• Radiation Oncology Journal
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• v.8 no.2
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• pp.261-267
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• 1990

Twenty patients with biopsy-proven Waldeyer's ring lymphoma were treated with radiotherpy between 1984 and 1990 at the Department of Radiation Therapy, Inje University Paik Hospital and seventeen evaluable patients were analysed retrospectively. Dose of radiation ranged from 35 to 50 Gy to Waldeyer's ring structure with an additional 5 and 10 Gy boost dose to the primary site. The lower cervical nodes received 35 to 60 Gy. The median follow-up period was 24 months (range;9 to 80 months). The 5-year overall survival rate was $50.2{\%}$ and 5-year disease free survival rate was $47.1{\%}$. The final local control rate was $82.4{\%}$. The relapse developed average 10 months after treatment. Most of relapses were systemic ($87.5{\%}$). The patients with stage I disease fared better than advance stage. The favorable histology of lymphoma showed better prognosis than unfavorable histology. There was no significant difference in survival rate between radiotherapy alone and combination of chemotherapy and radiotherapy in early stage lymphomas. But of the patients with advanced stage, those who received chemotherapy and radiotherapy had better prognosis than those treated with radiotherapy alone.

• Journal of the Korean Society of Radiology
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• v.10 no.3
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• pp.195-200
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• 2016

Acute promyelocytic leukemia(APL) is not just the poor grades of treating a type of blood cancer hayeoteul combination with chemotherapy despite concurrent radiation therapy are known to exhibit a greater effect and also works on normal cells to result in side effects. In this study, when after treatment with gamma rays, such as $TNF-{\alpha}$ in order to reduce these side effects was confirmed how affected the cell death of normal cells and cancer cells. HL-60 cells were used as the APL cell line HL-60 cells were differentiated with DMSO for treatment are shown the properties of normal granulocytes was used as a control group. As a result, HL-60 cells treated with $TNF-{\alpha}$ and gamma rays with only showed a cytotoxic effect by inducing the apoptosis cells were put to death. Consequently, $TNF-{\alpha}$ is thought to active substances that can increase the efficiency of cancer treatment to increase the removal of cancer cells when used with low-density gamma-ray treatment in order to eliminate the side effects of chemotherapy.

• Radiation Oncology Journal
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• v.9 no.1
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• pp.59-63
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• 1991

Thirty-one patients with previously untreated and locally advanced nasopharyngeal cancer were retrospectively reviewed for comparing the effects of radical radiotherapy alone with that of combining chemotherapy and radiotherapy from 1983 to 1989 at Kangnam 51. Mavy's hospital.23/31 were evaluable for recurrence and suwival. There were 8 patients for stage III, and 15 patients for stage IV. Eleven patients were treated with radical radiation therapy done (arm I). Twelve patients were given 1~3 courses of cisplatin-5FU or cisplatin-bleomycin-vincristine prior to radiation therapy (arm II). The two arms were comparable in patient characteristics Of 11 radiotherapy Patients, complete response was 55%(6/11) and Partial response 45%(5/11). Among 12 patients after induction chemotherapy, complete response was 25%(3/12) and partial response 75%(9/12). After subsequent radiotherapy, complete response was increased to 83%(10/12) and partial response was 17%(2/12). Treatment failure was 30%(local recurrence; 3/11, and regional recurrence; 1/11) in arm 1 and 33% (local recurrence; 1/12, regional recurrence; 2/12 and distant metastasis; 1/12) in arm ll . There was no significant difference in survival between arm I and arm II (p> 0.05). The toxicities of treatment were acceptable. More controlled clinical trials must be completed before acceptance of chemotherapy as part of a standard radical treatment for locally advanced nasopharyngeal cancer.

