• Analytical Science and Technology
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• v.36 no.3
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• pp.105-112
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• 2023

Lycopene, a carotenoid hydrocarbon is known to have effects on reducing cardiovascular risk factors, blood lipids, and blood pressure. Thus, a lot of supplementary foods with lycopene in several dosage forms like soft capsule filled with liquid and hard capsule filled with powder are available in a market. Recently, however, our research group found that the lycopene assay in Supplementary Food Code of South Korea is only valid for oily lycopene preparation. Thus, here, we developed a simple method to determine lycopene in solid preparations for Supplementary Food Code of South Korea using saponification and liquid chromatography with an absorbance detector. The method was validated following Ministry of Food and Drug Safety guidelines. All validation parameters observed in this study were within acceptable criteria of the guidelines (selectivity, linearity of r² ≥ 0.991, lower limit of quantification of 0.0149 mg/mL, accuracy as recovery (R) between 92.70 and 97.18 %, repeatability as relative standard deviation (RSD) values of R between 0.85 and 1.59 %, and reproducibility as the RSD value of interlaboratory R of 3.70 %). Additionally, the practical sample applicability of the validated method was confirmed by accuracy between 98.81 and 101.59 % observed from its lycopene certified reference material (CRM) analyses. Therefore, the present method could contribute to fortify the supplementary food safety management system in South Korea.

• The Korean Journal of Nuclear Medicine Technology
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• v.17 no.2
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• pp.3-9
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• 2013

Purpose: Currently commercially available phantom can reproduce and evaluate only a static situation, the study is incomplete research on phantom and system which is can confirmed functional situation in the kidney by time through dynamic phantom and blood flow velocity, various difference according to the amount of radioactive. Therefore, through this study, it has produced the dynamic kidney phantom to reproduce images through the dynamic flow of the kidney, it desire to evaluate the usefulness of nuclear medicine imaging. Materials and Methods: The production of the kidney phantom was fabricated based on the normal adult kidney, in order to reproduce the dynamic situation based on the fabricated kidney phantom, in this study it was applied the volume pump that can adjust the speed of blood flow, so it can be integrated continuously radioactive isotopes in the kidney by using $^{99m}Tc-pertechnate$. Used the radioactive isotope was supplied through the two pump. It was confirmed the changes according to the infusion rate, radioactive isotopes and the different injection speeds on the left and right, analysis of the acquired images was done by drawn ten times ROI in order to check the reproducibility of each on the front and rear of the kidney and bladder. Results: Under the same conditions infusion rate 40 mL/min fixed to adjust the pressure of the pump when the radiopharmaceuticals between 2-3 minutes in the most integrated in the kidney phantom was excreted inthe bladder. Glomerular filtration rate (GFR), respectively, by each device SYMBIA 1,091 mL/min, FORTE 1,232 mL/min, ARGUS 1,264 mL/min, INFINIA 1,302 mL/min in that there isno statistically significant difference was found, Tmax values and T1/2 values stars from all equipment with no statistically significant difference was found. CV values of the coefficient of variation less than 5% was found to be repeatable, and to 2.67% of the lowest SYMBIA appeared, INFINIA was the highest in the 4.86%. Conclusion: Through this study, the results showed that the dynamic kidney phantom system is able to similarly reproduce renogram in the actual clinical. Especially, the depicted over time for the flow to be excreted through the kidney into the bladder was adequately reproduce, it is expected to be utilized as basic data to check the quality of the dynamic images. In addition, it is considered to help in the field of functional imaging and quality control.

