• Journal of Hospice and Palliative Care
• /
• v.11 no.4
• /
• pp.181-187
• /
• 2008

Purpose: In order to establish efficient palliative treatment plans. It is important to estimate the survival time of a terminally ill cancer patient as accurate as possible. Proper estimation of life expectancy aids not only in improving the quality of life of the patient, it also promotes productive communication between the medical staff and the patient. The aim of this study is to determine the efficacy of neutrophil-lymphocyte ratio as a predictor of survival time in terminally ill cancer patients. Methods: Between January 2004 and June 2007, 67 terminally ill cancer patients who were admitted or transferred for palliative care, were included. Patients were categorized into three groups by Neutrophil-Lymphocyte Ratio. Demographic characteristics, clinical characteristics and blood samples were analyzed. Results: In univariate analysis, survival time of the highest Neutrophil-Lymphocyte Ratio group (${\geq}12.5$) was significantly shorter than that of the others (hazard ratio (HR)=3.270, P=0.001). After adjustment for low performance status (ECOG score 4) and dyspnea, high Neutrophil-Lymphocyte Ratio (${\geq}12.5$) was significantly and independently associated with short survival time (HR=2.907, P=0.007). Neutrophil-Lymphocyte Ratio was also significantly increased before death (P=0.001). Conclusion: Neutrophil-Lymphocyte Ratio can be useful in predicting life expectancy in terminally ill cancer patients.

• Korean Journal of Psychosomatic Medicine
• /
• v.25 no.2
• /
• pp.120-128
• /
• 2017

Objectives : Although antipsychotics are commonly used to control symptoms of delirium, there is a lack of research on the prescription pattern and its clinical effects. The purpose of this study was to investigate the effect of antipsychotics prescription pattern on clinical course of delirious patients consulted to psychiatry. Methods : During the period from July 2016 to February 2017, 212 patients who were referred for delirium were reviewed for their medical records. The duration of delirium was monitored using CAM-ICU, and duration of admission, mortality, and delirium at discharge were reviewed. Clinical course was compared among three groups according to the antipsychotic drug administration pattern: Continuous use group, optimal use group and PRN use group. Results : The pattern of taking antipsychotic medication longer than duration of delirium did not associated with better clinical course compared with the pattern of adapting to the period of delirium and rather increased the risk of taking antipsychotic medication at discharge. When used for a shorter period than the delirium period, it was associated with poor clinical course. Conclusions : The results of this study suggest that a strategy to administer antipsychotics for a minimum period, according to periods of delirium, is appropriate. Also, efforts are needed to minimize the use of antipsychotic drugs after recovery from delirium.

• Journal of Hospice and Palliative Care
• /
• v.9 no.1
• /
• pp.35-39
• /
• 2006

A 77-year-old female presented panperitonitis due to advanced gastric ranter during palliative care. In the case of panperitonitis following obstruction or perforation, surgical treatment is vital to avoid fatal sepsis and dehydration. However, the risk of surgery and the residual life of a patient must be carefully considered because of high mortality and complication rate in those patients with advanced disease due to the poor condition. The therapeutic value of aggressive hydration, nasogastric tube insertion, and the use of antibiotics is also questionable. Palliative surgery was not performed on this case, and she passed away peacefully in the presence of family after 4 days of palliative medical care. Here is the appropriate management for this kind of patients we would like to recommend through review of relevant references and long discussions. Firstly, we need to predict survival time using clinical variables. Secondly, considering patient status and risk of surgery, non surgical palliative care such as pain control, transient nasogastric tube insertion, and parenteral hydration is recommended. Minimal use of fluid is desirable to minimize complications such as edema and dyspnea if massive hydration in the beginning of treatment is not proved to be effective. Even though started earlier in the course of disease, discontinuation of antibiotics could be discussed with patients and their caregiver if patient status is not improved.

• International Journal of Highway Engineering
• /
• v.14 no.1
• /
• pp.63-72
• /
• 2012

While the number of crashes and fatalities has decreased for the last few decades, the proportion of elderly-involved crashes has continuously increased from 19.5% in 2001 to 29.6% in 2008. This paper aims to evaluate the effectiveness of traffic safety education to seniors, which has been conducted for the purpose of providing more systematic knowledge such as safety regulations and making the elderly more aware of the risks of crashes, and eventually to reduce elderly-involved crashes. First, we investigated the levels of traffic safety knowledge of the elder people who attend senior community centers and social welfare centers in Seoul and provided traffic safety education. Then, the effectiveness of traffic safety education was evaluated by using the before-and-after analysis. We set up two different groups to improve the reliability of evaluation: one for control group and the other for comparison group. The results showed that the average scores of the control group after education were significantly improved at the 95% significance level compared to the average scores before education, whereas the comparison group did not show a significant differences in the average scores before and after education except for two questions. This indicates that the levels of traffic safety knowledge of the control group have been improved through education and therefore, the safety education seem to be effective to some extent.

