• Journal of the Korea Academia-Industrial cooperation Society
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• v.12 no.2
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• pp.746-752
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• 2011

To evaluate the degree of obesity based on differential combinations of BMI and body fat ratio, and thereby to obtain the comprehensive determination of coronary heart disease risk factors. The present study was conducted among 3,731 individuals(male; 2,312, female; 1,419) who underwent general health checkup in the general health promotion center in a university hospital during 2-year period from Jan. 2008 to Dec. 2009. Based on the obesity categories from combinations of BMI and body fat ratio, 30.2% were "normal", 8.9% were "seemingly obese", 31.2% were "occult obese", and 29.8% were "obese". By sexual comparison, the proportion of "normal" and "seeming obese" individuals were higher in men than women, while "occult obese" and "obesity" individuals were preponderant in women compared to men. By age, the proportion of "obesity" individuals were higher in the 40' and 50's than in 30's and 60's. Based on the association between obesity categories and each of CRF, SBP, DBP, TC, HDL-C, LDL-C and TG was significantly higher in "seeming obese" and "obesity" group than in "normal" group, but SBP, TC and LDL-C was significantly higher in "occult obese" and "obesity" group than in "normal" group. For odds ratios of each of CRF for obesity categories, it was higher in "obesity" group, "seeming obese" group, "occult obese" group than in "normal" group in that order.

• The Korean Journal of Food And Nutrition
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• v.9 no.4
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• pp.441-446
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• 1996

This study chosed the 3 groups(lean type(41), the normal type(48) and the obese type(58)) according the BMI and then by comparing the nutrition intake and eating behaviors of each 3 groups. The results obtained were summarized as follows: A significantly difference of nutrition-intake in 3 groups is shown in the take daily food-intake and calorie-intake of snack, which the obese type intakes of protein most, the normal type that intakes of calcium most. The food-habit shown in the self report of each subject, is the irregularity of the food-eating in all 3 groups. In terms of self-estimation by actual physique, the obese type estimates mostly correctly his own physique. To compared self-estimation of eating behaviors, The estimation of the unbalanced deities mostly correct.

• Food Industry And Nutrition
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• v.10 no.3
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• pp.5-9
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• 2005

비만은 제2형 당뇨병, 심혈관계 질환, 그리고 암을 비롯해 각종 질병의 위험인자로 작용한다. 비만은 낮은 수준의 전신성 염증상태로 간주되며, 비만시 증가하는 염증성 분자는 제2형 당뇨병 또는 동맥경화등의 비만성 질병 발생과정에 깊이 관여한다. 따라서, 염증제어는 비만성 질환제어를 위해 매우 중요하다. 지방세포 비대에 따른 지방세포 기능이상은 아디포사이토카인의 분비 이상을 초래하고, 비만성 질환의 발생 및 촉진자로 작용한다. 비만환자에게서의 MCP-1과 같은 염증성 아디포사이토카인의 분비 제어는 비만성 질환을 예방하거나, 또는 질병 발생 및 진행을 지연시키는 전략적 가치가 있을 것으로 사료된다. 지방세포가 분비하는 케모카인 가운데 MCP-1은 비대한 지방조직내로의 대식세포의 침윤 및 활성화를 유도하며, 특히 비대한 지방조직에서의 염증반응을 증폭시키는 역할을 한다. MCP-1은 내 장지 방조직에서 특히 그 분비량이 높았고, 따라서, 복부비만 관련 질환의 타겟분자로서 가치가 있을 것으로 생각된다. 또한, MCP-1 작용을 저해하는 항염증성 phytochemical은 비만으로 인한 염증성 질환의 발생을 지연시키거나, 즉 예방적인 차원에서 유용할 것으로 사료된다.

• Development and Reproduction
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• v.16 no.2
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• pp.113-120
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• 2012

We examined the distribution of uterine mast cells in cycling mice of different ages between 7 weeks and 38 weeks by toluidine blue staining. Mast cell density increased gradually depending on the age and culminated at 30 weeks after birth. Of the estrous stages, uteruses at metestrus showed markedly higher density of mast cells than those at the other stages in cycling mice of all ages analysed in this study and the majority of the mast cells were found in myometrium. We also discriminated types of the uterine mast cells in cycling mice at 10 weeks old by Alcian blue-safranin double staining. Mucosal type was most abundant among three types, including connective-tissue types and mixed types, through the entire estrous cycles. The portion of mixed types increased slightly after estrous. The abundance of uterine collagen protein determined by Masson trichrome staining was exactly consistent with the density distribution of the uterine mast cells during estrous cycles. Taken together, these results may imply that uterine mucosal mast cells, together with collagen proteins, are heavily involved in tissue remodeling of cycling mouse uterus.

• 방재와보험
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• s.99
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• pp.45-47
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• 2003

최근 우리나라는 활동량은 적어지고 식생활의 서구화로 열량섭취가 증가하여 성인뿐만 아니라 소아에서도 비만증이 급격하게 증가하고 있다. 소아 및 청소년의 비만은 대개 증식형 비만 형태로 지방세포수가 일단 증가하면 체중조절이 어렵고, 특히 복부비만은 성인 비만으로 이행하기 쉬우며 실제로 어렸을 때 비만에 걸리면 그 중 60~80%가 성인 비만으로 이행된다고 보고되는 바 사회적 관심이 요구된다. 또한 성인과 마찬가지로 소아 비만 자체로도 고혈압, 고지혈증, 심혈관질환, 당뇨 등 다양한 합병증뿐만 아니라 우울증 및 다른 정신적 문제를 동반할 수 있어 보다 적극적인 치료가 필요하다.

