• The Science & Technology
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• v.29 no.1 s.320
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• pp.20-23
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• 1996

'과학과 기술'은 '세계명문대학 순례'난을 통해 전통을 자랑하는 유명대학을 집중조명한다. 이번호에는 1백20년의 전통과 수많은 노벨상수상자를 배출한 미국의 버클리대학교를 찾아본다.

• Korean Journal of Heritage: History & Science
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• v.24
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• pp.322-342
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• 1991

• Journal of the Korean Institute of Educational Facilities
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• v.27 no.5
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• pp.3-12
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• 2020

The purpose of this study is to suggest some interior design directions for university library in the circumstances of rapid change of user's demand for the library. In order to extract some ideas about designing the library, I analyzed the libraries of UC Berkeley which has tried to transform the existing condition of the building for satisfying user's new needs. Informations of compositions, layouts of furnitures and book shelves, environmental conditions of 25 branch libraries of UC Berkeley, and spatial behavior patterns in libraries were surveyed and analyzed to get insights to design a new model of library buildings. The interesting phenomena got from the survey is that most of the library users used their own laptop computer in the library regardless of environmental conditions of the library or book types. In conclusion, as the library is changing to the place of studying, not of reading books, four design directions for the library are suggested in this research as like these; 1) Establishing a Regulation Free Environment for a user, 2) Enhancing the Aura of Books as an Interior Design Element, 3) Supplying Personalized Spatial Characters, and 4) Providing an Impactful Space.

• Journal of Korean Society of Steel Construction
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• v.21 no.1
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• pp.63-70
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• 2009

Failure modes result in fracture or tearing, which may cause deterioration of resistance and reduction of inelastic deformation capacity. The potential failure modes for Special Concentrically Braced Frames (SCBFs) include fracture or tearing of the brace, net section fracture of the brace or gusset plate, fracture of the gusset plate welds, shear fracture of the bolts, block shear, excessive bolt bearing deformation, and buckling of the gusset plate. HSS tubular braces are commonly used in SCBFs, and net section fracture of the tubular brace may also occur through the brace net section at the end of the slot cut into the tube to slip over the gusset plate. This failure mode is categorized as a tension failure mode, and may cause dramatic loss of resistance and brittle behavior. Net section reinforcement is required according to AISC design specifications (AISC 2001). In this paper, the need to reinforce the net section area was discussed. Initially, the results of the net section fracture tests done by the University of California in Berkeley were presented with the modeling of these tests using FE models. To investigate the possibility of net section fracture in an actual frame, the slot end hole model was adapted to the frame FE model, and alternate near-fault histories were applied with tension-dominated cycles, since previous analyses showed that loading history was the most critical factor in net section fracture. The need for this reinforcement (cover plate) and the tension-dominated near-fault history were investigated.

• The Korean Journal of Applied Statistics
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• v.37 no.1
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• pp.61-72
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• 2024

The purpose of this study is to investigate retest reliabilities in longitudinal study, the same test is administered repeatedly over time. Linear mixed models were used to establish various situations of tests occurred in longitudinal study. Combination of two types of true value and three types of systematic error was considered. In order to apply the models to real longitudinal data, height data from the Berkeley growth study and vocabulary score data from the University of Chicago experimental school were used. Using the mixed model, there is an advantage that the reliability can be determined by selecting the covariance structure of the true value and the error separately. However, in order to properly analyze the reliability, researchers need to consider variations that can occur in measurement, such as characteristics of subject, the test, and the the treatment applied in the study. And the proper model should be selected and the quality of the measurement should be evaluated for each trial.

