• Journal of the Korea Convergence Society
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• v.11 no.5
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• pp.241-251
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• 2020

This study was performed to develop the cosmetics containing extract of U.davidiana, which has been confirmed as a functional ingredient of anti-microbial, anti-oxidant, and anti-inflammatory effects, and also to evaluate the improvement effects of dry and sensitive skin such as atopic dermatitis. Toxicity tests of the Ulmus davidiana supercritical fluid residue 60% EtOH extracts(USCFR), Ulmus davidiana supercritical fluid extracts(USCF) and preliminary formulations, DKBP-1903(gel), containing the USCFR and USCF were determined to be 'Non-toxic'. Based on this, the stability test of the lotion, cream, gel formulation was conducted and the results showed that cream and gel formulation were stable. A 48-hour moisturizing sustainability test and the improvement test on the pruritus caused by dryness were selected for the cosmetic efficacy test to evaluate the improvement of atopic dermatitis and as a result both cream and gel have been found to be relatively safe moisturizers that can help dry and sensitive skin.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.47 no.2
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• pp.179-184
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• 2021

Stratum corneum known as a skin barrier, which maintains water in skin, is the outer layer of the skin. Natural moisturizing factors (NMF) are one of the constituents in stratum corneum and amino acids are the highest components among NMF. In this study, we designed stearic acid-based solid lipid nanoparticles (SLNs) for improved skin penetration of serine (Ser). Ser-capsulated SLN was manufactured by double-melting emulsification method. The mean particle size and zeta potential of SLNs were 256.30 ~ 416.93 nm and -17.60 ~ -35.27 mV, respectively. The higher the degree of hydrophobicity or hydrophilicity of emulsifiers, the smaller the particle size and the higher the stability and capsulation rate. In addition, skin penetration was conducted using SkinEthic^TM RHE which is one of the reconstructed human epidermis models. The results of Ser penetration demonstrated that all SLNs enhanced than serine solution. The amount of enhanced Ser penetration from SLNs were approximately 4.1 ~ 6.2 times higher than that from Ser solution. Therefore, Ser-loaded SLN might be a promising drug delivery system for moisturizing formulation in cosmeceutical.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.27 no.3
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• pp.276-282
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• 1982

To estimate the responses of sesame plant in growth and yielding traits to different soil drainage conditions, a pot trial was conducted by using of sesame variety "Suweon-9" were introduced with 5 different mixing combinations of clay and sea-sand soils as 0:100, 25:75, 50:50, 75:25, and 100:0 percents in volumetric ratio. Also two irrigation methods as 20mm/6 days interval and 10mm/3 days interval were detected. As a result, water drainage was linearly decreased with increament of clay contents. And the excess drainage condition(such as pure sand soil) required more irrigation, however in crop growths, no significant differences among various soil drainage conditions except the pure sand were recognized. On the other hand, number of capsules per plant, among other yielding components, was most contributed factor to the yield, which was effectively given from the soil mixed with clay and sea-sand as 75% and 25%, respectively. Therefore, much similar responses were also detected from the seed yields per a sesame plant. However, the number of seeds per capsule and maturity function were more effectively composed under the soil mixed with clay and sea-sand as 25% and 75% respectively better than under the soil of 75% and 25%. As a conclusion, the yielding responses of sesame plant was advanced more effectively at the soil conditions of water conserved type (e.g. 25%/75% in clay/sand ratio) than of water-draining type (e.g. 75%/25% in clay/sand ratio).nd ratio).

• Journal of the Korean Applied Science and Technology
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• v.40 no.5
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• pp.936-944
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• 2023

The purpose of this study is to verify the effect of essence containing Coptis Japonica extract on skin barrier strengthening and moisturizing. The essence containing the Coptis Japonica extract was used by 22 subjects for four weeks, and the amount of percutaneous water loss (g/m²h) and water (A.U.) in the designated upper limit were measured. As a result of measuring percutaneous water loss using a vapometer, it was found to be 11.08±2.55 after 4 weeks of use from 14.82±4.01 before use, and the significance probability decreased significantly by 25.27% to p<0.001. The amount of skin moisture measured by the Corneometer was found to be 46.73±7.45 after use from 31.73±8.09 before use, and the significance probability increased by 47.26% to p<0.001, and the subject's subjective efficacy evaluation through a questionnaire showed that all subjects were 100% satisfied without skin adverse reactions. As a result of this, it has been confirmed that Coptis Japonica essence is effective in strengthening skin barriers and moisturizing, which is expected to be a cornerstone for the development of cosmetics using various activities of Coptis Japonica extract in the future.

• Journal of the Korean Applied Science and Technology
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• v.37 no.5
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• pp.1285-1297
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• 2020

