• Proceedings of the KSLP Conference
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• 1998.11a
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• pp.198-198
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• 1998

성악발성 시 전문적인 성악가와 비전문가에서 성대외근의 수축 경향을 파악함으로써, 성대외근이 성악발성에 갖는 중요성을 파악하고, 얻어진 자료를 토대로 성악발성 숙련도의 판정이나 성악인의 음성치료에 활용할 수 있는 가능성을 알아보고자 하였다. 서양음악을 전공한 지 10년 이상 된 20-30대의 소프라노 4인을 성악가 군으로, 비전공자 여성 4인을 대조군으로 하여, E3 부터 C6 내의 9개 음을 낮은 음부터 시작하여 차례로 /이/ 모음을 수초간 발성하게 하였다. Multi-Mode Program (UP) Plus (Nicolet, Viking IV)와 1개 채널의 음성신호 및 3개 채널의 surface electrode를 이용하여 발성 시설골상근, 설골하근, 견갑설골근의 활동전위를 측정한 뒤, 단위시간 당 근전위 진폭의 합을 구하여 두 군간에 그 양상을 비교하였다. (중략)

• Phonetics and Speech Sciences
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• v.14 no.2
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• pp.77-86
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• 2022

This study aimed to investigate the voice onset time (VOT) of plosives in the VCV syllables by the place of articulation and phonation type spoken by children with bilateral cochlear implants (CIs) in comparison with children with typical hearing (TH). In all, 15 children with bilateral CIs and 15 children with TH participated in this study, aged between 5 to 10 years. All children produced 9 VCV syllables and their VOT were analyzed by the Praat software. There was no significant difference in mean VOT between children with bilateral CIs and children with TH. However, there was a significant difference in mean VOT by the place of articulation, such that the VOT for velars were longer than those for bilabials and alveolars. Additionally, there was a significant difference in mean VOT by the phonation type, such that the VOT of aspirated consonants were longer than those of lenis and fortis consonants. The results of this study suggest that children with bilateral CIs can distinguish the acoustic properties of plosive consonants and control the speech timing between the structures of the larynx and the oral cavity at a similar level as children with TH.

• Korean Journal of Environment and Ecology
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• v.29 no.6
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• pp.858-864
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• 2015

Developmental changes in the vocal signals of serotine bats (Eptesicus serotinus) during their infancy were examined in this study. The analysis was conducted on 4 infant serotine bats from 1 to 40 days after their birth. Pulse duration (PD), pulse interval (PI), peak frequency (PF), maximum frequency ($F_{MAX}$), minimum frequency ($F_{MIN}$), and bandwidth (BW) were measured. As the bats grew, their vocalizations became increasingly consistent and similar to those of adults. For infant bats, PD and PI decreased as they grew older, whereas PF, $F_{MAX}$, $F_{MIN}$, and BW increased. The greatest change in vocalizations was observed between the $10^{th}$ and $20^{th}$ days after birth. Also, PF, $F_{MAX}$, $F_{MIN}$ and BW, which describe sound frequency, increased dramatically during the period between the $10^{th}$ and the $20^{th}$ days. In contrast, the greatest change in PD occurred between the $30^{th}$ and $40^{th}$ days after birth. The results collected in this study suggest that frequency increased as the contraction ability of the muscles developed by around 20 days of age. Muscle relaxation ability, which is related to PD, was found to develop significantly at 30 to 40 days of age. According to the results of this study, although 40 day-old infant bats are not yet able to fly, their vocal signals were similar to those of adults. This indicates that vocal development and flying activity develop separately in young bats.

• Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics
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• v.17 no.2
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• pp.107-110
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• 2006

Background and Objeetives : There are few studies reported that specifically examined the voice onset time(VOT) in patients with bilateral vocal nodules. The purpose of this study was to study the characteristics of voice onset in patients with bilateral vocal nodules. Materials and Methods : 52 female patients with bilateral vocal nodules were examined, aged from 20 to 54 years, and were compared with 25 normal female control group. All subjects produced five repetitions of the voiceless stops $/p^h,\;t^h\;k^h/$ in vowel context /ai_a/. VOT was measured by the time between the release of the stops and the onset of voicing. Results : VOTs of the voiceless stops $/p^h/\;and\;/t^h/$ in patients with bilateral vocal nodules were significantly shorter than those of normal subjects. VOT of the $/k^h/$ in them was shorter than those of normals, but the difference was not significant. This results showed that VOTs of the voiceless stops in patients with bilateral vocal nodules were shorter than those of normal subjects. Conclusion : The rapid onset of voicing in patients with bilateral vocal nodules might be associated with increased laryngeal muscle tension by hard glottal attacks. We suggest that VOT can be a clinically useful acoustic parameter for evaluating voice in patients with bilateral vocal nodules.

