• Korean Journal of Veterinary Research
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• v.37 no.4
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• pp.765-772
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• 1997

제주지역 돼지에서 각종 전염성 질병 원인체에 대한 항체를 조사하여 그간 전염성 병원체에 대한 역학조사가 미진하였던 부분을 보완하여 질병의 분포를 파악하고자 1995년부터 1996년에 걸쳐 제주도 전역에서 돼지의 혈청을 채취하여 각종 병원체에 대한 항체 분포율을 조사하였다. 본 연구에서 검사한 돼지 혈청 시료에서는 돼지 오제스키병 바이러스에 대한 항체는 전혀 검출되지 않았다. 돼지 콜레라바이러스에 대한 항체는 기대 수준 이하로 낮아 백신접종이 원활히 수행되고 있지 않음을 시사하였으며 특히 농장에 따라 항체 보유돈과 항체 음성돈이 혼재하는 농장과 항체가 전혀 검출되지 않는 농장 등 돼지 콜레라 방역의 사각지대가 존재할 가능성이 있음을 보여주었다. 유 사산 원인체인 돼지 파보바이러스 및 뇌심근염에 대한 항체가가 다양하게 나타나 일부 문제가 있을 것으로 사료되었다. 돼지 생식기호흡기증후군(PRRS) 바이러스에 대한 항체 분포율은 내륙 보다 다소 낮게 나타났고, 돼지 influenza virus, 위축성 비염, 흉막 폐염 등 각종 세균성 질환에 대한 항체수준도 다양하게 나타났다. 본 혈청학적인 연구결과는 제주지역에서의 양돈방역 정책수립 및 질병방제의 기초자료로 유용하게 이용될 것으로 사료된다.

• Korean Journal of Acupuncture
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• v.28 no.3
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• pp.221-231
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• 2011

Objectives : Kamibojungikgi-tang is one of the most frequently used medical treatment for the allergic rhinitis. The main symptoms of the allergic rhinitis are nasal obstruction, watery rhinorrhea, and sneezing. In this study, we investigated the medical effect of the Kamibojungikgi -tang with intradermal acupuncture treatment on the allergic rhinitis in 10-11 years old children. Methods : For 8 weeks, we administered Kamibojungikgi-tang to 84 patients and treated them with intradermal acupuncture. We checked their serum IgE and examined 10 symptoms of the allergic rhinitis (nasal obstruction, watery rhiorrhea, sneezing, nasal pruritus, hyposmia, quality of life, color of nasal mucosa, edema of nasal mucosa, postnasal drip, and complication). Results : 1. Serum IgE decreased 2.62 point. which showed no significance. 2. Nasal obstruction, watery rhiorrhea, sneezing, nasal pruritus, hyposmia, quality of life, color of nasal mucosa, edema of nasal mucosa, and postnasal drip were improved. (p<0.005) 3. Complication showed no significance. Conclusions : After treatment, we had a lower symptom index scores. Kamibojungikgi-tang with intradermal acupuncture treatment had an effect on the allergic rhinitis.

• Journal of Environmental Health Sciences
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• v.36 no.6
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• pp.465-471
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• 2010

This study aims to investigate the relationship between air pollution exposure and the prevalence of allergic rhinitis in a young population in the Ulsan metropolitan region (UMR). Data on physician-diagnosed allergic rhinitis (past 12 months) in 1,449 infants and children aged 1-18 years who lived within 1.5 or 2 km of air quality monitoring sites were collected in a cross-sectional health interview survey conducted between January-February 2006 in the UMR. Comparisons of the spatial distribution of the prevalence rates for allergic rhinitis and annual average pollutant concentrations over the region showed that a relatively high prevalence rate occurred around the coastal industrial area, with high PM10 concentrations. A linear correlation analysis demonstrated a positive correlation relationship between them (R = 0.680, p = 0.04). Multiple linear regression analysis revealed that the combined effect of the PM10 and $SO_2$ variables accounts for approximately 81% of the variance (R-square: 0.81) in the prevalence rate. From the multiple logistic regression analysis after adjustment by age, sex, and air-pollutant factors, the PM10 and $SO_2$ which were mainly from industrialrelated emissions were found to be significantly associated with an increased risk of allergic rhinitis (aOR: 1.76, 95% CI: 1.15-2.70 for PM10 ; aOR: 1.63, 95% CI: 1.12-2.35 for SO2).

