• Journal of Broadcast Engineering
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• v.22 no.5
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• pp.608-617
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• 2017

Methods of contrast enhancement have problem such as side effect of over-enhancement with non-gaussian histogram distribution, tradeoff enhancement efficiency against brightness preserving. In order to enhance contrast at various histogram distribution, segmentation to region with gaussian distribution and then enhance contrast each region. First, we segment an image into several regions using GMM(Gaussian Mixture Model)fitting by that k-mean clustering and EM(Expectation-Maximization) in $L^*a^*b^*$ color space. As a result region segmentation, we get the region map and probability map. Then we apply local contrast enhancement algorithm that mean shift to minimum overlapping of each region and preserve brightness histogram equalization. Experiment result show that proposed region based contrast enhancement method compare to the conventional method as AMBE(AbsoluteMean Brightness Error) and AE(Average Entropy), brightness is maintained and represented detail information.

• Journal of Digital Convergence
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• v.13 no.9
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• pp.431-437
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• 2015

This convergence study analyzed the effectiveness of contrast agent reduction by normal saline solution dilution in the computed tomography of arteries of lower limb. 48 patients of 125 cc contrast agent and 30 patients of the same amount divided at a ratio of 7:3 for the contrast agent and normal saline solution were studied. The average attenuation coefficient(HU) and signal to noise ratio(SNR) of abdominal aorta, femoral artery, popliteal artery and posterior tibial artery at each image were evaluated quantitatively and the four criteria in the five point scale was conducted qualitatively by two radiologists and four radiological technologists. In the quantitative evaluation, both HU and SNR had high average score before dilation but there were no statistical significance by independent t-test(p>0.05). In the qualitative evaluation, there were a little differences in the average scores between 4.86~4.77 of original contrast agent and 4.83~4.67 of dilated contrast agent but there were no statistical significance(p>0.05). In the computed tomography of arteries of lower limb, the dilated contrast agent doesn't influence image quality and reduces overall contrast agent and lowers iodine content per unit of molecular therefore will contribute to decrease side effect of contrast agent.

• Proceedings of the Korean Society for Emotion and Sensibility Conference
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• 2000.11a
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• pp.118-126
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• 2000

동양의학에서 인체의 주된 생리 정보는 체질과 맥진에서 얻어질 수 있다 체질은 선천적인 오장 육부 기능에 대한 정보를 제공한다. 체질에 대한 판단은 얼굴형상, 맥진, 사주 등의 방법에 의한다. 반면에 진맥은 현재의 오장육부의 건강 상태를 나타낸다. 오장육부의 생체정보는 인체경락의 전기 전도도를 측정하는 방법에 의해서도 얻어질 수 있으나 본 논문에서는 진맥에의한 방법만을 토론한다. 체질과 진맥 정보는 치병에 있어서 처방의 기간과 강도를 결정 할 수 있는 결정적인 변수이다. 이 두가지 정보 중에서 하나라도 결핍될 경우 병에 대한 효율적인 대응이 어려워진다. 그 이유는 처방의 강약 조절이 어렵고 그 결과 다른 부작용 유발가능성이 크다. 본 논문에서는 진맥이론의 일반적 전개를 위하여 음양오행 성질의 과학적인 정의를 기초로 하였다. 구체적인 맥상의 판단에는 (1) 음의 맥과 양의 맥의 절대적 크기와 상대적 비(즉 음양의 강도와 비), (2) 오행의 성질에 기초한 맥의 형상, 그리고 (3) 맥의 느낌이나 성질등 3가지 정보를 종합한 방법으로 맥상을 파악한다. 이러한 맥진기술 이론은 분류방법이 간단할 뿐만아니라 이론이 일반적이다. 그래서 한의학의 전문가는 물론이고 일반인 모두 쉽게 익혀 덜인의 건강상태를 스스로 파악하는 것이 가능하다. 진맥기 제작의 기년 이론으로서 역할을 할 수 있다. 오행이론에 기초 할 경우 맥상은 5가지 대표적인 맥으로 분류된다. 맥의 이름은 황제내경에 제시된 한의학적인 이름과 함께 맥상을 쉽게 유추 할 수 있는 실생활적인 이름을 병용하였다. 예를 들어 위장이 약할 때 나타나는 홍맥을 진빵같이 부드러운 맥으로, 폐가 나쁠 때 나오는 흩어지는 모맥을 도우너츠형 연기맥으로, 신장이 나쁠 때 나오는 단단한 석맥을 고구마형상의 돌덩어리맥으로, 간이 나쁠 때 나오는 긴장된 현맥을 팽팽한 고무줄맥으로 그리고 심장이 나쁠 때 나오는 작고 연한 구맥을 튀어오르는 물방울맥으로 명명하였다. 이외에 진맥에 의하여 인체의 한열이나 지삭 부침등의 정보가 가능하며, 이러한 정보는 고혈압이나 중풍 확률, 비만 가능성 지수, 골다공증 선행지수 그리고 심장기능 파악(불전맥이나 대맥) 등 다양한 인체 정보를 파악하는 데 응용될 수 있음을 강조한다.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2018.10a
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• pp.58-61
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• 2018

