• Journal of Sericultural and Entomological Science
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• v.17 no.2
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• pp.133-139
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• 1975

For developing the therapeutic agents to be administered orally for treating certain silkworm diseases and applying them to clinical conditions, vehicles suitable for the agents are needed. The author presumed that Lactose, Casein, and Urea, respectively, have an effectiveness as the vehicle. A series of experiments were carried out on these substances for conforming the applicability of the vehicles at the silkworm rearing house of the College of Agriculture, at Seoul National University during the spring silkworm rearing season of 1974 and the spring and autumn seasons of 1975. The author recognized, Lactose, Casein, and Urea, when put on the mulberry leaves in a powdered form, are eaten along with the leaves by silkworm. Thus, the systemic administration of them to silkworms are possible. The author administered these individual substances orally to silkworm larvae in doses of l0mg., 30mg., 50mg., and 100mg. per gram of the body weight of the silkworm larvae at intervals of once a day, once every two days, and once every three days for 15 days. This was carried out from the first day of the fourth instar to just before mounting. The influences of these substances on the growth of silkworm larvae and the cocoons made by the larvae were observed. The author found out after completing the experiment that Lactose had no effect on growth and cocoon formation. This was observed in all cases. Casein inhibited the growth of silkworms except in the case of administered doses of once every third day in whick the growth and the cocoons were normal but the administration of the agent brought considerably large numbers of abnormal cocoons in every case. Urea inhibited both the growth and the formation of tile cocoons in most cases. For the confirmation of the clinical effectiveness as the vehicles for some therapeutic agents, the three substances, Lactose, Casein, and Urea, will be investigated more closely for the mixing amounts needed and other pertinent data.

• Polymer(Korea)
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• v.32 no.2
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• pp.143-149
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• 2008

We synthesized PEG-PLA (or PLGA) amphiphilic di-block copolymers, which consist of PEG as biocompatible and hydrophilic block and PLA (or PLGA) as biodegradable and hydrophobic block, by ring opening polymerization of LA in the presence of methoxy PEG as a macroinitiator. The compositions and the molecular weights of the copolymers were controlled by changing the feed ratio of LA (and GA) to PEG initiator. The di-block copolymers could self-assemble in aqueous media to form micellar structure. A hydrophobic model drug, pioglitazone, was loaded into the polymer micelle using solid dispersion and dialysis methods, and the drug-loaded micelles were characterized by AFM, DLS and HPLC measurements. The drug loading capacity and in vitro release studies were performed and evaluated under various conditions. These results indicated that the amphiphilic di-block copolymers of PEG-PLA (or PLGA) could solubilize pioglitazone by solid dispersion method and the drug release was modulated according to micellar chemical compositions.

• Journal of Digital Convergence
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• v.12 no.11
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• pp.487-497
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• 2014

This study was to examine the effect of the Self-efficacy Promotion Exercise Program to the elderly hypertensive with Stage 1. This research was the quasi-experimental study. The Self-efficacy Promotion Exercise Program combined to Aerobic exercise which is incrementally at a level of 40~60% HRmax and the source of the Self-efficacy Promotion Exercise. This research was carried out to experimental(33 patients) and control(32 patients), 60 minutes per day, 3 times a week for 12 weeks. The Self-efficacy Promotion Program was effect on enhancing the general(p<.001) and exercise self-efficacy(p<.001), the self-care behaviors(p<.001) and decreasing the systolic blood pressure(p<.001) to the elderly hypertensives. The 12 weeks Self-efficacy Promotion Exercise Program will be considering to useful for various care settings to the elderly hypertensives.

• Journal of the Korea Convergence Society
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• v.13 no.1
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• pp.477-488
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• 2022

The purpose of this study is to identify the factors influencing the depression in workers with diabetes mellitus. Using data from the Korean National Health and Nutrition Examination Survey (KNHANES). 685 workers with diabetes mellitus who were ≥30 years of age were enrolled. Depression was evaluated on the basis of PHQ-9 levels. Data were analyzed by complex sample linear regression using SPSS/WIN 23.0. The factors influencing depression included gender, age, household type, household income level, education level, type of employment (p>.05). The additional factors included stress perception level, weekly walking days (p>.05). Therefore, it is necessary to prepare systematic programs for depression and a support system for health promotion plan for diabetes mellitus in work places and throughout society. In addition, research on depression management program development is needed.

