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Red Yeast Rice (Monascus purpureus) Extract Prevents Binge Alcohol Consumption-induced Leaky Gut and Liver Injury in Mice (알코올성 간 및 장 손상 마우스모델에서 홍국쌀 추출물의 항산화효과)

  • Gi-Seok Kwon;Dong-ha Kim;Hyun-Ju Seo;Young-Eun Cho;Jung-Bok Lee
    • Journal of Life Science
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    • v.33 no.2
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    • pp.183-190
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    • 2023
  • Red yeast rice, also known as Hong Qu and red Koji, has been used for a long time in Asian functional food and traditional medicine. It consists of multiple bioactive substances, which can potentially be used as nutraceuticals. Alcoholic liver disease (ALD) can range from simple steatosis or inflammation to fibrosis and cirrhosis, possibly through leaky gut and systemic endotoxemia. This study examined the liver and gut effects of red yeast rice (RYR) (Monascus purpureus) ethanol extract against binge ethanol-induced liver injury in mice. RYR extract was orally administered to C57BL/6N mice at a concentration of 200 mg/kg body weight per day for 10 days. Then, mice were administered binge alcohol (5 g/kg/dose) three times at 12 hr intervals. Binge alcohol exposure significantly elevated the endotoxin, aspartate aminotransferase (AST), and alanine transaminase (ALT) activity of plasma, as well as hepatic triglyceride levels; however, RYR treatments reduced these levels. In addition, RYR pretreatment significantly reduced the alcohol-induced oxidative maker protein and apoptosis maker in binge alcohol-induced gut and liver injuries. These results suggest that RYR may prevent alcohol-induced acute leaky gut and liver damage.

Co-occurrence of Matsumuraeses falcana and M. phaseoli (Lepidoptera: Tortricidae) in Soybean Fields, and Polymorphism of Cytochrome c Oxidase Subunit 1 Gene Nucleotide (콩 포장에서 어리팥나방과 팥나방(나비목: 잎말이나방과)의 동시 발생과 시토크롬 c 산화효소 1 유전자 염기서열의 다형성)

  • Jin Kyo, Jung;Eun Young, Kim;Taeman, Han
    • Korean journal of applied entomology
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    • v.61 no.4
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    • pp.641-649
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    • 2022
  • Leaf-rolling moths were collected from soybean fields and identified as Matsumuraeses falcana and Matsumuraeses phaseoli by comparison with laboratory-reared species based on the nucleotide sequence (658 bp) of the mitochondrial cytochrome c oxidase 1 subunit gene (COX1). Ten haplotypes with 0.15-0.46% genetic distance from each other in COX1 were found in 47 samples of M. falcana, in which haplotype A was dominant (approximately 70%). Only one type of COX1 was found in 30 samples of M. phaseoli, and its sequence showed 4.11-4.61% genetic distance from those of M. falcana. Amino acid sequences translated from COX1 were identical in all samples of both species, and they showed synonymous substitutions. Larvae of both species caused damage to soybean leaves and pods and co-occurred simultaneously in the field. The average density of M. falcana was 1.5 times higher than that of M. phaseoli. The results clearly indicate that soybean was the host plant for both species. In addition, Elodia flavipalpis (Diptera: Tachinidae) was found to be a larval parasitoid of Matsumuraeses sp. through identification of the COX1 gene.

A Kinetic Study on the Nucleophilic Substitution Reaction of 2,4-dinitrophenyl 5-substituted-2-furoates Under R2NH/R2NH2+ in 20 mol% DMSO(aq). Effects of Nonleaving Group and Leaving Group on the Reaction Mechanism (R2NH/R2NH2+-20 mol% DMSO(aq)의 조건에서 2,4-dinitrophenyl 5-substituted-2-furoates의 아실 이동반응에 대한 반응속도론적 연구. 반응 메커니즘에 미치는 비이탈기와 이탈기의 효과)

  • Sang Yong Pyun;Kyu Cheol Paik;Man So Han;Bong Rae Cho
    • Journal of the Korean Chemical Society
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    • v.67 no.3
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    • pp.191-198
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    • 2023
  • Acyl transfer reactions of 2,4-dinitrophenyl-5-substituted-2-furoates (1a-d) promoted by R2NH/R2NH2+ in 20mol% DMSO(aq) have been studied kinetically. The reactions are second-order and exhibit downward curves of the Brönsted plots with pKa0 = 9.5, β1 = 0.23-0.35 and β2 = 0.88-0.99. The k1 values increased with a stronger nucleophile and as the electron-withdrawing ability of the 5-furyl substituent increases. In contrast, the k2/k-1 values were nearly idential regardless of the 5-furyl substituents. From these results, a stepwise mechanism with a change in the rate-determining step(RDS) is proposed.

