• 한방안이비인후피부과학회지
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• 제20권3호
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• pp.204-211
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• 2007

Objectives : Allergic rhinitis is one of the most common allergic diseases. The aim of this study was to evaluate the clincal effect of herbal medicine(Gamitonggue-tang) in patients with allergic rhinitis by using acoustic rhinometry. Methods : A total of 22 individuals with allergic rhinitis who visited the Dept. of Oriental Medical Opthalmology & Otolaryngology & Dermatology of Daegu Hanny Oriental Medical Center from June 1st, 2006 to February 28th, 2007 were included in this study. In this study, they were only treated with Gamitonggue-tang. For 4 weaks the flow resistance of nasal cavity and total nasal volume, nasal minimum cross-sectional area were measured by acoustic rhinometry at the 1st, the 14th and the 28th day. And symptom score of nasal obstruction were recorded. Results : There were no significant differences on sex, age and onset. After treatment(2, 4 weeks) the calculated flow resistance of nasal cavity, total nasal volume and nasal minimum cross-sectional showed no significant changes(p>0.05). But symptom score of nasal obstruction showed significant changes(p<0.05). Conclusions : Considering the above results, treatment with herbal medine(Gamitonggue-tang) could be efficacious in allergic rhinitis. Further studies in other methods are needed.

• 한방안이비인후피부과학회지
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• 제26권1호
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• pp.35-49
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• 2013

Objectives : We aimed to determine therapeutic effects of probiotics-fermented Magnolia denudata(MD) in the allergic rhinitis model mice. Methods : Polyphenol production, DPPH radical scavenging activity and NO inhibition of fermented MD by different bacterial strains were evaluated to select the one that is most suitable for fermentation. Thirty C57BL/6 mice were divided randomly into 5 groups as follows: normal group, ovalbumin(OVA)-treated plus water fed(CON group), OVA-treated plus unfermented MD fed(UMD group), OVA-treated plus fermented autoclaved MD fed(A-FMD group) and OVA-treated plus fermented unautoclaved MD fed(FMD group). After 9 weeks, we observed changes in the blood cell count, OVA-specific IgE level, nasal rubbing, nasal mucosal tissue and body weight. Results : Extract of MD fermented by Bifidobacterium breve(BB) for 48 hours showed the highest anti-oxidant activity and anti-inflammatory activity out of all the other bacterial strains. The number of eosinophil count in A-FMD, FMD group and platelet count in FMD group showed statistically significant decrease(p<0.05). OVA-specific IgE level decreased in all 3 experimental groups, significantly in UMD and A-FMD group. Nasal symptoms were attenuated in all 3 experimental groups, statistically significant in A-FMD and FMD group (p<0.05). Histologically, infiltration of eosinophils into the nasal mucosa decreased in all 3 experimental groups, especially marked decrease in FMD group. Conclusions : According to the above results, it is considered that probiotics-fermented Magnolia denudata has inhibitory effects on the allergic rhinitis animal models.

• Journal of the Korean Data and Information Science Society
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• 제25권2호
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• pp.373-384
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• 2014

데이터 마이닝이란 대량의 데이터나 복잡한 구조의 데이터들을 정교한 통계분석과 모델링 테크닉을 이용하여 정확히 식별되지 않는 패턴이나 자료간의 상관관계를 밝혀내어 여러 가지 결과를 예측해 내는 통계적 기법이다. 이러한 데이터 마이닝 기법은 금융, 통신, 유통, 의학 등 다양한 분야에 활용되는데, 본 연구에서는 의학 분야에 적용하여 호흡기질환에 영향을 끼치는 요인을 선별하였다. 분석은 2012년도 경상북도 지역사회건강조사에 참여한 사람 중 의사에게서 폐결핵, 천식, 알레르기성 비염을 진단받은 경험이 있는 호흡기질환군과 건강군으로 정리한 자료를 대상으로 하였다. 호흡기질환이 영향을 끼치는 주요인을 선별하기 위해 인공신경망, 로지스틱 회귀모형, 베이지안 네트워크, C5.0, CART 기법을 이용하였다. 공정한 모형 평가를 위해 전체 데이터를 훈련용 데이터와 검증용 데이터로 나누었고, 훈련용 데이터에서 설정된 모형을 검증용 데이터에 적용하여 정확도를 비교하였다. 그 결과 CART가 최적 모형으로 선정되었으며 CART의 의사결정나무를 통하여 우울감 인지 여부, 현재 흡연여부, 스트레스 인지 여부 순으로 호흡기질환에 영향을 주는 것으로 나타났다. 그리고 호흡기질환의 주요인들에 대한 오즈비를 구하여 개별적인 영향력에 대해서도 밝혔다.

