관련성을 나타내어 향후 비만에 있어 다양한 혈액 성상의 변화 및 역할규명에 대한 연구가 이루어져야 할 것으로 본다.hat

• Journal of the KSME
• /
• v.34 no.11
• /
• pp.845-858
• /
• 1994

1988년 이전에는 한국의 석유화학공장은 다른 나라에 비하여 관리상태나 손해상황이 양호한 공 장으로 여겨져 거의 안전도조사(underwriting survey)가 실시되지 않았으나 1989년 이후부터 보험사고가 급격히 증가, 보험금 지급이 많아져 위험조사를 실시한 후 보험을 인수하게 되었다. 일반적으로 석유화학공업의 내용연수는 15년에서 20년으로 보고 있으며 미국, 일본 등 선진국 에서도 건설한지 20년을 전후해서 사고가 다발한다는 점은 국내 석유화학공장의 안전성 확보대 책에서 중요한 점을 시사한다. 석유화학공업의 안전성 확보대책으로서 해외재보험자가 요구하고 있는 "경영전반적인 위험관리"를 도입 추진하여야 할 것으로 사료된다. 여기에는 사전적 손해 방지대책을 포함하는 위험통제는 기본적으로 이루어져야 하며 사후적 대책인 위험재무도 경영 효율이 극대화되도록 하여야 한다. 그러나 최근 들어 국내공장의 사고빈발로 해외재보험자들이 재물손해의 자기부담금액(deductible)인상(business interuption)의 Time Excess연장(7일에서3 0일) 등의 보험조건을 강화하고 있다. 따라서 외국의 사고 경험에 비추어 국내 플랜트의 내용연 수가 거의 다 되어서 사고발생위험이 잠재하고 있고 석유화학공업의 특성상 사고빈도는 낮으나 손해규모가 대규모이고 국가경제에 기여하는 비율이 타산업에 비해 월등히 크다는 점 등에서 안전대책에 대한 경영자의 관심제고를 밑바탕으로 한 위험관리의 정착화, 안전기준 등의 국제 수준으로 향상 및 전문기술인력 확보를 통하여 사고발생 억제에 대하여 소홀히 해서는 안된다고 사료된다.안된다고 사료된다.작 원리 및 제조방법에 대하여 기술한다. 2차원 그래픽의 기능만으로도 충분한 역할을 수행할 수 있지만, 그 다음 단계인 기본설계나 상세설계와의 자료 공유를 생각하면, 3차원 그래 픽이 필요하다. 다만, 3차원 그래픽 기능을 추가하기 위해 많은 노력이 요구되는데, 현재 PHIG S와 x-window가 결합되어 PEX라는 라이브러리로 개발되고 있으므로 차후의 연구에 포함될 수 있을 것이며, 이 글에서는 간단한 2차원 그래픽 기능만을 이용하였다. 앞으로 PEX의 기능을 적 절히 구사하면, 좋은 효과를 볼 수 있을 것이다. 279cm 되게 하고 선축은 팬톰의 27번 절편과 28번 절편의 접변과 최대 전단면의 교차선과 일치시켜 양방향에서 15분씩 조사하여 전단면에서 선량을 측정하였다. 팬톰내 선축상 중앙점의 선량을 기준으로 다른 부위의 선량을 비교하였다. 두경부와 복부, 폐의 하반에서 선량의 차이는 $\pm$ 10% 이내였고, 폐의 상반과 어깨와 골반 부위에서 선량은 10%이상 저선량을 보였다. 특히 어깨부위에는 30%이상 저선량을 보였다. 이로부터 서울대병원과 유사한 조건에서 코발트로 전신조사하는 경우에는 폐나 두경부에 대응하는 조직보상체를 이용하기보다는 어깨부위에 선량을 추가하는 것이 바람직할 것이라고 생각한다.alpha$ 부분공간들의 합공간 역시 on-semistrbtifiable over $\alpha$ 하다. 6. 폐연속 net-cevering 함수에 의하여 cn-semistratifiable over $\alpha$ 성질이 보존된다. 보잘것이 없었고, 현재에도

• KOREAN JOURNAL OF CROP SCIENCE
• /
• v.49 no.6
• /
• pp.457-462
• /
• 2004

Lodging is one of the most serious problems in soybean cultivation. Therefore, improved cultural methods to reduce lodging as well as to increase photosynthetic ability should be mostly desirable to increase soybean production. The test variety was 'Hwangkeumkong' which was pinched at V7 stage. The greatest difference in canopy height between rows was shown when every other row was pinched, which also recorded the most effective reduction in lodging. The 9th leaf of soybean plants in non-pinching rows of alternative non-pinching and pinching plot showed the highest photosynthetic ability due to the greatest difference in canopy height. Although leaf area index was higher in pinched rows in average after 17 August, alternative pinching of every other row recorded the highest LAI on 5 September. Alternative pinching of every other row resulted $2\~14\%$ higher yield than non-pinching or complete pinching due to the increases of number of grains in the upper part of main stem and average grain weight of non-pinching rows and in alternative pinching.