The Relations among Meaning in Work, Life Satisfaction and Depression: The Mediating Effect of Work-Life Balance (일의 의미가 직장인의 삶의 만족 및 우울에 미치는 영향에서 일-삶 균형의 매개효과: 다집단 구조모형분석)

  • Jeong-Mi Lee ;Hwangyu Choi
    • The Korean Journal of Coaching Psychology
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    • v.7 no.1
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    • pp.33-57
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    • 2023
  • This study conducted an e-mail survey of office workers working in large companies in Seoul and Gyeonggi-do to verify the structural relationship between meaning in work, work-life balance, life satisfaction, and depression. The study participants were 329 male and 176 female workers, and a total of 505 ($\bar{M}=38.0$ yrs, $\bar{SD}=8.1$ yrs), and the measurement tools used the Korean version of work meaning scale, work-life balance scale, Korean version of life satisfaction scale, and shortened CES-D. After establishing a research model on the structural relationship between major variables, the measurement model and structural model were verified using the collected data, and the applicability of the model was reviewed through comparison according to group classification by gender and age group. As a result of the analysis, it was found that the work-life balance had a partial mediating effect on the effect of the meaning in work on the life satisfaction and depression of office workers. As a result of analyzing the multi-group structural model by age group, the mediating effect of work-life balance did not differ by age in the effect of meaning in work on life satisfaction, but the mediating effect of work-life balance on meaning in work on depression was different by age. These results suggest that the emphasis needs to vary depending on the target group in the practice of individual and group coaching and counseling.

A Study on the Mediating Effect of Motivation Factors between the Quality of Research Data Metadata and the Activation of Research Data Platform (연구데이터 메타데이터의 품질과 연구데이터플랫폼의 활성화의 관계에서 동기부여 요인의 매개효과 연구)

  • Seong-Eun Park
    • Journal of the Korean Society for Library and Information Science
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    • v.57 no.3
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    • pp.325-350
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    • 2023
  • This study focuses on the impact of research data metadata quality evaluation index on the revitalization of K-BDS, a research data platform in the bio field, and examines the mediating effect of motivation factors for utilizing the platform. The investigation employs a structural equation model analysis and bootstrap analysis to explore the interrelationships among the three variables. The findings demonstrate that researchers who prioritize the quality of metadata display higher motivation to use the research data platform, leading to an intention to activate the platform. The study also confirms the mediating effect of motivation factors. Moreover, a comprehensive understanding of the sub-factors within each variable is attained through regression analysis and Sobel test. The results highlight that enhancing searchability is crucial to activate research data sharing in the bio field, while improving discoverability is vital for research data reuse. Interestingly, the study reveals that citationability does not significantly impact platform activation. As a conclusion, to foster platform activation, it is imperative to provide systematic support by enhancing metadata quality. This improvement can not only increase trust in the platform but also institutionally solidify the benefits of citation.

Effects of Self-esteem, Locus of Control to Military Life on Soldiers Adjusting: Mediating effect of Social Support and Stress Coping Strategies (자기존중감 및 통제소재가 병사의 군 적응에 미치는 영향: 사회적 지지와 스트레스 대처 방식의 매개 효과)

  • Joo Hee Lee ;Jung Kyu Kim
    • Korean Journal of Culture and Social Issue
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    • v.21 no.3
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    • pp.299-315
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    • 2015
  • This study examines correlations among factors that reportedly affect adjustment to military life: self esteem, locus of control,, social support and stress coping strategies. The study also attempts to validate the structural model to enhance understanding of the process of adjusting to the military life. The subjects of the study were 447 listed soldiers from private to sergeant currently stationed and serving in an army post in Gangwon-Do, Korea. The following tools were used for this study. Based on self-inventory questionnaires, evaluations were made regarding self esteem, locus of control, social support, stress management, adaptation to military life. Reliability of each criterion was evaluated based on reliability examination, correlations among parameters were analyzed, and the structural equation model was validated to verify the research model. The results of the study can be summarized as follows. First, internal control and self esteem have significant positive influence on social support and stress coping. Second, internal control and self esteem affect adjusting to military life through social support and active coping, two factors mediated in this study to act as parameters between self-esteem and internal control and military adaption. This study emphasizes intervention such as establishment of a social support system and training for taking necessary actions as limitations of studies dealing with internal traits and military adaptation. Since the subjects of this study were chosen from an army based in a single location for convenience' sake, it may be difficult to generalize the results to analyze the entire military.

