• Journal of the Korean Institute of Intelligent Systems
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• v.19 no.5
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• pp.730-736
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• 2009

It is more important to analysis of huge gemonics data in Bioinformatics. Here we present a novel datamining approach to predict structure and function using protein's primnary structure only. We propose not also to develope n-Block substring search algorithm in reducing enormous search space effectively in relation to feature selection, but to formulate weighted linear algorithm in a prediction of structure and function of a protein using primary structure. And we show efficient in protein domain characterization and classification by calculation weight value in determining domain association in each selected substring, and also reveal that more efficient results are acquired through claculated model score result in an inference about degree of association with each CDS(coding sequence) in domain.

• Journal of Marine Bioscience and Biotechnology
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• v.14 no.1
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• pp.9-24
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• 2022

Low-molecular weight peptides derived from fish collagen exhibit several bioactivities, including antioxidant, antiwrinkle, antimicrobial, antidiabetic, and antihypertension effects. These peptides are also involved in triglyceride suppression and memory improvement. This study aimed to investigate the optimal processing condition for preparing low-molecular weight peptides from flounder skin, and the properties of the hydrolysate. The optimal processing conditions for peptic hydrolysis were as follows: a ratio of pepsin to dried skin powder of 2% (w/w), pH of 2.0, and a temperature of 50℃. Peptic hydrolysate contains several low-molecular weight peptides below 300 Da. Gly-Pro-Hyp(GPHyp) peptide, a process control index, was detected only in peptic hydrolysate on matrix-assisted laser desorption/ionization-time-of-flight(MALDI-TOF) spectrum. 2,2'-azinobis-(3-3-ethylbenzothiazolline-6- sulfonic acid(ABTS) radical scavenging activity of the peptic hydrolysate was comparable to that of 1 mM ascorbic acid, which was used as a positive control at pH 5.5, whereas collagenase inhibition was five times higher with the peptic hydrolysate than with 1 mM ascorbic acid at pH 7.5. However, the tyrosinase inhibition ability of the peptic hydrolysate was lower than that of arbutin, which was used as a positive control. The antibacterial effect of the peptic hydrolysate against Propionibacterium acne was not observed. These results suggest that the peptic hydrolysate derived from a flounder skin is a promising antiwrinkle agent that can be used in various food and cosmetic products to prevent wrinkles caused by ultraviolet radiations.

• Journal of the Korean Society of Food Science and Nutrition
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• v.46 no.11
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• pp.1308-1315
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• 2017

This study was conducted to develop Momordica charantia L. juice fermented by four Lactobacillus species such as Lactobacillus paracasei (LPA), Lactobacillus plantarum (LPL), Lactobacillus rhamnosus (LRH), and Lactobacillus reuteri (LRE) as well as to investigate their inhibitory effects against digestive enzymes and antioxidant activities. Fermentation was performed at $37^{\circ}C$ without nutrient supplementation for 72 h. The pH and total lactic acid contents were within the ranges of 3.75~3.96 and 5.21~10.04% in fermented juices, respectively. The type of starter culture and fermentation time induced changes in flavonoid contents more than total phenolic contents. All juices fermented for 48 h strongly inhibited ${\alpha}$-glucosidase activity with the percentage of inhibition ranging of 91.24~95.05%. Antioxidant activities of all juices mostly increased after 48 h of fermentation. Our results suggest that fermented juice possesses inhibitory activity against digestive enzymes and antioxidant activity, and they can be used as health functional beverages.

• Korean Journal of Food Science and Technology
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• v.34 no.1
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• pp.73-78
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• 2002

Bacillus polyfermenticus SCD, which is commonly called as Bisroot strain, is being used for functional foods through the treatment of long-term intestinal disorders, since the live strains in the form of active endospores can successfully reach the target intestine in both humans and animals. The cells of B. polyfermenticus SCD were treated for 24 h in artifical bile after incubation for 2 h in artificial gastric juice and final number of the strain was reached to around $3.3{times}10^7\;CFU/mL$. In test of API ZYM kit, ${\beta}-glucuronidase$ or ${\beta}-glucosidase$ was not produced by B. polyfermenticus SCD. B. polyfermenticus SCD was resistant to antibiotics, such as nisin, streptomycin, tetracycline, and rifamycin. B. polyfermenticus SCD was also affected by alcohol concentration up to 4%, but more than 8%, their growth was not affected significantly. Finally, B. polyfermenticus SCD was shown to inhibit the growth of Listeria monocytogenes ATCC 19111 completely within 24 h of incubation, which indicated its bactericidal nature.

• Korean Journal of Food Science and Technology
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• v.53 no.1
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• pp.104-110
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• 2021

In this study, vinegar was prepared using black raspberry pomace to increase its utilization capacity. As a result of alcohol fermentation, the final alcohol content was 8.90% and the sugar content was 7.03°Brix. The total acid content after acetic acid fermentation was 4.44%, which was 0.38% higher than that of the juice. Among the organic acid content, the acetic acid content was higher in the pomace than in the juice. The total polyphenol (51.58 TAE mg/mL), total flavonoid (9.55 RUE mg/mL), and total anthocyanin (6.05 CYE mg/mL) contents of vinegar produced using black raspberry residue were higher than those of the juice. In addition, 2,2'-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS) radical scavenging activity, reducing power, and ferric reducing antioxidant power (FRAP) activity were higher than those of the juice, indicating strong antioxidant properties. Thus, black raspberry pomace has excellent acetic acid fermentation ability and high antioxidant activity, indicating that it can be used as a functional fermented vinegar.