In this study, we report the results of a study on the clinical evaluation of wrinkle improvement by developing a method for liposome of high-purity Centella asiatica extract used in pharmaceuticals and cosmetics, and a cream using the same. In order to make Centellasome-10EX stabilizing centella asiatica extract in liposome lamella vesicle, it could be completed using 5% hydrogenated lecithin and 2% sucrose distearate. The appearance of Centellasome-10EX was a creamy form of low viscosity, the color was pale yellow, and the odor had the inherent odor of the raw material. The pH was about 6.12, the specific gravity was 1.09, and the acid value was about 0.35. The content of the main constituents of centella asiatica extract contained in the liposome vesicle contains 10,800 ppm of asiatic acid, 10,900 ppm of asiaticoside, 6,000 ppm of madecasic acid, and 1,600 ppm of madecassoside, and long-term storage. There was no discoloration even at the time, and it was found that the main component remained stable thermodynamically. To mechanistically analyze the structure of the liposome vesicle of Centellasome-10EX, as a result of observation with a transmission electron microscope (Cryo-TEM), the multilayer vesicles are formed and filled with moisture, and there are 10 to 60 multilayers around it. It was confirmed that the liposome lamella vesicle was formed. As a clinical trial (in-vivo) test, the moisturizing effect of centellasome cream after application for 5 weeks was 28.3%, which was significantly increased compared to placebo. The skin elasticity effect was 13.6%, which significantly increased the moisturizing power than the placebo. The effect of improving fine wrinkles around the eyes was improved by 23.52% compared to placebo cream. Through the results of this study, it was possible to study the formulation and manufacturing method for encapsulation and stabilization of the developed Centellasome-10EX in the liposome vesicle. It is expected that the results obtained through clinical research on the wrinkle improvement effect of the cream using this can be widely used to study skin science in the cosmetic industry and to develop high-quality cosmetics with high efficacy.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.23 no.2
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• pp.48-62
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• 1997

Chitosan oligosaccharides having aldehyde group at reducing end were prepared by oxidative-deamination reaction of chitosan by using sodium nitrite, and the resulting aldehyde group was reduced to 2, 5-anhydro-D-mannitol group. The obtained chitosan oligosaccharides showed an average degree of polymerization 2~3 by gel permeation chromatography analysis. It was highly soluble in hydrophilic solvents and thermally stable. N, N-diacyl, O-acyl chitosan oligosaccharides were obtained from the reaction between chitosan oligosaccharides and acyl chloried under dimethylaminopyridine. From differential scanning calorimetric measurement, N, N-dilauroyl, O-lauroyl chitosan oligosaccharides showed mesophase region, which was confirmed by polarized microscope as a thermotropic liquid crystalline state. X-ray diffraction pattern revealed that N, N-dilauroyl, O-lauroyl chitosan oligosaccharedes were highly crystalline, whereas chitosan oligosaccharides were not.

• Korean Journal of Food Science and Technology
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• v.27 no.2
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• pp.170-175
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• 1995

Physical and physiological properties of isomaltooligosaccaride (IMO), fructooligosaccharide (FO) and sucrose were investigated. The viscosity and moisture retention power of IMO were similar to those of FO. IMO had an excellent heat and pH stability compared with FO and sucrose. To investigate the effect of oligosaccharides on the growth of mice, each sample was administered orally to mice for 2 weeks. Weight change, moisture content of feces, weight of appendix and the ratio of Bifidobacterium to total microorganisms in the feces were examined. There were no significant differences in the weight increases and the efficiency of feeds. Moisture content of feces was highest in the IMO feeding group, and IMO promoted selectively the growth of Bifidobacterium. On the other hand, FO group showed bigger cecum than other groups.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.40 no.3
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• pp.247-257
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• 2014

Oil-in-water nanoemulsions of astaxanthin prepared by new vesicle, glyceryl citrate/ lactate/ linoleate/ oleate, were evaluated thoroughly in terms of cosmeceutical properties such as antioxidant effect, cell viability, influence of protein related enzyme, skin penetration, skin hydration and elasticity. Antioxidant effect and cell viability of nanoemulsion of astaxanthin were evaluated by DPPH and MTT assay. Also other properties of nanoemulsions of astaxanthin were measured by proteome analysis using 2D-PAGE, confocal laser scanning microscope and in-vivo test. We were able to find that the nanoemulsion of astaxanthin is good at scavenging of radical and inhibits the degradation of dermal extracellular matrix with the down-regulation of MMPs and other proteins related to MMP expression. CLSM was adopted for observing penetration of nanoemulsion of astaxanthin and showed high effective penetration rate compared to the nanoemulsion of astaxanthin prepared by conventional lecithin. In-vivo measurement of the nanoemulsions in hydration and elasticity were conducted to 11 Korean female adults for 28 days and showed better results.

• Journal of Convergence for Information Technology
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• v.11 no.11
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• pp.288-295
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• 2021

This study was conducted to investigate the effect of end paper adsorbed with mask pack active ingredients on hair during permanent wave treatment. Permanent wave was performed with purchasing mask packs containing green tangerine, collagen, and Houttuynia cordate active ingredients among commercially available mask packs and adsorbing them to the end paper. As experimental methods, hair thickness, hair moisturizing power, tensile strength, hair epidermis observation using SEM, and hair constituent element analysis using EDS were performed. As a result of the experiment, it was confirmed that the experimental group treated with Houttuynia cordate active ingredient on the end paper had a hair protection effect as a result of hair thickness, tensile strength, hair epidermis observation, and hair component analysis. In addition, it was confirmed that the experimental group treated with green tangerine active ingredient on the end paper contained a relatively large amount of moisture in the hair moisturizing power test result. It is hoped that the development and research of various materials and tools will proceed so that basic cosmetic products containing active ingredients can be developed and used as hair cosmetics, and applied during chemical treatment in the industrial field.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.20 no.1
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• pp.14-24
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• 1994

Mma-5 and Malva are extracts from a defined seaweed of the Rhodophyceae family and an annual or perenial plant, respectively. They have traditionally a significant stimulating properties such as protein synthesis, astringent, emollient, and et al.. In order to investigate the effect on wound healing, we studied for cell migration, cell attachment, and cell proliferation in vitro. The results of present study demonstrated that MMA-5 and Malva extract had the effect on wound healing, therefore we suggested that they could be effective materials to be applied to Cosmetic products.