• The korean journal of orthodontics
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• v.36 no.4
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• pp.284-294
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• 2006

Objective: Activating mutations in the fibroblast growth factor receptor-2 (FGFR2) have been shown to cause syndromic craniosynostosis such as Apert and Crouzon syndromes. The purpose of this pilot study was to investigate the resultant phenotypes induced by the two distinctive bone-targeted gene constructs of FGFR2, Pro253Arg and Cys278Phe, corresponding to human Apert and Crouzon syndromes respectively. Methods: Wild type and a transgenic mouse model with normal FGFR2 were used as controls to examine the validity of the microinjection. Micro-CT and morphometric analysis on the skull revealed the following results. Results: Both Apert and Crouzon mutants of FGFR2 induced fusion of calvarial sutures and anteroposteriorly constricted facial dimension, with anterior crossbite present only in Apert mice. Apert mice differed from Crouzon mice and transgenic mice with normal FGFR2 in the anterior cranial base flexure and calvarial flexure angle which implies a possible difference in the pathogenesis of the two mutations. In contrast, the transgenic mice with normal FGFR2 displayed normal craniofacial phenotype. Conclusion: Apert and Crouzon mutations appear to lead to genotype-specific phenotypes, possibly causing the distinctive sites and sequence of synostosis in the calvaria and cranial base. The exact function of the altered FGFR2 at each suture needs further investigation.

• Progress in Medical Physics
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• v.23 no.4
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• pp.309-316
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• 2012

Multimodal-imaging technique has been rapidly developed for improvement of diagnosis and evaluation of therapeutic effects. In despite of integrated hardware, registration accuracy was decreased due to a discrepancy between multimodal image and insufficiency of count in accordance with different acquisition method of each modality. The purpose of this study was to improve the PET image by event data resampling through analysis of data format, noise and statistical properties of small animal PET list data. Inveon PET listmode data was acquired as static data for 10 min after 60 min of 37 MBq/0.1 ml $^{18}F$-FDG injection via tail vein. Listmode data format was consist of packet containing 48 bit in which divided 8 bit header and 40 bit payload space. Realigned sinogram was generated from resampled event data of original listmode by using adjustment of LOR location, simple event magnification and nonparametric bootstrap. Sinogram was reconstructed for imaging using OSEM 2D algorithm with 16 subset and 4 iterations. Prompt coincidence was 13,940,707 count measured from PET data header and 13,936,687 count measured from analysis of list-event data. In simple event magnification of PET data, maximum was improved from 1.336 to 1.743, but noise was also increased. Resampling efficiency of PET data was assessed from de-noised and improved image by shift operation of payload value of sequential packet. Bootstrap resampling technique provides the PET image which noise and statistical properties was improved. List-event data resampling method would be aid to improve registration accuracy and early diagnosis efficiency.

• KIPS Transactions on Software and Data Engineering
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• v.6 no.2
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• pp.103-116
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• 2017

In this paper, we present the design and implementation of a large-scale qualitative spatial reasoner, which can derive new qualitative spatial knowledge representing both topological and directional relationships between two arbitrary spatial objects in efficient way using Aparch Spark SQL. Apache Spark SQL is well known as a distributed parallel programming environment which provides both efficient join operations and query processing functions over a variety of data in Hadoop cluster computer systems. In our spatial reasoner, the overall reasoning process is divided into 6 jobs such as knowledge encoding, inverse reasoning, equal reasoning, transitive reasoning, relation refining, knowledge decoding, and then the execution order over the reasoning jobs is determined in consideration of both logical causal relationships and computational efficiency. The knowledge encoding job reduces the size of knowledge base to reason over by transforming the input knowledge of XML/RDF form into one of more precise form. Repeat of the transitive reasoning job and the relation refining job usually consumes most of computational time and storage for the overall reasoning process. In order to improve the jobs, our reasoner finds out the minimal disjunctive relations for qualitative spatial reasoning, and then, based upon them, it not only reduces the composition table to be used for the transitive reasoning job, but also optimizes the relation refining job. Through experiments using a large-scale benchmarking spatial knowledge base, the proposed reasoner showed high performance and scalability.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.5
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• pp.79-85
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• 2017

