• Title/Summary/Keyword: 바이오 나노

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Rapid Synthesis and Sintering of Nanostructured MgTiO3 Compound by High-Frequency Induction Heating (고주파 유도 가열에 의한 급속 나노구조 MgTiO3 화합물 합성 및 소결)

  • Kang, Hyun-Su;Doh, Jung-Mann;Yoon, Jin-Kook;Park, Bang-Ju;Shon, In-Jin
    • Korean Journal of Metals and Materials
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    • v.50 no.12
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    • pp.891-896
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    • 2012
  • Nanopowders of MgO and $TiO_2$ were made by high energy ball milling. The rapid synthesis and sintering of the nanostructured $MgTiO_3$ compound was investigated by the high-frequency induction heated sintering process. The advantage of this process is that it allows very quick densification to near theoretical density and inhibition grain growth. Nanocrystalline materials have received much attention as advanced engineering materials with improved physical and mechanical properties. As nanomaterials possess high strength, high hardness, excellent ductility and toughness, undoubtedly, more attention has been paid for the application of nanomaterials. A highly dense nanostructured $MgTiO_3$ compound was produced with simultaneous application of 80 MPa pressure and induced current within 2 min. The sintering behavior, gain size and mechanical properties of $MgTiO_3$ compound were investigated.

Surface Modification of Gold Electrode Using Nafion Polymer and Its Application as an Impedance Sensor for Measuring Osmotic Pressure (나피온 폴리머를 이용한 금 전극의 표면 개질 및 이의 삼투압 측정용 임피던스 센서 응용)

  • Min Sik, Kil;Min Jae, Kim;Jo Hee, Yoon;Jinwu, Jang;Kyoung G., Lee;Bong Gill, Choi
    • Applied Chemistry for Engineering
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    • v.34 no.1
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    • pp.9-14
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    • 2023
  • In this work, we developed a Nafion polymer-coated impedance sensor with two gold electrode configurations to measure the ion concentration in solution samples. The gold electrodes were fabricated through the sputtering process, followed by surface modification using Nafion polymer. The resulting sensors enable the prevention of the polarization phenomenon on the electrode surface, resulting in stable measurement of electrochemical signals. Spectroscopy and scanning electron microscopy measurements revealed that the thin film of Nafion was coated uniformly onto the surface of the gold electrode. The Nafion-coated sensor exhibited more stable impedance signals than the conventional gold electrode. It showed a highly reliable calibration curve (R2 = 0.983) of the impedance sensor using a standard sodium chloride solution. In addition, a comparison experiment between the impedance sensor and a commercial conductivity sensor was performed to measure the ion concentration of artificial tears, showing similar results for the two sensors.

Triboelectric Nanogenerator based on Mandarin Peel Powder (감귤 과피 분말 기반 마찰전기 나노발전기 제작)

  • Kim, Woo Joong;Kim, Soo Wan;Park, Sung Hyun;Doh, Yang Hoi;Yang, Young Jin
    • Journal of the Korean Society of Manufacturing Process Engineers
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    • v.21 no.5
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    • pp.9-15
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    • 2022
  • Discarded bio-wastes, such as seeds and rinds, cause environmental problems. Multiple studies have recycled bio-wastes as eco-friendly energy sources to solve these problems. This study uses bio-waste to fabricate a mandarin peel powder based triboelectric nanogenerator (MPP-TENG). The MPP-TENG is based on the contact separation mode. It generates an open-circuit voltage and short-circuit current of 156V and 2µA, respectively. In addition, MPP-TENG shows stable operation over continuous 3000s without any deviation in output. Also, the device exhibits maximum power density of 5.3㎼/cm2 when connected to a resistance of 100MΩ. In an energy storage capacity test for 1000s, the MPP-TENG stores an energy of 171.6µJ in a 4.7µF capacitor. The MPP-TENG can power 9 blue LEDs and 54 green lettering LEDs. These results confirm that the MPP-TENG can provide a new avenue for eco-friendly energy harvesting device fabrication.

Surface modification of Poly-(dimethylsiioxane) using polyelectrolYte multilayers and its characterization (다층의 고분자 전해질을 이용한 Poly-(dimetnylsiloxane)의 표면 개질 및 특성)

  • Shim, Hyun-Woo;Lee, Chang-Hee;Lee, Ji-Hye;Hwang, Taek-Sung;Lee, Chang-Soo
    • KSBB Journal
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    • v.23 no.3
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    • pp.263-270
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    • 2008
  • A poly-(dimethylsiloxane) (PDMS) surface modified by the successive deposition of the polyelectrolytes, poly-(allylamine hydrochloride) (PAH), poly-(diallyldimethylammoniumchloride) (PDAC), poly-(4-ammonium styrenesulfonic acid) (PSS), and poly-(acrylic acid) (PAA), was presented for the application of selective cell immobilization. It is formed via electrostatic attraction between adjacent layers of opposite charge. The modified PDMS surface was examined using static contact angle measurements and fourier transform infrared (FT-IR) spectrophotometer. The wettability of the PDMS surface could be easily controlled and functionalized to be biocompatible through regulation of layer numbers. The modified PDMS surface provides appropriate environment for adhesion to cells, which is essential technology for cell patterning with high yield and viability in the patterning process. This method is reproducible, convenient, and rapid. It could be applied to the fabrication of biological sensing, patterning, microelectronics devices, screening system, and study of cell-surface interaction.

