• Proceedings of the Korea Water Resources Association Conference
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• 2012.05a
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• pp.593-593
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• 2012

본 연구는 화력 및 원자력 발전소로 취입된 냉각수(circulating and essential service water)가 복수기로부터 온배수 형태의 개수로 흐름으로 표층배수 될 경우 수온을 저감시키기 위해 주입하는 희석수(by-pass cooling water)와의 혼합효과의 효율성을 증대시키고, 불리한 수리현상을 야기하지 않으며, 경제적인 배수로 구조물을 고찰하기 위한 목적으로 시도되었다. 배수로 구조물 내 온배수와 희석수가 혼합되는 구간을 혼합지(mixing basin)라 하는데, 본 과업에서는 ${\bigcirc}{\bigcirc}$발전소의 배수로 구간 중 혼합지를 대상으로 FLOW-3D$^{(R)}$를 이용한 3차원 수치모형을 구축하고, 총 9개에 해당하는 각 대안별 현상을 분석하고 비교하였다. 각 대안들의 차이점은 배수로에 설치되는 보조구조물들의 형상과 배열 등이며, 복수기로부터 나오는 배출수의 수온은 $42^{\circ}C$, 희석수는 $35^{\circ}C$이고, 본 과업의 주요 관심대상 물리량은 유속과 온도이다. 배수로에 아무런 보조 구조물이 없는 형태인 기본 계획안을 검토한 결과, 평균 $3.31^{\circ}C$의 수온강하가 이루어졌으나, 우안 쪽으로 강한 흐름이 발생하여 수온의 좌우편차가 $4.61^{\circ}C$ 가량 발생하는 것으로 나타났다. 기본 계획안의 검토결과를 보완하기 위한 대안으로 연직 흐름의 소산을 위해 고안된 잠형 소파블록(baffle block) 설치안은 평균 $3.06^{\circ}C$의 수온강하가 이루어지고 $4.44^{\circ}C$의 수온 좌우편차가 발생했다. 지그재그(zigzag) 형태의 흐름을 만들어 혼합효과를 올리기 위한 미로형 수제(labyrinth groin) 설치안은 평균 $5.33^{\circ}C$의 수온강하가 이루어지고, $1.43^{\circ}C$의 수온 좌우편차를 보여줘 검토했던 대안들 중 가장 좋은 결과를 보여주었다. V자 배열 소파블럭(deformed block) 설치안은 연직 및 수평방향의 소산을 기대했으나 평균 $3.00^{\circ}C$의 수온 강하와 $4.41^{\circ}C$의 수온 좌우편차를 나타냈다. 벤츄리(Venturi) 형태의 흐름을 발생시키기 위한 병목형(bottleneck) 수로안은 평균 $3.18^{\circ}C$의 수온강하와 $3.94^{\circ}C$의 수온 좌우편차, 흐름의 소산과 흐름방향을 변화시키기 위한 와형 수제(swirl groin) 설치안은 평균 $2.24^{\circ}C$의 수온강하와 $1.48^{\circ}C$의 수온좌우편차, 우안 흐름을 지연시키기 위한 물방석(water cushion) 수로안은 평균 $3.03^{\circ}C$의 수온강하와 $4.50^{\circ}C$의 수온 좌우편차, 우안의 흐름을 좌안으로 보내기 위한 분사형(injector) 수로안은 평균 $3.13^{\circ}C$의 수온강하와 $4.45^{\circ}C$의 수온 좌우편차, 우안의 흐름을 막기 위한 외팔형 수제(cantilever groin) 설치안은 평균 $3.11^{\circ}C$의 수온강하와 $3.02^{\circ}C$의 수온 좌우편차가 발생하는 것으로 나타났다.

• Journal of Wetlands Research
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• v.23 no.4
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• pp.307-316
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• 2021

Due to rapidly increased urbanization, impervious area has been extended and concerns about urban flooding has been increased as well. A lot of effort has been made to restore the urban water circulation. Low Impact Development (LID) technology that consist of retention, infiltration, and evapotranspiration has begun to attract attention to simulate the hydrologic phenomenon before and after development. Many researches on the technique is being actively conducted. In this study, the effect on reducing runoff in urban catchment was analyzed and evaluated by applying LID techniques using SWMM and six scenarios. A SWMM-LID model was built for the Gasan 1 rainwater pumping station basin, and Green Roof and Permeable Pavement were selected as LID techniques to be applied. As a result, the reduction effect of the permeable pavement was larger than green roof. In the future, the results could be used to design a LID facility using the characteristics of the watershed, and other urban water resource factors such as river and groundwater levels that affect each other should be considered, so that the entire system can be considered.

