• 대한간호
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• 제22권5호통권123호
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• pp.50-65
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• 1983

• 대한한방부인과학회지
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• 제22권4호
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• pp.1-18
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• 2009

Purpose: This study was performed to elucidate the inhibitory effect of Mibaeksan (MB) on melanin synthesis in B16F10 mouse melanoma cell. Methods: To demonstrate the inhibitory effects of MB on melanin synthesis, we measured the amount of released and produced melanin in B16F10 melanoma cell. Also, we evaluated tyrosinase-activity in vitro as well as in B16F10 melanoma cell. And to investigate the action mechanism, we assessed the gene expression of tyrosinase, TRP-1, TRP-2, MMP-2, PKA, $PKC{\beta}$, ERK-1 ERK-2, AKT-1 and MITF in B16F10 melanoma cells. Results: 1. MB decreased the release and production of melanin in B16F10 melanoma cells. 2. MB decreased tyrosinase activity in vitro and in B16F10 melanoma cells. 3. MB decreased the expression of tyrosinase, TRP-1, TRP-2, PKA, $PKC{\beta}$ and MMP-2 in B16F10 melanoma cells. 4. MB increased the expression of ERK-1, ERK-2 and AKT-1 in B16F10 melanoma cells. 5. MB decreased the expression of MITF in B16F10 melanoma cells. Conclusion: From these results, it may be concluded that MB has the antimelanogenetic effects.

• 대한한방부인과학회지
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• 제24권2호
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• pp.126-133
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• 2011

Objectives: This paper was aim to report the effects of Gamisoyosan-gagambang (加味逍遙散加味方) on the Primary Dysmenorrhea patients. Methods: Two patients who had been suffering from primary dysmenorrhea were enrolled in this study. They received oriental treatment such as herbal medicine. We gave them Gamisoyosan-gagambang several times. During the treatments, we requested them to visit hospital once every two weeks. If they could not come to hospital, we called them to take follow-up. The progress of symptoms was evaluated by visual analogue scale(VAS). Results: After treatment, most symptoms were improved and also VAS was reduced. Conclusions: This clinical cases indicate that Gamisoyosan-gagambang is effective in treatment of the primary dysmenorrhea patients. More clinical data and studies are requested for the treatment of primary dysmenorrhea.

• 대한한방부인과학회지
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• 제30권3호
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• pp.158-166
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• 2017

Objectives: The purpose of this paper is to report the spontaneous pregnancy of Jokyung-san-gagam treatments on two infertile patients who were failed to in intrauterine insemination (IUI) by three times. Methods: Two patients, in this case, were who failed three times IUI were treated with Jokyung-san-gagam, acupuncture and moxibustion. Results: The two infertile women achieved spontaneous pregnancy after taking Jokyung-san-gagam without assisted reproductive technology. Conclusions: These cases suggest that Jokyung-san-gagam is effective in treating infertile female after failure in IUI and can be an effective option for patients who were failed in IUI. For further study, the clinical approach on infertile patients that is based on Korean medicine treatment including Jokyung-san-gagam would be sustained.

• 동국한의학연구소논문집
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• 제6권1호
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• pp.205-229
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• 1997

금원사대가(金元四大家) 중의 한 사람인 주진형(朱震亨)은 주화론(主火論)의 영향을 받았지만 독창적인 "상화론(相火論)"과 "음부족이양유여(陰不足而陽有餘)"하다는 견해를 밝히면서 보음정이억상화(補陰精而抑相火)를 위주로한 치법(治法)을 제창하여 후대(後代)에 "자음파(滋陰派)"라고 불리운다. 이러한 단계(丹溪)의 의학사상(醫學思想)과 한방부인과학(韓方婦人科學)과 관련된 이론을 개괄하여 단계(丹溪)의 이론과 처방이 우리나라 한방(韓方) 부인과학(婦人科學)의 발전과정에 미친 영향을 고찰하였다. 그 결과 첫째, 단계(丹溪)의 증치사상(證治思想)의 특징은 거습담(祛濕痰), 조기(調氣), 자음청열(滋陰淸熱)의 치법(治法) 운용(運用)과 금욕적(禁慾的) 섭생(攝生)을 통한 양생론(養生論)이었으며, 둘째로 단계(丹溪)의 이론(理論)과 처방(處方)들은 <의방류취(醫方類聚)>와 <동의보감(東醫寶鑑)>에서 <단계심법(丹溪心法)>과 <단계심법부여(丹溪心法附餘)>의 내용을 대폭 수용함으로써 우리나라 한방부인과학(韓方婦人科學) 이론(理論)의 주요한 부분을 형성하는 계기가 되었으며, 셋째로, 부인과질환과 관련하여 월경병(月經病)에 조기(調氣) 및 거습담(祛濕痰)을, 불임증(不姙症)에는 월경불조(月經不調)와의 관련성(關聯性)은 물론 체형(體型) 체질별(體質別) 병기(病機)와 치법(治法)을 구분하였으며, "산전당청열양혈(産前當淸熱養血)" 이론에 의한 황금(黃芩) 백출(白朮)을 위주로 한 안태론(安胎論), "종담론치(從痰論治)"한 악조치법(惡阻治法), 난산예방(難産豫防), 산후(産後)의 "대보기혈(大補氣血)"등의 이론을 제시하여 단계(丹溪)의 학술사상이 우리나라 한방부인과학에 미친 영향은 많았던 것으로 사료된다.

