• Title/Summary/Keyword: 발표논문

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Current State and Applications of the Electronic Clinical Trial Process in Korea (국내 임상시험 전자화 현황과 적용방안)

  • Wang, Boram;Choi, Inyoung
    • The Journal of the Korea Contents Association
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    • v.13 no.4
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    • pp.281-289
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    • 2013
  • As the number of clinical trials conducted in Korea increases, the need of the Electronic Data Capture (EDC) system for effective clinical data management is also increased. Recently, the Korea Food and Drug Association published 'Guideline for the Electronic Clinical Trial Data Management and Processing' and it would be the foundation for establishing regulation of electronic clinical data management. In this research, we conducted the survey regarding adoption rate of EDC system in clinical trials in hospitals, Contract Research Organizations (CRO), and pharmaceutical companies. And the perceived importance and the ease of application for the Guideline were investigated. The adoption rates of EDC system was 77.6% but it mostly applied to less than five trials. Also EDC system was mostly used in phase I and phase II trials and the utilization rate of CRO was the highest. The perceived importance for the Guideline was high among all three organizations but, in case of the perceived ease of its application, CRO was the highest. Also, the perceived importance of the clinical data standard was high and the standard for data collection was mostly required. However, the comprehension for the global standard of the electronic data was relatively low, so that education is required. This result would be the foundation to increase the electronic clinical trials and develop proper regulation and principles for clinical data standards in Korea.

A Study on 4D Special Effect Graphics Content Development Creative Processing and Preproduction Design : base on Special Effect Graphics of 'Namsadang' Character Preproduction Report in An-Sung (4D 특수영상에서의 캐릭터 개발과정 제작 공동 작품 연구 - 안성 특수 영상 남사당패 Pre-Production 작품 개발을 기반으로)

  • Cho, Hyun-Kyung
    • Cartoon and Animation Studies
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    • s.41
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    • pp.153-168
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    • 2015
  • In Kyung-GI DO, An-sung, Each local autonomous entity developed the character design to inform the public relations and revitalize local economy and culture. consequently, These have got benefits with marketing local speciality related to their an-sung character; we call it name is arum, pung-mul, duck-bugi who korea traditional face characters. On the contrary, Most of old characters which have been fallen off their formative qualities became a reason that unfit (4D,3D) special film at local doom movie theater. This thesis aims to study on the character of 'namsadang' group what have been produced in ansung-si, that the show up to people about an-sung 4D Contents what local actually character and to make it more competitive through 3D,4D spacial character project developing process. It is need for new various characters, that (3D,4D-VFX) -Graphics of new an-sung'namsadang' group. that will be total different and new development. total VFX; 4-Dimantion visual graphics released in next an-sung local festival, Business prospects are bright and receiving benefits are increasing. As seen in the case of the character of in 2015, it can be a measure to earn benefits as a higher value-added business if it is managed in the local autonomous entities. In this thesis, I propose what the of character in the local special graphics; VFX style characters design. also I was show up to '4D contents character;' ; 'namsadang' group; creative processing including planing. It is possible to be ranged from special 4D series animation, a feature-length special effct cartoon film, character products, and even local doom Theme parks show up film. which are all expected high profits. These profits will be returned back to the an-sung local autonomous entity, who can use them to develop new contents, one of foundations in local economy. As a result, it is helpful to make local traits and effective tourist attractions.

The study of Internal Meaning of Mise-en-Scène in Realism Movie -How Hong Sang-Su Handles His Realism with Ordinary Life- (리얼리즘 미학에 나타난 미장셴의 내적 의미 연구 -홍상수 영화의 일상과 리얼리즘 중심으로-)

  • Jin, Seung-Hyun
    • The Journal of the Korea Contents Association
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    • v.15 no.2
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    • pp.130-138
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    • 2015
  • Korean movies with a great variety of styles have recently succeeded in drawing people's attention Rule number one is "the more entertainment, the more audiences". On the top of box offices are always the movies that have a number of spectacular scenes, pounding sounds and big budget characters. Hong Sang Su movies, however, receive attention from the public without above noted descriptions. One of his effective methods of expression is "realism" He has illustrated the trivial episodes with his own wits and ways. Not only has his style become famous and popular but he has many followers. He enjoys using ordinary emotion and sentiment that are likely to happen to everyone. This paper uses two tools. One is the traditional analysis of realism. The other is how he can approach the public meaningfully by listing common elements he frequently uses in his movies. Nevertheless, we can't fully understand his realism by explaining how he shows our everyday life and how much his movie looks like it. Though admitting there are so many preceding papers on his works but this paper will try to look deep into his realism through the analysis of Mise-en-Sc$\grave{e}$ne.