• 대한한방소아과학회지
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• 제30권3호
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• pp.52-60
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• 2016

Objectives The purpose of this study is to analyze studies about the effects of topical application of Chinese herbal medicine for allergic rhinitis within randomized controlled trials (RCT). Methods The search database includes KJTK (Korean Traditional Knowledge Portal), OASIS (Oriental Medicine Advanced Searching Integrated system), CNKI (China National Knowledge Infrastructure), PubMed, and EMBASE. We used the following key search terms: "allergic rhinitis", "traditional Chinese medicine", "traditional Korean medicine", "Chinese herbal medicine", "randomized controlled trial", "clinical study", "nasal spray", and "nasal drop" Results Five studies were selected for analysis. Three studies used nasal spray of Chinese herbal medicine and two studies used nasal drops of Chinese herbal medicine for the intervention. Frequently used herbs were Magnoliae Flos (辛夷), Scutellariae Radix (黃芩), Coptidis Rhizoma (黃連), and Astragali Radix (黃芪). For the outcome measures, studies used symptom score, questionnaire of Quality of Life, nasal airway resistance, or laboratory studies. From all 5 studies, it has been shown that topical application of Chinese herbal medicine was effective for improving symptoms of allergic rhinitis. Two out of five studies showed statistical difference between study group and control group. Conclusions This study shows that topical application of Chinese herbal medicine can improve symptoms of allergic rhinitis. Well-designed RCT studies with low risk of bias and studies with outcome measures for assessing the immunomodulatory effects are necessary to confirm these findings.

• 턱관절균형의학회지
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• 제5권sup호
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• pp.11-18
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• 2015

본 증례에서는 극심한 삼차신경통 진단을 받고 안면부와 턱관절 통증으로 일상생활이 어려워 항간질약과 수술적 치료를 받았지만 통증이 개선되지 않던 환자에게서 음양균형장치를 포함한 자세조절훈련, 침치료 등 구조적 치료를 통해서 유의한 자각적 증상 개선뿐만 아니라 턱관절의 구조적 개선이 나타남을 관찰하였고, 요통과 경항통 및 비염 같은 제반 증상들의 호전과 척추의 구조적 개선이 관찰되었다.

• IMMUNE NETWORK
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• 제7권2호
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• pp.87-94
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• 2007

Background: Chronic rhino-sinusitis and persistent allergic rhinitis is often cited as risk factor for developing adenoid hypertrophy or adenoiditis, but this relationship has not been studied extensively. In this study, we evaluated the mucosal barrier, squamous changes of ciliated epithelium, IgA secretion and BCL-6 expression in adenoids, and adenoid size. Methods: Six children with allergic rhinitis and sinusitis, nine children with only allergic rhinitis, nine children with only sinusitis and six children without any history of allergic rhinitis and sinusitis were enrolled. H-E stain of adenoid for squamous metaplasia, immunohistochemical study of adenoid for IgA and BCL-6, cytokeratin stain for evaluation of mucosal barrier and lateral view X-ray for adenoid size were performed. ANOVA test was used in the analysis and data showing p value of less than 0.05 were considered significant. Results: The number of ciliated cells had tendency to be decreased and squamous metaplasia had tendency to be increased in three experimental groups (p>0.05). Deterioration of mucosal barrier had tendency to be detected in three experimental groups than control group (p>0.05). BCL-6 had tendency to be increased and IgA secretion had tendency to be decreased in three experimental groups (p>0.05). There is no difference in adenoid size between three experimental groups and control group. Conclusion: Despite the expectation that adenoid would be affectecd by allergic rhinitis and rhino-sinusitis, we found no evidence for influence of adenoid immunity.

• 대한한방소아과학회지
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• 제32권2호
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• pp.1-10
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• 2018