Characteristics of cell culture on the carbon based materials (카본재질의 세포 배양 특성)

  • Nam, Hyo-geun;Oh, Hong-gi;Park, Hye-Bin;Kim, Chang-man;Jhee, Kwang-hwan;Song, Kwang-soup
    • Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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    • 2012.10a
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    • pp.1000-1002
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    • 2012
  • The material with superior biocompatibility and physical-chemical stability is required to fabricate high sensitive biosensors. Many kinds of biomaterials have been evaluated to apply for bioindustry. Recently, carbon based diamond and graphene thin films have been focal pointed as bio applications and their possibility is partially evaluated. Diamond thin film has many advantages for electrochemical and biological applications, such as wide potential window (3.0~3.5V), low background current and chemical-physical stability. And graphene film has many advantages as biomaterial, chemical-physical stability and conductivity. In this work, we have cultured human nerve cell (SH-SY5Y) on the nanocrystalline diamond, mirocrystalline diamond, graphene film and cell culture dish. We use MTT assay to evaluate the characteristics of cell culture on the substrates. As a result, nerve cell is well cultured on the carbon based diamond and graphene films as similar as cell culture dish. We expect that carbon materials have been applied for bioindustry such as biosensors.

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Fabrication and Characteristics of a Highly Sensitive GMR-SV Biosensor for Detecting of Micron Magnetic Beads (미크론 자성비드 검출용 바이오센서에 대한 고감도 GMR-SV 소자의 제작과 특성 연구)

  • Choi, Jong-Gu;Lee, Sang-Suk;Park, Young-Seok
    • Journal of the Korean Magnetics Society
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    • v.22 no.5
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    • pp.173-177
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    • 2012
  • The multilayer structure of glass/Ta(5.8 nm)/NiFe(5 nm)/Cu(t nm)/NiFe(3 nm)/FeMn(12 nm)/Ta(5.8 nm) as typical GMR-SV (giant magnetoresistance-spin valve) films is prepared by ion beam sputtering deposition (IBD). The coercivity and magnetoresiatance ratio are increased and decreased for the decrease of Cu thickness when the thickness of nonmagnetic Cu layer from is varied 2.2 nm to 3.0 nm. It means that the decrease of non-magntic layer is effected to the interlayer exchange coupling of pinned layer and the spin configuration array of free layer. For experiment of detecting and dropping of magnetic beads we used the GMR-SV sensor with glass/Ta/NiFe/Cu/NiFe/FeMn/Ta structure. From the comparison of before and after for the dropping status of magnetic bead, the variations of MR ratio, $H_{ex}$, and $H_c$ are showed 0.9 %, 3 Oe, and 2 Oe, respectively. The fabrication of GMR-SV sensor was included in the process of film deposition, photo-lithography, ion milling, and MR measurement. Further, GMR-SV device can be easily integrated so that detecting biosensor on a single chip becomes possible.

Development of a general purpose molecular simulation system from microscopic to mesoscopic scales (미시영역에서 중간역역까지 적용 가능한 범용 분자 시뮬레이션 시스템의 개발)

  • Oh, Kwang-Jin
    • The KIPS Transactions:PartD
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    • v.12D no.6 s.102
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    • pp.921-930
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    • 2005
  • In this paper, a general purpose molecular simulation system which has been developed by the author, are described. One of the most advantageous features is that the molecular simulation system can handle a coarse-grained model as well as an all-atom mode. Therefore, we can simulate mesoscopic phenomena as well as microscopic phenomena with the help of Langevin dynamics simulation and dissipative particle dynamics simulation techniques. Thus we could study anesthesia, protein folding, biopolymer flow in microchannel with single framework, which spans from microscopic to mesoscopic scales. We expect that we can also simulate many other bio/nano systems of technological importance which are not feasible by means of molecular dynamics simulation technique. Finally, performance data are shown and a bottleneck is identified for future optimization.