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A study of worker's stress symptoms and coping related variables: Focusing on emotional support, self-efficacy, job-satisfaction and job-performance (직장인의 스트레스 증상과 대처 관련 변인에 대한 연구: 정서적 지원, 자기효능감, 직무만족도, 직무성취도를 중심으로)

  • Young-Shin Park;Kyung-Lan Lee;Ja-Young Ahn;Sang-Hee Lee
    • Korean Journal of Culture and Social Issue
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    • v.21 no.3
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    • pp.317-338
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    • 2015
  • The main purpose of this research is to examine the relation of variables related to the worker's stress symptoms and coping. The influence of emotional support(from family, colleague, and boss), self-efficacy (self-regulatory, social, relational, resiliency, and management of work), job-satisfaction, and job-performance on worker's stress symptoms and coping is analyzed. Participants were 559 teachers (elementary 205, junior high 203, senior high 151; male 132, female 427). The results were as follows: There were no significant differences in stress symptoms and coping among primary, junior and senior high school teachers. On the other hand, there were significant differences in stress symptoms and coping between male and female teachers. Female teachers experienced more stress symptoms than male teachers. At the same time female teachers coped more efficiently in stress situation than male teachers. With emotional support, self-efficacy, job-performance and job-satisfaction as independent variables, the result of multiple regression showed that job-satisfaction has a negative influence on stress symptoms. Positive influences on stress coping was found for resiliency of self-efficacy in case of male teachers, and in case of female teachers resiliency of self-efficacy, emotional support from colleague, job-performance, and emotional support from family. Therefore, regardless of the gender of the teachers, high job-satisfaction decreased stress symptoms and high resiliency of self-efficacy increased efficient stress coping. As for female teachers, not only resiliency of self-efficacy but also emotional support from colleague and family, job-performance contributed to coping with stress.

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The Effect of Group Success on Organizational Commitment: Collective Efficacy and Group Cohesiveness of Naval Officials (집단의 성공 경험이 조직몰입에 미치는 영향: 해군 간부들의 집단효능감과 집단응집성을 중심으로)

  • Gil-Hwan Kim ;Ju-Hyun Kim ;Dong-Gun Park
    • Korean Journal of Culture and Social Issue
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    • v.23 no.4
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    • pp.527-556
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    • 2017
  • The purpose of this study was to examine the effect of group success on organizational commitment in organizational situations. It also aimed to investigate the dynamics in the relevance of motivational attitudes to the individual and group level variables(collective efficacy, group cohesiveness). This study used a multi-level model and tested a series of hypotheses through meso-mediation procedure. The results from 613 naval officials in 36 groups provided evidence that; (1) collective efficacy mediated the relationship between group success and group cohesiveness, (2) the cross-level main effects of group success and collective efficacy were shown on vocationa[l self-efficacy, (3) group cohesiveness exerted positive influence on organizational commitment and (4) the meso-mediation effects among the variables at the multi-level were revealed. It was found that the degree of work motivation and motivational attitudes depended on the group's contextual factors, and that each group's shared perceptions on group performance outcomes could be an important motivational source and cornerstone leading to group cohesiveness. The implications and limitations of these study as well as the direction for future study were discussed.

A study on the Changes in the water level-flow relationship curve by the operation of Nakyang Weir in the Dongjin River (동진강 낙양 보 운영에 의한 수위-유량 관계곡선식의 변화)