• Proceedings of the KSLP Conference
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• 2003.11a
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• pp.201-204
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• 2003

호흡은 우리가 일상 생활에서 발화나 발성을 하는데 있어서 크기와 높낮이를 조절하는 중요한 역할을 하며 그 중에서 복식 호흡이 가장 이상적인 호흡이라 할 수 있겠다. 우리 인간이 처음 태어날 때는 복식 호흡을 가지고 태어난다. 예를 들면 갓난아이가 울 때 보면 배가 많이 움직이는 것을 볼 수 있으며 긴 시간을 울어도 울음의 소리의 변화가 거의 없다. 허나 성인이 갓난아이처럼 긴 시간을 운다면 울음소리의 변화가 온다. 이것은 우리 인간이 성장하면서 복식 호흡의 사용이 점차 줄고 흉식 호흡의 사용이 보편화되는데 그 이유는 우리 인간의 일상생활에서 복식 호흡이 크게 필요치 않기 때문이기도 하며 특히 여성의 경우는 대부분이 흉식 호흡을 사용하는데 갓난아이일 경우 남아나 여아가 복식 호흡을 사용하나 여아의 경우 성장하면서 즉 여아에서 여성으로 신체적 변화(첫 배란)가 시작되면서 호흡사용의 변화가 있지 않나 생각된다. 여성으로의 신체적 변화는 임신을 할 경우 자궁에서 태아의 성장에 자극을 피하기 위하여 흉식 호흡을 사용하며 성악도인 경우 여성이 남성보다 복식 호흡의 습득에 어려움이 있다 대부분의 여성 성악가의 경우 복식 호흡과 흉식 호흡의 중간을 사용한다. (중략)

• Journal of Acupuncture Research
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• v.22 no.1
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• pp.165-176
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• 2005

Objective : This study was to vertify the effect of Semen Sinapsis Albae Pressing at Sanyinjiao(SP6), Umnungchon(SP9) and Shinnsu(B23) on dysmenorrhea of Women's University Students. This study was an one group pretest-posttest experimental design. Methods : The subjects were 50 patients who was suffering for dysmenorrhea visited to D University Health center located in B city, from January to May, 2004. They had agreed to take part in this experiment, with didn't take any anodyne drugs. Results : The results of the study are as follows 1. Hypothesis 1 that "Semen Sinapsis Albae pressing in SP6, SP9 and B23 is decreased dysmenorrhea" is adapted(t=12.777, p=0.000). 2. Semen Sinapsis Albae pressing is more fast manifested in alleviation of pain, longer in duration of alleviation of pain, and had a less dysmenorrhea than anodyne drugs. Semen Sinapsis Albae pressing is probably more effective than who are dosed anodyne instead of pressing.

• Phonetics and Speech Sciences
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• v.16 no.2
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• pp.99-109
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• 2024

Coarticulation is affected by the continuous movement of the articulator within a limited time and space through the neighboring segments and various overlaps. This study investigated the differences in coarticulation characteristics of children with reading disabilities and nondisabled children in CVC and VCV syllables consisted of stops, affricates, and vowels (a, i, u). The subjects were 13 children with reading disabilities and nondisabled children in the 2nd to 6th grades in elementary school. Two second formants were measured. One was measured at the point where the vowel began, and the other was measured at the mid point of the vowel stable section. Regression analysis was performed with F2 onset and F2 of the following vowel to obtain the locus equation (LE). 3-way ANOVA was conducted to the slope of the LE according to the groups (reading disabilities vs. nondisabled), places of articulation, and phonation types. In CVC syllable, dyslexic children showed a flatter slope than nondisabled children. With respect to the places of articulation, velar or bilabial sounds showed steeper LE slope than alveolar or palatal sounds. There were no main effects regarding group and phonation types variable for VCV syllable, and the significant differences in the places of articulation were also differed from the results for the CVC syllables. This study confirmed that dyslexic children showed a different pattern of coarticulation slope depending on the syllable structure. We also found that the higher pause rate of the dyslexic children had a stronger effect on the coarticulation in VCV structures.

