• Proceedings of the Korean Society for Bioinformatics Conference
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• 2002.06a
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• pp.89-104
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• 2002

유전체연구사업단은 국내에서 발병 및 사망빈도가 가장 높은 위암과 간암의 퇴치를 목적으로 국가적 특목전략사업으로 연구를 추진하고 있다. 이와 별도로 보건복지부에서는 22개의 중요 질병별 유전체 연구센터를 전국적으로 추진하고 있다. 따라서, 연구가 성공적으로 진행되면 각 연구소에서 독자적으로 개발하여 제공하는 생명정보의 양은 거의 무한에 이를 것이다. 그러나 생명정보는 환자진료에 도움을 주기 위해서는 궁극적으로 임상정보와 함께 유기적으로 통합되어야 한다. 임상정보와의 통합을 위해서는 의료기관의 진료정보와 연구소의 생명정보가 연계되어 엄밀한 임상실험이 추가적으로 실시되어야 한다. 뿐만 아니라 생명정보학의 발전을 위해서는 연구대상의 임상정보가 공유되어야 한다. 유전체정보를 이용하는 생명정보학(Bioinformatics)은 각 국가마다 전략사업으로 간주하여 막대한 투자가 이루어지는 새로운 분야이다. 현재 선진국에서 개발 사용 중인 시스템의 연간 사용료가 고가이므로 국내 도입은 거의 불가능하거나 또는 매우 비효율적이다. 유전체 또는 생명정보의 임상활용 및 생명정보연구를 위한 임상정보 공유를 위해서는 우선 다음의 사항이 개발되어야 한다. 1) 다음과 같은 개별환자의 정보를 각 의료기관에서 제공 받아 저장 활용한다. - 진찰 및 임상소견, 수술기록, 경과기록, 검사결과 (임상병리, 해부병리, 방사선 등), - 영상정보 (X-ray, CT, MRI, 초음파, 전자현미경, 그래픽 등), - 환자개인기록(병력, 과거력, 가족력, 알러지 등), - 예방접종 기록 2) 각 연구소에서 첨단기술을 이용하여 개발되는 생명정보를 임상에 활용하기 위해서는 유전체연구센타와 병원간에 임상정보와 유전체 분석정보의 공유가 필수적으로 발생하게 됨으로, 유전체 정보와 임상정보의 통합은 미래 의료환경에 필수기능이 될 것이다. 3) 각 생명공학 연구소에서 사용하는 첨단 분석 장비와 생명공학 정보시스템의 자동 연계가 필요하다. 현재 국내에는 전국적인 초고속정보망이 가동되어 웹을 기반으로 하는 생명정보의 공유는 기술적으로 문제가 될 수 없으나 임상정보의 유전체연구에 그리고 유전체연구정보의 임상활용은 다양한 문제를 내포하고 있다. 이에 영상을 포함한 환자정보의 유전체연구센터와 병원정보시스템과의 효율적인 연계통합 운영을 위해 국내에서는 초기 도입단계에 있는 국제적인 보건의료정보의 표준인 Health Level 7 (textural information 공유), DICOM (image 및 wave 공유), 관련 ISO표준, WHO의 ICD9/10 (질병분류), LOINC (검사 및 관련용어), SNOMED International (의학용어) 등을 활용하여야 한다.

• The Korean Society of Law and Medicine
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• v.22 no.4
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• pp.159-184
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• 2021

The significance of the enactment of the 「Act On The Safety Of And Support For Advanced Regenerative Medicine And Advanced Biological Products」 is to break away from the regulation of the Pharmaceutical Affairs Act and expand patient treatment opportunities through a medical technology approach to regenerative medicine, which is essentially a medical practice called 'transplantation'. However, more than a year after the law was enacted, clinical study has not been activated, with not a single high-risk study approved by the Ministry of Food and Drug Safety being approved. The reason is that despite the legal purpose of expanding patient treatment opportunities, the data requirements for clinical study approval are set in connection with drug development despite the insufficient legal basis, making it difficult for many researchers to meet the data requirements. Prior to the enactment of the Act, submitted data for clinical study on cell therapy products within the Pharmaceutical Affairs Act were cosiderably exempted from quality and non-clinical test data, but with the enforcement of the Advanced Regenerative Bio Act, quality and non-clinical test data are required in accordance with pharmaceuticals when applying for approval of a clinical study plan. To rectify this, when considering the identity of clinical study on advanced regenerative medicine to expand treatment opportunities, recognize that there are limitations in connection with drug development. And it is necessary to preserve the identity of clinical study on advanced regenerative medicine, and on the other hand, in the case of drug product approval, clinical study results should be utilized while specifying usage requirements. Therefore, with the power of the market and the voluntary motive of the clinical researcher, it is necessary to prepare the necessary data by themselves rather than the basic requirements for clinical study approval.