SHA-256 based Encapsulated Electronic Medical Record Document Storage System (SHA-256 기반의 캡슐화된 전자의무기록 문서 저장 시스템)

  • Lee, Hyo-Seung;Oh, Jae-Chul
    • The Journal of the Korea institute of electronic communication sciences
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    • v.15 no.1
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    • pp.199-204
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    • 2020
  • With the development of IT. convergence systems are applied and operated in many different fields. A representative field among them is medical service, which develops in diverse types in combination with nano-technology and bio technology. However, there is a lack of technical innovation in terms of medical data operation and management. For example, data and documents are saved and integrated separately depending on their forms when electronic health records or data like SAM files are transmitted or kept. In other cases, such records and data are still kept after being recorded in paper. This study tries to design and implement the EMR system that makes it possible to capsulize forms of data and documents and to digitalize documents in work process as they are in terms of operation and storage. The system is expected to support efficient operation of electronic documents in the aspects of work and management.

질소를 함유한 양친매성 그래핀 양자점 합성

  • O, Ye-Rin;Mun, Byeong-Jun;Sin, Dong-Heon;Kim, Sang-Jin;Lee, Sang-Hyeon;Kim, Tae-Uk;Park, Min;Bae, Su-Gang
    • Proceedings of the Korean Vacuum Society Conference
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    • 2016.02a
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    • pp.352.1-352.1
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    • 2016
  • 양자점은 나노미터 크기의 반도체 결정으로 밴드갭에 따라 광학적, 전기적 성질이 달라지는 독특한 성질을 가지는 형광물질으로 활발히 연구되고 있다. 중금속을 기반으로 한 양자점은 높은 발광효율과 광안전성을 가지며, 가시광선 영역에서 빛을 내는 특징을 가지고 있다. 그러나 중금속을 사용하기 때문에 독성이 있어 인체나 환경에 유해하여 응용 연구에 제한적이다. 반면에, 탄소 기반의 양자점은 중금속 기반의 양자점과 비슷한 성질을 가질 뿐만 아니라, 높은 용해도와 낮은 독성으로 인해 생체적합성이 높다는 장점이 있다. 이를 이용하여 발광다이오드(LEDs), 태양전지, 광촉매 뿐만 아니라 바이오이미징, 바이오센서 등 생물학분야에도 응용 될 수 있다. 본 연구에서는 Bottom-up 합성 방법으로 유기전구체를 이용하여 질소를 함유하고 있는 양친매성 탄소 양자점(N-GQDs)을 합성하였다. 합성에 사용한 유기전구체는 기존에 보고된 유기전구체와 다르게 반응 진행 중에도 pH 측정 결과 중성을 나타내며, 반응 온도($225^{\circ}C$)와 유사한 온도에서도 pH 값은 여전히 6.0 이상의 값을 나타냈다. 중성을 띄는 특징으로 인해 추가적인 산제거 과정이나 표면안정화 과정이 필요 없다는 장점을 가지고 있다. 합성된 N-GQDs는 높은 결정성의 원형구조를 가지며, 원자힘현미경(AFM) 분석을 통해 높이가 ~ 1.5 nm 미만으로 3층 이하의 두께로 형성되었음을 확인하였다. 또한, 적외선 분광법(FT-IR) 분석을 통해 O-H기, 방향족 고리의 C = C (또는 C = N)기 및 C-N기가 각각 ~3250, ~1670과 ~1140 cm-1에서 확인할 수 있다. 합성된 양자점을 유기태양전지의 active layer에 소량(2 wt%) 첨가하여 양자점의 광학적, 전기적 성질을 확인하였다. 비교군 유기태양전지보다 N-GQDs가 첨가된 유기태양전지의 외부양자효율(PCE)이 7.3%에서 8.4%로 약 20%가 증가하는 것을 보였다. 이는 양자점이 상대적으로 흡수가 약한 단파장 영역의 빛을 흡수하고 PL을 내어 active layer로 에너지 트랜스퍼 현상이 일어나 전자전달을 원활하게 해 주기 때문이다. 앞으로 본 연구의 가능성과 추가적인 연구를 통해 더 많은 분야에 응용되기를 기대한다.

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Single Interaction Force of Biomolecules Measured with Picoforce AFM (원자 힘 현미경을 이용한 단일 생분자 힘 측정)

  • Jung, Yu-Jin;Park, Joon-Won
    • Journal of the Korean Vacuum Society
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    • v.16 no.1
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    • pp.52-57
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    • 2007
  • The interaction force between biomolecules(DNA-DNA, antigen-antibody, ligand-receptor, protein-protein) defines not only biomolecular function, but also their mechanical properties and hence bio-sensor. Atomic force microscopy(AFM) is nowadays frequently applied to determine interaction forces between biological molecules and biomolecular force measurements, obtained for example using AFM can provide valuable molecular-level information on the interactions between biomolecules. A proper modification of an AFM tip and/or a substrate with biomolecules permits the direct measurement of intermolecular interactions, such as DNA-DNA, protein-protein, and ligand-receptor, etc. and a microcantilever-based sensor appeared as a promising approach for ultra sensitive detection of biomolecular interactions.