• Journal of Veterinary Clinics
• /
• v.26 no.6
• /
• pp.659-662
• /
• 2009

The Korea Institute of Oriental White Stork Rehabilitation Research (KIOWSRR) is breeding oriental white storks for residential rehabilitation in South Korea. Three oriental white storks were referred with anorexia and depression. Two storks were died before examinations and one stork was died after 1 day of fluid therapy. On necropsy, salmon-colored subcutaneous and visceral fats were examined in all storks. Multiple focal necroses on liver surface were also examined. In gizzards, many gravels and grasses were severely tangled; therefore, it produced a large mass that blocked digestive system of the storks. Small intestinal segments of the stork, which was dead after the fluid therapy, were severely adhesive. On histopathology, diffuse necroses with/without inflammation were examined in the liver, gizzard and intestine in all storks. Bile stasis was additionally examined in the liver. According to the results of the examinations, all storks were diagnosed as gizzard impaction caused by parorexia.

• Journal of Life Science
• /
• v.14 no.4
• /
• pp.547-552
• /
• 2004

The present study was carried out to investigate the potential acute toxicity of amitraz by a single subcutaneous dose in beagle dogs. The test chemical was administered subcutaneously to male beagle dogs at dose levels of 0, 2, 10, or 50 mg/kg. Mortalities, clinical findings, and body weight changes were monitored for the 14-day period following the administration. At the end of 14-day observation period, hematology, serum biochemistry, and gross postmortem examinations were examined. A single dog in the 50 mg/kg group was found dead on day 3 after treatment and the other two dogs in the group were sacrificed because of the severe clinical signs on day 7 after treatment. Treatment related clinical signs, including anorexia, edema, mass and abscess formation in the injection sites, depression, vomiting, lacrimation, decreased locomotor activity, ataxia, recumbency, paresis in the limbs, and/or moribundity were observed in all treatment groups in a dose-dependent manner. Decreased or suppressed body weight gain was also observed dose-dependently in all treated groups. In autopsy, dead animals in the 50 mg/kg group showed muscular hemorrhage and inflammation in the injection sites and congestion in the liver and kidney. The terminal sacrificed animals in the 10 mg/kg group also exhibited muscular hemorrhage and inflammation in the injection sites. Whereas, no treatment related effects on hematology and serum biochemistry were observed on day 14 after treatment at any dose tested. On the basis of the results, it was concluded that a single subcutaneous injection of amitraz to beagle dogs resulted in increased incidence of abnormal clinical signs and death, decreased body weight, and increased incidence of abnormal gross findings. In the experimental conditions, the $LD_{50}$value of amitraz was 22.3 mg/kg (95% confidence limit not specified) and the no-observed-adverse-effect level (NOAEL) was considered to be below 2 mg/kg for male dogs.

• Journal of Digital Convergence
• /
• v.18 no.10
• /
• pp.33-39
• /
• 2020

In order to cope with traffic accidents efficiently, the maximum number of traffic accidents, deaths and serious injuries that can occur during the day should be presented quantitatively. In order to examine the characteristics of traffic accidents in different regions, it was divided into the Seoul metropolitan area, Chungcheong area, Gyeongbuk area, Honam area, and Gyeongnam area and was suitable for the generalized extreme value distribution (GEV). The parameters of the GEV distribution were estimated by the L-moments, and the Anderson-Darling test and the Cramer-von Mises test confirmed the suitability of the distribution. According to the analysis, the maximum number of traffic accidents that can occur once every 50 years is 401 in the Seoul metropolitan area, 168 in the South Gyeongsang region, 455 in the North Gyeongsang region, 136 in the Chungcheong region and 205 in the South Jeolla region. Compared to the Seoul metropolitan area, which has a large population and car registration, the number of traffic accidents is relatively high due to the large area, mountainous areas, and logistics movement caused by the industrial complex.