• Tunnel and Underground Space
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• v.31 no.5
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• pp.309-332
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• 2021

Natural barrier systems surrounding the geological repository for the high-level radioactive waste should guarantee the hydraulic performance for preventing or delaying the leakage of radionuclide. In the case of the behavior of a crystalline rock, the hydraulic performance tends to be decided by the existence of discontinuities, so the coupled hydro-mechanical(HM) processes on the discontinuities should be characterized. The discontinuum modelling can describe the complicated behavior of discontinuities including creation, propagation, deformation and slip, so it is appropriate to model the behavior of a crystalline rock. This paper investigated the coupled HM processes in discontinuum modelling such as UDEC, 3DEC, PFC, DDA, FRACOD and TOUGH-UDEC. Block-based discontinuum methods tend to describe the HM processes based on the fluid flow through the discontinuities, and some methods are combined with another numerical tool specialized in hydraulic analysis. Particle-based discontinuum modelling describes the overall HM processes based on the fluid flow among the particles. The discontinuum methods that are currently available have limitations: exclusive simulations for two-dimension, low hydraulic simulation efficiency, fracture-dominated fluid flow and simplified hydraulic analysis, so it could be improper to the modelling the geological repository. Based on the concepts of various discontinuum modelling compiled in this paper, the advanced numerical tools for describing the accurate coupled HM processes of the deep geological repository should be developed.

• Korean Journal of Clinical Laboratory Science
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• v.53 no.3
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• pp.233-240
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• 2021

Evaluation of the resected margins of the frozen section during breast-conserving surgery can determine the presence of cancer cells in a short time and have a significant impact on the scope of surgery and the prognosis of the patient. However, breast tissue is composed of adipose tissue, which affects the accuracy of the test. In this study, a new method was applied to the resected surface of the frozen section in which wiping the surface of the frozen section block with alcohol was expected to expose the parenchyma to the surface as the adipose tissue would melt momentarily. Indeed, of the total of 98 cases, 37 cases showed a better exposure ratio of the parenchyma in the improved frozen section test than in the previous frozen section test. Of the 37 cases with increased visibility of parenchymal sections obtained by this method, two cases of ductal carcinoma in situ (DCIS) were detected. Although there are limitations such as turnaround time (TAT), the diagnostic accuracy of histopathologic examination of the frozen section may improve through this method and may have a direct impact on patient safety, and should therefore be researched further.

• The Transactions of the Korea Information Processing Society
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• v.13 no.6
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• pp.260-268
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• 2024

Cervical cancer is the fourth most common cancer in women worldwide, and more than 604,000 new cases were reported in 2020 alone, resulting in approximately 341,831 deaths. The Cox regression model is a major model widely adopted in cancer research, but considering the existence of nonlinear associations, it faces limitations due to linear assumptions. To address this problem, this paper proposes ResSurvNet, a new model that improves the accuracy of cervical cancer mortality prediction using ResNet's residual learning framework. This model showed accuracy that outperforms the DNN, CPH, CoxLasso, Cox Gradient Boost, and RSF models compared in this study. As this model showed accuracy that outperformed the DNN, CPH, CoxLasso, Cox Gradient Boost, and RSF models compared in this study, this excellent predictive performance demonstrates great value in early diagnosis and treatment strategy establishment in the management of cervical cancer patients and represents significant progress in the field of survival analysis.

• Journal of Gastric Cancer
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• v.6 no.4
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• pp.250-256
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• 2006

Purpose: Recently, interest in peroxisome-proliferator-activated receptors (PPAR) has increased, although clinical studies of the effect of $PPAR-{\gamma}$ expression on gastric cancer have not been reported yet. In this study, we investigated the role of $PPAR-{\gamma}$ expression in gastric cancer patients. Materials and Methods: One hundred twenty-eight (128) samples of both gastric cancer and normal tissues were obtained from 128 patients who had undergone at a curative gastrectomy at Seoul Medical Center from Jan. 2001 to Dec. 2005. $PPAR-{\gamma}$ expression was determined by using immunohistochemical staining, and the results were analyzed. The statistical analysis was based on clinicopathological findings and the differences in survival rates. Results: The mean age of the patients was 6n, and the male : female ratio was 1.9 : 1. $PPAR-{\gamma}$ expression was significantly higher in cancer tissues than in normal tissue (81.3% vs. 57.0%, p<0.001). There was insignificant difference between well and moderately differentiated types and poorly differentiated types in terms of the expression of $PPAR-{\gamma}$ (87.0% vs. 74.6%, P=0.074). In the univariate analysis the survival rate was significantly increased when $PPAR-{\gamma}$ was expressed in normal tissue (P=0.003). In the multivariate analysis, only the UICC TNM staging had significance related to the survival rate. Conclusion: The rate of $PPAR-{\gamma}$ expression was higher in cancer tissue than it was in normal tissue from gastric cancer patients. In the univariate analysis, $PPAR-{\gamma}$ expression in normal tissue had significance with respect to survival, but the multivariate analysis showed no such significance. Thus, we should further evaluate more cases to determine whether or not such a significance exists.

