• 한국미생물·생명공학회지
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• 제30권1호
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• pp.8-14
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• 2002

Pseudomonas sp. S-47은 xylXYZLTE 유전자에 의하여 암호화되는 효소군에 의하여 4CBA를 분해하여 5-chloro-2-hydroxymuconic semialdehyde(5C-2HMS)를 생성하는데, 본 연구에서는 이 5C-2HMS의 다음 분해과정을 확인하였다. xylXYZLTE 유전자와 5-chloro-2-hydroxymuconic semialdehyde dehydrogenase(5C-2HMSD)를 암호화하고 xylG 유전자를 포함하는 재조합 균주인 pCSS202로부터, xylG 유전자를 포함하는 재조합 플라스미드 pENV5를 만들었다. 이 플라스미드는 2-hydroxymuconic semialdehyde, 3-chloro-muconate, 2-hydroxy-6-oxohepta-2,4-dienoate, 2-hydroxy-5-methylmuconic semialdehyde와 같은 aromatic compound 에서 분해능을 나타냈으며, 그 중 5C-2HMS에서 가장 높은 분해능을 나타내었다. 또한 5C-2HMSD를 암호화하는 유전자인 xylC의 염기서열을 분석한 결과, 약 1,600 bp의 염기와 486개의 amino acid residue를 갖고있는 것을 확인하였다. P. sp. S-47의 xylG 유전자를 비교 분석한 결과 P. putida CF600, P. putida G7과 P. putida mt-2 등의 5C-2HMS dehydro-genase와 85％ 이상의 amino acid homology를 보여주었다.

• 한국산학기술학회논문지
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• 제14권9호
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• pp.4437-4446
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• 2013

본 연구의 목적은 택시운전자를 위한 심뇌혈관질환 예방 프로그램을 개발하고 생리적 변수(혈압, 혈당, 혈청 지질), 신체적 변수(체지방율, 근지구력, 심폐지구력, 균형)에 미치는 효과를 검증하고자 시도하였다. 본 연구는 프로그램 개발과 효과 평가의 2단계로 진행하였다. 1단계는 택시 운전자를 위한 심뇌혈관질환 예방 프로그램을 개발하기 위해 2011년 3월 2일부터 4월 30일까지 택시 운전자 321명을 대상으로 건강상태 및 생활습관, 건강관리 요구도를 설문조사하였으며 이를 근거로 프로그램을 개발하였다. 2단계는 개발된 프로그램의 효과를 검증하기 위해 2011년 6월 1일부터 10월 5일까지 택시 운전자 51명에게 12주 동안 운동 1주 3회, 질병교육 4회, 영양 상담 2회 실시하였다. 연구결과는 프로그램 전보다 후에 혈압, 혈당, 혈청지질은 통계적으로 유의하게 감소하지 않았으나 체지방율은 유의하게 감소하였으며(t=3.108, p=.003), 근지구력(t=-7.621, p<.001), 심폐지구력(t=-3.388, p=.001), 균형(t=-4.133, p<.001)은 통계적으로 유의하게 증가한 것으로 나타났다. 이와 같은 결과를 근거로 운동, 질환교육, 영양상담으로 구성된 프로그램을 고혈압, 당뇨, 비만 등 심뇌혈관질환 선행질환 유병율이 높은 택시 운전자를 위한 심뇌혈관질환 예방프로그램으로 제안하고자 한다.