• 생명과학회지
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• 제14권2호
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• pp.221-224
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• 2004

일반적으로 오징어의 콜레스테롤 함량은 높다고 보고하고있지만, 이는 주요 가식부인 몸통육에 대한 것이고, 여타 스테롤도 함께 정량하는 비색법에 의한 정량 결과인 경우가 많아 신뢰하기 힘들다. 그리고 이런 단점을 개선한 효소법이나 GC법은 모두 다 또 다른 단점인 고가 효소 키트가 필요하다던가 복잡한 전처리가 필요하다던가 하여 적용하기가 쉽지 않다. 따라서, 오징어 몸통 이외의 새로운 가식부로 이용되고 있는 껍질부, 내장이나 간장부위 등에는 얼마만큼의 콜레스테롤이 함유되어 있는지 정량해 보고 아울러 기존 효소법이나 GC법의 단점을 모두 극복한 Iatroscan법에 의한 콜레스테롤 정량을 시도 확립해 보았다. 또한, 이 방법의 확립을 위해 필요한 오징어 부위별 수분함량과 지방함량 및 지방종 분석도 동시에 행하였다. 한국산 물오징어 중의 부위별 수분 및 지방함량에 있어서 간장부위가 각각 50.4%, 15%로서 다른 부위와 큰 차이를 보였고, 다른 부위는 각각 75.8∼83.6%, 1.9∼4.7% 수준으로서 큰 차이는 없었다. Iatroscan법에 의한 콜레스테롤 정량을 위한 근거가 되는 지방종 조성비에 있어서는 간장부위는 92.1%가 중성지방으로서 주성분을 이루고 있었고, 몸통육과 다리육이나 껍질부위는 인지질이 81.2∼87.9%%로서 주성분이었다. 5$\alpha$-cholestane을 내부표준물질로한 Iatroscan법에 의한 콜레스테롤 정량 결과 기존의 효소법과 GC법에 의한 수치와 큰 차이를 보이지는 않아 가장 간단히 콜레스테롤을 정량해 내는 법으로 사용할 수 있다고 판단되었다. 즉, Iatroscan법으로 오징어 부위별 콜레스테롤을 정량한 결과 오징어 간장 부위에 643.2 mg%, 껍질에 608.8 mg%, 다리육에 321.4 mg%, 눈 부위에 159.5 mg%, 주가식부인 몸통육에 178.9 mg% 수준으로 콜레스테롤이 함유되어 있었다.

• 대한한방부인과학회지
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• 제34권3호
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• pp.29-48
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• 2021