In Korea, current medical technology is the highest level in the world. As a result, many doctors have specialized knowledge of various disorders or diseases, and are proceeding in a better way. With such high medical technology, it is possible to increase the probability of success of surgery to provide high reliability to patients. Rehabilitation is also a form of medical treatment that reduces the side effects that occur after surgery that is done for quick cure. However, the situation in this section is slightly different. There are moves to develop rehabilitation devices and operations, but most of them are now dependent on foreign technology. Rehabilitation therapy, which we commonly know, is dominated by behavior. However, it is also a kind of rehabilitation to find out how much the patient's symptoms are improved or recovered. In this paper, we have studied the development of a program by using the Deeplearning method in order to detect the problem of the food swallowing operation by the severity.

• The Korean Journal of Applied Statistics
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• v.20 no.3
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• pp.449-458
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• 2007

Bipolar disorder, also known as manic-depressive illness, is a brain disorder that causes unusual shifts in person's mood, energy, and ability to function. Compared with manic episode, the depression episode causes more serious results such as restless, loss of interest or pleasure, or thoughts of death or suicide and the cure rate of depression episode is lower than that of manic episode. Furthermore, a long term use of antidepressants in bipolar patients may result in manic episode. Our interest is to investigate the effect of antidepressant on switch of moods of bipolar patients and to estimate the transition probabilities of switch between moods, depression and (hypo) manic. In this study, three approaches are applied in terms of multi state model. Parametric model is applied using left censoring data and nonparametric model is implemented under illness-death model with counting process. In order to estimate the effect of covariates, a multiplicative model is used. These all methods have similar results.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.26 no.2
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• pp.187-192
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• 2022

Even the announcing date for the staring date of "With Corona" has been decided, still many people have not completed vaccination, the most important condition for starting the With Corona, because of concerns for its side effects. In addition, although the economy may can be recovered by the With Corona, but the number of infected people may can be surged. In this paper, in order to awaken the people for the awareness of Corona 19 in advance of the With Corona, the Corona 19 is predicted through a non-linear probability process. Here, among the deep learning RNN, BI-LSTM, which is a bidirectional LSTM, and GRU, gates decreased than LSTM have been used. And this has been compared and analyzed through train set, test set, loss function, residual analysis, normal distribution, and autocorrelation, and compared and predicted for which has a better performance.

• Progress in Medical Physics
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• v.25 no.3
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• pp.176-184
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• 2014

In this study, we compared dose distributions from simultaneously integrated boost (SIB) method versus the RTOG 0631 protocol for spine radiosurgery. Spine radiosurgery plans were performed in five patients with localized spinal metastases from hepatocellular carcinoma. The computed tomography (CT) and T1- and T2-weighted magnetic resonance imaging (MRI) were fused for delineating of GTV and spinal cord. In SIB plan, the clinical target volume (CTV1) was included the whole compartments of the involved spine, while RTOG 0631 protocol defines the CTV2 as the involved vertebral body and both left and right pedicles. The CTV2 includes transverse process and posterior element according to the extent of GTV. The doses were prescribed 18 Gy to GTV and 10 Gy to CTV1 in SIB plan, while the prescription of RTOG 0631 protocol was applied 18 Gy to CTV2. The results of dose-volume histogram (DVH) showed that there were competitive in target coverage, while the doses of spinal cord and other normal organs were lower in SIB method than in RTOG 0631 protocol. The 85% irradiated volume of VB in RTOG 0631 protocol was similar to that in the SIB plan. However, the dose to normal organs in RTOG 0631 had a tendency to higher than that in SIB plan. The SIB plan might be an alternative method in case of predictive serious complications of surrounded normal organs. In conclusion, although both approaches of SIB or RTOG 0631 showed competitive planning results, tumor control probability (TCP) and normal tissue complication probability (NTCP) through diverse clinical researches should be analyzed in the future.

• Tuberculosis and Respiratory Diseases
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• v.44 no.6
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• pp.1296-1307
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• 1997