Objectives This study investigated the effects of Hataedock treatment with Douchi on induction of allergic rhinitis in obese induced NC/Nga mice. Methods NC/Nga mice were divided into control group (Ctrl), allergic rhinitis induced obese mice group (ARE), and allergic rhinitis induced obese mice group with Douchi Hataedock treatment (FGT). The 3-week-old mice of the FGT group were given one 10 mg/kg dose of Douchi Hataedock extract and sensitized with allergic antigens at weeks 4, 5, and 6. After 1 week of final sensitization, allergic rhinitis was induced primarily in mice nasal cavities for five days. After one week of the completion with the first induction, the second induction was introduced by the same method. After 1 week, few samples of the nasal mucosal tissues of each group were prepared. The factor of Th2 differentiation and inflammation control such that IL-4, STAT6, CD40, $Fc{\varepsilon}RI$, substance P, MMP-9, $NF-{\kappa}B$ p65, p-IkB, iNOS and COX-2 were observed by immunohistochemistry. Also, the difference in nasal mucosal injury was observed by histochemical method (PAS staining). Results The FGT group showed that reduced IL-4 production, STAT6 expression and CD40 expression by regulating excessive Th2 differentiation. Also, production of substance P and MMP-9 and activity of $Fc{\varepsilon}RI$ in mast cells were decreased. Inhibition of $NF-{\kappa}B$ p65 activity was induced by inhibition of p-IkB, and the production of inflammatory enzymes iNOS and COX-2 were decreased. In addition, the damage of intramural respiratory epithelium was low and excessive mucin secretion in goblet cells was low. Conclusions This study confirmed the possibility of controlling the allergic rhinitis in obese children who are expected to have an overactive inflammation.

• 대한예방한의학회지
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• 제17권1호
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• pp.199-207
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• 2013

Objectives : The prevalence of Allergic Rhinitis (AR) has increased during the last decade. However, a lot of decisions on the assessment and treatment of AR are made depending on the personal experiences and choices of physicians. To suggest preferable approaches and to minimize the variations according to physicians, guidelines for assessing anterior nasal cavity using nasal endoscopy on AR is needed. Methods : The Korean Oriental Medical Ophthalmology, Otolaryngology and Dermatology Society and the Korean Oriental Preventive Medical Society has set out to develop the guidelines for the assessing anterior nasal cavity using nasal endoscopy on AR. Results & Conclusions : This is the first Korean guideline for the assessment of AR and should be revised and supplemented in the future as new evidence becomes available.

• 동의생리병리학회지
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• 제24권6호
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• pp.1099-1104
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• 2010

Aim of this study was to determine if obesity or abdominal obesity is more prevalent in persons with allergic rhinitis compared with healthy persons and to determine if obesity or abdominal obesity affects severity of rhinitis's symptoms. We studied 44 allergic rhinitic patients and 47 healthy persons. BMI and WHR were measured by the In-body 520. And severity of rhinitis's symptoms were assessed by questionnaires. The prevalence of obesity in allergic rhinitis group(27.3%) was significantly higher than control group(10.6%). And the prevalence of abdominal obesity in allergic rhinitis group(43.2%) was higher than control group(40.4%), but was not statistically significant. Nasal obstruction score of obesity group was higher than control group, but was not statistically significant. And nasal obstruction, Korean Allergic Rhinitis Specific Quality of Life Questionnaire (KARQLQ) score of abdominal obesity group were significantly higher than control group. And when age and sex are corrected, allergic rhinitis and obesity's association was statistically significant. The prevalence of obesity in allergic rhinitis group was significantly higher than control group. Also when age and sex are corrected, allergic rhinitis and obesity's association was statistically significant. And nasal obstruction score was higher in obesity than control group, but was not significant. The other side, nasal obstruction and KARQLQ score in abdominal obesity group was significantly higher than control group. Thus, we thought that fixed various confounding factors and large-scale studies will be needed.

• 대한수의학회지
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• 제22권2호
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• pp.265-272
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• 1982

The traumatic hepatitis and splenitis were experimentally induced in Korean native goats. General examinations, hematological and blood biochemical findings were investigated up to 10 days after induction of traumatic hepatitis and splenitis. Body weight of goats with traumatic hepatitis and splenitis showed no change or only a slight decrease. Changes in body temperature and respiratory rate were not noted in both experimental groups. Heart rate hart not been changed in traumatic splenitis group but were a little increased in traumatic hepatitis group. Erythrocytic series such as erythrocyte counts, hemoglobin concentration and packed cell volume showed same variation within normal range during the period of observation. Total leucocyte counts showed the considerable increase in both experimental groups. The increase of the percentage of neutrophil and the decrease of the percentage of lymphocyte were more remarkable in traumatic hepatitis group than that of traumatic splenitis group. Serum aspartate transferase activity was increased in both experimental groups after surgery, while serum alkaline phosphatase activity has been decreased conciderably up to 7 days after surgery. Serum lactic dehydrogenase activity has been increased up to 3 days after operation and thereafter the activity has returned to normal level in traumatic hepatitis group and the activity increased only the first day after surgery in traumatic splenitis group. There were no changes in total protein and albumin contents in both experimental groups during the period of observation. Serum total cholesterol contents showed a slight increase in both experimental groups and the range of increase in traumatic hepatitis group was more wide. Serum bilirubin contents were net changed in traumatic hepatitis group, but showed a slight increase in traumatic splenitis group.