• Journal of Internet Computing and Services
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• v.14 no.6
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• pp.1-8
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• 2013

Data mining techniques are used to find important and meaningful information from huge databases, and pattern mining is one of the significant data mining techniques. Pattern mining is a method of discovering useful patterns from the huge databases. Frequent pattern mining which is one of the pattern mining extracts patterns having higher frequencies than a minimum support threshold from databases, and the patterns are called frequent patterns. Traditional frequent pattern mining is based on a single minimum support threshold for the whole database to perform mining frequent patterns. This single support model implicitly supposes that all of the items in the database have the same nature. In real world applications, however, each item in databases can have relative characteristics, and thus an appropriate pattern mining technique which reflects the characteristics is required. In the framework of frequent pattern mining, where the natures of items are not considered, it needs to set the single minimum support threshold to a too low value for mining patterns containing rare items. It leads to too many patterns including meaningless items though. In contrast, we cannot mine any pattern if a too high threshold is used. This dilemma is called the rare item problem. To solve this problem, the initial researches proposed approximate approaches which split data into several groups according to item frequencies or group related rare items. However, these methods cannot find all of the frequent patterns including rare frequent patterns due to being based on approximate techniques. Hence, pattern mining model with multiple minimum supports is proposed in order to solve the rare item problem. In the model, each item has a corresponding minimum support threshold, called MIS (Minimum Item Support), and it is calculated based on item frequencies in databases. The multiple minimum supports model finds all of the rare frequent patterns without generating meaningless patterns and losing significant patterns by applying the MIS. Meanwhile, candidate patterns are extracted during a process of mining frequent patterns, and the only single minimum support is compared with frequencies of the candidate patterns in the single minimum support model. Therefore, the characteristics of items consist of the candidate patterns are not reflected. In addition, the rare item problem occurs in the model. In order to address this issue in the multiple minimum supports model, the minimum MIS value among all of the values of items in a candidate pattern is used as a minimum support threshold with respect to the candidate pattern for considering its characteristics. For efficiently mining frequent patterns including rare frequent patterns by adopting the above concept, tree based algorithms of the multiple minimum supports model sort items in a tree according to MIS descending order in contrast to those of the single minimum support model, where the items are ordered in frequency descending order. In this paper, we study the characteristics of the frequent pattern mining based on multiple minimum supports and conduct performance evaluation with a general frequent pattern mining algorithm in terms of runtime, memory usage, and scalability. Experimental results show that the multiple minimum supports based algorithm outperforms the single minimum support based one and demands more memory usage for MIS information. Moreover, the compared algorithms have a good scalability in the results.

• Journal of the Korean Association of Geographic Information Studies
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• v.21 no.3
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• pp.176-188
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• 2018

Modern urban problems are increasingly becoming a market mix that can not be solved by the power of a single department and the necessity of establishing a cooperation system based on data communication between departments is increasing. Therefore, this study analyzed Busan metropolitan city's IT projects from 2014 to 2018 in order to understand the utilization and sharing status of departmental data from the viewpoint that cooperation between departments can start from the sharing of data with high common utilization. In addition, based on the results of the FGI(Focus Group Interview) conducted for the officials of the department responsible for the informatization project, we verified the results of data status analysis. At the same time, we figured out the necessity of data link between departments through SNA(Social Network Analysis) and presented data that should be shared first in the future. As a result, most of the information systems currently use limited data only within the department that produced the data. Most of the linked data was concentrated in the information department. Therefore, this study suggested the following solutions. First, in order to prevent overlapping investments caused by the operation of individual departments and share information, it is necessary to build a small platform to tie the departments, which have high connectivity with each other, into small blocks. Second, a local level process is needed to develop data standards as an extension of national standards in order to expand the information to be used in various fields. Third, as another solution, we proposed a system that can integrate various types of information based on address and location information through application of cloud-based GIS platform. The results of this study are expected to contribute to build a cooperation system between departments through expansion of information sharing with cost reduction.

