• Proceedings of the Korean Society of Applied Pharmacology
• /
• 1992.05a
• /
• pp.47-47
• /
• 1992

$\beta$수용체에 대한 차단약으로 propranolol이 1964년에 도입된 후, 현재까지 수십여종의 $\beta$-차단약이 개발되었다. 그중 특이 $\beta$1 수용체에 대해 선택적인 억제효과를 지닌 atenolol, metoprolol, betaxolol, celiprolol 및 최근에 bisoprolol 등이 개발되어 임상적으로 부정맥, 협심증, 고혈압의 치료에 사용되고 있다. 그 작용기전으로는 심박출량의 감소, renin 유리억제, 중추억제효과 등이 제시되고 있으나, 이들의 약효검색은 주로 $\beta$1수용체가 많이 존재하는 심장에 대한 억제효과를 중심으로 실시한다. 즉, SHR 및 개를 사용한 생체실험과 심장, 심방 ($\beta$1) 및 기완지, 혈관($\beta$2)을 이용한 적출장기실험을 통하여 isoproterenol에 대한 억제효과를 용량반응 곡선으로 그리고, Van rossum 법에 의해 pA$_2$ 치를 구하여 $\beta$-차단제의 효력을 평가한다. 특히, pA$_2$ 치가 클수록 $\beta$-차단제의 효력이 큰 약물이다. 또한 수용체 결합실험으로 소의 심실 세포막을 분리하여 $^3$H-DHA 와의 결합실험을 통해 해리항수(Kd) 를 측정하고, 이어서 $^3$H-DHA의 일정농도와 함께 미지의 $\beta$-차단제를 여러 농도로 변화시켜 가하여 치환곡선을 작성한다. 여기에서 얻은 치환약의 $IC_{50}$/ 치로부터 치환약의 해리항수(Ki)를 산출한다. 이때 약물과 수용체의 친화력은 해리항수의 역수이므로 해리항수가 적을수록 $\beta$ 수용체에 대한 친화력이 큰 약물이다. 시사되었으며, 이 조직에서 또한 5-$HT_2$와 5-$HT_3$ 수용체의 존재를 확인하고 각각의 기능을 분명히 했다.가 수월하게 하였고 메모리를 동적으로 관리할 수 있게 하였다. 또한 기존의 smpl에 디버깅용 함수 및 설비(facility) 제어용 함수를 추가하여 시뮬레이션 프로그램 작성을 용이하게 하였다. 예를 들면 who_server(), who_queue(), pop_Q(), push_Q(), pop_server(), push_server(), we(), wf(), printfct() 같은 함수들이다. 또한 동시에 발생되는 사건들의 순서를 조종하기 위해, 동시에 발생할 수 있는 각각의 사건에 우선순위를 두어 이 우선 순위에 의하여 사건 리스트(event list)에서 자동적으로 사건들의 순서가 결정되도록 확장하였으며, 설비 제어방식에 있어서도 FIFO, LIFO, 우선 순위 방식등을 선택할 수 있도록 확장하였다. SIMPLE는 자료구조 및 프로그램이 공개되어 있으므로 프로그래머가 원하는 기능을 쉽게 추가할 수 있는 장점도 있다. 아울러 SMPLE에서 새로이 추가된 자료구조와 함수 및 설비제어 방식등을 활용하여 실제 중형급 시스템에 대한 시뮬레이션 구현과 시스템 분석의 예를 보인다._3$", chain segment, with the activation energy of carriers from the shallow trap with 0.4[eV], in he amorphous regions.의 증발산율은 우기의 기상자료를 이용하여 구한 결과 0.05 - 0.10 mm/hr 의 범위로서 이로 인한 강우손실량은 큰 의미가 없음을 알았다.재발이 나타난 3례의 환자를 제외한 9례 (75%)에서는 현재까지 재발소견을 보이지 않고 있다. 이러한 결과는 다른 보고자들과 유사한 결과를 보이고 있지만 아직까지 증례가 많지 않기 때문에 생존율을 얻기에는 미흡한 점이

• Journal of the Korea Society for Simulation
• /
• v.17 no.2
• /
• pp.63-74
• /
• 2008

The design of best efficient production process is common requirements of the production strategy department and the process planning department to maximize the revenue and accomplish target production volumes in the production periods. And they use several general methods for that-line-balancing, removing of the bottle-neck process, facility ramp-up, increasing of the worker's utilization, etc. But, those methods have depended on analytic, static and arithmetic calculations, yet. So, irregular work-waiting time causing the delay time isn't include in extracting production capacity, especially in the line production process. The work-waiting time is changed irregularly along the variation of each machine and very important for calculate real product lead-time and forecasting target production volumes. At this thesis, i'm going to mention the importance of the delay time of conveyor system which can be extracted by discrete-event simulation. And suggest it as a new main variable that must be considered at designing new production system. Then experimented and tested that's effects in the H-company case, conveyor based line production process.