• 한국전기전자재료학회논문지
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• 제23권7호
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• pp.545-549
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• 2010

Low-frequency noise (1/f noise) has been measured in order to analyze the Vth instability of ZnO TFTs having two different active layer thicknesses of 40 nm and 80 nm. Under electrical stress, it was found that the TFTs with the active layer thickness of 80 nm shows smaller threshold voltage shift (${\Delta}V_{th}$) than those with thickness of 40 nm. However the ${\Delta}V_{th}$ is completely relaxed after the removal of DC stress. In order to investigate the cause of this threshold voltage instability, we accomplished the 1/f noise measurement and found that ZnO TFTs exposed the mobility fluctuation properties, in which the noise level increases as the gate bias rises and the normalized drain current noise level($S_{ID}/{I_D}^2$) of the active layer of thickness 80 nm is smaller than that of active layer thickness of thickness 40 nm. This result means that the 80 nm thickness TFTs have a smaller density of traps. This result correlated with the physical characteristics analysis performmed using XRD, which indicated that the grain size increases when the active layer thickness is made thicker. Consequently, the number of preexisting traps in the device increases with decreasing thickness of the active layer and are related closely to the $V_{th}$ instability under electrical stress.

• Journal of Trauma and Injury
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• 제27권3호
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• pp.50-56
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• 2014

Purpose: Rollover motor vehicle crashes have a higher injury severity and fatality than other motor vehicle crash types. From a left-quarter turn rollover accident of 25-passenger bus, we intend to assess the injury of the occupant and the injury severities according to the occupants' position. Methods: We carried out the 3 steps investigation of occupants' interview, visiting the repair shop and using the police report. We analyzed injuries sustained by occupants, and compared injury severities considering column, row in occupant's position and passenger interaction Results: The rollover involved 14 passengers in the bus who were all old women except a man driver. The most common injury was in the upper extremity, with six occurrences being a left clavicle fracture. Major injuries including hemothorax and pneumothorax were diagnosed at left side of the occupant. In the comparison of injury severity among driver's column (left side), mid column and passengercolumn, ISS of passenger column was the highest ($9.9{\pm}7.4$, $8.8{\pm}5.5$, and $10.3{\pm}4.0$, respectively, p>0.05). The injury severity of multiple occupants by row was higher than that of single occupant (10.8 vs. 3, p<0.05). Conclusion: An occupant must fasten their seat belt to prevent an injury by passenger interaction in the left-quarter turn rollover accident of a bus.

• Journal of Preventive Medicine and Public Health
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• 제29권4호
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• pp.843-851
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• 1996

To estimate the incidence of uterine cervix cancer among Korean women, we have conducted a study using the claim data on the beneficiaries of Korea Medical Insurance Corporation (KMIC). All medical records of the potential cases with diagnosis of ICD-9 180, 181, 182, 199, 219, 233 in the claims sent by medical care institutions in the whole country to the KMIC from January 1988 to December 1989, were abstracted and Gynecology specialist reviewed the records to identify the new cases of uterine cervix cancer among the potential cases during the corresponding period. Using these data, the incidence of uterine cervix cancer among Korean women was estimated as of July 1, 1988 to June 30, 1989. The crude rate was estimated to be 17.34(95% CI: $16.76\sim17.92$) per 100,000 and the cumulative rates for the ages $0\sim64\;and\;0\sim74$ were 1.7% and 2.2%, respectively. The age-adjusted rate for the world population was 19.93 per 100,000 which was higher than those of other Asian countries including China and Japan in $1983\sim1987$. The truncated rate for ages $35\sim64$ was 52.05 per 100,000 which was one of the highest in the world. With increasing age, the incidence rate increased to 78.11 per 100,000 in women aged $55\sim59$ years, then it decreased in the older groups. This finding suggests that detecting rate of uterine cervix cancer may decrease in women aged 60 years or older due to inadequate medical care seeking behavior. In the geographical area, the SIR of Jeju province was significantly low but it might be due to statistical unstability by small case numbers.

