• Journal of KIISE:Computing Practices and Letters
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• v.15 no.9
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• pp.700-704
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• 2009

In this paper, we propose a method for combining MR image with histopathology image of the prostate using image correction and multi-stage registration. Our method consists of four steps. First, the intensity of prostate bleeding area on T2-weighted MR image is substituted for that on T1-weighted MR image. And two or four tissue sections of the prostate in histopathology image are combined to produce a single prostate image by manual stitching. Second, rigid registration is performed to find the affine transformations that to optimize mutual information between MR and histopathology images. Third, the result of affine registration is deformed by the TPS warping. Finally, aligned images are visualized by the intensity intermixing. Experimental results show that the prostate tumor lesion can be properly located and clearly visualized within MR images for tissue characterization comparison and that the registration error between T2-weighted MR and histopathology image was 0.0815mm.

• Clinical and Experimental Pediatrics
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• v.46 no.12
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• pp.1266-1270
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• 2003

The advance of the immunobiology clarifies the nature of non-Hodgkin's lymphoma(NHL). In addition the proceed in the immunophenotyping renders the classification of NHL. According to the Revised European American Lymphoma(REAL) classification, classified by the etiologic factors, molecular biological characteristics, immunophenotype, cytogenetics and histologic feature, nasal T/NK-cell lymphoma(=angiocentric lymphoma) belongs to the category of peripheral T-cell and natural killer cell lymphoma. Nasal T/NK-cell lymphoma is a distinct clinicopathologic entity characterized by progressive necrotic lesions in the nasal cavity, nasopharynx, and palate. The cellular origin of this tumor has been controversial. Although most nasal T/NK-cell lymphomas are of NK-cell lineage, being CD56+, negative for surface CD3(Leu4), and unassociated with rearrangements of the T-cell receptor genes, other minor variants have been reported. This lymphoma is a rare disease and usually experienced in adult. Recently, we experienced a rare type lymphoma, nasal T/NK-cell lymphoma, in 14 years old boy. His soft mass occupied the right nasal cavity including the nasal septum and turbinate. Pathologically this nasal mass showed the infiltration into the vascular wall, illustrating angiodestructive lesion. The cellular origin was NK-cell lineage, being CD56+ and negative to CD3. Now, we report the case with a brief review of related literatures.

• Journal of KIISE:Software and Applications
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• v.37 no.1
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• pp.9-18
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• 2010

This paper proposes a deformable registration method using a demon algorithm for aligning the lungs between end-exhale and end-inhale CT scans. The lungs are globally aligned by affine transformation and locally deformed by a demon algorithm. The use of floating gradient force allows a fast convergence in the lung regions with a weak gradient of the reference image. The active-cell-based demon algorithm helps to accelerate the registration process and reduce the probability of deformation folding because it avoids unnecessary computation of the displacement for well-matched lung regions. The performance of the proposed method was evaluated through comparisons of methods that use a reference gradient force or a combined gradient force as well as methods with and without active cells. The results show that the proposed method can accurately register lungs with large deformations and can reduce the processing time considerably.

• Journal of Korea Multimedia Society
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• v.14 no.3
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• pp.348-355
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• 2011

In this paper, we propose an automatic prostate segmentation method from dynamic magnetic resonance (MR) images. Our method detects contrast-enhanced images among the dynamic MR images using an average intensity analysis. Then, the candidate regions of prostate are detected by the B-spline non-rigid registration and subtraction between the pre-contrast and contrast-enhanced MR images. Finally, the prostate is segmented by performing a dilation operation outward, and sequential shape propagation inward. Our method was validated by ten data sets and the results were compared with the manually segmented results. The average volumetric overlap error was 6.8%, and average absolute volumetric measurement error was 2.5%. Our method could be used for the computer-aided prostate diagnosis, which requires an accurate prostate segmentation.

• Korean Journal of Ichthyology
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• v.28 no.1
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• pp.28-34
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• 2016

The anatomy and histology of the olfactory organ in Favonigobius gymnauchen was investigated using a stereo microscopy, light microscopy and scanning electron microscopy. The paired olfactory organs in the dorsal snout are set in between the upper lip and the eyes. These organs are composed of two openings (anterior nostril with a tubular structure and posterior nostril), a single olfactory cavity, two nasal sac (ethmoidal and lacrimal sacs), olfactory nerve and olfactory bulb. The distributional pattern of the sensory epithelium is a only one type (continuous type). This epithelium is made up of the receptor cell, supporting cell and basal cell. The receptor cell has a only one type (ciliated receptor cell with 3~4 cilia). The non-sensory epithelium is built of the stratified epithelial cells and has mucous openings on the surface. Such an olfactory organ in F. gymnauchen may be considered to reflect its ecological habitat as a shallow water or tidal pool in the coastal zone.