• Journal of Korea Multimedia Society
• /
• v.9 no.8
• /
• pp.1037-1044
• /
• 2006

It's difficult to check cyber attacks and the performance of a security system in a real large-scale network. Generally, a new security system or the effect of a new security attack are checked by simulation. We use SSFNet to simulate our security system and cyber attack. SSFNet is an event-driven simulation tools based on process, which has a strength to be capable of expressing a large-scale network. But it doesn't offer any API's which can manipulate not only the related function of security but also the packet. In this paper, we developed a firewall and IPS class, used for a security system, and added to them components of SSFNet. The firewall is modelled a security system based on packet filtering. We checked the function of the firewall and the IPS with network modelled as using our SSFNet. The firewall blocks packets through rules of an address and port of packets. The result of this simulation shows that we can check a status of packets through a log screen of IPS installed in a router and confirm abnormal packet to be dropped.

• Journal of KIISE:Computing Practices and Letters
• /
• v.8 no.4
• /
• pp.457-467
• /
• 2002

In order to simulate cyber attacks and predict network behavior by attacks, we should represent attributes of network components in the simulation model, and should express characteristics of systems that carry out various cyber attacks and defend from these attacks. To simulate how network load may change under the cyber attacks, we extended SSF[9, 10] that is process-based event-oriented simulation system. We added a firewall class and a packet manipulator into the SSFNet that is a component of SSF. The firewall class, which is related to the security, is to simulate cyber attacks, and the packet manipulator is a set of functions to write attack programs for the simulation. The extended SSFNet enables to simulate a network with the security systems and provides advantages that make easy to port already exsiting attack programs and apply them to the simulation evironment. We made a vitual network model to verify operations of the added classes, and simulated a smurf attack that is a representative denial of sevive attack, and observed the network behavior under the smurf attack. The results showed that the firewall class and packet manipulator developed in this paper worked normaly.

• The Journal of the Korea Contents Association
• /
• v.13 no.9
• /
• pp.312-321
• /
• 2013

The purpose of this study was to develop a scenario suited for our clinical situations and evaluate the application possibility by evaluating students' problem solving ability and learning satisfaction in simulation learning. This study consisted of contents which could be applied for varied situations such as complications and symptoms related to liver cirrhosis, looking into hyperkalemia symptoms of patients with liver cirrhosis in emergency unit. The stage of developing scenario was organized in the order of setting simulation learning objectives and situations of scenario, making algorithm, writing checklists of clinical performance appraisal, and debriefing. The scenario was constructed with monitor setting(actions), patient/mannequin(actions), expected interventions(events), and cues in chronological order, according to the scenario progression outline of Jeffries (2007). The scenario was used in 2011, consisting of 4-5 people per group of 53 senior nursing students who registered for 'clinical performance appraisal' course. The problem solving ability improved from a score of 4.05 before simulation learning to a score of 4.30 after simulation learning (t=-3.97, p<.001). The score for learning satisfaction after the simulation learning was high (4.09/5). Considering that simulation learning encouraged students to be the main body of class, this learning method can be the effective way of nursing education.

• Journal of Korean Society of Transportation
• /
• v.32 no.4
• /
• pp.401-409
• /
• 2014

This study deals with capacity expansion planning of airport infrastructure in view of economic validation that reflect construction costs and social benefits according to the reduction of passengers' delay time. We first forecast the airport peak-demand which has a seasonal and cyclical feature with ARIMA model that has been one of the most widely used linear models in time series forecasting. A discrete event simulation model is built for estimating actual delay time of passengers that consider the passenger's dynamic flow within airport infrastructure after arriving at the airport. With the trade-off relationship between cost and benefit, we determine an economic quantity of conveyor that will be expanded. Through the experiment performed with the case study of Incheon international airport, we demonstrate that our approach can be an effective method to solve the airport expansion problem with seasonal passenger arrival and dynamic operational aspects in airport infrastructure.