• Journal of Preventive Medicine and Public Health
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• 제39권1호
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• pp.39-45
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• 2006

Objectives: This study estimated the burden of disease especially caused by psychiatric disorders in Korea by using DALY, a composite indicator that was recently developed by the Global Burden of Disease study group. Methods: First, 11 of the major psychiatric disorders in Korea were selected based on the ICD-10. Second, the burden of disease due to premature death was estimated by using YLLs (years of life lost due to premature death). Third, for the calculation of the YLD (years lived with disability), the following parameters were estimated in the formula: the incidence rate, the prevalence rate and the disability weight of each psychiatric disorder. Last, we estimated the DALY of the psychiatric disorders by adding the YLLs and YLDs. Results: The burden of psychiatric disorder per 100,000 people was attributed mainly to unipolar major depression (1,278 person-years), schizophrenia (638 person-years) and alcohol use disorder (287 person-years). For males, schizophrenia (596 person-years) and alcohol use disorder (491 person-years) caused the highest burden. For females, unipolar major depression (1,749 person-years) and schizophrenia (680 person-years) cause the highest burden. As analyzed by gender and age group, alcohol use disorder causes a higher burden than schizophrenia in men aged 40 years and older. For females, unipolar major depression causes the highest burden in all age groups. Conclusions: We found that each of the psychiatric disorders that cause the highest burden is different according to gender and age group. This study's results can provide a rational basis to plan a national health policy regarding the burden of disease caused by psychiatric disorders.

• Clinical and Experimental Reproductive Medicine
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• 제32권2호
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• pp.155-164
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• 2005

Objective: This study was performed to investigate the effects of pioglitazone, an insulin sensitizing agent, on insulin resistance, ovarian function and intraovarian stromal blood flow in patients with polycystic ovarian syndrome (PCOS). Material and Methods: Thirty patients with PCOS, aged 18~34 years, were recruited. Criteria for diagnosis of PCOS were as defined in 2003 Rotterdam consensus. They were treated for 6 months with pioglitazone at a dose of 30 mg/day orally. The hormonal blood profile, fasting serum glucose levels, a glycemic response to 75 g oral glucose tolerance test (OGTT), and an ovarian stromal artery (OSA) blood flow were assessed at baseline and after 6 months of treatment. Results: Eighteen (60.0%) of 30 patients treated with pioglitazone demonstrated a spontaneous ovulation After pioglitazone treatment, fasting insulin concentrations, serum glucose levels after 75 g OGTT significantly decreased (p=0.001, p=0.04, respectively), and fasting glucose to insulin (G/I) ratio significantly increased (p<0.001). The pioglitazone treatment induced a significant reduction in serum LH, testosterone (T) and free T levels (p<0.001, p=0.02, p=0.002, respectively). The resistance index (RI) values of OSA significantly increased after treatment (p<0.001). In analyzing pioglitazone-treated patients according to their body mass index (BMI), nonobese group as well as obese group showed a significant improvement in fasting G/I ratio (p<0.01). The pioglitazone treatment induced a significant reduction in serum LH and free T levels in nonobese group (p<0.001, p<0.05, respectively) as well as obese group (p=0.001, p<0.05, respectively). The RI values of OSA significantly increased in both nonobese and obese groups after pioglitazone treatment (p<0.001, p=0.003, respectively). Conclusions: Pioglitazone could ameliorate the glycoinsulinemic metabolism, and this beneficial effects of this drug could improve the endocrine-reproductive condition associated with the decrease of ovarian stromal artery blood flow, in both nonobese and obese patients with PCOS.

• 한국응용곤충학회지
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• 제61권4호
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• pp.529-537
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• 2022

시금치의 주요 해충인 흰띠명나방(Spoladea recurvalis) 유충의 살충제 5종에 대한 감수성을 검정하였다. Lufenuron EC, chromafenozide EC, chlorantraniliprole WP, tebufenozide WP, pyridalyl EW는 각각 2(12.5 ppm), 4(12.5 ppm), 8(2.5 ppm), 4(20.0 ppm), 8(12.5 ppm)배의 희석농도에서 90% 이상의 높은 살충활성을 보였다. 추천농도로 경엽처리 후 7일이 경과된 시금치 잎에 흰띠명나방 유충이 72시간 동안 노출되었을 경우 chromafenozide EC, chlorantraniliprole WP, tebufenozide WP, pyridalyl EW의 살충률은 각각 98.3%, 100%, 95.0%, 100%로 나타나 높은 잔효성을 보였다. 흰띠명나방에 대한 방제효과를 2개소(화성, 연천)에서 포장검정 결과, 5종의 약제 모두 2개소에서 약제처리 7일 경과 후 90% 이상의 방제효과를 보였으며 2배량에서도 약해가 없어 향후 흰띠명나방 방제약제로 시금치에 활용이 가능할 것으로 판단된다.