• Journal of Veterinary Clinics
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• v.28 no.3
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• pp.314-317
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• 2011

A 16-year-old, spayed female, Maltese dog weighing 4.3 kg was presented with a 2-week history of yellowish nose-and oral-discharge, anorexia and lethargy. In physical examination, indefinite ulcerative mass about $3{\times}3$ cm in size in the left sublingual region, severe gingivoperiodontitis, halitosis, moderate dental calculus, fever and swelling of mandible soft tissue were noted. In radiographic view, periodontitis and bone lysis findings on the left rostral part of maxilla and mandible were observed. In complete blood count and blood chemistry test, thrombocytosis, increased levels of serum $NH_3$, AST and ALP were obtained. Urinalysis revealed hematuria and proteinuria. In histological examination, squamous cell carcinoma was diagnosed. No surgery was performed, but combined treatment with carboplatin and piroxicam was initiated. Five days after initiation of medication, because of insistent vomiting, piroxicam was substituted to meloxicam. Although the therapeutic efficacy of meloxicam could not be known; administration of meloxicam might be less potential to gastrointestinal side-effects than piroxicam. The dog totally received 3 times of carboplatin infusion. Five days after third infusion of carboplatin, the dog was hospitalized with severe lethargy, vomiting and bloody diarrhea. In examination, severe renal failure signs were noted, and the dog was euthanized.

• The Korean Journal of Pharmacology
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• v.30 no.1
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• pp.137-143
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• 1994

Enhancement or diminution of leukocyte migration to the specific site might be important factors for the development of inflammatory diseases. To investigate the effects of non-steroidal anti-inflammatory drugs (NSAIDs) on chemotaxis of neutrophil, we obtained neutrophils by Hypaque-Ficoll step gradient centrifugation and tested the effects of seven drugs on the n-formyl-leucyl-phenylalanine (FMLP)-induced migration of neutrophil using a 48-well micro chemotaxis assembly. Oxyphenbutazone, phenylbutazone, sulindac, zomepirac, and ibuprofen suppressed the migration of neutrophil at the therapeutic concentrations, however, indomethacin showed stimulation effect. IC50s for inhibition of neutrophil migration by these drugs are less than 100uM. When drugs were preincubated with FMLP, no inhibition on migration of neutrophil was observed. These results indicated that inhibitory effects of these drugs on migration of neutrophil might be related to the receptor sites of neutrophil rather than molecular inactivation of chemoattractant (FMLP). In conclusion, we suggested that the property of inhibition effects on neutrophil migration of several NSAIDs might be another mode of pharmacological action for anti-iflammatory effect, which showed significant effects at concentrations below therapeutic levels, in addition to cyclooxygenase inhibition.

• Clinical and Experimental Pediatrics
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• v.50 no.8
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• pp.774-780
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• 2007

Purpose : The anthracyclines (AC) are widely used chemotherapeutic agents for pediatric cancers. However, the therapeutic use of these agents is limited by their cardiotoxicity. The aim of the present study was to investigate the usefulness of plasma B-type natriuretic peptide (BNP) levels as a marker for AC-induced cardiotoxicity compared to echocardiography in Korean children with cancer. Methods : Fifty-five pediatric cancer patients who had received chemotherapy including AC were enrolled. The cumulative AC doses, clinical symptoms, and two echocardiography parameters, left ventricular fractional shortening (LVFS) and left ventricular ejection fraction (LVEF), were studied and compared with plasma BNP levels. Results : In 55 patients, plasma BNP levels were measured 115 times and echocardiographies were performed 64 times. The median cumulative dose of AC was $325mg/m^2$ (range 120-600; mean 345) and the median plasma BNP level was 10 pg/mL (range 5-950; mean 31). The cumulative AC doses correlated significantly with the plasma BNP levels (P=0.002). The plasma BNP levels correlated significantly with LVFS (P=0.018) and LVEF (P=0.025). Dilated cardiomyopathies were identified in three patients. LVFS and LVEF decreased and plasma BNP levels increased in a patient with acute dilated cardiomyopathy and in that with symptomatic chronic dilated cardiomyopathy. However, LVFS, LVEF and plasma BNP levels were normal in a patient with asymptomatic chronic dilated cardiomyopathy. Conclusion : The results of this study demonstrated that plasma BNP levels could be used as a marker for AC-induced cardiotoxicity; they showed good correlation with echocardiography findings in pediatric cancer patients. Plasma BNP levels may be used for the detection and management of AC-induced cardiotoxicity in Korean children with cancer.