As the number of patients suffering from Pes Planus increases, research on a correctional insole that can cope with them is increasingly required. Therefore, the design of an insole for Pes Planus Correction was studied using the superelastic effect, which is one of the characteristics of the shape memory alloy in this paper. To design an effective insole, the effect of the contact pressure induced by the insole on the plantar fascia, which is the most important muscle in the foot structure, was evaluated. Three parameters (thickness, max. height and asymmetric ratio) were set as the main design factors of the insole, and the maximum contact pressure appearing on the plantar fascia was calculated by finite element analysis and analyzed using the Taguchi method. As a result of the analysis, it was confirmed that the contact pressure was influenced in the order of max. height, thickness, and asymmetric ratio. In addition, the contact pressure was converted to a feeling pressure that could be felt by a person, and then a safety correction range was established that would not cause any irritation to the plantar fascias, even though the correction effect could be expected. This indicates the best design for the safety correction range. The design method considering the important factors established through this study can form the basis for designing a personalized correctional insole in the future.

• Journal of The Korean Association For Science Education
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• v.36 no.6
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• pp.815-833
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• 2016

This study investigated children's (grade 3 to 9) responses to assessment items on energy as a cross-cutting concept in order to get basic information for a learning progression. The assessment consisted of 8 ordered multiple-choice items at the contexts of electric circuit, mechanical energy of falling objects, phase change of matter, dissolution, biological phenomena of a lizard, food chain, radiative equilibrium between Sun and Earth, and the system of water cycling. Children's responses to each item were analyzed with using cross-tabulations in terms of grades and item option levels and Wright map and Differential item functioning based on Rasch modeled item response analysis. The results offered empirical evidence of children's development of understanding energy from relation between energy and its phenomena, types of energy, transfer and conversion of energy, towards conservation and equilibrium of energy for all of eight contexts. Children of each grade did not fully understand energy conservation. As grade goes up, their understandings of energy transfer and conversion were differentiated across the contexts and topics of energy. According to Rasch analysis, children had easier understanding of energy on dissolution and poorer understanding of energy on water cycling than that on other contexts. It was discussed and suggested that the results of this study help us organize science topics with regard to energy when developing new national science curriculum.

• Communications of Mathematical Education
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• v.31 no.4
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• pp.433-456
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• 2017

The purpose of this study is to suggest the directions for the development and improvement of mathematics textbooks in Korea by examining these characteristics of German textbooks. As a result, German mathematics textbooks were free for unit order and names of units. German mathematics textbooks defined a function for various real life and natural phenomena, relation after intuitively knowing the correspondence between two variables through a graph. In addition, it exercises interpreting the characteristics and information of the graph, guides the activity of graphing various functional situations, and contents to convert various expression methods such as graphs, tables, relational expressions, mathematical terms and sentences. In the German mathematics textbooks, mathematical expressions of the functional relations of the materials in various contexts of daily life, and the activities of predicting and predicting the future, were made to feel the usefulness of mathematics. It has raised functional thinking and provided problems related to other subjects, thus enhancing connectivity with other disciplines. It also included open issues and issues that required mathematical communication.

• Journal of the Korean Institute of Intelligent Systems
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• v.26 no.5
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• pp.375-382
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• 2016