• Proceedings of the Korea Water Resources Association Conference
• /
• 2016.05a
• /
• pp.577-577
• /
• 2016

기후변화는 전 지구적 현상으로 이로 인한 홍수피해는 심화되고 있다. 기후변화 정부간 협의체 5차 보고서(IPCC, 2014)에 의하면 1980년대 이전 세계 평균 홍수피해액은 70억 달러 수준이었으나 2011년에는 240억 달러로 크게 증가한 것으로 나타났다. 2013년 필리핀에 태풍 '하이옌' 내습으로 인해 6,200여명이 사망하고, 2천여명이 실종되는 피해가 발생하였다. 국내의 경우 2014년 8월 경남 부산지역에는 시간당 130mm가 넘는 국지성 호우에 따라 차량 4,000여대가 침수, 5명 사망 등 약 125억원의 재산피해가 발생한 바 있다. 국회예산정책처(2012)와 소방방재청(2014)에 따르면, 자연재해 중 집중호우 및 태풍에 의한 호우피해가 85%를 차지하였으며, 전국 하천 피해액의 98.7%가 지방 및 소하천에서 발생하고 있다. 이에 따라 중소하천과 같이 소외된 지역의 물복지 향상을 위해서는 홍수재해 상황에 대하여 선제적 효과적 대응을 위한 과학적 체계적인 홍수통합관리 체계의 구축이 요구되고 있다. 특히 홍수관련 유관기관 자료를 연계한 실시간 상 하류 수문상황 모니터링, 홍수분석 및 하천수위별 대응기준 수립, 배수펌프장 등 수리시설원격 제어 등을 포함하는 홍수 통합관리체계 구축과 같은 비구조적 대책의 수립이 제방정비, 저류조 등 구조적 대책과 병행하여 반드시 추진되어야 한다. 이에 K-water는 ICT기반의 물관리기술력과 경험을 활용하여, 인력 기술력 예산 부족 등 열악한 재난관리 여건으로 어려움을 겪고 있는 지자체와 협업을 통해 홍수통합관리체계 구축을 지원하고 있다. 홍수통합관리체계 구축은 지자체 상 하류의 다양한 재난정보를 수집 통합하고, 수집된 정보를 활용한 홍수분석 및 홍수 대응기준 수립을 통해 예방적 재난대응 체계를 마련하는 것으로, K-water는 지난 2010년 남원시를 시작으로 무주군, 군산시, 진안군 등 21개 지자체의 홍수재해 통합관리체계 구축을 지원하고 있다. 특히 남원시의 경우 본 사업을 통한 시스템 구축후 홍수피해액이 50% 감소한 것으로 확인되는 등 재난관련 골든타임을 확보하고 홍수피해 최소화를 위한 홍수재해 통합관리 체계 구축은 이제 선택이 아닌 필수라 할 수 있다. K-water는 물관리 전문 공기업으로써의 역할을 다하고, 예방 중심의 재난관리 체계 마련을 위해 '지자체 맞춤형 홍수통합관리체계' 구축 지원을 지속적으로 확대해나갈 예정이다.

• Proceedings of the Korea Technical Association of the Pulp and Paper Industry Conference
• /
• 2000.11a
• /
• pp.132-132
• /
• 2000