A bibliography of six foreign plant collectors (Imai, Mills, Furumi, Nomura, Saito, and Okuyama) in North Korea (한반도 북부 채집을 시도한 외국인 6명과 지명 정리: Imai, Mills, Furumi, Nomura, Saito, Okuyama)

  • Chang, Chin-Sung;Kim, Hye-Won;Kim, Hui
    • Korean Journal of Plant Taxonomy
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    • v.46 no.1
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    • pp.65-82
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    • 2016
  • Korean Peninsula Flora Database (KPF database), developed by T.B. Lee Herbarium of Seoul National University comprises ca. 65,000 accessions of vascular plants collected from Korean peninsula from 1850 to 1945. Among these, material from North Korea (Democratic People's Republic of Korea) is represented with ca. 33,000 accessions. The largest part of this material [ca. 4287 accessions (13%) from North Korea] originates from five Japanese and one American collectors, such as Imai, Hanjiro, Mills, Ralph Garfield, Furumi, Masatomi, Nomura, Naohiko, Saito, Tatsumoto, and Okuyama, Shunki from 1909 to 1942. These data are the third largest holding (13%) of North Korean collections after Komarov, V.L and Nakai, T. A part of scientific report about the results of these expeditions had been published before, but the present publication set it sights on giving a first overview of the itineraries and the materials collected by five collectors in North Korea. Among these, Saito has by far the largest collection with 1,730 specimens, followed by five collectors in order with 1,067, 532, 510, 368 and 370 accessions by Mills, Nomura, Okuyama, Furumi, and Imai respectively.

An Empirical Analysis of the Relationship between Advertisement Expenses and Business Performance (광고선전비와 경영성과 간의 실증적 분석)

  • Park, Kyung-Lak
    • Korean Business Review
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    • v.11
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    • pp.277-293
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    • 1998
  • The purpose of this study is to analyse the overall relationship between the advertisement expenses and the two major indicies of business performance, that is, the total amount of sales and the discipline have contrasted the expenses for commercial advertisement with the total amount of sales or with the business performance, respectively, utilizing data on a specific product observed through 3 to 5 years. This study attempts to enlarge the scope of observation and the content of analysis. In order to attain the purpose of this study, the rate of increase in the advertisement expenses is taken as the independent variable and the two major indicies of business performance, the total amount of sales and the resultant interest, as the dependent variables. Business companies or firms which have continually been listed on the board of Korea Stock Exchange for 14 years, from 1982 to 1995, were grouped into four major business categories; 1)Food and beverage industries, 2)Fiber, clothings, and leather industries, 3) Medicine, chemistry, oil, coal, and rubber industries, and 4) Assembled mechanics and metallurgy, machinery, and maintenance industries. Utilizing the KIS-DATA, compiled by Korea Credit Evaluation, Ltd., 30 to 40 samples of business companies or firms were randomly selected from each category. Finally 125 samples were selected and put into regression analyses and follow-up tests by appropriate statistical models, in order to verify if there were any noticeable correlations. The final result obtained through the afore-mentioned research method shows that the amount of advertisement expenses has strong correlations with the amount of sales and the resultant interest. Viewed by business category, in the case of fiber, clothings, and leather industries, the relationship turned out to be significant only with the rate of increase in the total amount of sales, while, in the case of food and beverage industries, the rate of increase in the total amount of sales showed a negatively significant correlations.

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Study on High Degree of Efficiency Chemical Reactor for Air Purification Using the Glow Discharge (글로우 방전을 이용한 고효율 공기 정화용 화학 반응기의 특성관찰에 관한 연구)

  • Kim, Gi-Ho;Bu, Min-Ho;Lee, Sang-Cheon
    • Journal of the Korean Chemical Society
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    • v.50 no.1
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    • pp.14-22
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    • 2006
  • the basic model of chemical reactor using glow discharge, we used cathode discharge cell with vacant cavity in the middle. Currently glow discharge is widely studied as a radiation source or atomization device in atomic spectroscopy and remarkable technological achievements are made through the graft with other analysis devices such as microanalysis and steel analysis.1 Additionally, as the characteristics of basic glow discharge and radiation have been reviewed many times, those results could be used in this experiment.2-3 In 1993, an article regarding the treatment of poisonous gas in the air using low temperature plasma was published. According to this article, if DC Glow Discharge is used under continuous atmospheric flow, poisonous gases such as SO2 and NO can be removed.4 Based on those findings, we designed highly efficient reactor where stable air plasma is composed and all air flow pass the negative glow area passing through the tube. It was observed that the cathode tube type glow discharge developed in this study would be economical, easy to use and could be used as radiation source as well.