• Korean Journal of Food Science and Technology
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• v.54 no.2
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• pp.115-125
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• 2022

Flavonoids are bioactive plant metabolites that have a range of beneficial effects on human health. Quercetin 4'-glycoside (Q4'G), quercetin 3,4'-diglycoside (Q3,4'G), and quercetin aglycone (QA) are the main flavonoids found in onions. QA, in particular, is likely to have a greater biological effect than glycosides. To develop an onion extract with high quercetin content, the optimal extraction conditions for red onion powder containing the outer layer of the onion were determined. The effects of acid treatment on the concentration of quercetin glycosides and QA were evaluated. The flavonoids of red onion powder were optimally extracted under 60-70% ethanol at 70℃ for 2 h. The deglycosylation of Q3,4'G and an increase in Q4'G content occurred within 6 h of 0.2% acetic acid treatment. The QA content and deglycosylation of Q4'G eventually peaked at 24 h. In addition, QA content and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity were highly correlated, with a correlation coefficient of 0.90.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.37 no.2
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• pp.37-57
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• 2024

Objectives : The purpose of this study is to evaluate the efficacy and safety of hair Ampoules with Malva Verticillata Seed Extract in alopecia patients. Methods : This 24-week clinical study enrolled 70 patients with Alopecia. A series of clinical examinations, subjects were evaluated at 0, 8, 16 and 24-week, counting of the number of hairs on the crown, and subject survey after using the Ampoules. Results : The clinical evaluation showed a significantly difference (p<0.05) after 24 weeks of product use compared to the baseline in the change in hair count in the treatment group compared to the control group within and between groups. It showed greater improvement in the treatment group than in the control group in hair count, hair thickness, and hair loss symptoms in the top of the head and forehead. No severe adverse events were observed during the clinical trial. Counclusions : This suggests that this hair ampoules containing Malva Verticillata Seed Extract could help prevent hair loss in alopecia patients without inducing side effects.

• Proceedings of the Korean Information Science Society Conference
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• 2005.11a
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• pp.178-180
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• 2005

최근 센서네트워크에서는 코드 분배과 같이 신뢰성 있는 전송을 요구하는 새로운 기능들이 추가 되고 있다. 이를 위한 기존의 프로토콜은 센서노드 간의 높은 전송 실패율 때문에 홉간 손실 복구 기법을 제안하였다. 하지만 기존 프로토콜은 홉간 손실 복구를 위해 종단간 세션의 정보를 사용하기 때문에 모든 중간 노드들이 최근 받은 패킷의 순서 번호 같은 정보를 알고 있어야만 한다. 만약, 세션 중간에 경로가 바뀌어서 새로운 노드가 참가하게 된다면 기존 프로토콜은 잘 동작할 수가 없다. 본 논문은 홉간 순서 번호 기반의 손실 복구 기법인 HRS를 제안한다. 홉간 손실 복구에서는 종단간 세션의 순서 번호 대신에 홉간 순서 번호가 사용되기 때문에 중간 노드는 종단간 세션의 정보 없이도 손실복구에 바로 참가 할 수 있다. 시뮬레이션을 통해 제안하는 기법이 세션 중간에 경로 변화와 상관없이 잘 동작하고 경로 변화가 없더라도 기존의 프로토콜보다 대부분의 기준에서 우수하다는 것을 보였다.

• Proceedings of the KIPE Conference
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• 2007.11a
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• pp.202-205
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• 2007

현재 태양광, 풍력 및 연료전지 즉, 신재생에너지를 많이 사용하게 됨으로써 이를 계통과 병렬로 연결하여 쓰고 있다. 그러나 계통에 연결할 경우 여러 가지 문제가 발생할 수가 있는데 그중에서 대표적으로 단독운전을 들 수가 있다. 이를 방지하기 위한 검출기능은 시스템의 안전성 및 전기적 안전성 측면에서 매우 중요하다. 본 연구에서는 단독운전 검출을 위한 RPV 방식 및 제어알고리즘을 제안하였으며, 계통의 전압 위상을 기준으로 전류위상각도에 따른 주파수 변동 특성을 해석하였다. 해석 및 제안된 방법의 타당성은 EMTP 및 Matlab 을 이용하여 검증하였다.

• Proceedings of the Korean Information Science Society Conference
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• 2003.10c
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• pp.46-48
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• 2003

인터넷 비즈니스(e­Business)가 보편화되면서 다양하고 복잡한 서비스들이 제공되고 있다. 이러한 서비스들은 주로 정적 컨텐트를 사용했던 종전의 서비스와는 달리, 동적 컨텐트를 사용하여 급변하는 사용자의 요구에 부응하고자 한다. 하지만 동적 컨텐트는 정적 컨텐트에 비해 많은 시스템 자원을 필요로 하여 전체 시스템의 부하를 높이는 주요 원인으로 지적되고 있다. 한편, 서비스의 수요는 그 예측이 매우 어렵기 때문에 순간적으로 급증하는 수요에도 안정적인 서비스를 제공하는 방법이 시급히 요구되고 있다. 따라서 본 논문에서는 동적 확장성(dynamic scalability)을 제공하는 WADN 시스템을 제안한다. WADN은 서버의 부하를 검사하여, 이를 바탕으로 전체 서버의 수를 탄력적으로 조정한다. 그리고 요청된 애플리케이션을 자동으로 수정하는 기능을 구현하여 새로운 서버에 전송되면 바로 실행 될 수 있도록 하였다. WADN을 이용하면 인터넷에 있는 유휴 자원들을 효과적으로 이용할 수 있고, 시스템 관리자가 적은 비용으로 안정적인 서비스를 제공할 수 있다.