• Journal of Gastric Cancer
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• v.7 no.1
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• pp.23-30
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• 2007

Purpose: Evaluating the clinicopathologic characteristics of recurred gastric cancer is essential for early detection of the recurrence and for better clinical outcome. The aim of this study was to establish the patterns of the recurrence, the timing of the recurrence, and the clinical result after recurrence according to the clinicopathologic characteristics of gastric cancer. Materials and Methods: From June 1992 to December 2005, of the 1338 gastric cancer patients who underwent a curative gastric resection, 241 patients who recurred during the follow-up period were selected and their cases were analyzed. The clinicopathologic characteristics of the patients, the time to recurrence after operation and survival were determined retrospectively according to the type of recurrence. Results: For the recurrent group, the numbers of total gastrectomies, advanced stages, lymphatic and/or venous infiltrations, whole stomach cancer cases, large tumors, undifferentiated tumors, and Borrmann type 4 tumors were higher than they were for the non-recurrent group, and the differences were statistically significant. When the recurrence types were classified as peritoneal seeding, hematogenous recurrence, and locoregional recurrence, independent risk factors were female gender, stage III, upper third, and whlole stomach cancer, and undifferentiated- type, diffuse-type, and Borrmann type 4 tumors for peritoneal seeding; early gastric cancer, stage I for hematogenous recurrence; and Borrmann type 1, 2, and 3 tumors for locoregional recurrence. Survival duration after detection of the recurrence was shorter for peritoneal seeding than for hematogenous or locoregional recurrence (7.0 months vs. 9.5 months and 12.5 months). Conclusion: For early detection of the recurrence after curative surgery for gastric cancer, it is important to recognize that the high risk factors for recurrence vary with the clinicopathologic data for the patients.

• Journal of Veterinary Clinics
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• v.20 no.4
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• pp.431-436
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• 2003

The purpose of this study is to evaluate urine protein-to-creatinine ratio as a parameter for early detection of nephrotic syndrome and as a parameter for monitoring effectiveness in early course of treatment. Nine healthy dogs were sensitized by intravenous injection with 1 $\mu$g of endotoxin and 5 mg of native bovine serum albumin. After 1 week, 120 mg of cationized bovine serum albumin was injected intravenously 5 times a week. Among nine dogs, five dogs were confirmed as having developed glomerulonephritis and nephrotic syndrome by increase of urine protein-to-creatinine ratio(>1.0), hypoalbuminemia (<1.5 g/dl), hypercholesterolemia (> 240 mg/dl) and azotemia (BUN>40 mg/dl). During the induction of glomerulonephritis and the progression to nephrotic syndrome, the increase of urine protein-to-creatinine ratio was firstly detected. 1 to 4 weeks later, hypoalbuminemia, hypercholesterolemia, and azotemia were detected. Prednisolone (2.2 mg/kg, bid) was administered orally to the dogs with induced nephrotic syndrome. In early stage of treatment, the increase of serum albumin and decrease of serum cholesterol were detected. 1 to 4 weeks later, decrease of urine protein-to-creatinine ratio was detected. It was concluded that urine protein-to-creatinine ratio is a useful parameter for early detection of nephrotic syndrome, and serum albumin and cholesterol are useful parameters for the monitoring in early course of treatment in nephrotic syndrome.

• Journal of Oral Medicine and Pain
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• v.25 no.3
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• pp.315-323
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• 2000

측두하악장애의 치료에 이용되는 저주파 전자침 자극요법의 임상적 효과를 평가하기 위하여 치료를 시행한 28명과 치료를 전혀 시행하지 않은 10명의 대조군을 대상으로 치료전과 치료 2주 후에 경혈점의 압력통각역치와 임상지수를 측정하여 다음과 같은 결론을 얻었다. 1. 환자군에서 저주파 전자침 자극요법을 시행하기 전과 후의 임상지수가 유의하게 변화하였다(P<0.001). 2. 환자군에서 저주파 전자침 자극요법을 시행하기 전과 후의 압력통각역치는 G2, G21, Li4, S2, S3, S8, Si19 및 T17에서 유의하게 증가하였다(P<0.05). 3. 대조군에서 임상지수와 압력통각역치는 실험 전후에 차이가 없었다. 4. 환자군의 임상지수가 대조군에 비하여 유의하게 변화하였다 (P<0.05). 본 연구는 저주파 전자침 자극요법의 주관적 뿐만 아니라 임상적인 효과를 보여줌으로써 측두하악장애환자의 치료에서 저주파 전자침 자극요법이 유용한 방법임을 제시하였다.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.15 no.10
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• pp.6204-6214
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• 2014