• Journal of Gastric Cancer
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• v.9 no.3
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• pp.128-135
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• 2009

Purpose: The aim of this study was to compare synchronous and metachronous hepatic metastases in patients with gastric cancer to determine clinicopathologic features and differences in prognosis as a function of the timing of the metastasis and the treatment modality rendered. Materials and Methods: Sixty-seven patients who were diagnosed with gastric cancer metastatic to the liver and treated at the Hanyang University Hospital between June 1992 and December 2006 were retrospectively analyzed to study the pertinent clinicopathologic features and effect of treatment methods. Results: There was a significant difference with respect to lymphatic (P=0.041) and vascular invasion (P=0.036) in comparing the clinicopathologic features between the patients with synchronous and metachronous hepatic metastases. The 1-year survival rate and median survival time of patients with gastric cancer and liver metastases were 38.9% and 9.2 months in the entire patient cohort, 30.9% and 9.2 months in the synchronous group, and 44.5% and 9.7 months in the metachronus group, respectively (P=0.436). The group of patients undergoing local treatment (such as surgery and radiologic intervention) followed by systemic chemotherapy, the group of patients receiving systemic chemotherapy only, and the untreated group of patients were compared, and there was no difference between the synchronous and metachronous groups. The synchronous and metachronous groups had high survival rates with local treatment. Conclusion: In patients with gastric cancer and liver metastases, there was no difference in prognosis based on the timing of the hepatic metastases. Independent of the timing of hepatic metastasis, aggressive treatment, such as surgery and radiologic intervention, may help improve the prognosis.

• Proceedings of the Korea Information Processing Society Conference
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• 2000.10b
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• pp.1569-1572
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• 2000

본 연구에서는 가상현실을 이용한 의료 기술로서 손 재활 치료 시스템을 설계한다. 손 재활 치료는 직접적인 손의 손상으로 인한 환자뿐만 아니라 뇌손상이나 다른 신경의 손상을 입은 환자 등 다양한 원인에 의하여 발생한 환자들에게 필요하다. 많은 경우에, 손재활 치료를 통하여 운동력의 향상뿐만 아니라 판단력이나 사고력을 높이는 것까지 병행되어야 한다. 본 연구에서는 손재활 치료를 돕기 위하여 햅틱기술과 게임요소를 포함하는 컨텐트를 가진 시스템을 설계하여 테스트한다.

• Journal of Acupuncture Research
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• v.25 no.2
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• pp.27-40
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• 2008

목적 : 요통 환자에서 Sacro Occipital Technique(SOT)의 블로킹 기법을 침구 치료와 동시에 사용했을 때 Oswestry 장애 지수와 VAS의 변화 및 호전도를 비교 분석하고자 하였다. 방법 : 요통으로 내원한 72명의 환자를 대상으로 SOT 기법을 통해 하위 세 분류로 나누고 이에 따라 SOT 기법대로 침구 치료 시 블로킹 가법을 함께 사용하였다. 처음 방문 시에는 치료 전에 설문지를, 그 이후로는 치료 후에 설문지를 기입하여 변화를 관찰하였다. 결과 : 단독 침 치료군에 비해서 Category II와 Category III는 초진과 2차 방문 사이에 효과가 있었다. Category II는 초진과 3차 방문 사이에서 유의성이 더 있었으나 Category III는 유의성이 없었다. Category I은 단독 침 치료군에 비해서 효과가 없었다. VAS로 측정한 경우에는 SOT군 치료군 어느 군에서도 단독 침 치료군에 비해 통계적으로 유의미한 효과를 보이지 못했다. 결론 : 요통에 침구치료를 겸한 SOT 블로킹 치료는 선택적으로 효과를 보이며 그 가운데 Category II로 진단된 요통환자에게서 높은 효과를 보인다.

• The Journal of the Korean bone and joint tumor society
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• v.6 no.1
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• pp.41-46
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• 2000

We experienced the case of familiar hypercholesterolemia with multiple xanthomas which was treated by combined surgical and medical therapy. He was 26-year-old male patient of familiar hypercholesterolemia with multiple xanthomas in 22 sites on whole body, and was treated by 17 surgical excisions of the xanthomas and by medical therapy of the hypercholesterolemia. There was a normal healing process of the surgical wounds. Continual postoperative medical therapy of the hypercholesterolemia was done. There was no recurrence of the symptoms during more than 13 months of follow-up. But the serum level of the cholesterol was not lowered significantly, so we are treating him with drug therapy. Familial hypercholesterolemia is caused by a specific disorder of lipid metabolism, and is characterized by increased LDL cholesterol, tendon xanthomas, coronary disease associated with autosomal dominant transmission. Xanthomas usually appear in the second decade of life with familiar hypercholesterolemia which may have high risk for premature coronary atherosclerosis, which might be prevented with early diagnosis and medical treatment. So, orthopedic surgeons do not only excise the xanthomatosis surgically but also can diagnose the underlying hypercholesterolemia.

