• 월간산업보건
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• s.281
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• pp.2-4
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• 2011

• 월간산업보건
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• s.295
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• pp.11-14
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• 2012

Phenothiazine의 직업적 노출기준(TLV-TWA)은 $5mg/m^3$으로 권고되었다. TLV-TWA의 수준은 피부자극과 변색, 각막염 그리고 태양광에 직접 노출되었을 때 나타나는 광감작반응의 가능성을 최소화하기 위해 설정되었다. 고용량의 phenothiazine을 경구 투여하면 간과 신장이 손상되며 용혈성의 빈혈이 발생한다. Phenothiazine의 피부흡수에 의한 전신 독성이 증명되어 피부흡수 "Skin" 경고주석을 권고하였다. 감작제(SEN)와 발암성 경고주석 그리고 TLV-STEL을 설정하기에는 유용한 자료가 부족하다.

• 월간산업보건
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• s.257
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• pp.13-16
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• 2009

펜타클로로나프탈렌(Pentachloronaphthalene)의 직업적 노출기준은 0.5 $mg/m^3$으로 권고하였으며 이 수준은 염화물 형태의 간 손상과 피부염의 가능성을 최소화하기 위한 것이다. 피부 흡수 경고는 동물실험에서 pentachloronaphthalene이 피부접촉 시 흡수가 용이하다는 자료를 근거로 권고하였다. 두 종류 이상의 염화나프탈렌에 노출되는 경우는 상가작용을 적용하여야 하며 감작제, 발암성, TLV-STEL에 대한 권고는 충분한 자료가 확보되지 않아 아직은 설정하지 않고 있다.

• 월간산업보건
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• s.353
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• pp.29-33
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• 2017

수산화나트륨(Sodium hydroxide)의 직업적 노출에 대한 TLV-Ceiling은 $2mg/m^3$으로 권고하였다. 권고수준은 수산화나트륨 에어로졸이 눈, 점막, 피부에 심한 자극을 유발하고 수산화나트륨 분진이 상기도 기관에 자극을 유발하는 농도에 근거하였다. 노출기준은 눈과 상기도 기관에 자극을 최소화하기 위하여 권고하였다. 고농도의 수산화나트륨에 장기간 노출되면 비강 궤양과 눈과 피부에 심한 손상을 유발할 수 있다. "피부", "감작제(SEN)", "발암성"의 경고주석을 권고하기에는 유용한 자료가 충분하지 않다.

• Journal of the Korean Chemical Society
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• v.40 no.4
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• pp.229-234
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• 1996

Carcinogenicities of Benzo[a]pyrene(BP) and its metabolites were investigated by PM3. The 4, 5, 5a, and 6 positions forming transbutadiene(TB) frame in BP have been proved to be carcinogenic region by LUMO. We have found that the carcinogenic region of BP-triol, ultimate cacinogen, is shifted from 4, 5, 5a, and 6 positions of precarcinogen to 10, 10a, 12c, and 12b ones. The appreximate charge transfer quantities turned out to have the largest value between HOMO of Guanine and LUMO of BP-triol corresponding to TB region on each other.

• Environmental Mutagens and Carcinogens
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• v.8 no.1
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• pp.22-34
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• 1988

The biochemical changes of the hepatic tissues, induced by the carcinogen treatment such as diethylnitrosamine and acetamidofluorene in combination with the partial hepatectomy after Solt and Farber, were determined for the characterization of the induction of the proliferative capacity and the environmental adaptability of the carcinogenic tissues during the malignant transformation process. For the study of the proliferative capacity of the tissues, the activities of the enzymes, related with the nitrogen trapping mechanism, such as glutamine synthetase and gamma-glutamyltranspeptidase, were monitroed, while the cintents of cytochrome P450's and their isozymic patterns as well as the activities of the glutathione S-transferase were determined in the function of time after the hepatocarcinogenic stimuli.