This study examined effects of preceptorship in a clinical maternity nursing course. The study design was a quasi-experimental, nonequivalent control group post-test design. The control groups (n=70, from July to October, 2012) participated in traditional practice method and the experimental groups (n=70, from December, 2012, to February, 2013) participated by a preceptor who attended a systematic preceptor education program. The data analyzed included the numbers, percentages, mean, standard deviation, and t-test using SPSS 19.0/WIN. In the experimental group, the clinical competency and practice satisfaction showed significantly higher scores, and the stress of clinical practice showed significantly lower scores than control group. Consequently, the preceptorship was effective in clinical maternity nursing education for student nurses and it is necessary to adapt this many areas in the clinical nursing education field for nursing students.

• Journal of Oral Medicine and Pain
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• v.32 no.4
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• pp.455-460
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• 2007

Majority of toothache is caused by abnormality of pulpal or periodontal tissues. However, there are numerous nonodontogenic sources that may be responsible for pain felt in the tooth. Nonodontogenic toothache may result from muscle, maxillary sinus, neuropathic, neurovascular, even cardiac and psychogenic problems. Myofascial pain is one of the most common abnormality characterized by palpation of a hard band which acts as the trigger point that causes stiffness and fatigue of the muscle, referral pain in tooth, tension-type headache, and hyperalgesia. Masseter muscle particularly induce referral pain in maxillary and mandibular molars. This case reported the treatment of the pain in right mandibular molar originated from myofascial pain of the right masseter. The pain is improved by general and reversible treatments such as muscle exercise, physical therapy, and medication. Nonodontogenic toothache should undergo proper differential diagnosis in order to avoid unnecessary dental treatments, such as endodontic, periodontic treatment, and tooth extraction, which would fail to alleviate the symptom of the patient.

• Journal of Oral Medicine and Pain
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• v.33 no.4
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• pp.401-407
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• 2008

The most common type of orofacial pain is toothache. However, many other types of pain which derived from nonodontogenic problems can mimic toothache. Nonodontogenic toothache is heterotopic pain that the site of pain is not in the same location of the source of pain. This differs from primary pain, in which the site of pain is the actual site which the pain originates. Heterotopic pain can be alleviated by direct treatment toward the source of pain. The common sources of nonodontogenic toothache include neuropathic pain, sinus pain, Myofascial pain, neurovascular pain and even cardiac pain and psychogenic pain. Thus, clinicians should have a thorough knowledge about causes of nonodontogenic toothache, and through pain history and examination of dental and nondental structures are needed. This case report is about some cases of nonodontogenic toothache, and it also emphasizes essential considerations for proper differential diagnosis and appropriate treatment.

• Journal of Digital Convergence
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• v.14 no.8
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• pp.469-478
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• 2016

This Study aims to examine the differences in stress arising from clinical fieldwork of some of the students of occupational therapy department in accordance with the DISC behavioral style and the differences in the coping strategy. It is to provide basic data for the presentation of means of coping with stress that can occur at the time of clinical fieldwork in accordance with the behavioral styles of the students. As the results of the study, it was found that there are differences in the detailed items of clinical fieldwork stress in accordance with the DISC behavioral styles and differences in the strategy for copying with stress in accordance with the DISC behavioral styles. Therefore, there is a need to develop manual for fieldwork instructions and consultations in order for the students of occupational therapy department to cope with the clinical fieldwork stress at the time of clinical fieldwork by considering the behavioral styles of the students through additional researches in the future on the basis of aforementioned results of the study.

• Economic and Environmental Geology
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• v.37 no.5
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• pp.521-532
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• 2004

The aim of this study is to evaluate the susceptibility of landslides at Kangneung area, Korea, using a Geographic Information System (GIS) and remote sensing. Landslide locations were identified from interpretation of satellite image and field surveys. The topographic, soil, forest, geologic, lineament and land cover data were collected, processed and constructed into a spatial database using GIS and remote sensing data. Using frequency ratio model which is one of the probability model, the relationships between landslides and related factors such as slope, aspect, curvature and type of topography, texture, material, drainage and effective thickness of soil, type, age, diameter and density of wood, lithology, distance from lineament and land cover were calculated as frequency ratios. Then, the frequency ratio were summed to calculate a landslide susceptibility indexes and the landslide susceptibility maps were generated using the indexes. The results of the analysis were verified and cross-validated using actual landslide location data. The verification results showed satisfactory agreement between the susceptibility map and the existing data on landslide locations.