• The Korean Journal of Pesticide Science
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• v.16 no.4
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• pp.391-394
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• 2012

Exposure and risk assessment during mixing/loading of chlorpyrifos emulsifiable concentrate (EC, 20%) were carried out. Limit of detection and limit of quantitation were 0.02 and 0.1 ng, respectively. Calibration curve linearity and reproducibility were excellent. Recovery of chlorpyrifos from gloves was 72.3-103.4%. During mixing/loading procedure, average hand exposure amount of chlorpyrifos was 3.9 mg which is corresponding to 0.004% of total active ingredient in the prepared spray mixture. In calculation of MOS (Margin of Safety) for risk assessment, male Korean average body weight and AOEL (Acceptable Operator Exposure Level) were used. Nine events of mixing/loading procedure were assumed per day. And 75 percentile of 30 repetition (4.6 mg) was used as for the worst case. MOS was more than 1 for total repetition, indicating mixing/loading work was of least risk. However, MOS of individual repetition was examined, two cases were less than 1 suggesting careful work habit is essential in mixing/loading procedure.

• Journal of Technologic Dentistry
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• v.34 no.3
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• pp.213-220
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• 2012

Purpose: The aim of this study was to determine the repeatability and reproducibility of two dental scanners. Methods: The master die and the stone replicas(Kavo, Germany) were digitized in touch-probe scanner(Incise, Renishaw, UK), white light scanner(Identica, Medit, Korea) to create 3-dimensional surface-models. The number of points in the point clouds from each reading were calculated and used as the CAD reference model(CRM). Discrepancies between the points in the 3-dimensional surface models and the corresponding CRM were measured by a matching-software(Power-Inspect R2, Delcam Plc, UK). The t-student test for one samples were used for statistical analysis. Results: The reproducibility of both scanner was within $3{\mu}m$, based on mean value. The mean value between measurements made directly on the touch probe scanner digital models and those made on the white light scanner digital models was $2.20-2.90{\mu}m$, and was statistically significant(P<0.05). Conclusion: With respect to adequate data acquisition, the reproducibility of dental scanner differs. Three-dimensional analysis can be applied to differential quality analysis of the manufacturing process as well as to evaluation of different analysis methods.

• Journal of The Korean Association For Science Education
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• v.36 no.4
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• pp.617-628
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• 2016

This study aims to explore pre-service biology teachers' value orientation in terms of scientific observation and representation in plant cell microscope observation experiment. This study focuses on the pre-service teachers' value orientation in relation to objectivity. To achieve this aim, we used a hypothetical situation that pre-service teachers should teach tacit knowledge related to observation and representation during the cell observation class. We presented a hypothetical situation to fifty pre-service biology teachers and collected their answer about that hypothetical situation. These answers were categorized inductively based on constant comparative analysis. The result shows that four types of pre-service teachers' value orientation, 'presence confirmation', 'mechanical objectivity', 'students' subjectivity', and 'trained judgement', are confirmed. This result also shows that various value orientation could be reflected on teaching an experiment and tacit knowledge related to the experiment. Also, many pre-service teachers value 'mechanical objectivity' in observation and image representation. Also, pre-service teachers' value orientation and perception of objectivity in scientific practice could have an influence in teaching science, this result could give provide suggestions on science teachers' education in terms of scientific practice.

• Proceedings of the Korea Water Resources Association Conference
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• 2012.05a
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• pp.407-407
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• 2012