In this paper, we presents a signatures verification by using the nonlinear quantization histogram of polar coordinate based on multi-dimensional adjacent pixel intensity difference. The multi-dimensional adjacent pixel intensity difference is calculated from an intensity difference between a pair of pixels in a horizontal, vertical, diagonal, and opposite diagonal directions centering around the reference pixel. The polar coordinate is converted from the rectangular coordinate by making a pair of horizontal and vertical difference, and diagonal and opposite diagonal difference, respectively. The nonlinear quantization histogram is also calculated from nonuniformly quantizing the polar coordinate value by using the Lloyd algorithm, which is the recursive method. The polar coordinate histogram of 4-directional intensity difference is applied not only for more considering the corelation between pixels but also for reducing the calculation load by decreasing the number of histogram. The nonlinear quantization is also applied not only to still more reflect an attribute of intensity variations between pixels but also to obtain the low level histogram. The proposed method has been applied to verified 90(3 persons * 30 signatures/person) images of 256*256 pixels based on a matching measures of city-block, Euclidean, ordinal value, and normalized cross-correlation coefficient. The experimental results show that the proposed method has a superior to the linear quantization histogram, and Euclidean distance is also the optimal matching measure.

• Journal of the Institute of Convergence Signal Processing
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• v.19 no.2
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• pp.68-76
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• 2018

In this paper, we describe the correlation processing method of multi-polarization observation data of the Daejeon Correlator. VLBI observations include single or multiple polarized observations depending on the type of object. Polarization observations are performed to observe the characteristics of the object. During the observations of the celestial object, polarization measurements are also performed to determine the delay values and causes of changes in the object. Correlation processing of polarization observation data of the Daejeon correlator is proposed by OCTAVIA of a synchronous reproduction processing apparatus that outputs data input to each antenna unit by using an output bit selection function to convert bits and the order of the data streams is changed, And the input of the Daejeon correlator is configured to perform the polarization correlation processing by conducting correlation processing by setting the existing stream number to be the same. Correlation processing is conducted on the test data observed for the polarization correlation processing and it is verified through experiments that the polarization correlation processing method of the proposed Daejeon correlator is effective.

• Progress in Medical Physics
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• v.12 no.2
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• pp.177-184
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• 2001

The goal of radiation treatment is to deliver a prescribed radiation dose to the target volume accurately while minimizing dose to normal tissues. Due to inaccurate placement of field and shielding block and patient's movement, there could be displacement errors between the planed and treatment regions. In order to verify the location of radiation treatment, we in this study developed the registration algorithm of the x-ray simulator images and portal images and quantified the inaccuracy in terms of shift, scale and rotation. The algorithm for registration of pairs of radiation fields consists of the alignment of pairs of radiation images by points matching and field displacement analysis by field boundary matching. In the first step, paired surface landmarks are matched to calculate the transformation parameters (scale, rotation and shift) using the corresponding line pairs which are created by connecting two landmarks of each image. In the next step, portal field boundary is extracted and then the two field boundaries are matched by the $\rho$-$\theta$ technique. Applying the phantom portal images, detection errors were calculated to be less than 2mm in translation, 1$^{\circ}$ in rotation and 1% in scale. In conclusion, we quantitatively analyzed the displacement error of x-ray simulator images and portal images. The present results could contribute to the study of the radiation treatment verification.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.37 no.8B
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• pp.668-676
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• 2012

In this paper, on the assumption that MPI collective communication function is converted into a group of point-to-point communication functions in the transaction level, an algorithm that optimizes broadcast, scatter and gather function among MPI collective communication is proposed. The MPI hardware engine that operates the proposed algorithm was designed, and it was named the OCC-MPE (Optimized Collective Communication Message Passing Engine). The OCC-MPE operates point-to-point communication by using the standard send mode. The transmission order is arranged according to the algorithm that proposes the most frequently used broadcast, scatter and gather functions among the collective communications, so the whole communication time is reduced. To measure the performance of the proposed algorithm, the OCC-MPE with the Bus Functional Model (BFM) based on SystemC was designed. After evaluating the performance through the BFM based on SystemC, the proposed OCC-MPE is designed by using VerilogHDL. As a result of synthesizing with the TSMC $0.18{\mu}m$, the gate count of each OCC-MPE is approximately 1978.95 with four processing nodes. That occupies approximately 4.15% in the whole system, which means it takes up a relatively small amount. Improved performance is expected with relatively small amounts of area increase if the OCC-MPE operated by the proposed algorithm is added to the MPSoC (Multi-Processor System on a Chip).