• Journal of Korean Tunnelling and Underground Space Association
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• v.17 no.6
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• pp.637-652
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• 2015

In the present work, a number of three-dimensional (3D) parametric numerical analyses have been carried out to study the influence of tunnelling on the behaviour of adjacent piles considering the transverse distance of the pile tip from the tunnel. Single piles and $5{\times}5$ piles inside a group with a spacing of 2.5d were considered, where d is the pile diameter. In the numerical modelling, several key issues, such as the tunnelling-induced pile settlements, the interface shear stresses, the relative shear displacements, the axial pile forces, the apparent factors of safety and zone of influence have been rigorously analysed. It has been found that when the piles are inside the influence zone, the pile head settlements are increased up to about 111% compared to those computed from the Greenfield condition. Larger pile settlements and smaller axial pile forces are induced on the piles inside the pile groups than those computed from the single piles since the piles responded as a block with the surrounding ground. Also tensile pile forces are induced associated with the upward resisting skin friction at the upper part of pile and the downward acting skin friction at the lower part of pile. On the contrary, when the piles were outside the influence zone, tunnelling-induced compressive pile forces developed. Based on computed load and displacement relation of the pile, the apparent factor of safety of the piles was reduced up to about 45%. Therefore the serviceability of the piles may be substantially reduced. The pile behaviour, when considering the single piles and the pile groups with regards to the influence zone, has been analysed by considering the key features in great details.

• Journal of Chest Surgery
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• v.39 no.11 s.268
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• pp.828-837
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• 2006

Background: Tissue hypoxia is characteristic of many human malignant neoplasm, and hypoxia inducible factor-1(HIF-1) plays a pivotal role in essential adaptive response to hypoxia, and activates a signal pathway for the expression of the hypoxia-regulated genes, resulting in increasing $O_2$ delivery or facilitating metabolic adaptation to hypoxia. Increased level of HIF-$1{\alpha}$ has been reported in many human malignancies, but in non-small cell lung carcinoma the influence of HIF-$1{\alpha}$ on tumor biology, including neovascularization, is not still defined. In present study the relationship of HIF-$1{\alpha}$ expression on angiogenetic factors, relationship between the tumor proliferation and HIF-$1{\alpha}$ expression, interaction of HIF-$1{\alpha}$ expression and p53, and relationship between HIF-$1{\alpha}$ expression and clinico-pathological prognostic parameters were investigated. Material and Method: Archival tissue blocks recruited in this study were retrieved from fifty-nine patients with primary non-small cell lung carcinoma, who underwent pneumonectomy or lobectomy from 1997 to 1999. HIF-$1{\alpha}$, VEGF(vascular endothelial growth factor), and p53 protein expression and Ki-67 labeling index in tumor tissues were evaluated, using a standard avidin-biotin-peroxidase complex(ABC) immunohistochemistry. Relationship between the HIF-$1{\alpha}$ expression and VEGF, p53 overexpression and correlation between the HIF-$1{\alpha}$ expresseion and Ki-67 index were analyzed. Clinico-pathologic prognostic parameters were also analyzed. Result: HIF-$1{\alpha}$ expression in cancer cells was found in 24 of 59 cases of non-small cell lung carcinoma(40.7%). High HIF-$1{\alpha}$ expression was significantly associated with several pathological parameters, such as pathological TMN stage(p=0.004), pT stage(p=0.020), pN stage (p=0.029), and lymphovascular invasion(p=0.019). High HIF-$1{\alpha}$ expression was also significantly associated with VEGF immunoreactivity(p<0.001), and aberrant p53 expression(p=0.040). but was marginally associated with Ki-67 labeling index(p=0.092). The overall 5-year survival rate was 42.3%. The survival curve of patients with a high HIF-$1{\alpha}$ expression was worse than that of patients with low-expression(p=0.002). High HIF-$1{\alpha}$ expression was independent unfavorable factors with a marginal significance in multivariate analysis performed by Cox regression. Conclusion: It is suggested that high HIF-$1{\alpha}$ expression may be associated with intratumoral neovascularization possibly through HIF-VEGF pathway, and high HIF-$1{\alpha}$ expression could be associated with lymph node metastasis and post operative poor prognosis in patients with non-small cell lung carcinoma.