• Korean Chemical Engineering Research
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• v.48 no.5
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• pp.545-555
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• 2010

Recently, droplet-based microfluidic systems are widely used in various areas ranging from fundamental science including chemistry, biology, and physics to material science and engineering. This article reviews recent development in the droplet based microfluidic system from basic fabrication of tiny device, principle of droplet formation, merging, mixing, control of droplets, and application for the synthesis of novel functional materials. We discuss strong advantages of the droplet based microfluidics in point of control of particle size, morphologies, shapes, and structures.

• Korean Chemical Engineering Research
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• v.52 no.2
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• pp.141-153
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• 2014

Droplet based microfluidic systems have been developed for the application of biological and chemical research field. A picoliter droplet in microfluidic device provides a compartmentalized and well-defined reactor in miniaturized system. The microfluidic system with small droplets can reduce reagent cost and enhance efficiency through automated high-throughput screening system. In this review, we summarize the functionality of droplet based microfluidic system including droplet generation, precise droplet control, and various applications. In addition, this article reviews current applications in chemistry and biology, and discuss advantages of droplet based microfluidics compared with conventional manner.

• Proceedings of the KIEE Conference
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• 2005.11a
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• pp.116-118
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• 2005

열공압 방식으로 동작하는 마이크로 펌프와 밸브가 집적된 (polydimethylsiloxane)PDMS 미 세 유체 시스템을 제작하였다. 본 실험에서 제안한 미세 유체 시스템은 PDMS 마이크로 채널, PDMS membrane, 열공압 챔버, indium tin oxide(ITO) 히터로 구성되어 있다. 마이크로 펌프의 경우 가해주는 펄스 전압의 변화를 통해 유속을 최적화 하였고 마이크로 밸브의 경우 가해주는 직류 전압을 변화시켜 유체의 흐름을 제어할 수 있었다. 미세 유체 시스템의 최적화된 조건은 마이크로 펌프의 경우 duty 4%와 주파수 4Hz에서 최대 pumping rate을 나타냈고 그때의 pumping rate 68nl/min이었다. 마이크로 밸브의 유체를 closing 전력은 450mW이었다.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2003.10a
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• pp.38-38
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• 2003

• Journal of the KSME
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• v.50 no.11
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• pp.39-42
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• 2010

이 글에서는 미세유체시스템을 이용하여 암의 전이과정을 분석하고 관련된 치료제 및 기술을 개발하는 다양한 연구 성과에 대해 소개하고자 한다.

• Proceedings of the Korea Contents Association Conference
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• 2015.05a
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• pp.229-230
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• 2015

신생혈관 형성은 기존에 존재하는 혈관으로부터 새로운 혈관을 형성하는 기작으로 정상 세포에서 상처 치유, 세포의 발생 및 성장에 관여한다고 알려져 있다. 더 중요한 것은 이 기작이 암의 성장 및 전이에서도 매우 중요한 역할을 하고 있다는 사실이다. 특히, 엔지오제닌(Angiogenin)이 신생혈관형성을 촉진하는 것으로 알려져있다. 이러한 주요 물질을 최신 바이오칩 기술 중 하나인 액적 기반 미세유체 시스템을 활용하여 1 나노리터 수준의 시료 내에 존재하는 엔지오제닌을 정량하는 기술을 개발함으로써 현재 일반적으로 사용되고 있는 정량 기술에 비해 시간뿐만 아니라 비용을 절감할 수 있음을 보여주었다. 이외에도 본 연구에서 개발한 액적 기반 미세유체 시스템 기술은 수은과 같은 중금속의 검출도 가능하기 때문에 환경 센서로의 활용 가능성을 보여준다.

• Korean Chemical Engineering Research
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• v.50 no.4
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• pp.733-737
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• 2012

This study reports the microfluidic preparation of monodisperse multiple emulsions using hydrodynamic control. To generate multiple emulsions, we fabricate a microfluidic capillary device based on co-flowing stream without any surface modification of microchannels. Based on the system, we can successfully generate multiple emulsions (W/O/W) using water containing 0.5 wt% Tween 20, n-hexadecane with 5 wt% Span 80, and 10 wt% poly (vinyl alcohol) (PVA) aqueous solution, respectively. Furthermore, we control the number of inner droplets by modulation of flow rate of inner fluid at fixed flow rate of middle and outer fluid. The multiple emulsions having precisely controlled inner droplets' size and number can be applicable for multiple chemical reactions as an isolated microreactor.

• Korean Chemical Engineering Research
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• v.53 no.4
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• pp.472-477
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• 2015

This study presents modified microfluidic picoinjector combined Faraday moat with silver nanoparticle electrode to increase electrical efficiency and fabrication yield. We perform simple dropping procedure of silver nanoparticles near the picoinjection channel, which solve complicate fabrication process of electrode deposition onto the microfluidic picoinjector. Based on this approach, the microfluidic picoinjector can be reliably operated at 180 V while conventional Faraday moat usually have performed above 260 V. Thus, we can reduce the operation voltage and increase safety. Furthermore, the microfluidic picoinjector is able to precisely control injection volume from 7.5 pL to 27.5 pL. We believe that the microfluidic picoinjector will be useful platform for microchemical reaction, biological assay, drug screening, cell culture device, and toxicology.

• Korean Chemical Engineering Research
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• v.62 no.1
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• pp.105-111
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• 2024

The SLA (Stereolithography Apparatus) method is a type of 3D printing technique predicated on the transformation of liquid photocurable resin into a solid form through UV laser exposure, and its application is increasing in various fields. In this study, we conducted research to enhance the hydrophobicity and transparency of SLA 3D printing surfaces for microfluidic system production. The enhancement of surface hydrophobicity in SLA outputs was attainable through the application of hydrophobic coating methods, but the coating durability under different conditions varied depending on the type of hydrophobic coating. Additionally, to simultaneously achieve the required transparency and hydrophobic properties for the fabrication of microfluidic systems, we applied hydrophobic coatings to the proposed transparency enhancement method from prior research and compared the changes in contact angles. Teflon coating was proposed as a suitable hydrophobic coating method for the fabrication of microfluidic systems, given its excellent transparency and high coating durability in various environmental conditions, in comparison to titanium dioxide coating. Finally, we produced an Electrophoresis of Charged Droplet (ECD) chip, one of the digital microfluidics systems, using SLA 3D printing with the proposed Teflon coating method (Fluoropel 800). Droplet manipulation was successfully demonstrated with the fabricated chip, confirming the potential application of SLA 3D printing technology in the production of microfluidic systems.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.17 no.2
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• pp.447-452
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• 2013

Microfluidic devices can offer precise control for a verity of tasks involving biological specimen. In this paper, we propose an integrated system consisting of a microfluidic device along with a digital holographic microscope and present three-dimensional (3D) sensing and segmentation of biological microorganisms. When the individual microorganisms are inputted into the microfluidic channel, the holographic microscope records their holograms. The holograms are computationally reconstructed in 3D using Fresnel transform and the reconstructed phase images are used to search the position of microorganisms. Optical experiments are carried out and experimental results are presented to illustrate the usefulness of the proposed system.