• Spatial Information Research
• /
• v.6 no.1
• /
• pp.77-90
• /
• 1998

The complex interactions of climate, topography, geology, biota and hwnan activities result in the land cover patterns, which are impacted by natural disturbances such as fire, earthquake and flood. Natural disturbances disrupt ecosystem communities and change the physical environment, thereby generating a new landscape. Community ecologists believe that disturbance is critical in determining how diverse ecological systems function. Fires were once a major agent of disturbance in the North American tall grass prairies, African savannas, and Australian bush. The major focus of this research was to develop stochastic model of spatial process of disturbance or spatial events and simulate the process based on the developed model and it was applied to the fire arrival process in the Great Victoria Desert of Australia, where wildfires generate a mosaic of patches of habitat at various stages of post-fire succession. For this research, Landsat Multi-Spectral Scanner(MSS) data covering the period from 1972 to 1994 were utilized. Fire arrival process is characterized as a spatial point pattern irregularly distributed within a region of space. Here, nonhomogeneous planar Poisson process is proposed as a model for the fire arrival process and rejection sampling thinning the homogeneous Poisson process is used for its simulation.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.20 no.12
• /
• pp.167-175
• /
• 2019

Recently, health examination centers have been changing from auxiliary medical facilities to key and independent medical facilities. However, it is not easy to improve medical facilities, including health examination centers, due to the variable characteristics of the relationship between humans and space. Therefore, this study was done to develop a pedestrian-based discrete event simulation analysis program to examine the problems and develop methods for improvement. The program was developed to analyze five evaluation indices and the density of examinees. The problems were derived by analyzing the required time, capacity, and queue size for each examination through simulations. We reduced the examination time and moving distance, increased the capacity, and distributed the queues by adjusting the medical services and relocating the examination rooms. The results were then quantitatively verified by simulations.

• KDI Journal of Economic Policy
• /
• v.15 no.3
• /
• pp.131-160
• /
• 1993

본고(本稿)에서는 다양한 형태의 금융충격(金融衝擊)의 거시경제효과(巨視經濟效果)를 분석하기 위해, 모든 금융충격(金融衝擊)을 통화의 지불수단으로서의 이용률(利用率)을 급격하게 변화시킴으로써 화폐시장(貨幣市場)에 초과수요나 초과공급을 초래하는 현상으로 이해하고, 동 충격을 유통속도충격(流通速度衝擊)과 통화승수충격(通貨乘數衝擊)으로 분리하여 그 규모를 추정할 수 있도록 전자(前者)는 은행의 예금회전율(預金回轉率)과 현금통화보유성향(現金通貨保有性向)에 의해, 후자(後者)는 현금통화보유성향과 지급준비보유성향에 의해 설명하는 일반적인 모형을 개발했다. 동 모형을 아용하여 80년대 이후 우리나라의 금융충격사례(金融衝擊事例)에 대해 분석한 결과는 다음과 같다. 82년 거액어음사기사건과 7.3조치에 의한 실명제예고조치(實名制豫告措置)는 M2를 3% 이상 감소시키는 효과를 초래하였으나, 실제로는 통화당국의 대응으로 오히려 3.0% 수준의 M2가 초과공급된 반면, 1988년의 금융실명제(金融實名制) 실시예고와 민간(民間)에 의한 1993년 8월 12일의 금융실명제실시예견은 M2를 각각 3.9% 및 4.9% 감소시키는 효과를 초래하여 정부의 통화공급대응(通貨供給對應)에도 불구하고 결과적으로는 각각 0.8% 및 0.6% 수준의 M2 과소공급을 초래한 것으로 추정되었다. 93년 8월 12일의 금융실명제 전격실시는 개략적으로 7~8%의 M2 통화량감소효과를 초래한 것으로 추정되지만, 실제로는 통화당국(通貨當局)의 신축적 통화공급으로 0.3~0.6% 정도의 M2 초과공급이 이루어진 것으로 추정되었다. 한편 본고(本稿)에서는 이와 같이 추정된 사례별 금융충격의 거시경제효과(巨視經濟效果) 시뮬레이션 결과(結果)도 같이 보여주고 있다.

• Korean Journal of Construction Engineering and Management
• /
• v.19 no.2
• /
• pp.50-60
• /
• 2018

Recently, modular construction method has been widely applied to projects with repetitive processes including dormitory, the residential facility, and the hotel construction due to reduced labor input and shortened construction schedule. Generally, about 40% of total on-site construction cost excluding unit installation cost, is put on exterior finishing work, and thus management of finishing work is deemed important in maintaining the targeted schedule and cost. Since limited equipment is shared so that subsequent activities are not affected while carrying out on-site installation and finishing work, lifting plan becomes more important for modular projects with greater portion of finishing work load. In this regard, tower crane operation plan may take the form of a single cycle or multiple cycles in which equipment efficiency can be affected. However, difficulties exist in evaluating alternatives to tower crane operation plans supporting unit installation and finishing work. Therefore, this study aims to evaluate the alternative of tower crane operation method according to the cyclic period setting in modular building site to determine the effect on T/C uptime and process by parameterizing lifting time for unit and exterior finishing material, lift cycle for unit and exterior finishing material and time required for finishing work. Accordingly, this study develops a simulation model that can increase the tower crane efficiency by controlling the work speed. An academic contribution of this study is to suggest a resource leveling method applying the concept of lifting cycle, and further is expected to be managerially used as a basis for an alternative evaluation of equipment plan.