• Journal of Korean Public Health Nursing
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• v.10 no.2
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• pp.51-60
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• 1996

This study was conducted to provide basic knowledges of effective environmental control of patients with allergic rhinitis. From July to October 1995, 58 dust samples Were drawn from the bedrooms of patients with allergic rhinitis who were registerd at an allergy clinic of a hospital. Those samples were examined for the amount of house mite allergens & dusts. The data were analysed by using ANOVA and Pearson correiation coefficients. The results were as follows : 1. As for the amount of house mite allergens in terms of environmental factors, the amount of house mite allergens of using washing water temperature of bedding above than $55^{\circ}C$ was significantly lower than that of below $54^{\circ}C$. Other environmental factors such as type of house, area of bed room floor, bed in bedroom, bedroom cleaning by vacuum cleaner, days after bedding washing, relative humidity of bedroom were relate to the amount of house mite allergens. 2. As for the amount of dusts in terms of environmental factors, the amount of dusts of days of days after bedding washing more than 15 days was significantly lower than thant of less than 15days. Other environmental factors such as type of house, area of bedroom floor, bed in bedroom, bedroom cleaning by vacuum cleaner, was hing water taemperature of bedding, relative humidity of bedroom were not relate to the amount of dusts. 3. There was a significant positive correlation between the amount of house mite allergens and the amount of dusts. It may be conclusively said. the amount of dusts and house mite allergens were closely associated with the washing temperature and days after washing of bedding. Hence. intensive instruction for the methods of bedding washing was needs of the patients with allergic rhinitis.

• Clinical and Experimental Pediatrics
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• v.49 no.6
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• pp.593-601
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• 2006

Allergic rhinitis is a common disease of childhood characterized by nasal, throat, and ocular itching, rhinorrhea, sneezing, nasal congestion. Those affected with allergic rhinitis often suffer from associated inflammatory conditions of the mucosa, such as allergic conjunctivitis, rhinosinusitis, asthma, otitis media with effusion, and other atopic conditions, such as eczema and food allergies. Allergic rhinitis must be diagnosed and treated properly to prevent complications and impaired quality of life. Despite a high prevalence, allergic rhinitis isoften undiagnosed and inadequately treated, especially in the pediatric population. The first step in treatment is environmental control when appropriate. It may be difficult to eliminate all offending allergens effectively to reduce symptoms, so medications are often required. Many different classes of medications are now available, and they have been shown to be effective and safe in a large number of well-designed, clinical trials. Antihistamines are effective in treating immediate symptoms of sneezing, pruritus, watery eyes, and rhinorrhea. Second generation antihistamines are the preferred antihistamines because of their superior side effect profile. Thus, decongestants are commonly used with oral antihistamines. Intranasal corticosteroids are the most effective therapy for allergic rhinitis. Leukotriene modifier may be as effective as antihistamines in treating allergic rhinitis symptoms. Cromolyn sodium is an option for mild disease when used prophylactically, and ipratropium bromide is effective when rhinorrhea is the predominant symptom. When avoidance measures and medications are not effective, specific immunotherapy is an effective alternative. Only immunotherapy results in sustained changes in the immune system. Because of improved understanding of the pathogenesis, new and better therapies may be forthcoming. The effective treatment of allergic rhinitis in children will reduce symptoms and will improve overall health and quality of life, making a happier, healthier child.

• The Journal of Internal Korean Medicine
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• v.26 no.2
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• pp.467-474
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• 2005

The main symptoms of allergic rhinitis are sternulation, rhinorrhea and rhinanchon. It is also characterized by frontal headache, ohotophobia and epiphora. Alleric rhinitis occurs when inhaled alleren is in contact with nasal mucosa which causes immune response. Bojungiki-Tang is one of the most frequently used medical treatment for the allergic rhinitis. Two chronic perennial allergic rhinitis sutterers, whose alleraies are thought to be due to house dust and ticks, were investigated through the eosinoohil numerical index and the subject symptom numerical index for three months. After treatment, both patients showed a lower index for both tests. The symptom index scores diminished from 17 to 3, and from 16 to 5. The eosinophil numerical index taken through blood tests, diminised from 4 to 2, and from 4 to 3. The above results suggest that Bojungiki-Tang has the inhibitory effects on allergic rhinitis.