The Effects of Tacrolimus versus Cyclosporine on Acute Graft Rejection Episode and Acute Renal Dysfunction Following Pancreas Transplantation (췌장이식환자에서 Tacrolimus와 Cyclosporine이 급성거부반응과 신장장애에 미치는 영향)

  • Oh, Jung Mi;Klassen, David
    • Korean Journal of Clinical Pharmacy
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    • v.9 no.2
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    • pp.81-87
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    • 1999
  • 췌장이식의 성공률은 지난 10년 동안 상당히 상승되었다. International Pancreas Transplant Registry에 따르면 1995년 이래 미국에서만 매년 1,000건 이상의 췌장이식이 실시되고 있다. 장기이식후 나타나는 급성 거부반응은 이식 후 6개월 이내에 가장 높은 빈도수로 나타난다. 췌장이식환자에서는 신장을 이식한 것보다 두배나 높은 거부반응을 나타나며 이로 인한 입원율의 증가 항림프제(antilyinphocyte) 사용과 감염의 증가로 이환율이 높다. 더구나 Cyclosporine (CsA)을 기초로 한 면역억제제요법의 사용은 높은 급성 거부반응률(acute graft rejection)을 초래하여 이식한 장기의 조직손실이 문제가 되고 있다. 새로운 면역억제제인 Tacrolimus (FK506)의 사용은 이식환자에서의 거부반응을 감소시켜 생존율을 증가시키는 것으로 알려져 있다. Tacrolimus는 neutral macrolide로 cyclic peptide인 CsA과는 화학 구조는 매우 다르나 비슷한 면역억제 효과를 보인다. 하지만 Tacrolimus의 사용시 신경독성, 신독성, 특히 고혈당증의 발생률이 높아 일부 이식센터에서는 장기 이식 후에 사용하기를 꺼리기도 한다. 하지만 여러 연구논문에서 간과 신장 이식 후 급성 거부반응 예방에 Tacrolimus는 CsA에 비해 이점이 있는 결과를 발표하였다. 결과적으로, 현재 췌장이식 후 Tacrolimus를 기초로 한 면역억제의 효과에 대한 연구가 활발히 진행중이다. 따라서 본 연구에서는 1994-1996년 사이에 Tacrolimus 또는 CsA를 기초로 한 면역억제요법을 투여 받은 췌장이식환자 101명을 후향적으로 조사하여 Tacrolimus (n=54)와 CsA(n=57)의 급성 거부반응 예방 효과와 신부전 발생률을 비교하였다. 모든 환자는 항림프구 약물, Azathioprine, Prednisone을 이식 후 면역억제제로 투여 받았다 기준선으로부터 $20\%$ 이상의 혈청 creatinine의 상승이 있는 환자에서는 급성 신부전으로 정의하였고 신장생검법으로 거부반응을 진단하였다 Matched-pair analysis에 따르면 췌장이식환자의 6개월 생존율은 CsA군에서 $97\%$, Tacrolimus군에서 $96\%$로 별다른 차이가 없었으며 (p=0.57), 6개월간의 이식한 췌장의 보존율은 CsA군에서는 $88\%, Tacrolimus에서 $91\%$. 유의한 차이는 없었다(p=0.29). 췌장이식 후 6개월 동안 Tacrolimus의 사용은 생검으로 증명되는(biopsy-proven) 급성 거부반응의 발생빈도는 CsA보다 유의하게 낮았을 뿐만 아니라 (p<0.05) 거부반응 증상의 심각도 또한 감소시켰다 (p=0.03). 급성거부반응 발생빈도의 감소로 Tacrolimus군에서 antilymphocyte 치료가 유의하게 줄어들었다(p=0.01). CsA군에서 Tacrolimus보다 신부전의 발생률이 높았으나 통계학적 차이는 없었다. 췌장이식후의 최적의 면역억제요법의 결정하기 위해서는 향후 Tacrolimus와 CsA을 비교하는 전향적 무작위 연구가 필요하다.