• Korean Journal of Poultry Science
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• v.32 no.2
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• pp.97-100
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• 2005

Mast cells have been studied extensively in various animals including rats and mice, whereas little is known the morphological data about pheasant mast cells. Here, morphological features of Korean pheasant mast cells are described in this study using light and electron microscopes. For light microscopy, mast cells had many metachromatic granules stained with toluidine blue in the cytoplasm. The fixation with $10\%$ neutral buffered formalin blocked staining of most mast cells but a modified Karnovsky solution proved to be a good fixative. In Korean pheasants, toluidine blue stained more mast cells than did alcian blue. For electron microscopy, the mast cells of the Korean pheasant were round, oval, spindle-like and irregular form and occasionally had a few short cytoplasmic processes. These cells had membrane-bounded granules and poorly developed organells. Some granules in the cytoplasm of the mast cells had bilayer membrane. Most granules were round shape and the membrane of several granules was concave or convex. The granules were composed of three parts, homogenous, particulate and reticular pattern.

• The Journal of the Korea Contents Association
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• v.16 no.10
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• pp.435-442
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• 2016

Obesity extends the global economic burden and it causes that the failure of a reduction of physical activity, and diet management. In this work, nutritional information and personalized diet based on calorie supply system and is discriminatory utilized the obesity-related SNP information in order to recommend a personalized functional foods. This study performed a GWAS analysis for the excavation of a Korean-specific and obesity-related SNP, which utilizes genetic information were recommended by entering a personalized diet in accordance with the SNP genotype-phenotype information. In addition, we integrated Database with relation of nutrient for utilizing the USDA Food information and it was applied to recommend with Sickdanome. As a result, the obesity-related SNP information was confirmed in the sample which has the normal value BMI. In this study, we have recognized that the phenotype information related obesity, BMI is inconsistent with the SNP genotype information. This result is shown that it is necessary to provide the personalized dietary SickdanOme recommendation based on the both pheotype-genotype information.

• Journal of Preventive Medicine and Public Health
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• v.33 no.2
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• pp.193-198
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• 2000

Objective : To evaluate the relationship between serum leptin concentration and obesity indices in a rural population. Methods : Two hundred and nine subjects were randomly sampled from 1036 residents who had participated in the survey. Their obesity indices were measured by bioelectrical impedance analysis and anthropometry. Serum leptin concentrations were measured by immunoradiometric assay. Results : Serum leptin concentrations were positively correlated with body mass index, percent of body fat, fat mass, waist circumference, and hip circumference. Serum leptin concentrations were higher in obese or overweighted subjects than normal or thin subjects(8.5[0.9-31.4] compared with $2.7[0.1-12.0]{\mu}g/L$, p<0.01). Serum leptin concentrations were higher in women than men, even after an adjustment to body mass index$(\beta=4.183,\;p<0.01)$. According to body composition, serum leptin concentrations were more related with waist circumference in men, hip circumference in women. Conclusions : Serum leptin concentrations are positively correlated with obesity indices. Serum leptin concentrations are higher in obese subjects, in women, and more related with peripheral obesity. These findings support the hypothesis that human obesity is associated with leptin-resistance rather than leptin-deficiency.

• Journal of Life Science
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• v.18 no.10
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• pp.1348-1354
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• 2008

mi transcription factor (MITF) is important in regulating the differentiation of mast cells. In particular, MITF regulates the transcription of the mouse mast cell-specific serine protease (mMCP)-6 gene, which is generally expressed by the connective tissue-type of mast cells. In this study, we investigated alternative isoforms of MITF that regulate transcription of the mMCP-6 gene in bone marrow-derived cultured mast cells in mice. The expression of MITF isoforms was examined by RT-PCR. We observed that MITF-A, -E, -H and -Mc were expressed by mucosal-type mast cells cultured in the presence of IL-3, whereas the connective tissue-type mast cells cultured in the presence of stem cell factor (SCF) expressed MITF-A. Overexpression of MITF isoforms increased luciferase activity through the mMCP-6 promoter in NIH-3T3 cells and elevated the level of mMCP-6 expression in the MC/9 mast cell line. Moreover, mMCP-6 expression in mast cells was significantly inhibited by the depletion of MITF. The transcriptional activity and DNA binding of MITF-A was comparable to that of MITF isoforms, including MITF-E, -H, and -Mc. Our results therefore suggest that MITF-A may be an important isoform of MITF in regulating the transcription of mMCP-6 in mouse connective tissue mast cells.

• Proceedings of the Korean Society of Applied Pharmacology
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• 2001.04a
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• pp.3-30
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• 2001

비만은 고혈압, 제2형 당뇨병, 지방간, 고지혈증, 퇴행성관절염, 일부 암성 질환 등 다양한 만성 퇴행성 질환들을 유발할 수 있으므로 비만을 하나의 질환으로 인식하고 치료할 필요가 있다. 비만은 식사요법, 운동요법과 행동수정요법을 병행해야 최상의 치료효과를 거둘 수 있다고 알려져 왔지만, 비만 치료가 끝나고 4년 후에 빠진 체중의 절반만이라도 다시 늘지 않고 유지하고 있는 사람은 10-30%에 불과하다. 그러나 비만 문제가 중요하고 현재까지의 치료방법이 성공적이지 못함에도 불구하고 비만의 약물 치료의 적절성에 대해서는 논란이 있다. 그러나 최근 비만의 약물 치료에 대해 재평가가 이루어지고 있으며, 식사, 운동, 행동요법과 약물치료의 병합 요법이 효과가 있음을 입증하는 연구결과들이 보고되고 있다. 여기에서는 비만증의 진단기준과 치료원칙을 간단히 설명하고 비만증의 약물요법을 위주로 살펴보도록 하겠다.