• 한국산림과학회지
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• 제112권1호
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• pp.117-125
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• 2023

2020~2021년 은평구 봉산, 의왕시 청계산 등지에서 돌발적으로 대발생하여 산림에 피해를 주었던 대벌레(Ramulus mikado)의 친환경 방제를 위해 시판 중인 유기농업자재 6종과 산림 내에서 자연폐사한 대벌레에서 분리한 녹강균(Metarhizium anisopliae)의 살충 효과를 검정하였다. 유기농업자재 중에서는 azadirachtin과 geraniol을 포함하는 식물성 오일 3종이 85.2~100%로 높은 치사율이 확인되었으며 이는 화학 살충제인 페니트로티온 유제와 유사한 수준이었다. 녹강균의 분생포자를 희석하여 대벌레의 몸에 직접 분주하거나 사육장 내에서 분무기로 살포한 경우 모두 수일 내 100% 사망하는 것을 확인하였다. 본 연구를 통해 확인된 유기농업자재 3종과 녹강균 등은 향후 친환경 방제제 선발 및 사용 시 우선적으로 고려할 수 있을 것이라 판단된다.

• 한국학교ㆍ지역보건교육학회지
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• 제8권1호
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• pp.43-54
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• 2007

This study aimed at investigating the level of high school students' entrance exam stress and mental health first and also investigating if the entrance exam stress and mental health are related to gender, grade, character type, parenting style and economic status. This is expected to be used as a fundamental data for the development of health education program on high school students' stress and diagnosis of their mental health. To achieve those goals above, the questionnaire was used and the sample consisted of 600 students from general high schools in a large city, C and in a smaller city, A in Chungnam province through questionnaire and the conclusion, which was based on 582 proper questionnaires from the 600 questionnaires, through variable analysis, correlation analysis and multi-regression, is below. First, according to the information provided by respondents, the result showed the relationship between those background variables and the entrance exam stress and mental health level. As the students are more introverted and the parenting style is more authoritative, the entrance exam stress is higher and the mental health level is higher as the parenting style is more authoritative and the economic status is lower. In gender, the entrance exam stress level was high for male students in regard to parents pressure. For female students, it was due to the insufficient free time. In test performance, the good grade group showed high stress level when they don't have enough free time and the poor grade group showed high stress level when they have test tension and poor test performance. In character style, the introverted group showed high stress level in future uncertainty. In parenting style, the authoritative group showed significantly high level in all four sub-factors and there is no significant relationship with the stress level and economic statue. Female students reported higher mental health level than male students in somatization and depression. In academic achievement, the poor grade group showed high level in obsession, fear-anxiety and psychotism. In character style, the introverted group showed high level in sensitivity towards others and depression. And in parenting style, the authoritative group is higher in 9 sub-factors than the other two groups in the factor, economic status. The lower economic status group showed high mental health problem level in this order; in obsession, sensitivity towards others, depression, paranonia and psychotism. Second, the results revealed that there is a significant difference among the groups after comparing and analyzing the relationship between the mental health level according to the three groups, the first, second and third group divided by the degree of entrance exam stress. And the higher the entrance exam stress is, the higher the mental health problem level is. Verification showed that there was obvious difference among the groups. the entrance exam stress was positively correlated with the mental health level. The lack of free time, future uncertainty, test anxiety/poor test performance and parents pressure, these factors, in that order, were correlated with the mental health level. when the prediction variables which influenced on mental health are analyzed, test-anxiety/poor test performance was found to be related to mental health most. And after the factor, test-anxiety, future uncertainty and the lack of free time were listed(ranked), however results did not show any correlation with parents' pressure.