• Korean Journal of Clinical Laboratory Science
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• v.53 no.2
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• pp.158-164
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• 2021

Hypertriglyceridemia is the main risk factor for atherosclerosis. It is reported that triglyceride (TG) induces macrophage cell death, and is involved in the formation of plaques and development of atherosclerosis. We previously reported that TG-induced cell death of macrophages is mediated via pannexin-1 activation, which increases the extracellular ATP and subsequent increase in potassium efflux, thereby activating the caspase-2/caspase-1/apoptotic caspases, including the caspase-8 pathway. Contrarily, some studies have reported that caspase-8 is an upstream molecule of caspase-1 and caspase-2 in several cellular processes. Therefore, this study was undertaken to investigate whether caspase-8 influences its upstream molecules in TG-stimulated macrophage cell death. We first confirmed that caspase-8 induces caspase-3 activation and poly ADP-ribose polymerase (PARP) cleavage in TG-treated macrophages. Next, we determined that the inhibition of caspase-8 results in reduced caspase-1 and -2 activity, which are upstream molecules of caspase-8 in TG-induced cell death of macrophages. We also found that ATP treatment restores the caspase-8 inhibitor-induced caspase-2 activity, thereby implying that caspase-8 affects the upstream molecules responsible for increasing the extracellular ATP levels in TG-induced macrophage cell death. Taken together, these findings indicate that caspase-8 potentiates the TG-induced macrophage cell death by activating its upstream molecules.

• Journal of the Korean Geotechnical Society
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• v.22 no.5
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• pp.59-67
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• 2006

The centrifuge and 1-g shaking table tests were performed simultaneously to compare the dynamic behaviors of loose sands of the same geotechnical properties. The prototype soils were 10 m thick liquefiable loose sands. The geometric scaling factors were 20 for 1-g and 40 for centrifuge tests. The excess pore pressure, surface settlement, and acceleration in the soil were measured at the same locations in the 1-g and centrifuge tests. The total excess pore pressure from development to dissipation was measured. In the centrifuge test, viscous fluid was used as the pore water to eliminate the time scaling difference between dynamic time and dissipation time. In the 1-g tests, the steady state concept was applied to determine the unit weight of the model soil, and two different time scaling factors were applied for the dynamic time and the dissipation time. It is concluded that the 1-g tests can simulate the excess pore pressure of the prototype soil if the permeability of the model soil is small enough to prevent dissipation of excess pore pressure during shaking and the dissipation time scaling factor is properly determined.

• Korean Journal of Clinical Laboratory Science
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• v.55 no.4
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• pp.235-243
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• 2023

As next-generation sequencing has been developed and used widely, RNA-sequencing (RNA-seq) has rapidly emerged as the first choice of tools to validate global transcriptome profiling. With the significant advances in RNA-seq, various types of RNA-seq have evolved in conjunction with the progress in bioinformatic tools. On the other hand, it is difficult to interpret the complex data underlying the biological meaning without a general understanding of the types of RNA-seq and bioinformatic approaches. In this regard, this paper discusses the two main sections of RNA-seq. First, two major variants of RNA-seq are described and compared with the standard RNA-seq. This provides insights into which RNA-seq method is most appropriate for their research. Second, the most widely used RNA-seq data analyses are discussed: (1) exploratory data analysis and (2) pathway enrichment analysis. This paper introduces the most widely used exploratory data analysis for RNA-seq, such as principal component analysis, heatmap, and volcano plot, which can provide the overall trends in the dataset. The pathway enrichment analysis section introduces three generations of pathway enrichment analysis and how they generate enriched pathways with the RNA-seq dataset.

• Korean Journal of Clinical Laboratory Science
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• v.56 no.1
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• pp.10-20
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• 2024

RNA-sequencing (RNA-seq) is a technique used for providing global patterns of transcriptomes in samples. However, it can only provide the average gene expression across cells and does not address the heterogeneity within the samples. The advances in single-cell RNA sequencing (scRNA-seq) technology have revolutionized our understanding of heterogeneity and the dynamics of gene expression at the single-cell level. For example, scRNA-seq allows us to identify the cell types in complex tissues, which can provide information regarding the alteration of the cell population by perturbations, such as genetic modification. Since its initial introduction, scRNA-seq has rapidly become popular, leading to the development of a huge number of bioinformatic tools. However, the analysis of the big dataset generated from scRNA-seq requires a general understanding of the preprocessing of the dataset and a variety of analytical techniques. Here, we present an overview of the workflow involved in analyzing the scRNA-seq dataset. First, we describe the preprocessing of the dataset, including quality control, normalization, and dimensionality reduction. Then, we introduce the downstream analysis provided with the most commonly used computational packages. This review aims to provide a workflow guideline for new researchers interested in this field.