• Childhood Kidney Diseases
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• v.7 no.1
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• pp.1-8
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• 2003

Purpose : Focal segmental glomerulosclerosis(FSGS) is known to have a poor prognosis and a poor response to treatment. We performed a combination therapy of plasmapheresis, steroid pulse and immunoglobulin in 4 patients with relapsed steroid dependent(SD) or steroid resistant(SR) FSGS after steroid pulse therapy. Materials and Methods : 8 cycles of plasmapheresis were performed in 4 patients with biopsy proven FSGS who had relapsed after steroid pulse therapy from March 1988 to July 2002. Clinical findings and treatment courses were reviewed retrospectively. Results : Among the 4 patients, there were 3 males and 1 female. After 8 cycles of plasmapheresis, clinical remissions were obtained. Two of the four patients had two relapses and received 2 more cycles of plasmapheresis which resulted in remissions. One of these patients had two further relapses and was treated with oral steroid resulting in clinical remission. Three patients have maintained normal serum creatinine level and glomerular filtration rates during the follow-up period of 10 years, and the other 1 patient for 5 months. Conclusion : A combination therapy of plasmapheresis, steroid pulse and immunoglobulin led to a complete remission in patients with FSGS who were SD or SR and was effective in maintaining normal renal function.

• Journal of radiological science and technology
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• v.27 no.3
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• pp.59-69
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• 2004

By studying on the characteristics of cancer patients who receive radiotherapy and the attitudes of medical social workers, this thesis aims to suggest of requirements for medical social work intervention. The study was conducted using SPSS 10.0 for Windows to analyze data taken from a survey involving 90 cancer patients receiving radiotherapy in 4 general hospitals in Daejeon city. The data were collected form Oct. 1st to 15th, 2003, and its analyses used averages, correlation, and regression. The results were summarized as follows ; 1. The average family income in 67.8% of the cases was less than 2,000,000 won, which is a lower income bracket. In the disease characteristics, fatigue ware the highest (2.78) in the side effects of radiotherapy, which most patients were receiving alongside other forms of treatment. 2. It was shown that cancer patients receiving radiotherapy receive a high level of psychological and social support from doctors and other medical staffs, and that they also received a high average (4.38) of individual care and encouragement from family members. 3. In the psychosocial status, the need for financial assistance in the form of a national aid program or an expansion of medical insurance was great, especially in the need for house keeping service and night nurses. The need for psychosocial counselling rose following rises in treatment side effects and depression. Information for cancer patients was especially needed in the areas of treatment plans, treatment costs, and side effects of radiotherapy. The need for information rose in accordance with an elongation of hospital treatment and an escalation of care from family members.

• Journal of the korean academy of Pediatric Dentistry
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• v.46 no.3
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• pp.239-246
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• 2019

The purpose of this study was to examine dental complications and to evaluate the effects of initial treatment age, treatment modalities, and treatment duration on the disorder after radiation and chemotherapy in pediatric cancer patients. For 93 children with clinical and radiographic data, the number of teeth, the morphology of teeth, the shape of the roots, and development status of the dentition were evaluated. Dental development disorders were found in 61.3% of the children. The mostly found abnormality was root deformity with the prevalence of 31.2%. In children submitted to the therapy before the age of 6, the number of missing teeth (p = 0.029) and microdontia (p = 0.003) were greater compared to the children who started to receive the treatment after the age of 6. The combination of radiation and chemotherapy showed significantly greater incidences of missing teeth (p = 0.030), microdontia (p = 0.046), and root deformity (p = 0.009) when compared with the sole application of chemotherapy. When the children were submitted to anticancer therapy for 18 months or longer duration, greater number of missing teeth (p = 0.032), microdontia (p = 0.011), root deformity (p = 0.025), and total number of teeth affected (p = 0.036) were observed compared with duration less than 18 months. The number of dental abnormalities increased when the children were treated at earlier ages, with combination of radiation and chemotherapy, and for longer period of time.