• Journal of Korean Medical classics
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• v.18 no.2 s.29
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• pp.1-19
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• 2005

통과대명대저명의가(通過對明代著名醫家), 온보파창시자설기(溫補派創始者薛己)$(1487{\sim}1559)$적생애화의학사상(的生涯和醫學思想), 득출여하결론(得出如下結論): 설기생여의학세가(薛己生於醫學世家), 종소학습유학화의학(從小學習儒學和醫學), 기부사후(其父死後), 체부진입태의원성료의사(替父進入太醫院成了醫士), 지후선후역임태의원이목(之後先後歷任太醫院吏目), 남경태의원원판(南京太醫院院判), 원사등직(院使等職), 병어1540년(44세)기관회향(幷於1540年(44歲)棄官回鄕), 전심여치료환자여저술(專心於治療患者與著述). 설기적저작대부분내(薛己的著作大部分內) 용이의안형식서사(容以醫案形式書寫), 기내용포함내과(其內容包含內科), 외과(外科), 부산과(婦産科), 소아과(小兒科), 침구과(鍼灸科), 치과(齒科), 안과(眼科), 골과(骨科), 본초등(本草等). 기본인친(其本人親) 자저술적유이(自著述的有以)${\ulcorner}$내과적요(內科摘要)${\lrcorner}$위시약12종(爲始約12種), 교주적유이(校注的有以)${\ulcorner}$부인대전양방(婦人大全良方)${\lrcorner}$위시8종(爲始8種), 교감적의서약유6종(校勘的醫書約有6種), 공계대약(共計大約) 유26종지다(有26種之多). 설기수(薛己受)${\ulcorner}$내경(內經)${\lrcorner}$, ${\ulcorner}$난경(難經)${\lrcorner}$급장원소화금원사대가적영향교심(及張元素和金元四大家的影響較深). 재사대가중(在四大家中), 우기수동원화단계적영향최심(尤其受東垣和丹溪的影響最深). 차외(此外), 가지기수교주의서적영향역교대(可知其受校注醫書的影響亦較大), 기통과박람군서(其通過博覽群書), 대담실천(大膽實踐), 광수자료(廣收資料), 선우총결(善于總結), 최종성료일명의가(最終成了一名醫家). 설기수이동원(薛己受李東垣)${\ulcorner}$비위론(脾胃論)${\lrcorner}$적영향(的影響), 강조비위적중요성(强調脾胃的重要性), 병수차제출비통혈적이론(幷首次提出脾統血的理論) 기여이동원적학설부동지처시(其與李東垣的學說不同之處是), 재치료화쇠토약형허한증시(在治療火衰土弱型虛寒證時), 주장이보화생토지법내치료(主張以補火生土之法來治療), 인위비여신적생리작용호위관련(認爲脾與腎的生理作用互爲關聯), 비토화생정미(脾土化生精微), 이자양신여명문(以滋養腎與命門) 반과래(反過來), 신여명문역대위토기온후작용(腎與命門亦對緯土起溫煦作用); 이재병리방면(而在病理方面), 비토구허(脾土久虛), 가치신허(可致腎虛), 신허즉불능생토(腎虛則不能生土), 역가치비허(亦可致脾虛). 설기적극반대명대의가수금원지유풍(薛己積極反對明代醫家受金元之遺風), 이한양약공하(以寒凉藥攻下), 혹남용지백이강화(或濫用知柏以降火), 극벌생기적작법(克伐生氣的作法), 이주장용편온적약물진행조보(而主張用偏溫的藥物進行調補), 기상용적전인처방유보중익기탕(其常用的前人處方有補中益氣湯), 사물탕(四物湯), 사군자탕(四君子湯), 육군자탕(六君子湯), 독삼탕(獨蔘湯), 삼부탕(蔘附湯), 육미환(六味丸), 팔미환(八味丸), 신기환(腎氣丸), 회양탕(回陽湯), 당귀보혈탕등(當歸補血湯等).

• The Korean Journal of Emergency Medical Services
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• v.13 no.3
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• pp.71-76
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• 2009