환경오염과 이상기후의 영향으로 인한 수자원의 고갈과 함께 국내의 경우 수자원 개발 계획 및 수요량을 감안할 때 향후 7 년 내에 물부족 현상을 겪을 것이라는 보고가 있 었으며, 환경부담을 줄이기 위해 폐수의 배출기준은 강화되고 있다. 이러한 상황에서 제조 특성상 타 업종에 비해 폐수 발생량이 높은 편인 국내의 제지산업은 여러 해전부터 이에 대 한 방안을 모색하여 왔다. 일반적으로 폐수 수질 관리와 청수 사용량의 절감을 위해 고가의 폐수 처리 장치를 설치하거나 폐수 재활용을 통해 공정을 극도로 폐쇄화하는 방안으로 연구 가 진행되어 왔다. 이 중 용수의 재활용이 가장 경제적인 방법이지만, 재활용이 지속될수록 각종 무기염과 콜로이드성 유기물질이 축적되어 각종 약품의 효능 저하, 탈수속도의 저하 및 생산 제품의 품질 악화 등의 문제를 유발한다고 알려져 있다. 이를 해결하고자 하는 노 력으로 펄프 원료에 따른 공정수 내 용해성 물질의 분석과 재활용 횟수에 따른 각종 SS와 D DS의 축적 정도에 대한 기초 연구가 수행되었으며, 고폐쇄화된 공정에서 성능을 발휘할 수 있는 첨가제의 개발과 적용 방법에 대한 연구도 수행된 바 있다.여러 지종 가운데 골판지 원지는 용수의 재활용률이 상당히 높은 지종이기 때문에 공정수의 재활용이 진행될수록 열악한 저급 원료로부터 각종의 다양한 물질이 용출 혹은 배 출되며, 이러한‘물질은 골판지 원지의 강도 발현에 더욱 악영향을 미칠 것으로 판단되었다. 미세분으로 구성된 SS의 경우 이미 많은 연구를 통해 특성이 파악되었기 때문에 본 연구에 서는 ss를 제외한 공정수를 두 가지로 크게 나누어 고려하였다. 즉, ss로 측정되지 않지만 닥도를 유발할 수 있는 미세 무기물질과, 용해성의 무기염, 첨가제 및 추출물 둥으로 이루어 진 용해성 성분으로 나누어 분석하였으며, 또한 각각이 초지 특성에 미치는 영향을 살펴보 고자 하였다.을 해석코자 하였으며, 그 방법으 로 수치해석기법을 도입하였다. 또 실제 캘린더링 전후의 두께 변화를 측정하여 유리전이온도 의 도달 깊이와 비교하였다. 지필의 압축 정도는 롤의 직경과 닙 폭을 이용하여 MD 방향으 로 함수화하였으며, 열전달 계수로는 겉보기 값을 사용하였다. 이때 지펼은 균질한 것으로 가 정하였다. 함수율은 유리전이온도를 좌우하는 가장 큰 인자이나 본 연구에서는 항온항습처리 를 통해 유입지의 함수율을 고정시켰으며 캘린더링 시 함수율의 변이는 없다고 가정하였다. 그 결과 열침투깊이가 증가할수록 지필은 보다 변형되기 쉬운 상태가 되어 주어진 압력 조건에 대해 소성변형 정도가 증가하는 것으로 나타났다. 이는 캘린더링 전후에 두께 변화를 측정하여 정량적으로 평가할 수 있었다. 수치해석기법을 통해 같은 압력 조건에서 온도가 증 가함에 따라 혹은 같은 온도 조건에서 압력이 증가함에 따라 지필 내의 유리전이온도의 침투 깊이가 증가함을 알 수 있었으며 이는 캘린더링 전후의 두께 변화의 측정 결과와 일치하였 다. 또 NRT가 증가함에 따라서도 유리전이온도 침투 깊이가 증가하였다.합편에 비해 일부 우수한 양상을 보였지만 본 실험의 범위내에서는 통계적 정량적 차이를 제시할 수는 없었다. 향후 보다 광범위한 동물 실험이 필요할 것으로 사료된다.된다.하고도 완전교정술 도달 확률이 높은 치료전략이라는 사실을 입증하였으며 주대동맥폐동맥혈관부행지의 크기나 숫자가 단일화하기 쉬운 형태학적 특징을 지닌 경우에는 조기에 일단계완전교정술을 시행하여 양호한 결과를 얻을 수 있다는 사실을 발견하였다. 반면 본 환아군 중 단일화술을 먼저 시도한 군에서는 비록 단계적인 단일화를 시도한 군에서 단일화술과 관계된 수술사망율이 약간 낮기는 하였으나 완전교정술까지 완료될 가능성에는 차이가 없었다. 그러나 이 경우 보다 정련된 적응 환자의 선택을 통한 단일화 우선전략의 시도와 장기 추

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.19 no.11
• /
• pp.550-560
• /
• 2018

Many countries have provided support for research and development and implemented policies for Advanced Driver Assistance Systems (ADAS) for enhancing the safety of vehicles. With such efforts, the toll of casualties due to traffic accidents has decreased gradually. Korea has exhibited the lowest toll of casualties due to traffic accidents and is ranked 32nd in mortality among the 35 OECD members. Traffic accidents typically fall into three categories depending on the cause of the accident: vehicle to vehicle (V2V), vehicle to pedestrian (V2P), and vehicle independent. Most accidents are caused by drivers' mistakes in recognition, judgment, or operation. ADAS has been proposed to prevent and reduce accidents from such human errors. Moreover, the global automobile industry has recently been developing various safety measures, but on-road tests are still limited and contain various risks. Therefore, this study investigated the international standards for evaluation tests with regard to the assessment techniques in braking capability to cope with the limitations of on-road tests. A theoretical formula for braking force and a control algorithm are proposed, which were validated by comparing the results with those from an on-road test. These results verified the braking force depending on the functions of ADAS. The risks of on-road tests can be reduced because the proposed theoretical formula allows a prediction of the tendencies.