• Maxillofacial Plastic and Reconstructive Surgery
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• v.22 no.1
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• pp.15-21
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• 2000

Ameloblasotma is slowly growing, locally invasive neoplasm with a potentially destructive behavior. The epithelium of ameloblastoma is thought to have an intrinsic growth potential and has been shown to present a higher rate of proliferation as compared to odontogenic cysts with low local recurrence rate. The molecular mechanisms that regulate the cell growth and invasion of ameloblastoma cells are unknown. Bcl-2 protein, which prevent apoptosis, is expressed in immortalized ameloblastoma cell line(AM-1)(Harada et al 1998). Expression of bcl-2 protein occurs in tooth germs, whose epithelial component may act as the histogenic precursor of ameloblastoma. Bax is considered as a main effector of apoptosis. Bax forms homodimers and also heterodimers with bcl-2. p53 tumor supressor gene participates not only in cell proliferation control but also in induction of apoptosis. The objective of the present study was to evaluate the apoptosis related protein expression in odontogenic cyst and ameloblastoma. A total of 10 dentigerous cysts and 16 ameloblastomas were used in the present study. Dentigerous cyst showed negative or slight positive for p53 and bcl-2 but strongly positive for bax, ameloblastoma, on the other hand, strongly positive for p53 and bcl-2 but weekly positive for bax. Bcl-2 was expressed for ameloblastoma mainly in outer layer or whole layer of epithelium and for dentigerous cyst mainly in basal layer. The difference in expression of apoptosis related protein in dentigerous cyst and ameloblastoma might explain the peculiar aggressive growth pattern of ameloblastoma.

• The korean journal of orthodontics
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• v.27 no.3 s.62
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• pp.515-521
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• 1997

The purpose of this case report is to provide the information of the treatment of the impacted-displaced teeth associated with the disease in the jaw. A 10-year-old boy presented with a large radiolucent lesion accompanying the displacement of the second premolar and first molar in the left mandibular body area. The lesion was diagnosed as unicystic ameloblastoma. As a surgical procedure for the present case, marsupialization was executed. For the eruption of displaced impacted teeth, no orthodontic intervention was done for second premolar while a helical spring was used for the forced eruption of first molar. Goof occlusion was established by simple orthodontic intervention.

• The Journal of the Korean dental association
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• v.25 no.3 s.214
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• pp.263-272
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• 1987

• The Journal of the Korean dental association
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• v.26 no.3 s.226
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• pp.192-193
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• 1988

• The Journal of the Korean dental association
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• v.26 no.2 s.225
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• pp.102-102
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• 1988

• Maxillofacial Plastic and Reconstructive Surgery
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• v.11 no.2
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• pp.53-59
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• 1989

The ameloblastoma is the most common form of the odontogenic tumors exhibiting minimal inductive change in connective tissue, it comprising 1% of all tumor and cysts of the jaws. It is a true neoplasm, generally considered to be a benign but persistent or, locally malignant lesion. The tumor occurs most commonly in persons between the age of 20 and 50 years. 80% and 90% of all lesions are in the mandible. The presenting clinical signs and symptoms of the ameloblastoma very from patient to patient, but most common symptom was swelling, followed by pain, draining sinuses, and superficial ulcerations. It is slow-growing lesion, and the radiographic features of the ameloblastoma depend large one the nature and the local bone reaction to the particular tumor. Recurrence rate is about 33%, but this is probably due to incommplete initial removal of lesion. We had operated a patient ; 29-year-old female immediate reconstruction combined with autocompression plate and iliac bone graft and screw fixation after hemimandibulaectomy with recurred ameloblastoma involving from premolar to ascending ramus at right side mandible. We obtained favorable results of good function, short intermaxillary fixation periods and easy operation precedure than the other reconstruction methods.

• Journal of Korean Academy of Oral and Maxillofacial Radiology
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• v.25 no.2
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• pp.555-559
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• 1995

ameloblastoma는 일반적으로 경조직을 형성하지 않는 진성 종양으로 알려져 있으나 최근에 저자는 종양내에 골형성을 수반한 경우의 ameloblasoma를 경험하고 이것을 보고하였다. 이 드물게 나타나는 ameloblastoma는 desmoplastic ameloblastoma로 명명되고 있으며 방사선 사진상으로 fibro-osseous lesion 과 감별을 요한다.

• The Journal of the Korean dental association
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• v.9 no.12
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• pp.837-840
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• 1971

The Auther have diagnosed the 9 cases Dentigerous Ameloblastoma from mandible in Korean. 1) All 9 cases were Korean patients. 2) Clinical Diagnosis of 9 cases were cyst but microscopical Diagnos's of all cases were Dentigerous Ameloblastoma. 3) Patients of all cases were sedated with 100mg. Demerol and anesthetized with 2% Lidocain hydrochloride. The surgical procedure was performed in the usual manner.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.13 no.2
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• pp.160-166
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• 1991

In 1977, Robinson & Martinez described a distinct varient of ameloblastomas in which the response to curettage was found to be favorable, with a recurrence rate of 25%. They referred to this varient as unicystic ameloblastoma. Unicystic ameloblastoma occur most commonly in the second and third decades of life, which is considerablly younger than the average age of discovery for the classical ameloblastoma. For the accurate histopathological diagnosis of the unicystic ameloblastoma, the specimen obtained the excisional biopsy, complete enucleation or incisional biopsy from the multiple site of the lesion. The purpose of this report is to review of the literature and to present three cases in which an unicystic ameloblastoma appear to be arising in the wall of a dentigerous cyst.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.14 no.1_2
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• pp.160-168
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• 1992

Ameloblastoma is an aggressive but benign epithelial neoplasm of odontogenic origin, and the occurrence of odontogenic epithelium in the wall of a dentigerous cyst is well-known entity. The presence of ameloblastic proliferation in the walls of odontogenic cysts has been reported for many years. Cahn in 1933 described a case in which he considered an ameloblastoma to have originated in a dentigerous cyst, and numerous other cases of ameloblastomatous proliferation have since been reported. In 1977, Robinson and Martinez described a distinct variant of ameloblastoma in which the response to curettage was found to be favorable with a recurrence rate of 25%. The gross and microscopic features indicated that this variant vas associated with a large cystic cavity with either luminal or mural proliferation of ameloblastic tumor cells, and they referred to this variant as unicystic ameloblastoma. Unicystic ameloblastoma occurs most commonly in the second and third decades of life, which is considerably younger than the average age of discovery for the classical ameloblastoma. For the accurate histopathological diagnosis of the unicystic ameloblastoma, the specimen obtained the excisional biopsy, complete enucleation or incisional biopsy from the multiple site of the lesion. This article provides histopathologic evidence of multilocular unicystic ameloblastoma in which ameloblastic tissue was associated with a dentigerous cyst that was found in a 31-year-old female, and complete radiographic, photographic, and microscopic documentation is presented.