• Tuberculosis and Respiratory Diseases
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• v.43 no.4
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• pp.547-557
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• 1996

Background : An excessive accumulation of neutrophils in lung tissue has been known to play an important role in mediating the tissue injury among the adult respiratory distress syndrome, idiopathic pulmonary fibrosis and cystic fibrosis by releasing toxic oxygen radicals and proteolytic enzymes. Therefore, it is important to understand a possible mechanism of neutrophil accumulation in lung tissue. In many species, exposure to hyperoxic stimuli can cause changes of lung tissues very similar to human adult respiratory distress syndrome and neutrophils are also functioning as the main effector cells in hyperoxic lung injury. The purpose of the present study was to examine whether neutrophils function as a key effector cell and to study the nature of possible neutrophil chemotactic factors found in bronchoalveolar lavage fluid from the hyperoxia exposed rats. Methods : We exposed the rats to the more than 95% oxygen for 24, 48, 60 arid 72 hours and bronchoalveolar lavage(BAL) was performed. Neutrophil chemotactic activity was measured from the BAT- fluid of each experimental groups. We also evaluated the molecular weight of neutrophil chemotactic tractors using fast performance liquid chromatography and characterized the substances by dialyzer membrane and heat treatment. Results : 1) The neutrophil proportions in bronchoalveolar lavage fluid began to rise from 48 hours after oxygen exposure, and continued to be significantly increased with exposure times. 2) chemotactic index for neutrophils in lung lavages from rats exposed to hyperoxia was significantly higher in 48 hours group than in control group, and was significantly increased with exposure time. 3) No deaths occured until after 48 hours of exposure. However, mortality rates were increased to 33.3 % in 60 hours group and 81.3 % in 72 fours group. 4) Gel filtration using fast performance liquid chromatography disclosed two peaks of neutrophil chemotactic activity in molecular weight of 104,000 and 12,000 daltons. 5) Chemotactic indices of bronchoalveolar lavage fluid were significantly deceased when bronchoalveolar lavage fluid was treated with heat ($56^{\circ}C$ for 30 min or $100^{\circ}C$ for 10 min) or dialyzed (dialyzer membrane molecular weight cut off : 12,000 daltons). Conclusion : These results suggested that the generation of neutrophil chemotactic factor and subsequent neutrophil influx into the lungs are playing an important roles in hyperoxia-induced acute lung injury. Neutrophil chemotactic factor in the lung lavage fluids consisted of several distinct components having different molecular weight and different physical characteristics.

• Journal of Veterinary Clinics
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• v.32 no.6
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• pp.544-547
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• 2015

An 11-year-old, intact male Pekingese was brought to the Veterinary Teaching Hospital of Kangwon National University with a 10-day history of seizures. Fifteen days before coming to Kangwon National University, the dog had visited a local animal hospital for lameness, and non-steroidal anti-inflammatory drugs were prescribed to treat this symptom. However, 10 days before coming to our hospital, the dog experienced generalized seizures. Two days before his arrival, generalized ataxia and mental dullness also occurred. Our examinations revealed no remarkable findings on a routine blood test or X-ray. However, the neurological examinations confirmed mental dullness, generalized ataxia, and a lack of menace response and pupillary light reflexes. Nine hours later, dyspnea occurred, and 12 hours after that, the patient was euthanized per the client's request. A necropsy of transverse sections confirmed the presence of a prominent midline shift due to extended tumor growth. On histopathological analyses, pseudopalisading necrosis of the glial cells and microvascular proliferation were observed. In immunohistochemical analysis, glial fibrillary acidic protein, proliferating cell nuclear antigens, and ionized calcium binding adaptor molecule 1 immunoreactive cells were observed in the tumor area. Based on the results, the tumor was confirmed to be a glioblastoma. Primary intracranial tumors are rare in the veterinary field. This case report describes the clinical and histopathological findings of glioblastoma in a Pekingese.

• Parasites, Hosts and Diseases
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• v.29 no.3
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• pp.267-278
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• 1991

The natural killer (NK) cell activity of splenocytes and recycling capacity of NK cells were observed by combining the $^{51}Cr-release$ cytotoxicity assay and single cell cytotoxicity assay against YAC-1. The ICR mice were infected intranasally with Naegleria fewleri, that is a pathogenic free-living amoeba. The mice infected with $1{\times}10^5$ trophosoites showed mortality rate of 76.7% and mean survival time of 12. 9 days. The cytotoxic activity of NK cells in infected mice was significantly higher than that of non-infected mice during the period between 12 hours and day 3 after infection, and highest on day 1. The target-binding capacity of NK cells in infected mice was not different from that of non-infected ones. Maximal killing potential and maximal recycling capacity were remarkably increased in infected mice as compared with the control. The results obtained in this observation indicated that elevated NK cell activity in mice infected with N. fowieri was not due to target-binding capacity of NK cells but due to the increased activity of NK cells and increased recycling capacity of individual NK cells.