• Korean Journal of Clinical Laboratory Science
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• v.48 no.4
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• pp.365-370
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• 2016

Atopic dermatitis refers to a chronic, recurrent, skin condition, typically typified by itching, inflamed skin. It precedes other allergic diseases, such as asthma, food allergies, and allergic rhinitis, and is usually accompanied by various other immune disorders and secondary symptoms. In this study, we discovered that when treating TNF-${\alpha}$ and IFN-${\gamma}$-stimulated HaCaT cells with various concentrations of Picea wilsonii Mast (PwM) extracts, the cell viability was excellent. In addition, we measured the inflammatory cytokines associated with atopic dermatitis, including IL-6, IL-8, IL-13, and MCP-1. The production of IL-6, IL-13, and MCP-1 decreased in the presence of PwM extracts, whereas there was no significant difference in the production of IL-8. Further studies are necessary to develop an effective cure for atopic dermatitis and inflammation using foreign plant extracts, and PwM efficacy should be determined with an in-depth, objective verification process using protein and mechanism analysis.

• The Journal of Pediatrics of Korean Medicine
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• v.21 no.2
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• pp.1-12
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• 2007

Objectives : Allergic children have known to have multiple behavior problems. Among them, attentional ability disorder is one of the most common problems. This study is to examine relationship between learning ability and allergic rhinitis by analyzing EEG status of children. Methods : We analyzed cognitive functions of two different children groups; 21 children with allergic rhinitis and 19 normal children with CANS 3000(Central & Autonomic Nervous System, LAXTHA Inc., Korea), cognitive functions assessment program by EEG. Results : 1. According to mean active EEG rhythm of Theta, Alpha, SMR, M-beta, there were no significant difference between allergic rhinitis and the normal group. 2. According to mean active EEG rhythm of right H-beta, Gamma wave allergic rhinitis group's value was significantly higher than that of the normal group. 3. According to mean cognitive strength, response, concentration, left / right brain activity and learning ability score, there were no significant difference between allergic rhinitis and the normal group. 4. According to mean workload score, allergic rhinitis group's value was significantly higher than that of the normal group. Conclusions : It is likely that allergic rhinitis group, which showed relatively high frequency EEG rhythm, is more fragile to stress and less active on mental processing. Along side with physical examination, psychological assessment should also be conjugated on treating children with allergic rhinitis.

• The Journal of Pediatrics of Korean Medicine
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• v.15 no.2
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• pp.167-175
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• 2001

Background : Allergic rhinitis is found in approximately 20% of the general population. And the prevalence of allergic rhinitis in the pediatric population also appears to be rising. Despite allergic rhinitis reportedly occurs very frequently, this disease is often overlooked or undertreated. The oriental medicine, allergic rhinitis is belong to the BiGu, BunChe. The symptoms are watery rhinorrhea, sneezing and nasal obstruction. The cause of disease is the weak of lung, spleen and kidney, and invasion in to nasal cavity of Poong Han etc a wrong air. Objective : To allergic rhinitis patients, we use herbal medicine and acupuncture treated. To demonstrate the effect of oriental medicine therapy in the allergic rhinitis before and after treatment. Materials and methods: Thirty five patients (18 male and 17 female) treated in our hospital between February 2001 and October 2001 were studied. Ages ranged from 10 to 56 years (mean age : 27 years). Seventy seven patients had a underlying family history (allergy or sinusitis of parents or brothers). In the past history, 63% patients have atopic disease. Illness period was from 1 month to 20 years (mean period : 5.7 year). Mean duration of treatment were 39 days. Gamihyunggyeyungyo-tang was administered mainly. Result : The symptoms of allergic rhinitis were nasal obstruction(94%), rhinorrhea(86%), itching(80%), sneezing(60%), eye itching(17%), headache(11%), nose bleeding(8%) and nose pain(6%). Compared with before and after treatment, the fourth symptoms of allergic rhinitis - sneezing, rhinorrhea, nasal obstruction and itching- improved significant statistically. (significant <0.005) Conclusion : We know that herbal medicine therapy and acupuncture were the effective treatment of Allergic rhinitis.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.7 no.4
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• pp.749-752
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• 2006

The house dust mites are well known to the most important causative allergens of major allergic diseases like pediatric asthma, allergic rhinitis or atopic dermatitis. This study was done for assessment of naphthalene effect against breeding suppression of the house dust mites. Twenty live adult house dust mites(Dermatophaogoides pteronyssinus) were each inoculated on mixed culture media containing 0 mg (control), 1mg, 2 mg, 3 mg, 5 mg, and 10 mg naphthalene and incubated at $25^{\circ}C$ with a relative humidity of 75%. After 4 weeks mean number of live house dust mites were 191.5, 24.3, 1.3, 1.3, 0, and 0, respectively. Above results showing that the naphthalene can suppress of breeding the house dust mites in vitro.