• Korean Journal of Head & Neck Oncology
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• v.2 no.1
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• pp.13-22
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• 1986

Nasal fossae 의 암이란 비강과 부비동들에서 발생하는 것으로서 환자를 가장 괴롭히며 또한 가장 믿을수 없는 악성종양들중의 하나이다. 비록 본 예수병원 암환자 등록부에 의하면 전 암환자의 2.2% 발생빈도로서 주요한 발생빈도를 보이지는 않지만, 이 부위의 암을 치유하는데는 세심하고 철저한 모든 진단적 검사와 과감한 외과 및 치료방사선의 병합치료가 요구된다. 저자들은 지난 22 년간 비강 및 부비동 (Nasal fossae) 에서 발생한 원발성 악성종양중 치유목적의 근치수술을 시행한 68 예를 임상고찰 하였다. 근치수술을 시행했던 68 예중 91% 에서 제 3 병기 또는 4 병기의 진행된 경우 이었다. 외과적 수술은 한예의 사골동 (篩骨洞) 종양적출술 및 부분상악동(上顎洞)절제술 한 예를 제외한 66 예 모두에서 전상악동(全上顎洞)절제술 (total maxillectomy) 또는 확장 전상악동(全上顎洞)절제술 (extended total maxillectomy) 을 시 하였다. 저자들은 역학적(疫學的), 병리학적(病理學的), 병기(病期) 및 치료, 재발율과 생존율들을 분석 고찰하였으며 3가지 치료형태를 서로 비교하였다. 즉 수술만 시행한 군, 수술전 방사선 치료 및 수술병합군, 수술과 수술후 방사선치료 병합 군으로 나눴다. 저자들의 예비적 (preliminary) 관찰 결과는 2 년간 무병생존율 (disease-free 2-year survival) 만을 볼때, 수술만 시행한 군에서 40%로써 통계학적으로는 가장 좋았으나 실제는 수술만 시행한 군에서는 단지 40%만이 제 4 병기(病期)의 진행된 경우였으나 수술전 방사선치료 또는 수술후 방사선치료등의 병합치료에서는 제 4 병기(病期)의 진행된 상태가 무려 60 %나 되었다. 전체적인 재발율 (Overall recurrence rate) 은 68.2%로써 무서울 정도로 높았으며 전체적인 2 년 무병율은 23.7%였다. 저자들은 이 분야에서 실패의 원인분석과 치료방법의 선택등에 대한 지침을 제시하고저 한다.

• Journal of the Korean Institute of Intelligent Systems
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• v.24 no.5
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• pp.536-541
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• 2014

Data through meteorological radar includes ground echo, sea-clutter echo, anomalous propagation echo, clear echo and so on. Each echo is a kind of non-precipitation echoes and the characteristic of individual echoes is analyzed in order to identify with non-precipitation. Meteorological radar data is analyzed through pre-processing procedure because the data is given as big data. In this study, echo pattern classifier is designed to distinguish non-precipitation echoes from precipitation echo in meteorological radar data using RBFNNs and echo judgement module. Output performance is compared and analyzed by using both HCM clustering-based RBFNNs and FCM clustering-based RBFNNs.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.13 no.3
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• pp.338-345
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• 1991

Velopharyngeal incompetence (VPI) is a condition of inadequate functional valving between the oral and nasal cavities that results in hypernasal speech and nasal air escape. VPI is caused by the following factors ; cleft palate, soft palate defect, pharyngomegaly, velopharyngeal sphincter muscle anomaly and maxillary advancement surgery, etc. Velopharyngeal function is assessed by a variety of measures that include speech evaluation, cephalogram, airflow study, videofluoroscopy and nasoendoscopy. The management of VPI is classified into four main groups ; prosthesis, insertion of implant, palatoplasty and pharyngoplasty. Pharyngeal flap is the most common surgical procedure for correcting VPI since Schoenborn's report in 1875. We report seven cases of VPI which were treated by modified modified superiorly based pharyngeal flap with good results.

• Korean Journal of Ichthyology
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• v.28 no.4
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• pp.223-228
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• 2016

The anatomy and histology of the olfactory organ in Oryzias sinensis was researched using a stereo microscope and light microscope. In the gross structure, the paired olfactory organs on the dorsal part of the head consist of two nostrils (a circular anterior nostril and a slit posterior nostril in a distance), a single olfactory chamber and a single accessory nasal sac. In the histological study, the epithelium of the olfactory chamber is classified into both sensory and non-sensory regions. The sensory epithelium consists of olfactory receptor neurons, supporting cells, basal cells and vesicles, and is islet in distributional pattern. The non-sensory epithelium is composed of stratified epithelial cells and two types of mucous cells (acidic and neutral cells). The epithelium of the accessory nasal sac has swollen stratified epithelial cells, mucous cells with a rich glycoprotein. Such an olfactory anatomy and histology of O. sinensis may reflect its habitat surrounding stagnant and polluted water.

• Proceedings of the KOR-BRONCHOESO Conference
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• 1981.05a
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• pp.12.2-12
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• 1981

The papilloma of the nose and the sinuses is uncommon benign neoplasm that was pro bably first described by Billroth in 1855 as a "villiform cancer": It may polypoid or papillomatous in the nose or sinuses and is frequently multiple. Clinically, there are 3types of the papilloma found in the nasal cavity and sinuses, vestibule, fungiform, inverting. The vestibular type is the keratotic lesion arise from the squamous epithelium lining the vestibule of the nose. The inverting type, which is covered by the columnar or metaplastic squamous epithelium is pliable, pink and tends to bleed quite easily. The fungiform type is covered by the stratified squamous epithelium which shows varying degree of cornification. It is more caulflow like than the inverting type and does not bleed easily. Recently, the authors experienced a case of the fungiform type papilloma which occupied right nasal cavity and nasopharynx. So, we reports the case, with review of the current brief literatures. A 55 year old man was admitted with the chief complaints of right nasal obstruction by the protruded movable mass on right nasal cavity, which was noticed about 7 months ago. The biopsy report revealed fungiform type papilloma.(length 18cm. width 2.5 cm. weight 41 gr.) The tumor mass was removed surgically through intranasal approach under the general anesthesia. Postoperative course was uneventful and the patient was discharged after 7 days hospitalization. No evidence of recurrence has been observed up to date.