서론(Introduction) : 의학 시뮬레이션(medical simulation)은 교육생 학습과정에서 내재된 위험이 환자에게 가해짐 없이 교육생이 실제적인 환자 상황을 경험할 수 있게 하고 여러 다양한 임상내용이 포함한 상황에 적용될 수 있다. 시뮬레이션 기술의 사용은 의학교육(medical education), 인증서(certification), 면허교부(Licensure)와 의료의 질 형성에 큰 잠재력을 가지고 있다. 복강경 수술, 내시경검사, 전문심장구조술, 응급기도관리와 외상소생을 포함한 다양한 임상시술의 수행에서 시뮬레이션이 교육생의 술기를 달성하고, 측정하고, 유지하는 유효성을 증명하였다 컴퓨터로 조절되는 시뮬레이터는 맥박, 혈압, 호흡, 대화가 가능하고, 중증질환 또는 외상환자의 치료에 필요한 같은 인명구조 시술을 수행할 수 있다. 의학 시뮬레이션은 의사, 간호사, 응급구조사와 응급 진료를 필요로 하는 환자를 치료하는 사람에게 필요하다. 최신 전문심장구조술 과정수업은 전통적인 강의와 제한된 팀 상호작용이 포함된 이틀 과정이다. 우리는 비 영어권 국제 응급구조학생의 전문심장구조술 술기능력을 알아보고, 그것을 미국 응급구조학생과 비교하고자 한다. 목적(Objective) : 이 연구의 목적은 다양한 전문심장구조술 증례 시나리오를 가진 의학 시뮬레이터를 이용하여 미국과 한국의 응급구조 학생의 능력을 비교하는 것이다. 시행 장소(Site Location) : 이 연구는 한국 제주도에 위치한 제주한라대학 스토니브룩 응급의료교육원에서 진행되었다. 학생들의 평가는 스토니브룩에 위치한 스토니브룩 대학 의료원의 한 명의 평가자(Dr. lee)에 의해 수행되었다. 방법(Methods) : 15명의 한국 응급구조학생들은 세 팀으로 무작위로 선정하였다. 5명이 한 팀이 되어 같은 증례의 시나리오를 받았다. 세 가지 시나리오는 : 첫째, 천식지속상태(Status asthmaticus), 둘째, 긴장기흉을 동반한 만성폐쇄성폐질환(COPD with tension penumothorax) 그리고 마지막으로 메가코드(megacode)를 가진 심정지 이다. 세 팀을 각각 그리고 기본인명구조술(BLS)과 전문심장구조술(ACLS)과정을 마친 미국 응급구조학생들과 비교하였다. 15명의 미국 응급구조학생들 또한 세 팀으로 무작위로 선정하였다. 이 응급구조 학생들은 플러싱병원 의료원 소속으로 그곳에서 이 연구에 참여할 뿐만 아니라 지속적인 의학교육(CME)이수를 받았다. 이들에게도 같은 세 가지 증례의 시나리오가 주어졌고 Dr lee는 총 여섯 팀을 평가하였다(한국 세 팀과 미국 세팀). 결과(Results) : 양 국가의 모든 15명의 학생이 의학시뮬레이터를 사용하여 전문심장구조술 메가코드시험을 포함한 시험에 모두 통과하였다. 비록 학생들을 무작위로 세 팀으로 나누었지만 한 팀이 이 모든 세 증례에서 다른 팀보다 뛰어났다. 제주한라대학 2번 팀은 더 나은 기도관리, 리듬인식과 임상술기를 가진 모든 중요한 활동을 얻기에서 우수했다. 그들은 핵심요구사항을 90% 이상 충족시겼다. 한국의 2번팀(G2K)은 메가코드에서 기도개방, 호흡평가, 순환징후 그리고 흉부압박수와 같은 신체검진 술기에서도 탁월했다. 게다가 다른 팀과 비교 시 리듬인식, 약물지식과 임상술기에서도 높은 점수를 받았으며 2번팀(G2K)이 6팀 중에 가장 뛰어나게 역활수행을 하였다. 결론(Conclusion) : 이 비교 연구에서 한국학생과 미국학생간에 전문심장구조술 메가코드 시험의 통과율에는 차이가 없었다. 그러나 미국학생은 세 팀 사이에 더 적은 변이로 더 일괄된 점수를 받았다. 한국학생들도 모든 세 가지 증례를 통과하였지만 이 세 팀은 미국학생 팀보다 점수에서 더 큰 변이를 보였다.

• Korean Journal of Psychosomatic Medicine
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• v.23 no.1
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• pp.20-25
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• 2015

Objective:To review the patterns of the dermatologic consultations of psychiatric adolescent inpatient and to explore the relationship between the dermatologic disorders and psychiatric disorders. Methods:We retrospectively studied the data from 22 cases referred by psychiatric adolescent for a dermatologic consultation over 10 years in Daegu Catholic University Medical Center and compared with the data from 108 cases referred by the other department adolescent patients. Results:The mean age of patients was 15.9. The male to female ratio was 1:1.44. The most common psychiatric and dermatologic disorder was major depressive disorder and acne, respectively. The most frequent reason for consultation was to ask for dermatologic disease or condition(54.5%) followed by to perform cosmetic procedure of patients need(40.9%) and to perform dermatologic test(4.6%). Conclusions:More than just a cosmetic disfigurement, dermatologic disorders are associated with a variety of psychopathologic problems that can affect the patient. Increased understanding of biopsychosocial approaches and liaison among psychiatrists and dermatologists could be beneficial.