• Proceedings of the Korea Air Pollution Research Association Conference
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• 2001.11a
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• pp.39-40
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• 2001

최근 들어서 환경유해물질이 인체의 건강에 미치는 영향에 대한 관심이 커지고 있다. 특히 환경 중에 존재하는 발암성 물질에 대한 연구가 활발히 진행되면서 이들 물질에 의한 인체에 미치는 위해성이 밝혀지고 있다. Polycyclic Aromatic Hydrocarbons(PAHs)는 환경에 존재하는 중요한 발암물질, 돌연변이 유도체이다. PAHs는 여러 종류의 배출원이나 배출원 가까이 있는 환경에서만 발견되는 것이 아니라, 장기간에 걸쳐 대기 중에서 멀리 운반되어 전세계적으로 확산되어진다. 건식 침적은 대기중 PAHs의 주요 제거기작 중 하나이다. (중략)

• Environmental Mutagens and Carcinogens
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• v.22 no.1
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• pp.54-59
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• 2002

We have used cDNA microarray hybridization to identify gene regulated in response to gamma-irradiation in U-937 cell. The cDNA-chip was composed entirely of 1,000 human cancer related gene including apoptosis and angiogenesis etc. In gamma-irradiated U-937 cell, highly charged protein, ribosomal protein L32, four and a half LIM domains 3, lipocalin 2 (oncogene 24p3) and interleukin 15, ataxia telangiectasia mutated (includes complementation groups A, C and D) genes showed increased level of its transcription, and cell division cycle 25A, dihydrofolate reductase, topoisomerase (DNA) II beta(180kD), kinase suppressor of ras and strarigin genes showed reduced level of its transcription compared to untreated U-937 cell. The significant change of level of transcription was not found in well-known ionizing radiation(IR)-responsive gene, such as transcription factor TP53 and p53 related gene, except ataxia telangiectasia mutated gene.

• Journal of Food Hygiene and Safety
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• v.14 no.4
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• pp.386-396
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• 1999

Commonly eaten fish, meat and other protein-containing foods show some level of mutagenic activity following normal cooking such as broiling, frying, grilling, roasting etc. The main food mutagens found in cooked products are“heterocyclic aromatic amines”. Several of them have been shown to be carcinogenic in rodent and suggested to be relevant for human cancer etiology. This review summarizes the chemistry, formation, occurrence and toxicity of food-borne heterocyclic aromatic amines. Factors that influence the formation of them are also discussed with special emphasis on dietary factors. From a health safety point of view, it is desirable to estimate the intake of heterocyclic amines via foods, and reduce or prevent the formation of food mutagens.

• Journal of Environmental Impact Assessment
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• v.28 no.2
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• pp.152-168
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• 2019

The element arsenic, which is abundant in the Earth's crust, is used for various industrial purposes including materials for disease treatment and household goods. Various human activities, such as the disposal of soil waste, metal mining and smelting, and combustion of fossil fuels, have caused the pollution of the environment with arsenic. Recently, guidelines for arsenic in rice have been adopted by the Korean ministry of food and drug safety to prevent health risks based on rice consumption. Because of the exposure to arsenic and its accumulation in the human body through various channels, such as air inhalation, skin contact, ingestion of drinking water, and food consumption, integrated multimedia risk assessment is required to adopt appropriate risk management policies. Therefore, integrated human health risk assessment was carried out in this study using integrated exposure assessment based on multimedia (e.g., air, water, and soil) and multi-route (e.g., oral, inhalation, and dermal) scenarios. The results show that oral uptake via drinking water is the most common pathway of arsenic into the human body, accounting for 57%-96% of the total arsenic exposure. Among various age groups, the highest exposures to arsenic were observed in infants because the body weight of infants is low and the surface areas of infant bodies are large. Based on the results of the exposure assessment, the cancer and non-cancer risks were calculated. The cancer risk for CTE and RME is in the range of 2.3E-05 to 6.7E-05 and thus is negligible because it does not exceed the cancer probability of 1.0E-04 for all age groups. On the other hand, the cancer risk for RME varies from 6.4E-05 to 1.8E-04 and from 1.3E-04 to 1.8E-04 for infants and preschool children, exceeding the excess cancer risk of 1.0E-04. The non-cancer risks range from 5.4E-02 to 1.9E-01 and from 1.5E-01 to 6.8E-01, respectively. They do not exceed the hazard index 1 for all scenarios and all ages.