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An Experimental Study on the Microstructure Characteristics of Cementitious Composites by MIP (MIP를 통한 혼합 시멘트계 재료의 미세구조 특성에 관한 실험적 연구)

  • Kim, Tae-Sang;Jung, Sang-Hwa;Chae, Seong-Tae;Lee, Bong-Chun;Woo, Young-Je;Song, Ha-Won
    • Proceedings of the Korea Concrete Institute Conference
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    • 2008.04a
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    • pp.533-536
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    • 2008
  • Recently, in Korea, there has been an increasing number of research papers published which are to improve durability of concrete, particularly by analyzing correlation between diffusivity of chloride and porosity/pore size distribution. In these studies, such test methods as mercury intrusion porosimetry(MIP), gas adsorption or image analysis method are used to analyze the microstructure of materials while MIP is most widely used for concrete. This study analyzes the results of porosity and pore size distribution of paste and concrete adding fly ash or blast furnace slag by using MIP equipment which is widely used for determining micro-porosity structure of cementitious materials. A variation in porosity and pore size distribution at the curing day 3, 7 and 28 has been observed by using MIP equipment for cement paste 35%, 40%, 45%, 50%, 55%, 60% of W/C when using $300kg/m^3$ of cement, 35%, 45%, 55% of W/C when replaced 60% with blast-furnace slag, and 35%, 45%, 55% of W/C when replaced 30% with fly ash. For long-term water cured normal OPC concrete and mixed concrete replaced 60% with blast-furnace slag powder, micro-structure of the sample has been analyzed by using MIP equipment when W/C indicated 40%, 45%, 50% respectively and the binder varied $300kg/m^3$, $350kg/m^3$, $400kg/m^3$, and $450kg/m^3$.

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A Study on Solution of Anomaly due to Integrated of Inheritance and Concurrency (상속성과 병행성에서 오는 상속변칙 문제 해결에 관한 연구)

  • Park, Young-Ok;Moon, Jeong-Hwan;Lee, Chiol-Seong;Hong, Seong-Pyo;Lee, Ho-Young;Lee, Joon
    • Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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    • 2002.05a
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    • pp.485-489
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    • 2002
  • The concepts from OOP have been integrated in a concurrency, leading to the emergence of concurrent OOP. Concurrency of concurrent OOP and various model technique of OOP language are integrated had been proposed. Concurrent programming and OOP technique unite that can gain various kinds advantage to develop concurrency application program. There have been a number of models proposed for integrating concurrency and OOP However, concurrency and inheritance are two paradigms which are difficult to combine in a suitable manner. The inheritance anomaly is the conclicted phenomena, which occurs only when concurrency is integrated with inheritance. The inheritance anoay is referred to as the serious difficulty in integrating inheritance and concurrency in a simple and efficient manner within a concurrent OOP. Concurrency and inheritance with integrated that Drop reusability of object remarkably and require re-justice of code that is inherited in subclass. So concurrency and inheritance with integrated Collision that happen between two special qualitys or Interference phenomenon is inheritance anomaly. Effect of inheritance anomaly minimum Much study findings announced about access method to improve code reusability. Wish to approach in paper that is division by synchronization code and method code to solve interference problem between and concurrency.

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Review for Evaluation Criteria for the Establishment of Conservation Areas in Korea (한국에서 적용가능한 보전지역 평가기준에 대한 고찰)

  • 신현탁;김용식
    • Korean Journal of Environment and Ecology
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    • v.15 no.3
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    • pp.247-256
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    • 2001
  • The purpose of the present study is to prepare the conservation category to establish the Natural Ecosystem Conservation Area(NECA) in Korea. The authors prepared the conservation category for the NECA based on the previous relevant papers and reports. This draft of conservation category was examined by way of the case study. From this, the possible factors are introduced to prepare the final conservation category that can be applied directly in Korean situation for the conservation of natural areas. The present conservation category was prepared based on the possible data, while some factors of which do not possess the adequate raw data at the moment was removed. According to the reference analyses from the previous conservation categories reported in order to prepare the conservation category in the NECA, a total of 27 factors was assessed; 21 for rarity and 15 fur utility and diversity, 13 far size, for both naturalness and human influence, 13 for typicalness 12 and 10 for fragility. From the literature reviews, the categories which quantitatively assessed was 13: 9 for rarity, 8 far human influence, and 5 for size. From the 27 conservation categories assessed, the factors such as rarity, taxonomic distinctiveness and threat was regarded as applicable to the Korean situation. Furthermore, the criteria such as use could be applied further when this is supported by the augmentative research and field studies.

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