우리나라 뿐 아니라 전 세계적으로 지구온난화에 따른 기후변화에 의해 홍수 및 이상가뭄이 빈발하고 있다. 또한 산업화와 도시화에 따른 물수요 및 각종 오폐수의 증가로 수질오염도 심화되어 물 사용의 한계를 느끼게 되는 심각한 상황을 맞이하고 있다. 특히 우리나라는 1990년 이후 남부지역을 중심으로 겨울에서 봄철까지의 만성적인 가뭄 횟수가 증가하고 여름철에는 태풍과 집중호우가 빈번하게 발생함으로써, 가뭄 및 홍수로 인한 피해가 늘어나고 있는 실정이다(한국수자원공사, 2002). 이러한 상황에서 가뭄은 홍수에 비해 체계적인 종합대책 마련이 미비한 실정이다. 가뭄은 불가피성과 반복성을 가진 자연 현상이므로 가뭄 발생 전 사전대비계획과 가뭄발생시 가뭄관리체계 구축을 통해 그 피해를 최소화해야 한다. 또한 가뭄의 특성상 다른 자연재해와는 달리 진행속도가 느리므로 사전에 대처할 수 있는 시간적 여유가 있다. 따라서 가뭄 진행상황의 모니터링을 통해 신속한 대처와 피해경감 효과를 기대할 수 있다. 본 연구에서는 대상지역의 가뭄심도를 평가하여 가뭄상황에 대처하고자 우리나라에 적합한 가뭄 분류기준을 제시하였다. 관측년수 30년 이상의 강우자료를 확보한 61개 지점에 대해 1973년부터 37년 치의 월강우량 자료를 사용하였고 현 정부기관에서 사용되고 있는 가뭄상황단계를 그대로 활용하여 본 연구에서도 통일화된 가뭄 구간을 총 4등급으로 구분하였다. 한국수자원공사에서 제시한 주요가뭄발생현황을 참고하여 우리나라에 맞는 가뭄심도의 분류기준을 가뭄 발생의 누가 확률 98-100%를 예외적인 가뭄(Exceptional Drought), 94-98%를 극심 가뭄(Extreme Drought), 90-94%는 심한 가뭄(Severe Drought), 86-90%는 보통 가뭄(Moderate Drought)으로 구분하였다. 각 지점의 가뭄지수(SPI, PDSI)를 내림차순으로 작성하여 가뭄심도 분류기준에 맞는 가뭄지수의 정량적 값을 산정하였다. SPI와 PDSI의 가뭄심도 분류 결과와 실제 가뭄을 비교하기 위해 년 단위 비교와 월 단위 비교를 분석한 결과, 년 단위 비교와 SPI의 월 단위 비교는 각 지역의 가뭄지수 평가가 대부분 일치하게 나타났으나 같은 기간의 PDSI의 월 단위 비교는 실제 기록과 분석치가 일치하지 않았다. 이는 이들 지수의 상호보완에 대한 추후 연구의 필요성을 보여주는 것으로 판단된다.

• Journal of the Institute of Electronics and Information Engineers
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• v.51 no.11
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• pp.221-228
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• 2014

The color and shape of the tongue reflect the physiological and clinico-pathological condition of the body. Recently, various tongue image acquisition devices have been developed for accurate diagnosis based on quantitative and objective tongue features. Since a color information is essential for tongue diagnosis, the performance of an illuminator is very important for the tongue image acquisition device. In this study, we developed an indirect illumination, which is possible to improve a homogeneity of light intensities on the tongue surface, and evaluated its performances. In order to realize the indirect illumination (II), a semi-ellipsoidal solid structure (SESS) for the light reflex was located in the system, and two high-brightness white LEDs were placed for illuminating the areas under frontal camera in the SESS. The tongue surface was illuminated by reflected light from the SESS. The light homogeneity induced by three different illuminations including the II was evaluated by calculating coefficient of variation (CV) of illuminance of five regions. The II showed less than 0.01 of CV and the direct illumination (DI) and the direct illumination with a light diffusion plate (DILDP) showed 0.16 and 0.13, respectively. The reflexed pixel ratios of tongue phantom images show 5.76%, 4.22%, 1.79% for the DI, the DILDP and the II, respectively. The homogeneity of a tongue phantom was evaluated by calculating CV of mean pixel values of six different tongue regions, and showed less than 0.06 in the II. If the II technique apply to tongue diagnosis system, it is expected to improve diagnostic accuracy in clinic.

