• Journal of Veterinary Clinics
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• v.21 no.2
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• pp.93-96
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• 2004

We examined the responses of PBMCs to house dust mite (HDM) allergen in atopic and healthy, non-atopic dogs to identify differences in lymphocyte reactivity that might reflect the immunologic status of atopic dermatitis. Thirteen of 20 (65%) atopic dogs showed a positive lymphocyte proliferative response to HDM allergen. The rate of response was significantly higher in the atopic dogs than that in healthy, non-atopic dogs insensitive to the allergen (P = 0.007). The proliferative responses were positively correlated with the level of HDM-specific IgE in serum (P = 0.035), and were thereby confirmed to reflect the activity of lymphocytes competent to promote IgE production. These results suggest that HDM-specific lymphocytes were present in peripheral blood and played a role in the pathogenesis of canine atopic dermatitis.

• Journal of Oral Medicine and Pain
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• v.26 no.3
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• pp.181-187
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• 2001

스트레스가 인체의 항상성에 영향을 미쳐 다양한 질병 및 동통을 일으킬 수 있다는 것은 선학들의 연구에 의해 증명되어 왔다. 특히 정서적으로 중요한 구강안면영역에는 스트레스와 관련된 질병 및 동통이 많이 존재하는데, 이에대한 병리적 기전은 아직 뚜렷하게 밝혀져 있지 않다. 이에 저자는 스트레스와 말초 및 중추신경과의 병리적 관계를 알아보고자, 구속스트레스하에서 구강안면영역의 감각과 운동에 중요한 역할을 하는 삼차신경의 집합체인 삼차신경절과 뇌간조직의 단백질 변화를 western blot을 통해 살펴보았다. 실험동물은 생후 8주된 Sprague-Dawley계 웅성 백서 (323-367 g/bw)를 대조군 3마리, 실험군 15마리로 배정하였고 실험군은 실험 전기간에 걸쳐 구속스트레스를 부여하였다. 실험동물의 삼차신경절과 뇌간은 희생 즉시 적출되었으며, western blot을 시행하여 다음과 같은 결론을 얻었다. 1. 삼차신경절의 모든 군에서 약 18 KDa의 단백질이 균일하게 나타났다. 2. 뇌간의 모든 군에서 약 18 KDa 단백질이 발현되었으며, 정상 대조군, 실험 즉일, 1일, 3일, 7일에서는 뚜렷한 변화가 없었으나 실험 5일군에서는 현저한 감소를 보였다. 구속스트레스에 의해 뇌간의 5일군에서 약 18 KDa의 특수한 단백질이 뚜렷이 감소된 후 7일 군에서 다시 증가되었던 것은 스트레스에 의한 뇌간세포의 반응으로 생각되며, 뇌간에서와 다르게 삼차신경절에서는 그 변화가 나타나지 않았던 것은 스트레스에 대한 조직의 반응 차이라고 생각된다. 따라서 이를 명확하게 확인하기 위해서는 향후 수종의 스트레스와 관련된 단백질 변화에 대한 추가적인 연구가 필요하리라 사료된다.

• The Journal of Korean Physical Therapy
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• v.3 no.1
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• pp.75-90
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• 1991

This study is to characterize the effects of swimming exercise on the composition of muscle fibers in rats lower limb tissue. By comparing the exercised group (4, 8 weeks) with the control group, we analyzed the difference histologically, histochemically and morphometrically. The obtained results are as follows ; 1. In the histological view, the distance between the individual muscle fibers and the muscle bundles in exercised group was shorter than that of control group. The irregular shape of sarcolemma in exercised group was observed. 2, In the histochemical view(NADH-TR. and Myosin ATPase reaction analysis), the increased populations of red and intermediate fibers were observed, whereas the white fiber was decreased. 3. In the morphometrical view, the red and intermediate fibers of tibialis anterior and gastrocnemius in exercised group were quantitatively increased, compared with control group. However, the white fiber and connective tissue in exercised group were decreased.