  • Young Jun Ohk;Seung Hyun Kim;Kang Han Lee;Da Jin Lee
    • Proceedings of the Korea Water Resources Association Conference
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    • 2023.05a
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    • pp.312-312
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    • 2023
  • 동진강 유역은 김제평야를 품고 있어 다른 지역에 비해 농지면적이 차지하는 비중이 크며, 이에 따라 전체 용수 사용량에서 농업용수의 비중이 절대적으로 높은 유역이다. 낙양 보는 동진강 중·상류에 위치한 이수시설로 상류에 위치한 섬진강댐과 같이 동진강 유역의 농업용수 공급에 중요한 역할을 하고 있다. 낙양 보는 현재 동진강 방수문 4문, 김제간선 취입수문 2문, 정읍간선 취입수문 1문이 설치되어 있다. 관개기에는 동진강 도수로의 수문을 폐쇄하여 동진강 본류로의 하천유지용수를 차단하고 김제 배수로의 수문을 운용하여 농업용수를 공급하고 있으며 수혜구역의 용수수요 변화 및 기상상황, 하천상황에 따라 탄력적으로 운영하고 있다. 이러한 가동 보 운영으로 인하여 다양한 수위-유량관계의 변동성이 발생한다. 본 연구에서는 가동 보 운영에 따른 수위-유량관계 곡선식의 변동성을 확인하기 위해 동진강 유역 낙양보 상류에 위치한 정읍시(거산교)관측소를 대상관측소로 선정하였다. 정읍시(거산교)관측소는 2012년에 개발된 수위-유량관계곡선을 2021년까지 사용하였고, 2022년 수위-유량관계곡선식 검증과 재개발을 위하여 유량측정을 실시하였다. 2012년에 개발된 수위-유량관계곡선은 검토 결과 강우에 의한 수위 상승시 보 완전 개방 상태의 측정성과를 확보하여 수위-유량관계 곡선식을 개발하였다. 그 결과 가동 보를 운영하는 3월~9월은 상류에 위치한 정읍시(행정교)관측소와 상하류 역전 현상이 발생하였고, 매년 비정상적인 유량이 산정되는 결과를 초래하였다. 2022년 신뢰도 높은 유량자료와 수위-유량관계곡선식 개발을 위해 낙양 보 완전개방 및 부분개방에 따른 다양한 유량측정성과와 낙양 보 수문 모니터링 결과를 확보하였다. 낙양 보는 2022년 1월~3월, 10월~12월은 수문 6문을 완전 개방하여 동진강에 하천유지용수를 공급하고, 4월부터 동진강 방수문을 폐쇄하여 농번기 농업용수를 확보한 후, 5월~9월에 확보된 농용수를 김제 배수문 2문을 부분개방하면서 공급하는 방식이다. 이 기간동안 낙양 보 수문에 대한 모니터링을 위해 정읍시(거산교)관측소 수위자료에 대한 검토를 실시하였으며, 유량측정시에는 정확한 유량측정성과와 곡선식 확인을 위하여 동일한 위치에서 측정을 수행하였다. 또한, 수위 또는 유량이 변하는 구간은 연속측정을 실시하였으며, 모니터링 결과와 유량측정성과를 바탕으로 수위-유량관계 변화를 분석하였다. 그 결과 저수위1식은 수문 완전개방, 저수위2식은 수문 완전폐쇄, 저수위3~6식은 수문 부분개방 곡선식을 개발하였으며, 저수위 구간은 낙양보 운영에 따라 총 27차례 기간분리가 발생하였다. 결과적으로 본 연구에서는 낙양 보 운영에 따른 다수의 유량측정성과와 모니터링 자료를 확보하였으며, 확보한 유량측정성과의 분석을 통한 신뢰도 높은 수위-유량관계곡선식을 개발하였고 이를 통해 생산된 유량자료는 정확도가 매우 높은 것으로 분석되었다.

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The Moderating Effect of Gender in the Relationship between Physical Education and Adolescents' Internalizing and Externalizing Problem Behaviors: Using Multi-level Growth Modeling (체육시간과 청소년의 외현화·내재화 문제와의 관계에서 성별의 조절효과: 다층성장모형의 적용)

  • Taekho Lee;Seokyoung Lee;Yoonsun Han
    • Korean Journal of Culture and Social Issue
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    • v.21 no.2
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    • pp.131-158
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    • 2015
  • This study examined the relationship between physical education and externalizing(aggression) and internalizing(depression, social withdrawal) problem behaviors among adolescents. The moderating role of gender and time in the association between physical education and problem behavior was also identified. This study used data from the second, third, and fourth waves of the middle school student cohort (N=2,133, N=2,151, N=1,979) of the Korean Children-Youth Panel Survey(KCYPS). Main analyses involved multilevel growth model with interaction terms. The dependent variables were aggression, depression, and social withdrawal. The independent variables were gender and physical education (exercise hours) at school. The control variables were abuse, school-adjustment, annual household income and parents' highest level of education. The major longitudinal findings of this study are as follows: First, there was significant change according to the passage of time only in aggression among externalizing and internalizing problems. Second, gender differences exist in aggression and depression. Third, exercise hours of physical education had a negative relationship with internalizing problems. Fourth, there were no gender differences over time in both externalizing and internalizing problems. Fifth, the interaction between exercise hours of physical education and time was statistically significant for social withdrawal. Sixth, the interaction between exercise hours of physical education and gender was statistically significant for depression. The results of this study may become an academic basis for suggesting policy directions that promote increased exercise hours in physical education classes at school.

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