Objectives: Banchong-san (BCS) is a herbal formula composed of 13 korean medicinal herbs and is traditionally used to treat inflammatory diseases and pain. The object of this study was to research the antioxidant, anti-inflammatory, antipruritic and antimicrobial effects of the BCS in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. Methods: In this experiment, effects of BCS on the following four were measured as follows: (1) Anti-oxidative effects were evaluated by 1,1-diphenyl-2-picryl-hydrazyl (DPPH) Radical scavenging activity, 2,2-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS) Radical scavenging activity. (2) Anti-inflammatory effects were evaluated by the production amount of Reactive oxygen species (ROS), Nitric oxide (NO), Interleukin-1β (IL-1β), Interleukin 6 (IL-6), tumor necrosis factor-α (TNF-α), Prostaglandin E2 (PGE₂), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2)(the previous two are "mRNA"), extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), p38 mitogen-activated protein kinases (p38), inhibitor of nuclear factor kappa B (IκBα), nuclear factor kappa B (NF-κB) (the previous five are "Protein") in LPS-Stimulated RAW 264.7 cells. (3)Antipruritic effects were evaluated by the production amount of histamine, Leukotriene B4 (LTB4), LeukotrieneC4 (LTC4) Levels in phorbol 12-myristate 13-acetate(PMA)/ionomycin-stimulated MC/9 mast cell. (4) Anti-microbial effects were evaluated by the growth suppression of Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Aspergillus niger. Results: The following results were obtained through each measurement: (1) DPPH Radical Scavenging Activity, ABTS Radical Scavenging Activity evoked a significant concentration-dependent increase. (2) ROS, NO, IL-1β, IL-6, TNF-α, PGE₂ production amount, iNOS, COX-2 mRNA expression were significantly reduced in the BCS extraction group compared with the control group and significantly decreased the amount of ERK, JNK, p38, NF-κB Protein expression. The amount of IκB-α Protein Expression have increased significantly. (3) The amounts of histamine, LTB4, LTC4 were significantly decreased. (4) The antibacterial efficacy, BCS inhibited the growth of Escherichia coli, Pseudomonas aeruginosa at concentrations of 5 ㎍/ml, but did not suppress the growth of staphylococcus aureus and aspergillus niger. Conclusions: The experimental results show that BCS has anti-oxidant, anti-inflammatory, antipruritic and antimicrobial properties.

• 대한한방부인과학회지
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• 제33권3호
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• pp.187-197
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• 2020

Objectives: This case report aims to report the clinical effectiveness of the combination treatment of Korean medicine on a post-laparoscopic myomectomy patient's lower urinary symptoms (LUTS). Methods: The patient who diagnosed with uterine myoma had Laparoscopic myomectomy. After the operation, the patient complained of dysuria, nocturia, frequent urination, urgent urination and urinary retention. The patient received combination treatment of Korean medicine during 14 days of hospitalization. The treatment included Ohrim-san, acupuncture, moxibustion, and pharmacoacupuncture. The effects were evaluated through the Numeric Rating Scale (NRS), Overactive Bladder Symptom Score (OABSS), Frequency-Volume chart, and 5-Level version of EuroQol-Five Dimension (EQ-5D-5L). Results: After the treatment, the clinical symptoms such as dysuria, nocturia, frequent urination, urgent urination, urinary retention were improved. Also, the quality of life was enhanced. Conclusions: This case report shows that the combination treatment of Korean Medicine with Ohrim-san may be effective for treating lower urinary tract symptoms (LUTS) after laparoscopic myomectomy.

• 성인간호학회지
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• 제24권4호
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• pp.358-369
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• 2012

Purpose: This study was performed to compare the costs of nursing interventions implemented for the obstetrical and gynecological patients using Korean Reimbursement System and ABC codes system developed in the US for costing out interventions performed by health care professional. Methods: First, the narrative data on nursing interventions were extracted from electronic medical record system of a tertiary university and mapped with Nursing Intervention Classification (NIC) by two researchers until 100% consent was reached. Narrative nursing interventions mapped with NIC were then remapped with ABC codes system using the electronic program developed in the research. The mapping data were analyzed with real numbers, frequency, percentage, mean, and standard deviation. Results: More nursing interventions were mapped with ABC codes than Korean reimbursement system. Total of 97 different types of narrative interventions could be mapped with NIC, 43 NIC interventions could be reimbursed by ABC code but only 16 NIC interventions were reimbursed by Korea Reimbursement System. Conclusion: Korean medical insurance fee system needs amendment to include more comprehensively interventions performed by nurses which are very important to patient outcomes. Further study is needed to develop strategies to costing out nursing interventions.

• 대한한방부인과학회지
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• 제20권3호
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• pp.229-237
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• 2007

Purpose: The purpose of this study was to report the clinical application of traditional korean medicine(TKM) treatment to hyeolheopungyeol type of dermatoses gravidarum. Methods: We experienced four patients who had been suffering from itching, plaque, erythema during pregnancy. They had already been treated with antihistamine or ointment, but they were not improved. We diagnosed their case as hyeolheopungyeol type of dermatoses gravidarum, and treated with sopungsan-gaml. Results: After TKM treatment, itching, plaque and erythema were alleviated or resolved. And they gave birth to a healthy baby. Conclusion: The results indicate that TKM, sopungsan-gami can be effective for the management of hyeolheopungyeol type of dermatoses gravidarum.