• Journal of Nutrition and Health
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• v.23 no.6
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• pp.418-426
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• 1990

This study examines the effects of choline deficiency and 2-acetylaminofluorene(2-AAF) on the lipid peroxide values, glucose 6-phosphatase(G6Pase) and glutathione S-transferase (GST) activities in rats fed different dietary fats. Weanling Sprague Dawley male rats fed the diets containing 15% beef tallow or 15% corn oil with vitamin fortification mixture or choline free vitamin mixture for 10 weeks. At 3th and 5th week, 2-AAF was injected twice each week intraperitoneally. Total 2-AAF injection was four times. 2-AAF and choline deficiency increased lipid peroxidation in corn oil groups, so the role of 2-AAF and choline deficiency in lipid peroxidation was more important in corn oil groups than beef tallow groups. G6Pase activities tended to be decreased by 2-AAF in choline deficient groups, and in corn oil groups, the enzyme activities were decreased significantly in all subgroups compaired to beef tallow groups. GST activities were increased by 2-AAF in beef tallow groups and choline deficiency in corn oil groups, and might defence against carcinogen metabolism and lipid peroxidation.

• Proceedings of the Korean Environmental Sciences Society Conference
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• 2002.05b
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• pp.475-476
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• 2002

$SO_2$ 폭로군의 기관 상피층의 섬모에서 DBA 및 SBA는 50ppm 이하 $SO_2$ 폭로군에서는 대조군에 비해 증가하였으며 sWGA 및 UEA-1은 대부분의 $SO_2$ 폭로군에서 대조군에 비해 증가하였다. 섬모세포에서 LCA 및 Con A는 100ppm 및 200ppm $SO_2$ 폭로군에서 대조군에 비해 약간 증가하였다. 배상세포에서는 대부분의 렉틴의 반응성이 50ppm 이하의 $SO_2$ 폭로군에서는 증가하였다가 100ppm 및 200 ppm $SO_2$ 폭로군에서는 현저히 감소하였다. 장액선포에서는 LCA 및 Con A는 모든 $SO_2$ 폭로군에서 대조군보다 증가하는 경향을 보였으며 점액선포에서는 대조군에서 관찰되지 않았던 RCA-1은 50ppm 및 100ppm $SO_2$ 폭로군의 일부 선포에서 증가하였다. 위의 결과로 보아 $SO_2$는 기관에 심대한 병리조직학적 변화뿐만 아니라 glycoconjugates대사에 심대한 영향을 미쳐 심한 병변을 야기시킴을 알 수 있었다. 전반적으로 $SO_2$의 호흡기 영향은 고농도로 갈수록 심한 영향을 나타내었다. 저농도에서도 폭로 시간이 길어짐에 따라 나타나는 $SO_2$의 영향이 고농도와 유사한 경향을 나타내며 또한 모든 $SO_2$의 농도를 비교해보면 폭로 시간이 길어질수록 그 영향이 더 심하게 나타났다.

• Journal of the Korean Society of Radiology
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• v.82 no.4
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• pp.876-888
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• 2021

Purpose The aim of this study was to compare the diameter and volume of liver metastases on CT images in relation to overall survival and tumor response in patients with gastric cancer liver metastases (GCLM) treated with chemotherapy. Materials and Methods We recruited 43 patients with GCLM who underwent chemotherapy as a first-line treatment. We performed a three-dimensional quantification of the metastases for each patient. An independent survival analysis using the Response Evaluation Criteria in Solid Tumors (RECIST) was performed and compared to volumetric measurements. Overall survival was evaluated using Kaplan-Meier analysis and compared using Cox proportional hazard ratios following univariate analyses. Results When patients were classified as responders or non-responders based on volumetric criteria, the median overall survival was 23.6 months [95% confidence interval (CI), 8.63-38.57] and 7.6 months (95% CI, 3.78-11.42), respectively (p = 0.039). The volumetric analysis and RECIST of the non-progressing and progressing groups showed similar results based on the Kaplan-Meier method (p = 0.006) and the Cox proportional hazard model (p = 0.008). Conclusion Volumetric assessment of liver metastases could be an alternative predictor of overall survival for patients with GCLM treated with chemotherapy.

