• Title/Summary/Keyword: 베타 방사선

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Anti-tumor Effect of Combined Betacarotene with X-irradiation in the Mouse Fibrosarcoma : Cytotoxicity and Tumor Growth Delay (쥐 섬유육종에서 베타카로틴과 방사선조사 병용의 항종양 효과: 세포독성 및 종양성장 지연에 미치는 영향)

  • Kwon Hyoung-Cheol;Yang Moon-Sik
    • Radiation Oncology Journal
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    • v.18 no.2
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    • pp.133-137
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    • 2000

  • Purpose :To investigate whether combined beta-carotene with X-Irradiation has more enhanced radition response than X-irradiation or not, we peformed a experiment about in vitro cytotoxlcity of beta-carotene and/or X-irradiation in the fibrosarcoma cells, tumor growth delay of combined beta-caroten with/or X-irradiation in the mouse fibrosarcoma. Materials and Methods : 2$\%$ emulsion of beta-carotene was serially diluted and used. X-Irradiation was given by 6 MeV linear accelerator. The cytotoxicity of beta-carotene in vitro was evaluated from clonogenic assay. To compare the cytotoxiclty between combined beta-carotene with X-irradiation and X-irradiation group, 2 mg/ml of beta-carotene was contacted to fibrosarcoma (FSall) cells for 1 hour before X-irradiation. For the tumor growth delay, single 20 Gy was given to FSall tumor hearing C3H/N mice whic was classified as beta-crotene with X-irradiation group (n=5) and X-irradiation alone group (n=5). 0.2 ml of 20 mg/kg of beta-carotene were i.p. injected to mice 30 minute before X-irradiation in the beta-crotene with X-irradiation group. The tumor growth delay defined as the time which reach to 1,000 mm$^{3}$ of tumor volume. Results : (1) Cytotoxicity in vitro: 1) survival fraction at beta-carotene concentration of 0.002,0.02,0.2 and 2 mg/ml were 0.69$\pm$0.07, 0.59$\pm$0.08, 0.08$\pm$0.008 and 0.02$\pm$0.006, respectively. 2) each survival fraction at 2, 4, 6 and 8 Gy in the 2 mg/ml of beta-carotene + X-irradiation group were 0.13$\pm$0.05, 0.03$\pm$0.005, 0.01 $\pm$0.002 and 0.009$\pm$0.0008, respectively. But each survival fraction at same irradiation dose in the X-irradiation group were 0.66$\pm$0.05, 0.40$\pm$0.04, 0.11$\pm$0.01 and 0.03$\pm$0.006, respectively(p<0.05). (2) The time which reach to 1,000 mm$^{3}$ of tumor volume of beta-carotene + X-irradiation group and X-irradiation alone group were 18, 19 days, respectively(p>0.05) Conclusion : The contact of beta-caroten to Fsall cells showed mild cytotoxicity which 띤as increased according to concentration. The cytotoxicity of combined beta-carotene with X-irradiation more increased than that of X-irradiation, additionally, And there was significant difference of cytotoxicity between two groups. But there were no significant difference of the growth delay of fibrosarcoma between two groups.

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Intercomparison of the KAERI Reference Photon and Beta Radiation Measurements (한국원자력연구소 기준 광자 및 베타선장 측정의 국제상호비교)

  • Chang, Si-Yeong;Kim, Bong-Hwan;Kim, Jang-Lyul;McDonald, J.C.;Murphy, M.K.
    • Journal of Radiation Protection and Research
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    • v.21 no.4
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    • pp.255-262
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    • 1996

  • This paper describes the results of intercomparison measurements of KAERI reference photon and beta radiation fields between the KAERI and the PNNL(Pacific Northwest National Laboratory), recently performed at KAERI radiation calibration and dosimetry laboratory on the basis of the ANSI N13.11 criteria for personal dosimeter performance test. Each laboratory used her own radiation detectors or measurement devices traceable to her national primary standard in measuring the exposure rates for photon fields, the absorbed dose rates for beta radiation fields. The agreements in reference radiation measurements between two laboratories were found to be less than ${\pm}2.0%$ for photon fields, ${\pm}1.0%$ for beta radiation fields. Therefore, it could be concluded that KAERI reference radiation fields comply well with the international standard and thus can further serve as a national basis for the researches and developments in radiation protection dosimetry in Korea.

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A Study on Micro-Battery using Beta Source (베타선원을 이용한 마이크로전지 구현연구)

  • Lee, Nam-Ho;Jung, Hyun-Kyu;Jung, Seung-Ho
    • Proceedings of the KIEE Conference
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    • 2006.04b
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    • pp.369-371
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    • 2006

  • 반도체에 이온화 방사선을 조사시키면 소자 내부에서 전자-전공쌍(Electron-Hole Pair, EHP) 생성현상이 나타난나. 이 발성 전하는 방사선원에 따라 반영구적인 전원으로 활용이 가능하다. 본 논문에서는 반감기가 100여년인 Ni-63 베타 방사성 능위원소와 PN 접합형 반도체 소자를 사용한 방사선 전지를 개발하기 위한 연구의 일환으로 효율적인 방사광 변환 법과 전류 발생방법 및 전지회로 구현에 대해서 고찰하였다. 또한 Ni-63 방사선의 베타선 스펙트럼을 계산하고 이에 해당하는 광입력 특성에 대한 실리콘 PN 접합 다이오드의 반응특성을 태양광 시뮬레이션용 소프트웨어를 사용하여 검증하였다.

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