Background : Erdosteine is a thiol derivative developed for the treatement of chronic obstructive bronchitis, including acute infective exacerbation of chronic bronchitis. Erdosteine has mucomodulating and antioxidant properties and especially exhibits excellent gastrointestinal tolerability. Methods : The study was conducted as a prospective evaluation, with 2 comparative groups orally treated with erdosteine 300mg (bid.) or ambroxol 30mg (b.i.d.) for 7 days and the design of trial was double-blind. The treatments have been assigned randomly to patients (n=80) with acute or chronic bronchitis. The primary end-point used to determine efficacy in this study was subjective symptoms including expectorating frequence, expectoration volume, expectorating difficulty, expectoration viscosity, cough intensity and dyspnea. The secondary end-points of efficacy was the result of arterial blood gas analysis and pulmonary function test. Safety was evaluated with adverse drug reactions and laboratory tests monitoring. 61 patients was included in the efficacy analysis, due to the fact that 19 patients drop-out for different reasons. The obtained values have been analyzed with paired Hest., ANOVA test., multivariate $t^2$-test, repeated measures analysis of covariance, two sample t-test, loglinear-logit model analysis, Fisher's exact test. Results : 1) There was no significant difference on demographic data and vital signs between erdosteine and ambroxol treated groups. 2) The comparison between erdosteine and ambroxol treated groups showed no significant difference in improvement of each symptom in spite of the more favorable efficacy obtained with erdosteine. No difference on the contrary was observed for arterial blood gas analysis and pulmonary function test. 3) As safety is concerned, no clinical significant changes in laboratory test and symptom were induced in erdosteine and ambroxol treated group and two patients in ambroxol treated group drop-out for adverse reactions in symptom. 4) In the evaluation of final clinical efficacy, erdosteine improved more effectively patient's overall symptoms {very good effect (11/31), good effect (12/31), moderate effect (6/31), no effect (2/31), aggravation (0/31)} than ambroxol {very good effect (6/30), good effect (14/30), moderate effect (5/30), no effect (4/30), aggravation (2/30)}. And the probability of symptomatic improvement by erdosteine compared to ambroxol was 2.5 times. (p<0.05). Conclusion : This study showed that erdosteine was clinically effective and safe drug for treatment of acute and chronic bronchitis.

• Progress in Medical Physics
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• v.27 no.1
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• pp.14-24
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• 2016

Since the head and neck region is densely located with organs at risk (OAR), OAR-sparing is an important issue in the treatment of head and neck cancers. This study-in which different treatment plans were performed varying the head tilt angle on brain tumor patients-investigates the optimal head elevation angle for sparing normal organs (e.g. the hippocampus) and further compares the dosimetric characteristics of different types of radiation equipment. we performed 3D conformal radiation therapy (3D-CRT), intensity-modulated radiation therapy (IMRT), and tomotherapy on 10 patients with brain tumors in the frontal lobe while varying the head tilt angle of patients to analyze the dosimetric characteristics of different therapy methods. In each treatment plan, 95% of the tumor volume was irradiated with a dose of 40 Gy in 10 fractions. The step and shoot technique with nine beams was used for IMRT, and the same prescription dose was delivered to the tumor volume for the 3D-CRT and tomotherapy plans. The homogeneity index, conformity index, and normal tissue complication probability (NTCP) were calculated. At a head elevation angle of $30^{\circ}$, conformity of the isodose curve to the target increased on average by 53%, 8%, and 5.4%. In 3D-CRT, the maximum dose received by the brain stem decreased at $15^{\circ}$, $30^{\circ}$, and $40^{\circ}$, compared to that observed at $0^{\circ}$. The NTCP value of the hippocampus observed in each modality was the highest at a head and neck angle of $0^{\circ}$ and the lowest at $30^{\circ}$. This study demonstrates that the elevation of the patients' head tilt angle in radiation therapy improves the target region's homogeneity of dose distribution by increasing the tumor control rate and conformity of the isodose curve to the target. Moreover, the study shows that the elevation of the head tilt angle lowers the NTCP by separating the tumor volume from the normal tissues, which helps spare OARs and reduce the delivered dose to the hippocampus.

• The Journal of Korean Society for Radiation Therapy
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• v.18 no.1
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• pp.13-19
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• 2006

Purpose: To evaluate whether modified MUPIT applicator can effectively eradicate recurrent tumor in uterine cervix cancer and reduce rectal complication after complete radiation treatment. Materials and Methods: Modified MUPIT applicator basically consists of an acrylic cylinder with flexible brain applicator, an acrylic template with a predrilled array of holes that serve as guides for interstitial needles and interstitial needles. CT scan was peformed to determine tumor volume and the position of interstitial needles. Modified MUPIT applicator was applied to patient in operation room and the accuracy for position of interstitial needles in tumor volume was confirmed by CTscan. Brachytherapy was delivered using modified MUPIT applicator and RALS(192-lr HDR) after calculated computer planning by orthogonal film. The daily dose was 600cGy and the total dose was delivered 3,000 cGy in tumor volume by BID. Rectal dose was measured by TLD at 5 points so that evaluated the risk of rectal complication. Results: The application of modified MUPIT applicator improved dramatically dose distributions in tumor volume and follow-up of 3 month for this patient was clinically partial response without normal tissue complication, Rectal dose was measured 34.1 cGy, 57.1 cGy, 103.8 cGy, 162.7 cGy, 165.7 cGy at each points, especially the rectal dose including previous EBRT and ICR was 34.1 cGy, 57.1 cGy. Conclusion: Patients with locally recurrent tumor in uterine cervix cancel treated with modified MUPIT applicator can expect reasonable rates of local control. The advantages of the system are the fixed geometry provided by the template and cylinders. and improved dose distributions in irregular tumor volume without rectal complication.