• Defense and Technology
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• no.2 s.288
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• pp.50-59
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• 2003

전술$C^4I$체계가 전력화되어 작전반응이 더욱 빨라지고 획득한 정보가 필요한 부서와 제대에 모두 공유되고, 부대의 각종 자산을 충분히 활용 가능하며, 전장상황의 인식이 더욱 용이해지게 된다. 또한 전술$C^4I$체계 구축을 통해 미래 지상전장 운용개념인 "다차원 동시 통합전투"가 비로소 가능해진다. 이런 직접적인 효과 이외에도 군의 과학화 마인드를 확산시키며, 민간의 선진기술이 군에 적용되는 간접적인 효과가 있을 것이다. 우리 군이 현재 미래 전장환경과 주변국 위협에 대비하여 장거리 타격수단에 표적을 제공하기 위한 대부대용 UAV를 전력화하여 전천후 감시로 실시간 장거리 영상정보를 수집하고 있는 것은 획기적인 사실이다.

• The Korean Journal of Pharmacology
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• v.28 no.1
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• pp.49-60
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• 1992

This study was designed to evaluate the responses of cardiovascular system to endothelin (ET) and neuropeptide Y (NPY) in 12 week-old SHR treated with or without enalapril (ENP) for 6 weeks. The diastolic blood pressure and heart rate were lower in ENP-treated SHR than in control. The pressor response to intravenous, but not intracerebroventricular, ET or NPY was attenuated by ENP treatment. The chronotropic action induced by electrical stimulation was attenuated by ENP or ET. The negative chronotropic action of ET was blocked by yohimbine. The increase in aortic tension induced by electrical field stimulation (EFS) was depressed in ENP-treated group as compared with non-treated group, and enhanced by ET, but not NPY, in the non-treated group. The ET-induced increase in tension was enhanced by removal of endothelium in the control group but not in ENP-treated group. The plasma concentration of norepinephrine and ET-induced increase in concentration of norepinephrine and epinephrine in plasma were decreased in ENP-treated group. These results suggest that preventive effect of enalapril on the development of hypertension may result from depressing vasoactive action of endothelin and neuropeptide Y, and sympathetic neurotransmission at peripheral nervous system.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.15 no.1
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• pp.91-100
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• 2004

Objectives：The effects of repeated maternal separation on the expression of glucocorticoid receptor (GR) and cyclooxygenase-2(COX-2) in the hippocampus of rat pups at preweanling stage were evaluated. Methods：The experimental, Repeated Maternal Separation group(N=4) was separated from the mother for four hours a day over a period of ten days beginning with postnatal day 4. The Control group(N=4), on the other hand, did not separated from the mother at all. GR and COX-2 expression in the hippocampus was examined by immunohistochemistry on postnatal day 14. Results：It was determined that the number of GR-immunopositive cells in the dentate gyrus of the hippocampus was significantly increased in the Repeated Maternal Separation group. The numbers of COX-2-immunopositive cells in the CA1 and CA3 were also significantly higher in the Repeated Maternal Separation group. Conclusion：These results suggest that maternal separation may be a significant developmental stress that induces GR and COX-2 expression in the hippocampus of developing pups.

• Korean Journal of Biological Psychiatry
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• v.18 no.1
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• pp.36-45
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• 2011

Objectives : Though a proportion of Alzheimer's disease(AD) patients treated with donepezil have shown positive response on cognition, but the responders' characteristics are still uncertain. This study attempts to identify whether a single oral dose of donepezil(5mg) can change cognition and the relationship between single dose responder items and long-term responder are examined. Methods : Twenty-three AD patients for single donepezil challenge study group and eleven AD patients for controls were participated in the study. Seven days after baseline study for neuropsychological test and EEG, same studies were rechecked after donepezil medication in study group. In donepezil study groups, 12 weeks after donepezil medication, neuropsychological test and EEG were rechecked. Results : After single donepezil challenge, forward digit span, Rey-Osterrieth Complex Figure Test copy, SVLT delayed recall were significantly improved, and beta spectra power in anterior, theta spectra power in posterior field were significantly decreased. According to linear regression analysis, forward digit span after single donepezil challenge was significantly positive correlated with long-term responders. Conclusions : This study suggests that single donepezil medication can significantly change cognitive functions and EEG in AD patients. Among these responsive items, forward digit span was significantly correlated with long-term responder.