• Journal of radiological science and technology
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• v.36 no.1
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• pp.49-55
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• 2013

Currently, commercially available phantom can reproduce and evaluate only a static situation, the study is incomplete research on phantom and system which is can confirmed functional situation in the kidney by time through dynamic phantom and blood flow velocity, various difference according to the amount of radioactive. Therefore, through this study, it has produced the dynamic kidney phantom to reproduce images through the dynamic flow of the kidney, it desires to evaluate the usefulness of nuclear medicine imaging. The production of the kidney phantom was fabricated based on the normal adult kidney, in order to reproduce the dynamic situation based on the fabricated kidney phantom, in this study, it was applied the volume pump that can adjust the speed of blood flow, so it can be integrated continuously radioactive isotopes in the kidney by using $^{99m}Tc$-pertechnate. Used the radioactive isotope was supplied through the two pump. It was confirmed the changes according to the infusion rate, radioactive isotopes and the different injection speeds on the left and right, analysis of the acquired images was done by drawn five times ROI in order to check the reproducibility of each on the front and rear of the kidney and bladder. Depending on the speed of injection, radioisotope was a lot of integrated and emissions up when adjusting the pressure of the pump as 30 stroke, it was the least integrated and emissions up when adjusting as 40 stroke. The integration of the left & right kidney was not reached in the amount of the highest when adjusting as 10 stroke. In the changes according to the amount of the radioactive isotope, 0.6 mCi(22.2 MBq), 0.8 mCi (29.6 MBq)was showed up similar tendency but, in the result of the different injection 0.8 mCi, it was showed up counts close to double of 0.6 mCi. In the result of the differently injection speed of the left & right kidney, as a result of different conditions that injection speed was 20 stroke through left kidney phantom, the injection speed was 30 stroke through right kidney phantom, it was enough difference in the resulting image can be easily distinguished with the naked eye. Through this study, the results showed that the dynamic kidney phantom system is able to similarly reproduce renogram in the actual clinical practice. Especially, the depicted over time for the flow to be excreted through the kidney into the bladder was adequately reproduce, it is expected to be utilized as basic data to check the quality of the dynamic images. In addition, it is considered to help in the field of functional imaging and quality control.

• Progress in Medical Physics
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• v.25 no.1
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• pp.31-36
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• 2014

We aimed to evaluate the dosimetric characteristics of reproducibility, linearity and dose dependence of optical stimulated luminance dosimeter (OSLD) in the Co-60 Gamma-rays and to analyze with a precedent study in field of the diagnostic radiography and radiotherapy. The reproducibility was 0.76% of the coefficient of variation, the homogeneity was within 1.5% of the coefficient of variation and OSLD had supra-linear response more than 3 Gy. So the correlation between dose and count was fitted by quadratic function. The count depletion by repeated reading was 0.04% per reading regardless of the irradiated dose. And the half time of decay curve according to the irradiated dose was 0.68 min. with 1 Gy, 1.04 min. with 5 Gy, and 1.10 min. with 10 Gy, respectively. In case of annealing for 30 min, the removal rate was 88% with 1 Gy, 90% with 5 Gy, and 92% with 10 Gy, respectively and 99% in case of annealing time for 4 hour. It is feasible to use OSLDs for dose evaluation in Co-60 Gamma-rays when considering the uncertainty on the procedure according to the irradiated dose.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.13 no.3
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• pp.373-384
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• 2000

To assess the safety of nonlinear steel frame structures subjected to short duration dynamic loadings, especially seismic loading, a nonlinear time domain reliability analysis procedure is proposed in the context of the stochastic finite element concept. In the proposed algorithm, the finite element formulation is combined with concepts of the response surface method, the first order reliability method, and the iterative linear interpolation scheme. This leads to the stochastic finite element concept. Actual earthquake loading time-histories are used to excite structures, enabling a realistic representation of the loading conditions. The assumed stress-based finite element formulation is used to increase its efficiency. The algorithm also has the potential to evaluate the risk associated with any linear or nonlinear structure that can be represented by a finite element algorithm subjected to seismic loading or any short duration dynamic loading. The algorithm is explained with help of an example and verified using the Monte Carlo simulation technique.